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This page gives details of CPPsite entry with ID 2478
Primary information
CPPsite ID2478
PEPTIDE SEQUENCEKGRKKRRQRRRPPQ
PEPTIDE NAMEd-NTD
CHIRALITYL
LINEAR/CYCLICLinear
SOURCEProtein derived
CATEGORYCationic
SUB CELLULAR LOCALIZATIONLysosome
N-TERMINAL MODIFICATIONAcetylation
C-TERMINAL MODIFICATIONAmidation
CHEMICAL MODIFICATIONDoxorubicin is attached by a cathepsin B degradable tetrapeptide linker (-Gly-Phe-Leu-Gly-).
UPTAKE EFFICIENCYd-NTD is the most potent conjugate against HepG2 human liver cancer cells
PROPOSED UPTAKE MECHANISMEndocytic pathway
INVITRO/INVIVOIn vitro
CELL LINEHepG2
CARGOSmall molecule drug (Doxorubicin)
PMID24892976
PATENTUnknown
LENGTH14
Secondary StructureCHHHHTTTTSSCCC
SMILESN[C@@H](CCCC[NH3])C(=O)NCC(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)N)C=O
Tertiary Structure
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  (PEPstrMOD)