Details of CPPsite entry with Sequence MVTVLFRRLRIRRACGPPRVRV |
Primary information | |
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PEPTIDE SEQUENCE | MVTVLFRRLRIRRACGPPRVRV |
CPPsite ID | 2157, 3000, 3009, 1447, |
PEPTIDE NAME | M918, Pepfect 2, M918, M918 |
CHIRALITY | L, Modified, L, L |
LINEAR/CYCLIC | Linear, Linear, Linear, Linear |
SOURCE | Synthetic, Synthetic, Synthetic, Protein derived |
CATEGORY | NA, NA, NA, Amphipathic |
SUB CELLULAR LOCALIZATION | NA, NA, NA, Vesicles |
N-TERMINAL MODIFICATION | Free, Stearylation, NA, Conjugation with fluorescein |
C-TERMINAL MODIFICATION | Free, Amidation, Amidation, Amidation |
CHEMICAL MODIFICATION | NA, NA, NA, NA |
UPTAKE EFFICIENCY | NA, NA, NA, Higher than Penetratin |
PROPOSED UPTAKE MECHANISM | Endocytosis, Endocytosis, Endocytosis, Mainly via endocytic process,and in particular macropinocytosis, but independent of glycosaminoglycans on the cell surface |
INVITRO/INVIVO | In vitro, In vitro, In vitro, In vitro |
CELL LINE | HT-29-luc cells, HeLa cells, HeLa cells, HeLa, MCF-7, CHO K1, and Hifko cells |
In VIVO MODEL | NA, NA, NA, NA |
CARGO | PNA, Nucelic acid (pGL3 plasmid, SCO), Nucleic acid (SCO), Fluorophore (fluorescein) |
PMID | 25185512, 17622242 |
PATENT | Unknown, US 2014/0140929 A1, US 2014/0140929 A1, Unknown |
Tertiary Structure (Technique) | 2157 (PEPstrMOD), 3000 (PEPstrMOD), 3009 (PEPstrMOD), 1447 (PEPstrMOD), |