ApoCanD

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	AN3CA	Cell Line	ENDOMETRIUM	NP_001158	c.47A>G	p.D16G	CCLE	PASSENGER/OTHER	Benign
2	COLO704	Cell Line	OVARY	NP_001158	c.712C>T	p.R238*	CCLE	NP	NP
3	ECC12	Cell Line	STOMACH	NP_001158	c.1045_1047delGAG	p.E350del	CCLE	NP	NP
4	EN	Cell Line	ENDOMETRIUM	NP_001158	c.1045_1047delGAG	p.E350del	CCLE	NP	NP
5	GCIY	Cell Line	STOMACH	NP_001158	c.1045_1047delGAG	p.E350del	CCLE	NP	NP
6	HEC151	Cell Line	ENDOMETRIUM	NP_001158	c.1372A>G	p.I458V	CCLE	CANCER	Possibly Damaging
7	HMC18	Cell Line	BREAST	NP_001158	c.1045_1047delGAG	p.E350del	CCLE	NP	NP
8	ISHIKAWAHERAKLIO02ER	Cell Line	ENDOMETRIUM	NP_001158	c.1074A>G	p.K358K	CCLE	NP	NP
9	KMRC3	Cell Line	KIDNEY	NP_001158	c.1045_1047delGAG	p.E350del	CCLE	NP	NP
10	KO52	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_001158	c.1045_1047delGAG	p.E350del	CCLE	NP	NP
11	KP2	Cell Line	PANCREAS	NP_001158	c.1045_1047delGAG	p.E350del	CCLE	NP	NP
12	NCIH1105	Cell Line	LUNG	NP_001158	c.1180G>T	p.E394*	CCLE	NP	NP
13	NCIH1568	Cell Line	LUNG	NP_001158	c.1254G>C	p.Q418H	CCLE	PASSENGER/OTHER	Probably Damaging
14	NCIH2286	Cell Line	LUNG	NP_001158	c.817G>T	p.G273W	CCLE	PASSENGER/OTHER	Probably Damaging
15	RCC10RGB	Cell Line	KIDNEY	NP_001158	c.1045_1047delGAG	p.E350del	CCLE	NP	NP
16	RKO	Cell Line	LARGE INTESTINE	NP_001158	c.977_splice	p.G326_splice	CCLE	NP	NP
17	RL952	Cell Line	ENDOMETRIUM	NP_001158	c.872C>T	p.A291V	CCLE	PASSENGER/OTHER	Possibly Damaging
18	RS411	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_001158	c.1327C>T	p.R443C	CCLE	PASSENGER/OTHER	Probably Damaging
19	SNU175	Cell Line	LARGE INTESTINE	NP_001158	c.1162G>A	p.D388N	CCLE	PASSENGER/OTHER	Benign
20	SNU81	Cell Line	LARGE INTESTINE	NP_001158	c.905A>G	p.H302R	CCLE	PASSENGER/OTHER	Benign
21	H1155	Cell Line	LUNG	ENST00000434753	c.1310C>T	p.T437I	COSMIC	NP	NP
22	HCC41T	Tumour	LIVER	ENST00000434753	c.493G>T	p.A165S	COSMIC	NP	NP
23	HCC65T	Tumour	LIVER	ENST00000434753	c.1349G>T	p.C450F	COSMIC	NP	NP
24	HCC94T	Tumour	LIVER	ENST00000434753	c.132A>G	p.A44A	COSMIC	NP	NP
25	NCI-H2009	Cell Line	LUNG	ENST00000434753	c.766C>G	p.L256V	COSMIC	NP	NP
26	OV207	Tumour	OVARY	ENST00000434753	c.185G>A	p.R62Q	COSMIC	NP	NP
27	PD4132a	Tumour	BREAST	ENST00000434753	c.269G>A	p.C90Y	COSMIC	NP	NP
28	S00539	Tumour	LUNG	ENST00000434753	c.233C>A	p.S78*	COSMIC	NP	NP
29	S00946	Tumour	LUNG	ENST00000434753	c.263C>A	p.P88Q	COSMIC	NP	NP
30	TCGA-05-4427-01	Tumour	LUNG	ENST00000434753	c.1339G>T	p.E447*	COSMIC	NP	NP
31	TCGA-05-4427-01	Tumour	LUNG	ENST00000434753	c.786G>T	p.M262I	COSMIC	NP	NP
32	TCGA-10-0938-01	Tumour	OVARY	ENST00000434753	c.1385T>A	p.F462Y	COSMIC	NP	NP
33	TCGA-13-1482-01	Tumour	OVARY	ENST00000434753	c.533A>G	p.H178R	COSMIC	NP	NP
34	TCGA-22-1002-01	Tumour	LUNG	ENST00000434753	c.447A>G	p.I149M	COSMIC	NP	NP
35	TCGA-30-1718-01	Tumour	OVARY	ENST00000434753	c.1109T>C	p.I370T	COSMIC	NP	NP
36	TCGA-34-5236-01	Tumour	LUNG	ENST00000434753	c.1415A>G	p.K472R	COSMIC	NP	NP
