Details of CPPsite entry with Sequence KGRKKRRQRRRPPQ |
Primary information | |
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PEPTIDE SEQUENCE | KGRKKRRQRRRPPQ |
CPPsite ID | 2478, 2479, |
PEPTIDE NAME | d-NTD, q-NTD |
CHIRALITY | L, L |
LINEAR/CYCLIC | Linear, Linear |
SOURCE | Protein derived, Protein derived |
CATEGORY | Cationic, Cationic |
SUB CELLULAR LOCALIZATION | Lysosome, Lysosome |
N-TERMINAL MODIFICATION | Acetylation, Acetylation |
C-TERMINAL MODIFICATION | Amidation, Amidation |
CHEMICAL MODIFICATION | Doxorubicin is attached by a cathepsin B degradable tetrapeptide linker (-Gly-Phe-Leu-Gly-)., Doxorubicin is attached by a cathepsin B degradable tetrapeptide linker (-Gly-Phe-Leu-Gly-). |
UPTAKE EFFICIENCY | d-NTD is the most potent conjugate against HepG2 human liver cancer cells, q-NTD accumulated most effectively within cancer cells |
PROPOSED UPTAKE MECHANISM | Endocytic pathway, Endocytic pathway |
INVITRO/INVIVO | In vitro, In vitro |
CELL LINE | HepG2, HepG2 |
In VIVO MODEL | NA, NA |
CARGO | Small molecule drug (Doxorubicin), Small molecule drug (Doxorubicin) |
PMID | 24892976, 24892976 |
PATENT | Unknown, Unknown |
Tertiary Structure (Technique) | 2478 (PEPstrMOD), 2479 (PEPstrMOD), |