ApoCanD

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	2334192	Cell Line	LUNG	ENST00000361842	c.335G>A	p.C112Y	COSMIC	NP	NP
2	587376	Tumour	LARGE INTESTINE	ENST00000361842	c.631C>T	p.R211C	COSMIC	NP	NP
3	587386	Tumour	LARGE INTESTINE	ENST00000361842	c.394C>T	p.R132C	COSMIC	NP	NP
4	B8	Tumour	URINARY TRACT	ENST00000361842	c.166C>A	p.Q56K	COSMIC	NP	NP
5	H1672	Cell Line	LUNG	ENST00000361842	c.335G>A	p.C112Y	COSMIC	NP	NP
6	HCT-15	Cell Line	LARGE INTESTINE	ENST00000361842	c.244C>T	p.R82C	COSMIC	NP	NP
7	SNB75	Cell Line	CENTRAL NERVOUS SYSTEM	ENST00000361842	c.484G>T	p.E162*	COSMIC	NP	NP
8	TCGA-55-8089-01	Tumour	LUNG	ENST00000361842	c.559C>G	p.P187A	COSMIC	NP	NP
9	TCGA-AA-A00J-01	Tumour	LARGE INTESTINE	ENST00000361842	c.50C>A	p.S17Y	COSMIC	NP	NP
10	TCGA-AG-A002-01	Tumour	LARGE INTESTINE	ENST00000361842	c.28A>T	p.N10Y	COSMIC	NP	NP
11	TCGA-AP-A056-01	Tumour	ENDOMETRIUM	ENST00000361842	c.804T>C	p.S268S	COSMIC	NP	NP
12	TCGA-CH-5750-01	Tumour	PROSTATE	ENST00000361842	c.516T>C	p.C172C	COSMIC	NP	NP
13	TCGA-CM-5348-01	Tumour	LARGE INTESTINE	ENST00000361842	c.564A>T	p.E188D	COSMIC	NP	NP
14	TCGA-EW-A1OV-01	Tumour	BREAST	ENST00000361842	c.859C>T	p.R287W	COSMIC	NP	NP
15	TCGA-GV-A3QI-01	Tumour	URINARY TRACT	ENST00000361842	c.651A>T	p.I217I	COSMIC	NP	NP
16	YUDUTY	Tumour	SKIN	ENST00000361842	c.203A>G	p.K68R	COSMIC	NP	NP
17	BFTC909	Cell Line	KIDNEY	ENST00000361842	c.303C>T	p.H101H	COSMIC	NP	NP
18	CALU3	Cell Line	LUNG	ENST00000361842	c.632G>C	p.R211P	COSMIC	NP	NP
19	COLO680N	Cell Line	OESOPHAGUS	ENST00000361842	c.792G>A	p.L264L	COSMIC	NP	NP
20	D392MG	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000361842	c.438T>C	p.A146A	COSMIC	NP	NP
21	EFO21	Cell Line	OVARY	ENST00000361842	c.745C>T	p.P249S	COSMIC	NP	NP
22	EN	Cell Line	ENDOMETRIUM	ENST00000361842	c.528A>G	p.S176S	COSMIC	NP	NP
23	H290	Cell Line	PLEURA	ENST00000361842	c.40C>A	p.H14N	COSMIC	NP	NP
24	H4	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000361842	c.86G>A	p.R29Q	COSMIC	NP	NP
25	H513	Cell Line	PLEURA	ENST00000361842	c.507+3G>T	p.?	COSMIC	NP	NP
26	JEKO1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000361842	c.471C>T	p.N157N	COSMIC	NP	NP
27	KATOIII	Cell Line	STOMACH	ENST00000361842	c.394C>A	p.R132S	COSMIC	NP	NP
28	KMH2	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000361842	c.551T>A	p.V184D	COSMIC	NP	NP
29	NCIH1155	Cell Line	LUNG	ENST00000361842	c.507G>A	p.M169I	COSMIC	NP	NP
30	NCIH1963	Cell Line	LUNG	ENST00000361842	c.763_764delAG	p.G256fs*2	COSMIC	NP	NP
31	NCIH358	Cell Line	LUNG	ENST00000361842	c.484G>T	p.E162*	COSMIC	NP	NP
32	PA1	Cell Line	OVARY	ENST00000361842	c.32+1G>A	p.?	COSMIC	NP	NP
33	SCC9	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000361842	c.847C>T	p.Q283*	COSMIC	NP	NP
34	SHP77	Cell Line	LUNG	ENST00000361842	c.635C>A	p.P212Q	COSMIC	NP	NP
35	SNB75	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000361842	c.484G>T	p.E162*	COSMIC	NP	NP
36	SNU81	Cell Line	LARGE_INTESTINE	ENST00000361842	c.537G>T	p.K179N	COSMIC	NP	NP
37	SW48	Cell Line	LARGE_INTESTINE	ENST00000361842	c.291G>A	p.K97K	COSMIC	NP	NP
38	TE4	Cell Line	OESOPHAGUS	ENST00000361842	c.261G>A	p.K87K	COSMIC	NP	NP