37	TCGA-34-5927-01	Tumour	LUNG	ENST00000434753	c.1235C>T	p.A412V	COSMIC	NP	NP
38	TCGA-38-4626-01	Tumour	LUNG	ENST00000434753	c.252G>T	p.R84S	COSMIC	NP	NP
39	TCGA-39-5030-01	Tumour	LUNG	ENST00000434753	c.270C>A	p.C90*	COSMIC	NP	NP
40	TCGA-42-2591-01	Tumour	OVARY	ENST00000434753	c.1336G>C	p.E446Q	COSMIC	NP	NP
41	TCGA-43-3920-01	Tumour	LUNG	ENST00000434753	c.819G>A	p.G273G	COSMIC	NP	NP
42	TCGA-44-8117-01	Tumour	LUNG	ENST00000434753	c.481T>A	p.Y161N	COSMIC	NP	NP
43	TCGA-63-5128-01	Tumour	LUNG	ENST00000434753	c.1138A>G	p.I380V	COSMIC	NP	NP
44	TCGA-69-7979-01	Tumour	LUNG	ENST00000434753	c.249C>A	p.H83Q	COSMIC	NP	NP
45	TCGA-95-7043-01	Tumour	LUNG	ENST00000434753	c.1474C>A	p.Q492K	COSMIC	NP	NP
46	TCGA-A2-A0CZ-01	Tumour	BREAST	ENST00000434753	c.358T>A	p.Y120N	COSMIC	NP	NP
47	TCGA-A5-A0GP-01	Tumour	ENDOMETRIUM	ENST00000434753	c.64G>T	p.E22*	COSMIC	NP	NP
48	TCGA-A8-A07I-01	Tumour	BREAST	ENST00000434753	c.285C>A	p.G95G	COSMIC	NP	NP
49	TCGA-AA-3672-01	Tumour	LARGE INTESTINE	ENST00000434753	c.470A>G	p.N157S	COSMIC	NP	NP
50	TCGA-AA-A010-01	Tumour	LARGE INTESTINE	ENST00000434753	c.1191T>G	p.I397M	COSMIC	NP	NP
51	TCGA-AD-5900-01	Tumour	LARGE INTESTINE	ENST00000434753	c.2T>C	p.M1T	COSMIC	NP	NP
52	TCGA-AK-3436-01	Tumour	KIDNEY	ENST00000434753	c.1056+2T>C	p.?	COSMIC	NP	NP
53	TCGA-AN-A0FL-01	Tumour	BREAST	ENST00000434753	c.1461C>G	p.V487V	COSMIC	NP	NP
54	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000434753	c.1121C>A	p.P374H	COSMIC	NP	NP
55	TCGA-AP-A0LM-01	Tumour	ENDOMETRIUM	ENST00000434753	c.157C>A	p.L53I	COSMIC	NP	NP
56	TCGA-AX-A0J0-01	Tumour	ENDOMETRIUM	ENST00000434753	c.26C>A	p.S9Y	COSMIC	NP	NP
57	TCGA-AY-6197-01	Tumour	LARGE INTESTINE	ENST00000434753	c.347A>G	p.K116R	COSMIC	NP	NP
58	TCGA-AZ-4315-01	Tumour	LARGE INTESTINE	ENST00000434753	c.1479A>C	p.K493N	COSMIC	NP	NP
59	TCGA-B0-5706-01	Tumour	KIDNEY	ENST00000434753	c.872C>T	p.A291V	COSMIC	NP	NP
60	TCGA-B5-A0JR-01	Tumour	ENDOMETRIUM	ENST00000434753	c.698G>A	p.R233Q	COSMIC	NP	NP
61	TCGA-B5-A0JV-01	Tumour	ENDOMETRIUM	ENST00000434753	c.1262G>A	p.S421N	COSMIC	NP	NP
62	TCGA-B5-A0JY-01	Tumour	ENDOMETRIUM	ENST00000434753	c.1345C>T	p.L449F	COSMIC	NP	NP
63	TCGA-B5-A0JY-01	Tumour	ENDOMETRIUM	ENST00000434753	c.703C>A	p.L235I	COSMIC	NP	NP
64	TCGA-B5-A0JY-01	Tumour	ENDOMETRIUM	ENST00000434753	c.86G>T	p.R29I	COSMIC	NP	NP
65	TCGA-BG-A0MQ-01	Tumour	ENDOMETRIUM	ENST00000434753	c.309G>A	p.T103T	COSMIC	NP	NP
66	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000434753	c.1132G>A	p.E378K	COSMIC	NP	NP
67	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000434753	c.1199C>A	p.S400Y	COSMIC	NP	NP
68	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000434753	c.504G>T	p.K168N	COSMIC	NP	NP
69	TCGA-CA-6717-01	Tumour	LARGE INTESTINE	ENST00000434753	c.1482T>G	p.I494M	COSMIC	NP	NP
70	TCGA-CJ-4897-01	Tumour	KIDNEY	ENST00000434753	c.776A>G	p.N259S	COSMIC	NP	NP
