| Primary information |
|---|
| ID | 1180 |
| Peptide Name | Immunosuppressive epitope of retroviral plSE |
| Sequence | not available |
| Length | 17 |
| Chirality | L |
| N-terminal Modification | None |
| C-terminal Modification | None |
| Chemical Modification | None |
| Linear/ Cyclic | Linear |
| Nature | Protein Derived |
| Source of Origin | Retroviral protein pl5E |
| Target | IL-2, TNF-α, protein kinase-C |
| Mechanism of Action | Inhibits human mitogen and alloantigen-stimulated lymphocyte proliferation, natural killer cell activity, interleukin 1-mediated monocyte tumor killing, interleukin 2 production, immunoglobulin synthesis, TNF-α mRNA expression and protein kinase C activity |
| In vitro/In vivo | Both |
| Cell Line | U937, P2, JLS-V5 |
| Inhibition Concentartion | NA |
| In vivo Model | BALB/c mice (Female, 12- week-old) |
| Assay | NA |
| Lethal Dose | NA |
| Combination Therapy | NA |
| Pubmed ID | 7511054 |
| Year of Publication | 1994 |
| 3-D Structure | NA |
