Browse result page of B3Pdb

The total number entries retrieved from this search are 235, scroll left/right for detailed information.
B3pdbIDPEPTIDE NAMEPEPTIDE SEQUENCE (1-letter)PEPTIDE SEQUENCE (3-letter)N-TERMINAL MODIFICATIONC-TERMINAL MODIFICATION CHEMICAL MODIFICATIONPEPTIDE LENGTHPEPTIDE CONFORMATIONPEPTIDE NATURESOURCE/ORIGIN OF PEPTIDESMILESCELL LINEIn vitro CONCENTRATIONIn vitro METHODIn vitro RESULTANIMAL MODELIn vivo CONCENTRATIONIn vivo MODE OF DELIVERYIn vivo METHODIn vivo RESULTACTIONTRANSPORT TYPESUBCELLULAR LOCALISATIONCOMBINATIONPHYSICAL CONDITIONRESPONSERESULTLABELPMID
b3pdb_1138Neuromedin BGNLWATGHFMGly-Asn-Leu-Trp-Ala-Thr-Gly-His-Phe-Met-NH2NANANA10LinearNAhumanNANANANANANANAIntravenous NANA NA Permeability NA NA NA Initial disrobution volume 0.00799 ml/g Direct iodination 27040796
b3pdb_1139Arginine vasopressinCYFQNCPCys-Tyr-Phe-Gln-Asn-Cys-ProNANACys1-Cys67LinearNAhumanN[C@@]([H])(CS)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CS)C(=O)N1[C@@]([H])(CCC1)C(=O)ONANAInitial concentration in donor chamber-CultureNANANANANANA NA non saturable NA NA NA Permeability index 46 (x 10-4) cm/min NA 2732952
b3pdb_1140Arginine vasopressinCYFQNCCys-Tyr-Phe-Gln-Asn-CysNANACys1-Cys66LinearNAhumanN[C@@]([H])(CS)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CS)C(=O)ONANAInitial concentration in donor chamber-CultureNANANANANANA NA Permeability NA NA NA Permeability index 30 (x 10-4) cm/min NA 2732952
b3pdb_1141[Ser7-O-βGlc]dermorpYaFGYPS-NH2Tyr-(D)Ala-Phe-Gly-Tyr-Pro-Ser-NH2NANANA7LinearNAhumanNANANAanti-nociceptionNANANANANANA NA Permeability NA NA NA ICV/SC ratio 0.0000195 NA 9723966
b3pdb_1142[Ser7-O-βGlc(Ac)4]deYaFGYPS-NH2Tyr-(D)Ala-Phe-Gly-Tyr-Pro-Ser-NH2NANANA7LinearNAhumanNANANAanti-nociceptionNANANANANANA NA Permeability NA NA NA ICV/SC ratio 0.0000098 NA 9723966
b3pdb_1143[Ala7-C-αGal]dermorpYaFGYPS-NH2Tyr-(D)Ala-Phe-Gly-Tyr-Pro-Ser-NH2NANANA7LinearNAChemically synthesizedNANANAanti-nociceptionNANANANANANA NA Permeability NA NA NA ICV/SC ratio 0.0000334 NA 9723966
b3pdb_1144[Ala7-C-αGal(Ac)4]deYaFGYPS-NH2NANANANA7LinearNAChemically synthesizedNANANAanti-nociceptionNANANANANANA NA Permeability NA NA NA ICV/SC ratio 0.0000089 NA NA
b3pdb_1150BeauvericinNANANANANA6LinearNAChemically synthesizedNANANAEfflux study ICUNANANANANANA NA Permeability NA NA NA Brain elemination rate constant -0.1205 min-1 Direct iodination 27349679
b3pdb_1151BeauvericinNANANANANA6LinearNAChemically synthesizedNANANACapillary depletionNANANANANANA NA NA NA NA NA % parenchyma 91.92% Direct iodination 27349679
b3pdb_1152BeauvericinNANANANANA6LinearNAChemically synthesizedNANANACapillary depletionNANANANANANA NA NA NA NA NA % parenchyma 8.08% Direct iodination 27349679
b3pdb_1153BeauvericinNANANANANA6LinearNAChemically synthesizedNANANANANANANAIntravenous NANA NA Permeability NA NA NA Unidirectional influx rate constant 0.01115 mL/(g x min) Direct iodination 27349679
b3pdb_1154BeauvericinNANANANANA6LinearNAChemically synthesizedNANANANANANANAIntravenous NANA NA Permeability NA NA NA Initial disrobution volume 0.02191 ml/g Direct iodination 27349679
b3pdb_1155PepH1VQQLTKRFSLValGlnGlnLeuThrLysArgPheSerLeuNANANA10LinearNAChemically synthesizedN[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(C)C)C(=O)ONANAInitial concentration in donor chamber-CultureNANANANANANA NA Permeability NA NA NA Translocated 73.83% 99mTc(CO)3+ 28263555
b3pdb_1156PepH1VQQLTKRFSLValGlnGlnLeuThrLysArgPheSerLeuNANANA10LinearNAChemically synthesizedNANANANANANANAIntravenous NANA NA Permeability NA NA NA % injected dose 0.02 %/g 99mTc(CO)3+ 28263555
