ApoCanD

Mutation Data (+)

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	ABC1	Cell Line	LUNG	NP_003780	c.908G>T	p.G303V	CCLE	NP	NP
2	HEC59	Cell Line	ENDOMETRIUM	NP_003780	c.839C>T	p.A280V	CCLE	NP	NP
3	NCIH596	Cell Line	LUNG	NP_003780	c.826G>A	p.E276K	CCLE	NP	NP
4	NCIN87	Cell Line	STOMACH	NP_003780	c.333G>C	p.S111S	CCLE	NP	NP
5	OPM2	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_003780	c.34G>T	p.V12L	CCLE	NP	NP
6	112539	Tumour	LUNG	ENST00000345057	c.179A>G	p.Q60R	COSMIC	NP	NP
7	587222	Tumour	LARGE INTESTINE	ENST00000345057	c.833G>A	p.R278H	COSMIC	NP	NP
8	ME029T	Tumour	SKIN	ENST00000345057	c.448G>A	p.E150K	COSMIC	NP	NP
9	TCGA-22-4604-01	Tumour	LUNG	ENST00000345057	c.842C>T	p.T281M	COSMIC	NP	NP
10	TCGA-60-2708-01	Tumour	LUNG	ENST00000345057	c.438G>A	p.R146R	COSMIC	NP	NP
11	TCGA-64-1676-01	Tumour	LUNG	ENST00000345057	c.99G>T	p.A33A	COSMIC	NP	NP
12	TCGA-85-6560-01	Tumour	LUNG	ENST00000345057	c.768C>T	p.Y256Y	COSMIC	NP	NP
13	TCGA-97-7937-01	Tumour	LUNG	ENST00000345057	c.635G>C	p.R212P	COSMIC	NP	NP
14	TCGA-AA-3977-01	Tumour	LARGE INTESTINE	ENST00000345057	c.69G>T	p.L23L	COSMIC	NP	NP
15	TCGA-AA-A01D-01	Tumour	LARGE INTESTINE	ENST00000345057	c.131C>T	p.A44V	COSMIC	NP	NP
16	TCGA-AU-6004-01	Tumour	LARGE INTESTINE	ENST00000345057	c.128G>T	p.R43M	COSMIC	NP	NP
17	TCGA-AZ-6601-01	Tumour	LARGE INTESTINE	ENST00000345057	c.667G>A	p.A223T	COSMIC	NP	NP
18	TCGA-BH-A0C1-01	Tumour	BREAST	ENST00000345057	c.98C>T	p.A33V	COSMIC	NP	NP
19	TCGA-BP-5001-01	Tumour	KIDNEY	ENST00000345057	c.59A>G	p.E20G	COSMIC	NP	NP
20	TCGA-CJ-4900-01	Tumour	KIDNEY	ENST00000345057	c.46T>C	p.Y16H	COSMIC	NP	NP
21	TCGA-D1-A17H-01	Tumour	ENDOMETRIUM	ENST00000345057	c.66G>A	p.S22S	COSMIC	NP	NP
22	ABC1	Cell Line	LUNG	ENST00000345057	c.906G>T	p.L302L	COSMIC	NP	NP
23	ABC1	Cell Line	LUNG	ENST00000345057	c.908G>T	p.G303V	COSMIC	NP	NP
24	CCRFCEM	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000345057	c.679G>A	p.G227S	COSMIC	NP	NP
25	DG75	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000345057	c.86C>T	p.S29L	COSMIC	NP	NP
26	DND41	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000345057	c.66G>A	p.S22S	COSMIC	NP	NP
27	JHU011	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000345057	c.762C>T	p.Y254Y	COSMIC	NP	NP
28	KYSE150	Cell Line	OESOPHAGUS	ENST00000345057	c.662C>A	p.T221K	COSMIC	NP	NP
29	LC41	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000345057	c.662C>A	p.T221K	COSMIC	NP	NP
30	OPM2	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000345057	c.34G>T	p.V12L	COSMIC	NP	NP
31	OPM2	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000345057	c.662C>A	p.T221K	COSMIC	NP	NP
32	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000345057	c.66G>A	p.S22S	COSMIC	NP	NP
33	TE10	Cell Line	OESOPHAGUS	ENST00000345057	c.662C>A	p.T221K	COSMIC	NP	NP