39	2334192	Cell Line	LUNG	ENST00000361842	c.335G>A	p.C112Y	COSMIC	NP	NP
40	587376	Tumour	LARGE INTESTINE	ENST00000361842	c.631C>T	p.R211C	COSMIC	NP	NP
41	587386	Tumour	LARGE INTESTINE	ENST00000361842	c.394C>T	p.R132C	COSMIC	NP	NP
42	B8	Tumour	URINARY TRACT	ENST00000361842	c.166C>A	p.Q56K	COSMIC	NP	NP
43	H1672	Cell Line	LUNG	ENST00000361842	c.335G>A	p.C112Y	COSMIC	NP	NP
44	HCT-15	Cell Line	LARGE INTESTINE	ENST00000361842	c.244C>T	p.R82C	COSMIC	NP	NP
45	SNB75	Cell Line	CENTRAL NERVOUS SYSTEM	ENST00000361842	c.484G>T	p.E162*	COSMIC	NP	NP
46	TCGA-55-8089-01	Tumour	LUNG	ENST00000361842	c.559C>G	p.P187A	COSMIC	NP	NP
47	TCGA-AA-A00J-01	Tumour	LARGE INTESTINE	ENST00000361842	c.50C>A	p.S17Y	COSMIC	NP	NP
48	TCGA-AG-A002-01	Tumour	LARGE INTESTINE	ENST00000361842	c.28A>T	p.N10Y	COSMIC	NP	NP
49	TCGA-AP-A056-01	Tumour	ENDOMETRIUM	ENST00000361842	c.804T>C	p.S268S	COSMIC	NP	NP
50	TCGA-CH-5750-01	Tumour	PROSTATE	ENST00000361842	c.516T>C	p.C172C	COSMIC	NP	NP
51	TCGA-CM-5348-01	Tumour	LARGE INTESTINE	ENST00000361842	c.564A>T	p.E188D	COSMIC	NP	NP
52	TCGA-EW-A1OV-01	Tumour	BREAST	ENST00000361842	c.859C>T	p.R287W	COSMIC	NP	NP
53	TCGA-GV-A3QI-01	Tumour	URINARY TRACT	ENST00000361842	c.651A>T	p.I217I	COSMIC	NP	NP
54	YUDUTY	Tumour	SKIN	ENST00000361842	c.203A>G	p.K68R	COSMIC	NP	NP
55	BFTC909	Cell Line	KIDNEY	ENST00000361842	c.303C>T	p.H101H	COSMIC	NP	NP
56	CALU3	Cell Line	LUNG	ENST00000361842	c.632G>C	p.R211P	COSMIC	NP	NP
57	COLO680N	Cell Line	OESOPHAGUS	ENST00000361842	c.792G>A	p.L264L	COSMIC	NP	NP
58	D392MG	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000361842	c.438T>C	p.A146A	COSMIC	NP	NP
59	EFO21	Cell Line	OVARY	ENST00000361842	c.745C>T	p.P249S	COSMIC	NP	NP
60	EN	Cell Line	ENDOMETRIUM	ENST00000361842	c.528A>G	p.S176S	COSMIC	NP	NP
61	H290	Cell Line	PLEURA	ENST00000361842	c.40C>A	p.H14N	COSMIC	NP	NP
62	H4	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000361842	c.86G>A	p.R29Q	COSMIC	NP	NP
63	H513	Cell Line	PLEURA	ENST00000361842	c.507+3G>T	p.?	COSMIC	NP	NP
64	JEKO1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000361842	c.471C>T	p.N157N	COSMIC	NP	NP
65	KATOIII	Cell Line	STOMACH	ENST00000361842	c.394C>A	p.R132S	COSMIC	NP	NP
66	KMH2	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000361842	c.551T>A	p.V184D	COSMIC	NP	NP
67	NCIH1155	Cell Line	LUNG	ENST00000361842	c.507G>A	p.M169I	COSMIC	NP	NP
68	NCIH1963	Cell Line	LUNG	ENST00000361842	c.763_764delAG	p.G256fs*2	COSMIC	NP	NP
69	NCIH358	Cell Line	LUNG	ENST00000361842	c.484G>T	p.E162*	COSMIC	NP	NP
70	PA1	Cell Line	OVARY	ENST00000361842	c.32+1G>A	p.?	COSMIC	NP	NP
71	SCC9	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000361842	c.847C>T	p.Q283*	COSMIC	NP	NP
72	SHP77	Cell Line	LUNG	ENST00000361842	c.635C>A	p.P212Q	COSMIC	NP	NP
73	SNB75	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000361842	c.484G>T	p.E162*	COSMIC	NP	NP
74	SNU81	Cell Line	LARGE_INTESTINE	ENST00000361842	c.537G>T	p.K179N	COSMIC	NP	NP
75	SW48	Cell Line	LARGE_INTESTINE	ENST00000361842	c.291G>A	p.K97K	COSMIC	NP	NP
76	TE4	Cell Line	OESOPHAGUS	ENST00000361842	c.261G>A	p.K87K	COSMIC	NP	NP