b3pdb_1158PepH3AGILKRWAlaGlyIleLeuLysArgTrpNANANA7LinearNAviralNANANAInitial concentration in donor chamber-CultureNANANANANANA NA Permeability NA NA NA Translocated 67.23% 99mTc(CO)3+ 28263555
b3pdb_1159PepH3AGILKRWAlaGlyIleLeuLysArgTrpNANANA7LinearNAviralNANANANANANANAIntravenous NANA NA Permeability NA NA NA % injected dose 0.03 %/g 99mTc(CO)3+ 28263555
b3pdb_1168PepNegSGTQEEYSer-Gly-Thr-Gln-Glu-Glu-TyrNANANA7LinearNAChemically synthesizedNANANAInitial concentration in donor chamber-CultureNANANANANANA NA Permeability NA NA NA Translocated 42.50% NA 29057814
b3pdb_1171LLVV-H4LLVVYPWTLeu-Leu-Val-Val-Tyr-Pro-Trp-ThrNANANA8LinearNAChemically synthesizedNANANANANANANANANANA NA NA NA NA NA NA NA NA NA
b3pdb_1172LVV-H4LVVYPWTLeu-Val-Val-Tyr-Pro-Trp-ThrNANANA7LinearNAChemically synthesizedNANANAInitial concentration in donor chamber-CultureNANANANANANA NA Permeability NA NA NA Area 3.2 Counts NA 29692758
b3pdb_1173VV-H4VVYPWTVal-Val-Tyr-Pro-Trp-ThrNANANA6LinearNAHemoglobinNANANAInitial concentration in donor chamber-CultureNANANANANANA NA Permeability NA NA NA Area 4 Counts NA 29692758
b3pdb_1174VV-H7VVYPWTQRFVal-Val-Tyr-Pro-Trp-Thr-Gln-Arg-PheNANANA8LinearNAHemoglobinNANANAInitial concentration in donor chamber-CultureNANANANANANA NA Permeability NA NA NA Area 4.4 Counts NA 29692758
b3pdb_1175H7YPWTQRFTyr-Pro-Trp-Thr-Gln-Arg-PheNANANA7LinearNAHemoglobinNANANAInitial concentration in donor chamber-CultureNANANANANANA NA Permeability NA NA NA Area 1 Counts NA 29692758
b3pdb_1188NT2Cav-RPYILCav-Arg-Pro-Tyr-Ile-LeuNANANA6LinearNAChemically synthesizedNANANANANANANAPAMPANANA NA Permeability NA NA NA Translocated 85% NA 30374780
b3pdb_1189NT4R-Cav-PYILArg-Cav-Pro-Tyr-Ile-LeuNANANA6LinearNAChemically synthesizedNANANANANANANAPAMPANANA NA Permeability NA NA NA Translocated 90% NA 30374780
b3pdb_1205OP5NFDVLTEQAsn - Phe - Asp - Val - Leu - Thr - Glu - GlnNANANA8LinearNAChemically synthesizedNANANANANANANAIntravenous NANA NA Permeability NA NA NA Unidirectional influx rate constant 0.0396 ml/g H3/C14 29966196
b3pdb_1206SLSHSPQSLSHSPQSer - Leu - Ser - His - Ser - Pro - GlnNANANA7LinearNAChemically synthesizedNANANANANANANANANANA NA NA NA NA NA NA NA NA NA
b3pdb_1207NTGSPYENTGSPYEAsn - Thr - Gly - Ser - Pro - Tyr - GluNANANA7LinearNAChemically synthesizedNANANANANANANANANANA NA NA NA NA NA NA NA NA NA
b3pdb_1211P15VQITYKNAN-terminal acetylationC-terminal amidationNA6LinearNAChemically synthesizedNAHuman brain endothelial cells (EA.hy926)NAField-emission transmission electron microscopeA3 peptide treated with this peptide, showed higher folds of decrease in fluorescence intensities aNANANANANA Trojan peptides are capable of translo- cating the BBB, without affecting its interity. Translocation NA Comined with A3 pepide Tauopathies These peptides were capable of reducing the tau elicit toxicity by accelerating or impeding the self These peptide-based modulators (Trojans) were non-amyloidogenic, stable in serum and showed minimal NA 32114026
b3pdb_1212P16VQILYKNAN-terminal acetylationC-terminal amidationNA6LinearNAChemically synthesizedNAHuman brain endothelial cells (EA.hy926)NAField-emission transmission electron microscopeA3 peptide treated with this peptide, showed higher folds of decrease in fluorescence intensities aNANANANANA Trojan peptides are capable of translo- cating the BBB, without affecting its interity. Translocation NA Comined with A3 pepide Tauopathies These peptides were capable of reducing the tau elicit toxicity by accelerating or impeding the self These peptide-based modulators (Trojans) were non-amyloidogenic, stable in serum and showed minimal NA 32114026