71	TCGA-D1-A17Q-01	Tumour	ENDOMETRIUM	ENST00000434753	c.1016T>C	p.I339T	COSMIC	NP	NP
72	TCGA-D5-5538-01	Tumour	LARGE INTESTINE	ENST00000434753	c.1145T>C	p.M382T	COSMIC	NP	NP
73	TCGA-D5-6539-01	Tumour	LARGE INTESTINE	ENST00000434753	c.533A>G	p.H178R	COSMIC	NP	NP
74	TCGA-G4-6317-01	Tumour	LARGE INTESTINE	ENST00000434753	c.766C>A	p.L256I	COSMIC	NP	NP
75	TCGA-G4-6588-01	Tumour	LARGE INTESTINE	ENST00000434753	c.536T>C	p.L179P	COSMIC	NP	NP
76	YUKRIN	Tumour	SKIN	ENST00000434753	c.934_935CC>TT	p.P312F	COSMIC	NP	NP
77	A204	Cell Line	SOFT_TISSUE	ENST00000434753	c.1099+3A>G	p.?	COSMIC	NP	NP
78	AN3CA	Cell Line	ENDOMETRIUM	ENST00000434753	c.47A>G	p.D16G	COSMIC	NP	NP
79	ATN1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000434753	c.1045_1047delGAG	p.E350delE	COSMIC	NP	NP
80	ECC12	Cell Line	STOMACH	ENST00000434753	c.1045_1047delGAG	p.E350delE	COSMIC	NP	NP
81	EN	Cell Line	ENDOMETRIUM	ENST00000434753	c.1045_1047delGAG	p.E350delE	COSMIC	NP	NP
82	GAMG	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000434753	c.878-5C>T	p.?	COSMIC	NP	NP
83	GB1	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000434753	c.1045_1047delGAG	p.E350delE	COSMIC	NP	NP
84	GCIY	Cell Line	STOMACH	ENST00000434753	c.1045_1047delGAG	p.E350delE	COSMIC	NP	NP
85	GOTO	Cell Line	AUTONOMIC_GANGLIA	ENST00000434753	c.1045_1047delGAG	p.E350delE	COSMIC	NP	NP
86	HT115	Cell Line	LARGE_INTESTINE	ENST00000434753	c.713G>A	p.R238Q	COSMIC	NP	NP
87	JHU029	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000434753	c.1138A>G	p.I380V	COSMIC	NP	NP
88	KARPAS45	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000434753	c.463C>A	p.P155T	COSMIC	NP	NP
89	KO52	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000434753	c.1045_1047delGAG	p.E350delE	COSMIC	NP	NP
90	KP2	Cell Line	PANCREAS	ENST00000434753	c.1045_1047delGAG	p.E350delE	COSMIC	NP	NP
91	KYAE1	Cell Line	OESOPHAGUS	ENST00000434753	c.1045_1047delGAG	p.E350delE	COSMIC	NP	NP
92	LC2AD	Cell Line	LUNG	ENST00000434753	c.1045_1047delGAG	p.E350delE	COSMIC	NP	NP
93	MCC13	Cell Line	SKIN	ENST00000434753	c.1121C>T	p.P374L	COSMIC	NP	NP
94	MCC13	Cell Line	SKIN	ENST00000434753	c.146G>A	p.R49Q	COSMIC	NP	NP
95	NCIH1105	Cell Line	LUNG	ENST00000434753	c.1180G>T	p.E394*	COSMIC	NP	NP
96	NCIH1155	Cell Line	LUNG	ENST00000434753	c.1310C>T	p.T437I	COSMIC	NP	NP
97	NCIH1568	Cell Line	LUNG	ENST00000434753	c.1254G>C	p.Q418H	COSMIC	NP	NP
98	RCC10RGB	Cell Line	KIDNEY	ENST00000434753	c.1045_1047delGAG	p.E350delE	COSMIC	NP	NP
99	RKO	Cell Line	LARGE_INTESTINE	ENST00000434753	c.977+2T>A	p.?	COSMIC	NP	NP
100	RL952	Cell Line	ENDOMETRIUM	ENST00000434753	c.872C>T	p.A291V	COSMIC	NP	NP
101	RS411	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000434753	c.1327C>T	p.R443C	COSMIC	NP	NP
102	SKMG1	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000434753	c.974C>A	p.P325Q	COSMIC	NP	NP
103	SNU175	Cell Line	LARGE_INTESTINE	ENST00000434753	c.1162G>A	p.D388N	COSMIC	NP	NP
