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Details of CPPsite entry with Sequence AGYLLGKINLKALAALAKKIL
Primary information
PEPTIDE SEQUENCEAGYLLGKINLKALAALAKKIL
CPPsite ID 2037, 2038, 2177, 2289, 2296, 2297, 2419, 2438, 2497, 2523, 2524, 2837, 2843, 2852, 2998, 3001, 3006, 1052, 1389, 1449, 1807,
PEPTIDE NAMENF53, NF61, TP10, Transportan 10, F(SG)4TP10, G(SG)4TP10, TP10, PF3, TP10, TP-10, TP10-biot1, Transportan 10 (TP10), Rho-biotinyl-TP10, PF6, Stearyl-TP10, Pepfect 3, TP10, TP10, TP10, TP10, Transportan
CHIRALITYModified, Modified, L, L, L, L, L, L, Modified, L, L, L, L, Modified, Modified, Modified, L, L, L, L, L
LINEAR/CYCLICLinear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear, Linear
SOURCESynthetic, Synthetic, Protein derived, Chimeric, Protein derived, Protein derived, Chimeric, Synthetic, Chimeric, Chimeric, Chimeric, Protein derived, Synthetic, Synthetic, Protein derived, Synthetic, Chimeric, Chimeric, Chimeric, Chimeric, Chimeric
CATEGORYAmphipathic, Amphipathic, Amphipathic, Amphipathic, Amphipathic, Amphipathic, Amphipathic, Amphipathic, Amphipathic, Cationic and Amphipathic, Cationic and Amphipathic, Amphipathic, NA, Amphipathic, Amphipathic, Amphipathic, Amphipathic, Amphipathic, Amphipathic, Amphipathic, Amphipathic
SUB CELLULAR LOCALIZATIONNA, NA, Vesicles, NA, NA, NA, Cytoplasm, NA, NA, Cytoplasm, Cytoplasm, Mitochondria, Cytoplasm, Cytoplasm, NA, NA, NA, Cytoplasm and nucleus and intracellular membranous structures, Unknown, Unknown, Unknown
N-TERMINAL MODIFICATIONStearylation, Stearylation, Conjugation with Oregon Green 488, Conjugation with 5(6)-Carboxyfluorescein, Acetylation, Acetylation, Free, Stearylation, Free, Conjugated with FITC labelled streptavidin, Biotinylation, Free, Free, Stearylation, Stearylation, Stearylation, NA, Biotinylation at amino group of Lys, Conjugation with fluorescein, Conjugation with fluorescein, Conjugation with rhodamine B
C-TERMINAL MODIFICATIONAmidation, Amidation, Amidation, Free, Amidation, Amidation, Amidation, Conjugation with FAM to ?-NH2 group of additional lysine, Amidation, Amidation, Amidation, Amidation, Amidation, Amidation, Amidation, Amidation, Amidation, Free, Amidation, Amidation, Free
CHEMICAL MODIFICATION?-NH2 group of Lys7 for subsequent synthesis, ?-NH2 group of Lys7 for subsequent synthesis, NA, NA, NA, NA, NA, NA, Oregon Green 488 coupled to Lys7, NA, NA, NA, Biotinylation, Trifluoromethylquinoline moietie is added at amino froup of Lys7, NA, NA, NA, NA, NA, NA, NA
UPTAKE EFFICIENCY10-100 fold higher than stearyl-TP10, 10-100 fold higher than stearyl-TP11, NA, NA, Higher uptake efficiency for flourophore, Higher uptake efficiency for flourophore, NA, Lower uptake efficiency, NA, NA, Comparable efficiency only in HCT116 cells but not in HT29 cells, NA, NA, NA, NA, NA, NA, Comparable to Transportan, Unknown, Comparable to Penetratin, Less than polyarginine and pAntp but equal to Tat
