Welcome to Sequence Card of Peptide
Details of CPPsite entry with Sequence RRRRRRRRRRR |
| Primary information | |
|---|---|
| PEPTIDE SEQUENCE | RRRRRRRRRRR |
| CPPsite ID | 2062, 2068, 2130, 2472, 2473, 2474, 2476, 2621, 2684, 2688, 1036, 1809, |
| PEPTIDE NAME | R11, R11, poly-arginine, Cys(BSH)-Arg11-NH2, Cys(BSH)-Lys[Cys(BSH)-]Arg11-NH2, [Cys(BSH)]4-(Lys)3-Arg11-NH2, Cys(BSH)-R11, R11, TMR-R11, p53-R11, R10, R11 |
| CHIRALITY | L, L, L, L, L, L, L, L, L, L, L, L |
| LINEAR/CYCLIC | Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear |
| SOURCE | Synthetic, Synthetic, Synthetic, Synthetic, Synthetic, Synthetic, Synthetic, Synthetic, Synthetic, Synthetic, Synthetic, Synthetic |
| CATEGORY | NA, Cationic, Cationic, Cationic, Cationic, Cationic, Cationic, Cationic, Cationic, Cationic, Cationic, Cationic |
| SUB CELLULAR LOCALIZATION | NA, Cytosol, Cytoplasm and Nucleus, Cytoplasm and Nucleus, Cytoplasm and Nucleus, Cytoplasm and Nucleus, Cytoplasm, Cytoplasm, Cytoplasm, NA, Probably cytoplasm and nucleus, Unknown |
| N-TERMINAL MODIFICATION | Free, Free, Free, Addition of cysteine and BSH, Addition of cysteine and BSH, Addition of cysteine and BSH, Addition of cysteine and BSH, Conjugation with FITC, Conjugation with TMR, Conjugated to p53, Free, Conjugation with rhodamine B |
| C-TERMINAL MODIFICATION | Free, Free, Conjugation with 6His-tag, Amidation, Amidation, Amidation, NA, NA, NA, NA, Conjugation with fluorescein by C-terminal Gly Cys amide, Free |
| CHEMICAL MODIFICATION | Histidine tagged, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA |
| UPTAKE EFFICIENCY | NA, NA, It recognized the cis-acting DNA TFBS and promoted the downstream gfp gene to be con- stitutively expressed as expected, Higher uptake efficiency, Lower uptake efficiency than 8BSH-11R, Lower uptake efficiency than 8BSH-11R, Lower uptake efficiency than 8BSH-11R, NA, NA, NA, High, less than R8, Greater than pAntp, Tat and transportan |
| PROPOSED UPTAKE MECHANISM | NA, NA, NA, NA, NA, NA, NA, NA, lipid raft dependent macropinocytosis, NA, Non-endocytic pathway, Unknown |
| INVITRO/INVIVO | In vitro, In vitro, In vitro, In vitro and in vivo, In vitro and in vivo, In vitro and in vivo, In vitro and in vivo, In vitro, In vitro, In vitro, In vitro, In vitro |
| CELL LINE | Skin with Franz diffusion cells, A549, Primary cell cultures were initiated from spermary tissue of T. rubripes, U87 DEGFR and PA U87 glioma, U87 DEGFR and PA U87 glioma, U87 DEGFR and PA U87 glioma, U87 DEGFR and PA U87 glioma, HEK and HeLa cells, U251-MG, HeLa, HEK293 cells, LNZ308, K562 cells, Primary rat fibroblasts cells and U87 cells, LNZ308 cells, RAW 264.7, CHO K1, HeLa, A549 cells |
| In VIVO MODEL | Porcine ear skin, NA, NA, Female nude mice (15e20 g, BALB/c Slc-nu/nu), Female nude mice (15e20 g, BALB/c Slc-nu/nu), Female nude mice (15e20 g, BALB/c Slc-nu/nu), Female nude mice (15e20 g, BALB/c Slc-nu/nu), NA, NA, NA, NA, NA |
| CARGO | Nanoparticles [Nanostructured lipid carriers (NLC) and Ibuprofen (Ibu)], Nucleic acid (pDNA), Protein (Oct-4 protein), BSH, BSH, BSH, BSH, Fluorophore (FITC), Fluorophore (TMR), Protein (p53), Fluorophore (fluorescein), Fluorophore (rhodamine) |
| PMID | 23187866, 23534410, 25199543, 24452095, 24452095, 24452095, 24452095, 22076844, 22465335, 22465335, 11084031, 15937518 |
| PATENT | Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown |
| Tertiary Structure (Technique) | 2062 (PEPstrMOD), 2068 (PEPstrMOD), 2130 (PEPstrMOD), 2472 (PEPstrMOD), 2473 (PEPstrMOD), 2474 (PEPstrMOD), 2476 (PEPstrMOD), 2621 (PEPstrMOD), 2684 (PEPstrMOD), 2688 (PEPstrMOD), 1036 (PEPstrMOD), 1809 (PEPstrMOD), |