104	SNU387	Cell Line	LIVER	ENST00000434753	c.1045_1047delGAG	p.E350delE	COSMIC	NP	NP
105	SNU81	Cell Line	LARGE_INTESTINE	ENST00000434753	c.905A>G	p.H302R	COSMIC	NP	NP
106	SW1271	Cell Line	LUNG	ENST00000434753	c.93A>G	p.K31K	COSMIC	NP	NP
107	TASK1	Cell Line	BONE	ENST00000434753	c.1045_1047delGAG	p.E350delE	COSMIC	NP	NP
108	TGBC24TKB	Cell Line	BILIARY_TRACT	ENST00000434753	c.1045_1047delGAG	p.E350delE	COSMIC	NP	NP
109	TK10	Cell Line	KIDNEY	ENST00000434753	c.878-5C>T	p.?	COSMIC	NP	NP
110	AN3CA	Cell Line	ENDOMETRIUM	NP_001158	c.47A>G	p.D16G	CCLE	PASSENGER/OTHER	Benign
111	COLO704	Cell Line	OVARY	NP_001158	c.712C>T	p.R238*	CCLE	NP	NP
112	ECC12	Cell Line	STOMACH	NP_001158	c.1045_1047delGAG	p.E350del	CCLE	NP	NP
113	EN	Cell Line	ENDOMETRIUM	NP_001158	c.1045_1047delGAG	p.E350del	CCLE	NP	NP
114	GCIY	Cell Line	STOMACH	NP_001158	c.1045_1047delGAG	p.E350del	CCLE	NP	NP
115	HEC151	Cell Line	ENDOMETRIUM	NP_001158	c.1372A>G	p.I458V	CCLE	CANCER	Possibly Damaging
116	HMC18	Cell Line	BREAST	NP_001158	c.1045_1047delGAG	p.E350del	CCLE	NP	NP
117	ISHIKAWAHERAKLIO02ER	Cell Line	ENDOMETRIUM	NP_001158	c.1074A>G	p.K358K	CCLE	NP	NP
118	KMRC3	Cell Line	KIDNEY	NP_001158	c.1045_1047delGAG	p.E350del	CCLE	NP	NP
119	KO52	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_001158	c.1045_1047delGAG	p.E350del	CCLE	NP	NP
120	KP2	Cell Line	PANCREAS	NP_001158	c.1045_1047delGAG	p.E350del	CCLE	NP	NP
121	NCIH1105	Cell Line	LUNG	NP_001158	c.1180G>T	p.E394*	CCLE	NP	NP
122	NCIH1568	Cell Line	LUNG	NP_001158	c.1254G>C	p.Q418H	CCLE	PASSENGER/OTHER	Probably Damaging
123	NCIH2286	Cell Line	LUNG	NP_001158	c.817G>T	p.G273W	CCLE	PASSENGER/OTHER	Probably Damaging
124	RCC10RGB	Cell Line	KIDNEY	NP_001158	c.1045_1047delGAG	p.E350del	CCLE	NP	NP
125	RKO	Cell Line	LARGE INTESTINE	NP_001158	c.977_splice	p.G326_splice	CCLE	NP	NP
126	RL952	Cell Line	ENDOMETRIUM	NP_001158	c.872C>T	p.A291V	CCLE	PASSENGER/OTHER	Possibly Damaging
127	RS411	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_001158	c.1327C>T	p.R443C	CCLE	PASSENGER/OTHER	Probably Damaging
128	SNU175	Cell Line	LARGE INTESTINE	NP_001158	c.1162G>A	p.D388N	CCLE	PASSENGER/OTHER	Benign
129	SNU81	Cell Line	LARGE INTESTINE	NP_001158	c.905A>G	p.H302R	CCLE	PASSENGER/OTHER	Benign
130	H1155	Cell Line	LUNG	ENST00000434753	c.1310C>T	p.T437I	COSMIC	NP	NP
131	HCC41T	Tumour	LIVER	ENST00000434753	c.493G>T	p.A165S	COSMIC	NP	NP
132	HCC65T	Tumour	LIVER	ENST00000434753	c.1349G>T	p.C450F	COSMIC	NP	NP
133	HCC94T	Tumour	LIVER	ENST00000434753	c.132A>G	p.A44A	COSMIC	NP	NP
134	NCI-H2009	Cell Line	LUNG	ENST00000434753	c.766C>G	p.L256V	COSMIC	NP	NP
135	OV207	Tumour	OVARY	ENST00000434753	c.185G>A	p.R62Q	COSMIC	NP	NP
136	PD4132a	Tumour	BREAST	ENST00000434753	c.269G>A	p.C90Y	COSMIC	NP	NP
137	S00539	Tumour	LUNG	ENST00000434753	c.233C>A	p.S78*	COSMIC	NP	NP
138	S00946	Tumour	LUNG	ENST00000434753	c.263C>A	p.P88Q	COSMIC	NP	NP
139	TCGA-05-4427-01	Tumour	LUNG	ENST00000434753	c.1339G>T	p.E447*	COSMIC	NP	NP