34	ABC1	Cell Line	LUNG	NP_003780	c.908G>T	p.G303V	CCLE	NP	NP
35	HEC59	Cell Line	ENDOMETRIUM	NP_003780	c.839C>T	p.A280V	CCLE	NP	NP
36	NCIH596	Cell Line	LUNG	NP_003780	c.826G>A	p.E276K	CCLE	NP	NP
37	NCIN87	Cell Line	STOMACH	NP_003780	c.333G>C	p.S111S	CCLE	NP	NP
38	OPM2	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_003780	c.34G>T	p.V12L	CCLE	NP	NP
39	112539	Tumour	LUNG	ENST00000345057	c.179A>G	p.Q60R	COSMIC	NP	NP
40	587222	Tumour	LARGE INTESTINE	ENST00000345057	c.833G>A	p.R278H	COSMIC	NP	NP
41	ME029T	Tumour	SKIN	ENST00000345057	c.448G>A	p.E150K	COSMIC	NP	NP
42	TCGA-22-4604-01	Tumour	LUNG	ENST00000345057	c.842C>T	p.T281M	COSMIC	NP	NP
43	TCGA-60-2708-01	Tumour	LUNG	ENST00000345057	c.438G>A	p.R146R	COSMIC	NP	NP
44	TCGA-64-1676-01	Tumour	LUNG	ENST00000345057	c.99G>T	p.A33A	COSMIC	NP	NP
45	TCGA-85-6560-01	Tumour	LUNG	ENST00000345057	c.768C>T	p.Y256Y	COSMIC	NP	NP
46	TCGA-97-7937-01	Tumour	LUNG	ENST00000345057	c.635G>C	p.R212P	COSMIC	NP	NP
47	TCGA-AA-3977-01	Tumour	LARGE INTESTINE	ENST00000345057	c.69G>T	p.L23L	COSMIC	NP	NP
48	TCGA-AA-A01D-01	Tumour	LARGE INTESTINE	ENST00000345057	c.131C>T	p.A44V	COSMIC	NP	NP
49	TCGA-AU-6004-01	Tumour	LARGE INTESTINE	ENST00000345057	c.128G>T	p.R43M	COSMIC	NP	NP
50	TCGA-AZ-6601-01	Tumour	LARGE INTESTINE	ENST00000345057	c.667G>A	p.A223T	COSMIC	NP	NP
51	TCGA-BH-A0C1-01	Tumour	BREAST	ENST00000345057	c.98C>T	p.A33V	COSMIC	NP	NP
52	TCGA-BP-5001-01	Tumour	KIDNEY	ENST00000345057	c.59A>G	p.E20G	COSMIC	NP	NP
53	TCGA-CJ-4900-01	Tumour	KIDNEY	ENST00000345057	c.46T>C	p.Y16H	COSMIC	NP	NP
54	TCGA-D1-A17H-01	Tumour	ENDOMETRIUM	ENST00000345057	c.66G>A	p.S22S	COSMIC	NP	NP
55	ABC1	Cell Line	LUNG	ENST00000345057	c.906G>T	p.L302L	COSMIC	NP	NP
56	ABC1	Cell Line	LUNG	ENST00000345057	c.908G>T	p.G303V	COSMIC	NP	NP
57	CCRFCEM	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000345057	c.679G>A	p.G227S	COSMIC	NP	NP
58	DG75	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000345057	c.86C>T	p.S29L	COSMIC	NP	NP
59	DND41	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000345057	c.66G>A	p.S22S	COSMIC	NP	NP
60	JHU011	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000345057	c.762C>T	p.Y254Y	COSMIC	NP	NP
61	KYSE150	Cell Line	OESOPHAGUS	ENST00000345057	c.662C>A	p.T221K	COSMIC	NP	NP
62	LC41	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000345057	c.662C>A	p.T221K	COSMIC	NP	NP
63	OPM2	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000345057	c.34G>T	p.V12L	COSMIC	NP	NP
64	OPM2	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000345057	c.662C>A	p.T221K	COSMIC	NP	NP
65	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000345057	c.66G>A	p.S22S	COSMIC	NP	NP
66	TE10	Cell Line	OESOPHAGUS	ENST00000345057	c.662C>A	p.T221K	COSMIC	NP	NP