b3pdb_1213P17VQIIYKNAN-terminal acetylationC-terminal amidationNA6LinearNAChemically synthesizedNAHuman brain endothelial cells (EA.hy926)NAField-emission transmission electron microscopeA3 peptide treated with this peptide, showed higher folds of decrease in fluorescence intensities aNANANANANA Trojan peptides are capable of translo- cating the BBB, without affecting its interity. Translocation NA Comined with A3 pepide Tauopathies These peptides were capable of reducing the tau elicit toxicity by accelerating or impeding the self These peptide-based modulators (Trojans) were non-amyloidogenic, stable in serum and showed minimal NA 32114026
b3pdb_1214P18VQIVYKNANAC-terminal amidationNA6LinearNAChemically synthesizedNAHuman brain endothelial cells (EA.hy926)NAField-emission transmission electron microscopeA3 peptide treated with this peptide, showed higher folds of decrease in fluorescence intensities aNANANANANA Trojan peptides are capable of translo- cating the BBB, without affecting its interity. Translocation NA Comined with A3 pepide Tauopathies These peptides were capable of reducing the tau elicit toxicity by accelerating or impeding the self These peptide-based modulators (Trojans) were non-amyloidogenic, stable in serum and showed minimal NA 32114026
b3pdb_1215P19VQILYKNANAC-terminal amidationNA6LinearNAChemically synthesizedNAHuman brain endothelial cells (EA.hy926)NAField-emission transmission electron microscopeA3 peptide treated with this peptide, showed higher folds of decrease in fluorescence intensities aNANANANANA Trojan peptides are capable of translo- cating the BBB, without affecting its interity. Translocation NA Comined with A3 pepide Tauopathies These peptides were capable of reducing the tau elicit toxicity by accelerating or impeding the self These peptide-based modulators (Trojans) were non-amyloidogenic, stable in serum and showed minimal NA 32114026
b3pdb_1216P20VQIYKNANAC-terminal amidationNA6LinearNAChemically synthesizedNAHuman brain endothelial cells (EA.hy926)NAField-emission transmission electron microscopeA3 peptide treated with this peptide, showed higher folds of decrease in fluorescence intensities aNANANANANA Trojan peptides are capable of translo- cating the BBB, without affecting its interity. Translocation NA Comined with A3 pepide Tauopathies These peptides were capable of reducing the tau elicit toxicity by accelerating or impeding the self These peptide-based modulators (Trojans) were non-amyloidogenic, stable in serum and showed minimal NA 32114026
b3pdb_1217P21VQIVYKNANAC-terminal amidationNA6LinearNAChemically synthesizedNAHuman brain endothelial cells (EA.hy926)NAField-emission transmission electron microscopeA3 peptide treated with this peptide, showed higher folds of decrease in fluorescence intensities aNANANANANA Trojan peptides are capable of translo- cating the BBB, without affecting its interity. Translocation NA Comined with A3 pepide Tauopathies These peptides were capable of reducing the tau elicit toxicity by accelerating or impeding the self These peptide-based modulators (Trojans) were non-amyloidogenic, stable in serum and showed minimal NA 32114026
b3pdb_1222AP9NPNDKYEPFNANAC-terminal amidationNA9LinearNAChemically synthesizedNANANANANAMice20 mg/kgIntravenous Evans blue dyeThe preservation of the protective effect of double AP9 administration in the postischemic period. It induce β-arrestin-2-dependent cytoprotective pathways. NA NA Alone Photothrombosis - induced ischemia NA NA NA 32547356