140	TCGA-05-4427-01	Tumour	LUNG	ENST00000434753	c.786G>T	p.M262I	COSMIC	NP	NP
141	TCGA-10-0938-01	Tumour	OVARY	ENST00000434753	c.1385T>A	p.F462Y	COSMIC	NP	NP
142	TCGA-13-1482-01	Tumour	OVARY	ENST00000434753	c.533A>G	p.H178R	COSMIC	NP	NP
143	TCGA-22-1002-01	Tumour	LUNG	ENST00000434753	c.447A>G	p.I149M	COSMIC	NP	NP
144	TCGA-30-1718-01	Tumour	OVARY	ENST00000434753	c.1109T>C	p.I370T	COSMIC	NP	NP
145	TCGA-34-5236-01	Tumour	LUNG	ENST00000434753	c.1415A>G	p.K472R	COSMIC	NP	NP
146	TCGA-34-5927-01	Tumour	LUNG	ENST00000434753	c.1235C>T	p.A412V	COSMIC	NP	NP
147	TCGA-38-4626-01	Tumour	LUNG	ENST00000434753	c.252G>T	p.R84S	COSMIC	NP	NP
148	TCGA-39-5030-01	Tumour	LUNG	ENST00000434753	c.270C>A	p.C90*	COSMIC	NP	NP
149	TCGA-42-2591-01	Tumour	OVARY	ENST00000434753	c.1336G>C	p.E446Q	COSMIC	NP	NP
150	TCGA-43-3920-01	Tumour	LUNG	ENST00000434753	c.819G>A	p.G273G	COSMIC	NP	NP
151	TCGA-44-8117-01	Tumour	LUNG	ENST00000434753	c.481T>A	p.Y161N	COSMIC	NP	NP
152	TCGA-63-5128-01	Tumour	LUNG	ENST00000434753	c.1138A>G	p.I380V	COSMIC	NP	NP
153	TCGA-69-7979-01	Tumour	LUNG	ENST00000434753	c.249C>A	p.H83Q	COSMIC	NP	NP
154	TCGA-95-7043-01	Tumour	LUNG	ENST00000434753	c.1474C>A	p.Q492K	COSMIC	NP	NP
155	TCGA-A2-A0CZ-01	Tumour	BREAST	ENST00000434753	c.358T>A	p.Y120N	COSMIC	NP	NP
156	TCGA-A5-A0GP-01	Tumour	ENDOMETRIUM	ENST00000434753	c.64G>T	p.E22*	COSMIC	NP	NP
157	TCGA-A8-A07I-01	Tumour	BREAST	ENST00000434753	c.285C>A	p.G95G	COSMIC	NP	NP
158	TCGA-AA-3672-01	Tumour	LARGE INTESTINE	ENST00000434753	c.470A>G	p.N157S	COSMIC	NP	NP
159	TCGA-AA-A010-01	Tumour	LARGE INTESTINE	ENST00000434753	c.1191T>G	p.I397M	COSMIC	NP	NP
160	TCGA-AD-5900-01	Tumour	LARGE INTESTINE	ENST00000434753	c.2T>C	p.M1T	COSMIC	NP	NP
161	TCGA-AK-3436-01	Tumour	KIDNEY	ENST00000434753	c.1056+2T>C	p.?	COSMIC	NP	NP
162	TCGA-AN-A0FL-01	Tumour	BREAST	ENST00000434753	c.1461C>G	p.V487V	COSMIC	NP	NP
163	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000434753	c.1121C>A	p.P374H	COSMIC	NP	NP
164	TCGA-AP-A0LM-01	Tumour	ENDOMETRIUM	ENST00000434753	c.157C>A	p.L53I	COSMIC	NP	NP
165	TCGA-AX-A0J0-01	Tumour	ENDOMETRIUM	ENST00000434753	c.26C>A	p.S9Y	COSMIC	NP	NP
166	TCGA-AY-6197-01	Tumour	LARGE INTESTINE	ENST00000434753	c.347A>G	p.K116R	COSMIC	NP	NP
167	TCGA-AZ-4315-01	Tumour	LARGE INTESTINE	ENST00000434753	c.1479A>C	p.K493N	COSMIC	NP	NP
168	TCGA-B0-5706-01	Tumour	KIDNEY	ENST00000434753	c.872C>T	p.A291V	COSMIC	NP	NP
169	TCGA-B5-A0JR-01	Tumour	ENDOMETRIUM	ENST00000434753	c.698G>A	p.R233Q	COSMIC	NP	NP
170	TCGA-B5-A0JV-01	Tumour	ENDOMETRIUM	ENST00000434753	c.1262G>A	p.S421N	COSMIC	NP	NP
171	TCGA-B5-A0JY-01	Tumour	ENDOMETRIUM	ENST00000434753	c.1345C>T	p.L449F	COSMIC	NP	NP
172	TCGA-B5-A0JY-01	Tumour	ENDOMETRIUM	ENST00000434753	c.703C>A	p.L235I	COSMIC	NP	NP
173	TCGA-B5-A0JY-01	Tumour	ENDOMETRIUM	ENST00000434753	c.86G>T	p.R29I	COSMIC	NP	NP
174	TCGA-BG-A0MQ-01	Tumour	ENDOMETRIUM	ENST00000434753	c.309G>A	p.T103T	COSMIC	NP	NP
