Welcome to Sequence Card of Peptide
Details of CPPsite entry with Sequence Cyclo (FΦRRRRQ) |
| Primary information | |
|---|---|
| PEPTIDE SEQUENCE | Cyclo (FΦRRRRQ) |
| CPPsite ID | 2240, 2241, 2243, 2244, 2245, 2246, 2247, 2251, 2252, 2253, 2254, 2255, 2256, |
| PEPTIDE NAME | cFΦR4-Rho, cFΦR4-Dex, cFΦR4-FITC, cFΦR4-R5, cFΦR4-A5, cFΦR4-F4, cFΦR4-PCP, bicyclo(FΦR4-A5)Rho, bicyclo(FΦR4-A7)Rho, bicyclo(FΦR4-RARAR)Rho, bicyclo(FΦR4-DADAD)Rho, monocyclo(FΦR4-A5)Rho, monocyclo(FΦR4-A7)Rho |
| CHIRALITY | Modified, Modified, Modified, Modified, Modified, Modified, Modified, Modified, Modified, Modified, Modified, Modified, Modified |
| LINEAR/CYCLIC | Cyclic, Cyclic, Cyclic, Cyclic, Cyclic, Cyclic, Cyclic, Cyclic, Cyclic, Cyclic, Cyclic, Cyclic, Cyclic |
| SOURCE | Synthetic, Synthetic, Synthetic, Synthetic, Synthetic, Synthetic, Synthetic, Synthetic, Synthetic, Synthetic, Synthetic, Synthetic, Synthetic |
| CATEGORY | Amphipathic, Amphipathic, Amphipathic, Amphipathic, Amphipathic, Amphipathic, Amphipathic, Amphipathic, Amphipathic, Amphipathic, Amphipathic, Amphipathic, Amphipathic |
| SUB CELLULAR LOCALIZATION | Cytoplasm and Nucleus, Cytoplasm and Nucleus, Cytoplasm and Nucleus, Cytoplasm and Nucleus, Cytoplasm and Nucleus, Cytoplasm and Nucleus, Cytoplasm and Nucleus, Cytoplasm and Nucleus, Cytoplasm and Nucleus, Cytoplasm and Nucleus, Cytoplasm and Nucleus, Cytoplasm and Nucleus, Cytoplasm and Nucleus |
| N-TERMINAL MODIFICATION | Free, Free, Free, Free, Free, Free, Free, Free, Free, Free, Free, Free, Free |
| C-TERMINAL MODIFICATION | Amidation, Amidation, Amidation, Amidation, Amidation, Amidation, Amidation, Amidation, Amidation, Amidation, Amidation, Amidation, Amidation |
| CHEMICAL MODIFICATION | ?, L-2-naphthylalanine, ?, L-2-naphthylalanine, ?, L-2-naphthylalanine, ?, L-2-naphthylalanine, ?, L-2-naphthylalanine, ?, L-2-naphthylalanine, ?, L-2-naphthylalanine,miniPEG, 8-amino-3,6-dioxaoctanoic acid, ?, L-2-naphthylalanine, J, l-2,3-diaminopropionic acid, Tm, trimesoyl, ?, L-2-naphthylalanine, J, l-2,3-diaminopropionic acid, Tm, trimesoyl, ?, L-2-naphthylalanine, J, l-2,3-diaminopropionic acid, Tm, trimesoyl, ?, L-2-naphthylalanine, J, l-2,3-diaminopropionic acid, Tm, trimesoyl, ?, L-2-naphthylalanine, ?, L-2-naphthylalanine |
| UPTAKE EFFICIENCY | Higher efficiency, Higher efficiency, Higher efficiency than Tat and R9, NA, NA, NA, Higher efficiency, Higher efficiency, Higher efficiency, Higher efficiency, Higher efficiency, Lower efficiency than bicyclic, Lower efficiency than bicyclic |
| PROPOSED UPTAKE MECHANISM | Endocytic pathway, Endocytic pathway, Endocytic pathway, Endocytic pathway, Endocytic pathway, Endocytic pathway, Endocytic pathway, Endocytic pathway, Endocytic pathway, Endocytic pathway, Endocytic pathway, Endocytic pathway, Endocytic pathway |
| INVITRO/INVIVO | In vitro, In vitro, In vitro, In vitro, In vitro, In vitro, In vitro, In vitro, In vitro, In vitro, In vitro, In vitro, In vitro |
| CELL LINE | HEK293, HeLa, MCF-7, NIH 3T3, A549, Jurkat, H1650, and H1299 cells, HEK293, HeLa, MCF-7, NIH 3T3, A549, Jurkat, H1650, and H1299 cells, HEK293, HeLa, MCF-7, NIH 3T3, A549, Jurkat, H1650, and H1299 cells, HEK293, HeLa, MCF-7, NIH 3T3, A549, Jurkat, H1650, and H1299 cells, HEK293, HeLa, MCF-7, NIH 3T3, A549, Jurkat, H1650, and H1299 cells, HEK293, HeLa, MCF-7, NIH 3T3, A549, Jurkat, H1650, and H1299 cells, HEK293, HeLa, MCF-7, NIH 3T3, A549, Jurkat, H1650, and H1299 cells, HEK293, HeLa, MCF-7, NIH 3T3, A549, Jurkat, H1650, and H1299 cells, HEK293, HeLa, MCF-7, NIH 3T3, A549, Jurkat, H1650, and H1299 cells, HEK293, HeLa, MCF-7, NIH 3T3, A549, Jurkat, H1650, and H1299 cells, HEK293, HeLa, MCF-7, NIH 3T3, A549, Jurkat, H1650, and H1299 cells, HEK293, HeLa, MCF-7, NIH 3T3, A549, Jurkat, H1650, and H1299 cells, HEK293, HeLa, MCF-7, NIH 3T3, A549, Jurkat, H1650, and H1299 cells |
| In VIVO MODEL | NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA |
| CARGO | Fluorophore (Rhodamine), Protein (GFP), Dexamethasone, Fluorophore (FITC), Peptide (RRRRR), Peptide (AAAAA), Peptide (FFFF), Peptide [PCP, miniPEG-DE(pCAP)LI-NH2], Cyclic peptide (Tm(AAAAA)), Cyclic peptide Tm(AAAAAAA)K, Cyclic peptide Tm(RARAR)K, Cyclic peptide Tm(DADAD)K, Peptide AAAAA, Peptide AAAAAAA |
| PMID | 24896852, 24896852, 24896852, 24896852, 24896852, 24896852, 24896852, 24896852, 24896852, 24896852, 24896852, 24896852, 24896852 |
| PATENT | Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown |
| Tertiary Structure (Technique) | Not Predicted), Not Predicted), Not Predicted), Not Predicted), Not Predicted), Not Predicted), Not Predicted), Not Predicted), Not Predicted), Not Predicted), Not Predicted), Not Predicted), Not Predicted), |