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This page gives details of CPPsite entry with ID 1447
Primary information
CPPsite ID1447
PEPTIDE SEQUENCEMVTVLFRRLRIRRACGPPRVRV
PEPTIDE NAMEM918
CHIRALITYL
LINEAR/CYCLICLinear
SOURCEProtein derived
CATEGORYAmphipathic
SUB CELLULAR LOCALIZATIONVesicles
N-TERMINAL MODIFICATIONConjugation with fluorescein
C-TERMINAL MODIFICATIONAmidation
UPTAKE EFFICIENCYHigher than Penetratin
PROPOSED UPTAKE MECHANISMMainly via endocytic process,and in particular macropinocytosis, but independent of glycosaminoglycans on the cell surface
INVITRO/INVIVOIn vitro
CELL LINEHeLa, MCF-7, CHO K1, and Hifko cells
CARGOFluorophore (fluorescein)
PMID17622242
PATENTUnknown
LENGTH22
Secondary StructureCTTTTGGGGGGTTSCSSTTTCC
SMILESN[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](C)C(=O)N[C@@H](CS)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](C(C)C)C=O
Tertiary Structure
(Technique)		View in Jmol  OR Download Structure
  (PEPstrMOD)