175	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000434753	c.1132G>A	p.E378K	COSMIC	NP	NP
176	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000434753	c.1199C>A	p.S400Y	COSMIC	NP	NP
177	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000434753	c.504G>T	p.K168N	COSMIC	NP	NP
178	TCGA-CA-6717-01	Tumour	LARGE INTESTINE	ENST00000434753	c.1482T>G	p.I494M	COSMIC	NP	NP
179	TCGA-CJ-4897-01	Tumour	KIDNEY	ENST00000434753	c.776A>G	p.N259S	COSMIC	NP	NP
180	TCGA-D1-A17Q-01	Tumour	ENDOMETRIUM	ENST00000434753	c.1016T>C	p.I339T	COSMIC	NP	NP
181	TCGA-D5-5538-01	Tumour	LARGE INTESTINE	ENST00000434753	c.1145T>C	p.M382T	COSMIC	NP	NP
182	TCGA-D5-6539-01	Tumour	LARGE INTESTINE	ENST00000434753	c.533A>G	p.H178R	COSMIC	NP	NP
183	TCGA-G4-6317-01	Tumour	LARGE INTESTINE	ENST00000434753	c.766C>A	p.L256I	COSMIC	NP	NP
184	TCGA-G4-6588-01	Tumour	LARGE INTESTINE	ENST00000434753	c.536T>C	p.L179P	COSMIC	NP	NP
185	YUKRIN	Tumour	SKIN	ENST00000434753	c.934_935CC>TT	p.P312F	COSMIC	NP	NP
186	A204	Cell Line	SOFT_TISSUE	ENST00000434753	c.1099+3A>G	p.?	COSMIC	NP	NP
187	AN3CA	Cell Line	ENDOMETRIUM	ENST00000434753	c.47A>G	p.D16G	COSMIC	NP	NP
188	ATN1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000434753	c.1045_1047delGAG	p.E350delE	COSMIC	NP	NP
189	ECC12	Cell Line	STOMACH	ENST00000434753	c.1045_1047delGAG	p.E350delE	COSMIC	NP	NP
190	EN	Cell Line	ENDOMETRIUM	ENST00000434753	c.1045_1047delGAG	p.E350delE	COSMIC	NP	NP
191	GAMG	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000434753	c.878-5C>T	p.?	COSMIC	NP	NP
192	GB1	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000434753	c.1045_1047delGAG	p.E350delE	COSMIC	NP	NP
193	GCIY	Cell Line	STOMACH	ENST00000434753	c.1045_1047delGAG	p.E350delE	COSMIC	NP	NP
194	GOTO	Cell Line	AUTONOMIC_GANGLIA	ENST00000434753	c.1045_1047delGAG	p.E350delE	COSMIC	NP	NP
195	HT115	Cell Line	LARGE_INTESTINE	ENST00000434753	c.713G>A	p.R238Q	COSMIC	NP	NP
196	JHU029	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000434753	c.1138A>G	p.I380V	COSMIC	NP	NP
197	KARPAS45	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000434753	c.463C>A	p.P155T	COSMIC	NP	NP
198	KO52	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000434753	c.1045_1047delGAG	p.E350delE	COSMIC	NP	NP
199	KP2	Cell Line	PANCREAS	ENST00000434753	c.1045_1047delGAG	p.E350delE	COSMIC	NP	NP
200	KYAE1	Cell Line	OESOPHAGUS	ENST00000434753	c.1045_1047delGAG	p.E350delE	COSMIC	NP	NP
201	LC2AD	Cell Line	LUNG	ENST00000434753	c.1045_1047delGAG	p.E350delE	COSMIC	NP	NP
202	MCC13	Cell Line	SKIN	ENST00000434753	c.1121C>T	p.P374L	COSMIC	NP	NP
203	MCC13	Cell Line	SKIN	ENST00000434753	c.146G>A	p.R49Q	COSMIC	NP	NP
204	NCIH1105	Cell Line	LUNG	ENST00000434753	c.1180G>T	p.E394*	COSMIC	NP	NP
205	NCIH1155	Cell Line	LUNG	ENST00000434753	c.1310C>T	p.T437I	COSMIC	NP	NP
206	NCIH1568	Cell Line	LUNG	ENST00000434753	c.1254G>C	p.Q418H	COSMIC	NP	NP
207	RCC10RGB	Cell Line	KIDNEY	ENST00000434753	c.1045_1047delGAG	p.E350delE	COSMIC	NP	NP
