Primary information |
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ID | 1060 |
Peptide Name | Margatoxin |
Sequence | TIINVKCTSPKQCLPPCKAQFGQSAGAKCMNGKCKCYPH |
Length | 39 |
Chirality | L |
N-terminal Modification | None |
C-terminal Modification | None |
Chemical Modification | None |
Linear/ Cyclic | Linear |
Nature | Natural |
Source of Origin | From venom of the new world scorpion Centruroides margaritatus |
Target | Kv1.3 channels |
Mechanism of Action | Blocks with high affinity and specificity the Kv1.3 channel |
In vitro/In vivo | In vitro |
Cell Line | Human peripheral T-Lymphocytes, rat brain synaptic plasma membrane vesicles, bovine aortic sarcolemmal membrane vesicle |
Inhibition Concentartion | 36 pM |
In vivo Model | NA |
Assay | competition binding with Kv1.3 (Potassium channel) |
Lethal Dose | NA |
Combination Therapy | NA |
Pubmed ID | 8360176 |
Year of Publication | 1993 |
3-D Structure | View in Jmol or Download Structure |