*NP: Not Predicted

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	4.5656	4.575	-0.2378	-0.09234
BILIARY TRACT	5.6159	4.9302	-0.2135	-0.3225
BONE	6.4454	6.291	-0.0583	-0.0352
BREAST	6.1519	5.6517	-0.2320	-0.15375
CENTRAL NERVOUS SYSTEM	6.6460	6.3532	-0.1102	-0.01298
ENDOMETRIUM	5.4087	4.6761	-0.0197	-0.0153
HAEMATOPOIETIC AND LYMPHOID TISSUE	7.0949	6.8945	-0.2878	-0.0526
KIDNEY	6.1966	5.911	-0.0002	0.0859
LARGE INTESTINE	5.5388	4.83175	-0.2754	-0.11755
LIVER	5.3286	4.8091	-0.1672	-0.2333
LUNG	5.3469	4.69545	-0.1583	-0.09805
OESOPHAGUS	5.1320	4.86855	0.0794	0.10855
OVARY	5.9322	5.2699	-0.3420	-0.2623
PANCREAS	6.6336	6.6151	-0.3710	-0.4088
PLEURA	7.1455	6.3182	-0.0711	-0.0688
PROSTATE	4.4903	4.43845	0.0708	0.04535
SALIVARY GLAND	6.8439	6.8439	0.3252	0.3252
SKIN	5.9260	5.1376	-0.1291	-0.01281
SMALL INTESTINE	4.8328	4.8328	0.0092	0.009153
SOFT TISSUE	5.4228	4.79475	-0.1013	-0.01035
STOMACH	5.4312	4.87115	-0.2683	-0.15475
THYROID	6.4889	5.9445	-0.1184	-0.09015
UPPER AERODIGESTIVE TRACT	7.1941	7.04345	0.0576	0.036105
URINARY TRACT	6.6848	6.41835	-0.3480	-0.3506

Domain ID	Domain Name	Start Site	End Site	E-value
PF02176	zf-TRAF	55	101	1.1e-05
PF12230	PRP21_like_P	147	169	0.25
PF02176	zf-TRAF	55	101	1.1e-05
PF12230	PRP21_like_P	147	169	0.25

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
XAF1	XAF1	XAF1	ENSP00000341029	Q6GPH4
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
Q6GPH4	XAF1	ENSP00000341029	XAF1	Q6GPH4
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
XAF1	ENSP00000341029	606717	Q6GPH4	PA162409299

Protein: XAF1

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)

Modelled Structure	Structures available in PDB
	2LXW