PROPOSED UPTAKE MECHANISMNA, NA, Non-endocytosis, NA, Endocytic pathway, Endocytic pathway, Clathrin dependent uptake, NA, Non endocytosis pathway, Endocytosis-independent, Endocytosis-independent, Direct Translocation, Direct Translocation, Endocytic pathway, Endocytosis, Endocytosis, Endocytosis, Probably non-receptor mediated endocytic pathway, Unknown, Unknown, Unknown
INVITRO/INVIVOin vitro, in vitro, In vivo, In vitro, In vitro, In vitro, In vitro, In vitro, In vitro, In vitro, In vitro, In vitro, In vitro, In vitro, In vitro, In vitro, In vitro, In vitro, In vitro, In vitro, In vitro
CELL LINECHO, HeLa pLuc705, HEK293,U2OS, U87, MEF, U2OSEBNALTD3, Jurkat cells, A20 cells and CHOEBNALT85, CHO, HeLa pLuc705, HEK293,U2OS, U87, MEF, U2OSEBNALTD3, Jurkat cells, A20 cells and CHOEBNALT85, RBL-2H3 cells, CHO-K1, HeLa, HeLa, KG1a cells, HeLa, KG1a cells, HeLa, CHO and Jurkat cells, HeLa, Rat basophilic leukemia RBL-2H3 cells and CHO-K1, HT29 and HCT116, HT29 and HCT116, Swiss 3T3 cells and bovine spermatozoa, Swiss 3T3 cells and bovine spermatozoa, Luc-U2OS and uc-HEK cells, Hela pLuc 705 cells, HeLa cells, HeLa cells, Human bowes melanoma cells, MCF-7 and MDA MB 231, HeLa, CHO K2, CHO K1, HeLa, A549 cells
In VIVO MODELNA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, C57Bl/6JOlaHsd (Harlan) females, NA, NA, NA, NA, NA, NA, NA
CARGONucleic acid (Plasmid DNA, SCO and siRNA), Nucleic acid (Plasmid DNA, SCO and siRNA), Fluorophore (Oregon Green 488), Fluorophore (Carboxyfluorescein), Fluorophore (Alexa488), Protein (bovine serum albumin) and Nanoparticle (quantum dots), Fluorophore (Alexa488), Protein (bovine serum albumin) and Nanoparticle (quantum dots), Fluorophore [5(6)-carboxyfluorescein], Nucleic acid (pGL3, siRNA, SCO), Fluorophore (Fluorescein), Nucleic acid (siRNA), Protein (Streptavidin conjugated with FITC), Fluorophore (TAMRA), Fluorophore (TAMRA), Nucleic acid (siRNA), Nucleic acid (SCO), Nucelic acid (pGL3 plasmid, SCO), Nucleic acid (SCO), Biotin, Fluorophore (fluorescein), Fluorophore (fluorescein), Fluorophore (rhodamine)
PMID23357356, 23357356, 25016968, 24937132, 25108152, 25108152, 24870379, 25135660, 25016968, 25511292, 25511292, 23585561, 23585561, 21245043, 10930519, 17984975, 17622242, 15937518
PATENTUnknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, Unknown, EP 2 491 952 A1, US 2014/0140929 A1, US 2014/0140929 A1, Unknown, Unknown, Unknown, Unknown
Tertiary Structure
(Technique)
2037 (PEPstrMOD), 2038 (PEPstrMOD), 2177 (PEPstrMOD), 2289 (PEPstrMOD), 2296 (PEPstrMOD), 2297 (PEPstrMOD), 2419 (PEPstrMOD), 2438 (PEPstrMOD), 2497 (PEPstrMOD), 2523 (PEPstrMOD), 2524 (PEPstrMOD), 2837 (PEPstrMOD), 2843 (PEPstrMOD), 2852 (PEPstrMOD), 2998 (PEPstrMOD), 3001 (PEPstrMOD), 3006 (PEPstrMOD), 1052 (PEPstrMOD), 1389 (PEPstrMOD), 1449 (PEPstrMOD), 1807 (PEPstrMOD),