208	RKO	Cell Line	LARGE_INTESTINE	ENST00000434753	c.977+2T>A	p.?	COSMIC	NP	NP
209	RL952	Cell Line	ENDOMETRIUM	ENST00000434753	c.872C>T	p.A291V	COSMIC	NP	NP
210	RS411	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000434753	c.1327C>T	p.R443C	COSMIC	NP	NP
211	SKMG1	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000434753	c.974C>A	p.P325Q	COSMIC	NP	NP
212	SNU175	Cell Line	LARGE_INTESTINE	ENST00000434753	c.1162G>A	p.D388N	COSMIC	NP	NP
213	SNU387	Cell Line	LIVER	ENST00000434753	c.1045_1047delGAG	p.E350delE	COSMIC	NP	NP
214	SNU81	Cell Line	LARGE_INTESTINE	ENST00000434753	c.905A>G	p.H302R	COSMIC	NP	NP
215	SW1271	Cell Line	LUNG	ENST00000434753	c.93A>G	p.K31K	COSMIC	NP	NP
216	TASK1	Cell Line	BONE	ENST00000434753	c.1045_1047delGAG	p.E350delE	COSMIC	NP	NP
217	TGBC24TKB	Cell Line	BILIARY_TRACT	ENST00000434753	c.1045_1047delGAG	p.E350delE	COSMIC	NP	NP
218	TK10	Cell Line	KIDNEY	ENST00000434753	c.878-5C>T	p.?	COSMIC	NP	NP

*NP: Not Predicted

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	9.0018	8.9563	0.0660	0.00665
BILIARY TRACT	9.4746	9.5458	0.3539	0.4494
BONE	9.2007	9.2485	-0.0010	0.00477
BREAST	9.3308	9.34765	0.0792	0.006613
CENTRAL NERVOUS SYSTEM	9.2178	9.2491	0.0307	0.006588
ENDOMETRIUM	8.9158	8.8119	0.0213	-3e-04
HAEMATOPOIETIC AND LYMPHOID TISSUE	9.2077	9.1877	0.0442	0.0138
KIDNEY	9.1864	9.133	0.0172	0.00793
LARGE INTESTINE	9.4199	9.43775	0.0388	0.00805
LIVER	9.4011	9.3491	0.0476	0.0226
LUNG	9.3078	9.3448	0.0764	0.017085
OESOPHAGUS	9.4332	9.59215	0.1707	0.03051
OVARY	9.0668	9.0831	0.0663	0.0049
PANCREAS	9.5149	9.5901	0.1305	0.0178
PLEURA	9.0157	8.9858	-0.1083	0.0019
PROSTATE	9.2206	9.26855	0.0162	0.01095
SALIVARY GLAND	9.6645	9.6645	0.0479	0.0479
SKIN	9.0630	9.0346	-0.0274	0.0058
SMALL INTESTINE	9.5677	9.5677	0.0521	0.0521
SOFT TISSUE	9.1800	9.17215	0.0988	0.01335
STOMACH	9.2958	9.17665	0.0334	0.01633
THYROID	9.7061	9.6474	0.0992	0.01159
UPPER AERODIGESTIVE TRACT	9.3010	9.3771	0.1299	0.0232
URINARY TRACT	9.3625	9.3692	0.1567	0.02434

Domain ID	Domain Name	Start Site	End Site	E-value
PF00653	BIR	29	93	4.9e-20
PF00653	BIR	166	230	4.3e-23
PF00653	BIR	268	330	2.7e-19
PF00901	Orbi_VP5	381	453	0.17
PF10217	DUF2039	442	486	0.49
PF13920	zf-C3HC4_3	447	489	4.8e-13
PF00653	BIR	29	93	4.9e-20
PF00653	BIR	166	230	4.3e-23
PF00653	BIR	268	330	2.7e-19
PF00901	Orbi_VP5	381	453	0.17
PF10217	DUF2039	442	486	0.49
PF13920	zf-C3HC4_3	447	489	4.8e-13

Domain ID	Start Site	End Site	E-value
0036727	257	344	8.77e-43
0035887	128	235	3.66e-37
0036727	257	344	8.77e-43
0035887	128	235	3.66e-37

S. No.	Position	Amino acid	Type	Description
1	10	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
2	116	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
3	12	C	S-nitrosylation	S-nitrosocysteine
4	123	S	Phosphorylation	Phosphoserine
5	139	Y	Phosphorylation	Phosphotyrosine
6	139	Y	Phosphorylation	Phosphotyrosine.