*NP: Not Predicted

Copy number variation and expression profile (+)

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	7.1569	6.992	0.0437	0.02586
BILIARY TRACT	8.4187	8.4362	-0.1137	-0.1799
BONE	8.0169	8.1758	-0.0697	0.007
BREAST	8.2823	8.2839	-0.0577	0.00175
CENTRAL NERVOUS SYSTEM	8.2738	8.2997	0.0088	0.04665
ENDOMETRIUM	8.0943	8.2205	0.0068	-0.0059
HAEMATOPOIETIC AND LYMPHOID TISSUE	8.1920	8.1112	-0.0427	0.0035
KIDNEY	8.8018	8.7146	0.0722	0.06856
LARGE INTESTINE	8.2298	8.25335	-0.0080	-0.0077
LIVER	8.0242	8.0562	-0.0947	-0.105
LUNG	8.1508	8.27725	0.0182	0.04214
OESOPHAGUS	8.7261	8.6479	0.1744	0.15505
OVARY	8.0981	8.1363	-0.0585	0.0168
PANCREAS	8.7232	8.734	0.1088	0.1432
PLEURA	8.6083	8.7197	0.1129	0.1606
PROSTATE	8.2868	8.32025	-0.1511	-0.0353
SALIVARY GLAND	8.4274	8.4274	-0.0896	-0.0896
SKIN	8.2013	8.2063	-0.1074	-0.04821
SMALL INTESTINE	8.0531	8.0531	0.0151	0.0151
SOFT TISSUE	7.8628	7.94015	0.0027	-0.01
STOMACH	8.0260	8.00135	-0.0410	-0.03841
THYROID	7.9169	8.136	-0.4593	-0.0518
UPPER AERODIGESTIVE TRACT	8.8868	8.88045	0.1245	0.067725
URINARY TRACT	8.4817	8.40185	0.0500	0.01215

Gene Essentiality Data (+)

Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.

test

Tertiary structure (+)

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Modelled Structure	Structures available in PDB
	1F2H, 1F3V

Structure Domains (+)

1. PFAM Domains:

Domain ID	Domain Name	Start Site	End Site	E-value
PF09034	TRADD_N	51	161	3.2e-49
PF00531	Death	223	301	1.4e-07
PF09034	TRADD_N	51	161	3.2e-49
PF00531	Death	223	301	1.4e-07

2. Superfamily Domains:

Domain ID	Start Site	End Site	E-value
0046699	8	164	2.62e-68
0036368	221	305	1.65e-14
0046699	8	164	2.62e-68
0036368	221	305	1.65e-14

Sequence Alignment (+)

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1. Variants are not present in 1000 Genomes!!

2. Sequence alignment with CCLE mutants:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

3. Sequence alignment with COSMIC mutants:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

4. Sequence alignment with homologus proteins:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

Sequence Profiles (+)

HMM
With Uniprot database	With Mutants	With 1000 Genome Variants

PSSM
With Uniprot database	With Mutants	With 1000 Genome Variant

Post Translational Modifications (+)

S. No.	Position	Amino acid	Type	Description
1	163	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
2	215	S	Phosphorylation	Phosphoserine
3	296	S	Phosphorylation	Phosphoserine
4	163	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
5	215	S	Phosphorylation	Phosphoserine
6	296	S	Phosphorylation	Phosphoserine

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
TRADD	TRADD	TRADD	ENSP00000341268	Q15628
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
Q15628	TRADD	ENSP00000341268	TRADD	Q15628
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
TRADD	ENSP00000341268	603500	Q15628	PA36707

Protein: TRADD

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)