| Primary information |
|---|
| ID | 1110 |
| Peptide Name | H17 |
| Sequence | LQNRRGLDLLTAEKGGL |
| Length | 17 |
| Chirality | L |
| N-terminal Modification | None |
| C-terminal Modification | Amidation |
| Chemical Modification | None |
| Linear/ Cyclic | Linear |
| Nature | Protein Derived |
| Source of Origin | Human endogenous retroviruses HERV-H/env60 (HERV-H) |
| Target | NA |
| Mechanism of Action | Induces CCL19 production in tumor cells, promotion of both CD271+ cell-governing immunosuppression and tumor invasion via the Twist-PI3K pathway. |
| In vitro/In vivo | Both |
| Cell Line | Colon cancer Colo320 and HCT116,pancreatic cancer MIAPaca and Panc1,melanoma Hs294T, andnormal epithelial cell ARPE19 |
| Inhibition Concentartion | NA |
| In vivo Model | Female BALB/c nu/nu mice |
| Assay | WST1 assay |
| Lethal Dose | NA |
| Combination Therapy | NA |
| Pubmed ID | 24590808 |
| Year of Publication | 2014 |
| 3-D Structure |  View in Jmol or Download Structure |
