1392 | SEQ ID19 | RSCIDTIPKSQCTAFQCKHSXKYRLSFCRKTCGTC | 35 | L | None | None | X = norleucine (nL) | Linear | Natural | Shk toxin of S.helianthus | T Lymphocytes Kv1.3 channels | By blocking the potassium channel, Kv1.3 of T lymphocytes | Both | Peripheral blood human lymhocytes | 1 nM | CD18-nullPL/J mice | Enzyme-linked immunosorbent assay (ELISA), HPLC | NA | Charybdotoxin (ChTX) | US 6077680 | 2000 |
1394 | SEQ ID21 | RSCIDTIPKSRCTAFQCKHSMXYRLSFCRKTCGTC | 35 | L | None | None | X = norleucine (nL) | Linear | Natural | Shk toxin of S.helianthus | T Lymphocytes Kv1.3 channels | By blocking the potassium channel, Kv1.3 of T lymphocytes | Both | Peripheral blood human lymhocytes | 1 nM | CD18-nullPL/J mice | Enzyme-linked immunosorbent assay (ELISA), HPLC | NA | Charybdotoxin (ChTX) | US 6077680 | 2000 |
1463 | SEQ ID35 | R-nL-nL-nL-R-nL-nL-nLGY | 10 | L | Acetylation | Amidation | nL = norleucine | Linear | Protein Derived | (HLA-B) α1-domain | NA | Inhibited T-cell proliferation, various inflammatory cytokines production. | Both | RAW264.7 macrophages cells | NA | CBA mice | Enzyme-linked immunosorbent assay (ELISA) | NA | LPS | US 6696545 B1 | 2004 |
1493 | SEQ ID1 | r-nL-nL-nL-r-nL-nL-nLgy | 10 | D | None | None | nL = norleucine | Linear | Protein Derived | (HLA-B) α1-domain | Gut Associated Lymphoid Tissue (GALT) | Increased CD4+ and CD8+ T-cells | In vivo | None | NA | Rhesus macaques | NA | NA | NA | US 7094413 B2 | 2006 |
1520 | SEQ ID13 | r-nL-nL-nL-r-nL-nL-nLGy | 10 | Mix | Acetylation | Amidation | nL = norleucine | Linear | Synthetic | NA | NA | Inhibited T-cell proliferation, various inflammatory cytokines production. | In vivo | None | 2.5-10micromolar against binding to peptides to HSC95 | C57BL6/J, Balb/c and CBA/J mice | Enzyme-linked immunosorbent assay (ELISA) | NA | LPS | US 7267822 B2 | 2007 |