7	168	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
8	213	C	S-nitrosylation	S-nitrosocysteine
9	300	C	S-nitrosylation	S-nitrosocysteine
10	303	C	S-nitrosylation	S-nitrosocysteine
11	31	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
12	322	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
13	322	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin).
14	327	C	S-nitrosylation	S-nitrosocysteine
15	328	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
16	328	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin).
17	351	C	S-nitrosylation	S-nitrosocysteine
18	355	T	Phosphorylation	Phosphothreonine
19	356	T	Phosphorylation	Phosphothreonine
20	358	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
21	40	S	Phosphorylation	Phosphoserine
22	430	S	Phosphorylation	Phosphoserine
23	433	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
24	436	S	Phosphorylation	Phosphoserine
25	450	C	S-nitrosylation	S-nitrosocysteine.
26	470	T	Phosphorylation	Phosphothreonine
27	87	S	Phosphorylation	Phosphoserine
28	87	S	Phosphorylation	Phosphoserine (PKB_group;PKB_beta)
29	87	S	Phosphorylation	Phosphoserine; by PKB.
30	87	S	Phosphorylation (AKT1)	Phosphoserine
31	87	S	Phosphorylation (AKT2)	Phosphoserine
32	90	C	S-nitrosylation	S-nitrosocysteine
33	10	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
34	116	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
35	12	C	S-nitrosylation	S-nitrosocysteine
36	123	S	Phosphorylation	Phosphoserine
37	139	Y	Phosphorylation	Phosphotyrosine
38	139	Y	Phosphorylation	Phosphotyrosine.
39	168	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
40	213	C	S-nitrosylation	S-nitrosocysteine
41	300	C	S-nitrosylation	S-nitrosocysteine
42	303	C	S-nitrosylation	S-nitrosocysteine
43	31	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
44	322	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
45	322	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin).
46	327	C	S-nitrosylation	S-nitrosocysteine
47	328	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
48	328	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin).
49	351	C	S-nitrosylation	S-nitrosocysteine
50	355	T	Phosphorylation	Phosphothreonine
51	356	T	Phosphorylation	Phosphothreonine
52	358	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
53	40	S	Phosphorylation	Phosphoserine
54	430	S	Phosphorylation	Phosphoserine
55	433	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
56	436	S	Phosphorylation	Phosphoserine
57	450	C	S-nitrosylation	S-nitrosocysteine.
58	470	T	Phosphorylation	Phosphothreonine
59	87	S	Phosphorylation	Phosphoserine
60	87	S	Phosphorylation	Phosphoserine (PKB_group;PKB_beta)
61	87	S	Phosphorylation	Phosphoserine; by PKB.
62	87	S	Phosphorylation (AKT1)	Phosphoserine
63	87	S	Phosphorylation (AKT2)	Phosphoserine
64	90	C	S-nitrosylation	S-nitrosocysteine

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
XIAP	XIAP	XIAP	ENSP00000347858	P98170
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
P98170	XIAP	ENSP00000347858	XIAP	P98170
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
XIAP	ENSP00000347858	300079	P98170	PA25361

Protein: XIAP

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)

Modelled Structure	Structures available in PDB
	1C9Q, 1F9X, 1G3F, 1G73, 1I3O, 1I4O, 1I51, 1KMC, 1NW9, 1TFQ, 1TFT, 2ECG, 2JK7, 2KNA, 2OPY, 2OPZ, 2POI, 2POP, 2QRA, 2VSL, 3CLX, 3CM2, 3CM7, 3EYL, 3G76, 3HL5, 3UW4, 3UW5, 4EC4, 4HY0, 4IC2, 4IC3, 4J3Y, 4J44, 4J45, 4J46, 4J47, 4J48, 4KJU, 4KJV, 4KMP