ApoCanD

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	DND41	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_003801	c.747G>A	p.E249E	CCLE	NP	NP
2	DND41	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_003801	c.76C>A	p.L26M	CCLE	PASSENGER/OTHER	Probably Damaging
3	HCC1588	Cell Line	LUNG	NP_003801	c.726C>T	p.I242I	CCLE	NP	NP
4	HCT15	Cell Line	LARGE INTESTINE	NP_003801	c.657T>C	p.P219P	CCLE	NP	NP
5	HEC59	Cell Line	ENDOMETRIUM	NP_003801	c.230G>A	p.C77Y	CCLE	PASSENGER/OTHER	Probably Damaging
6	HGC27	Cell Line	STOMACH	NP_003801	c.517G>A	p.E173K	CCLE	PASSENGER/OTHER	Probably Damaging
7	HMC18	Cell Line	BREAST	NP_003801	c.706G>T	p.E236*	CCLE	NP	NP
8	HS944T	Cell Line	SKIN	NP_003801	c.708A>C	p.E236D	CCLE	PASSENGER/OTHER	Benign
9	HT	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_003801	c.681A>G	p.R227R	CCLE	NP	NP
10	HT55	Cell Line	LARGE INTESTINE	NP_003801	c.433A>T	p.K145*	CCLE	NP	NP
11	K029AX	Cell Line	SKIN	NP_003801	c.196G>A	p.D66N	CCLE	PASSENGER/OTHER	Probably Damaging
12	KMM1	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_003801	c.721T>G	p.S241A	CCLE	PASSENGER/OTHER	Probably Damaging
13	LS513	Cell Line	LARGE INTESTINE	NP_003801	c.726C>T	p.I242I	CCLE	NP	NP
14	MALME3M	Cell Line	SKIN	NP_003801	c.753G>A	p.K251K	CCLE	NP	NP
15	MHHCALL4	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_003801	c.163G>A	p.A55T	CCLE	PASSENGER/OTHER	Probably Damaging
16	NCIH650	Cell Line	LUNG	NP_003801	c.517G>T	p.E173*	CCLE	NP	NP
17	NUGC4	Cell Line	STOMACH	NP_003801	c.708A>C	p.E236D	CCLE	PASSENGER/OTHER	Benign
18	RERFLCAD1	Cell Line	LUNG	NP_003801	c.253C>T	p.R85C	CCLE	PASSENGER/OTHER	Probably Damaging
19	SNU1	Cell Line	STOMACH	NP_003801	c.537_537delA	p.K179fs	CCLE	NP	NP
20	SW48	Cell Line	LARGE INTESTINE	NP_003801	c.606C>T	p.N202N	CCLE	NP	NP
21	TGBC11TKB	Cell Line	STOMACH	NP_003801	c.296C>T	p.T99I	CCLE	PASSENGER/OTHER	Benign
22	24T	Tumour	SKIN	ENST00000241261	c.587T>A	p.I196K	COSMIC	NP	NP
23	24T	Tumour	SKIN	ENST00000241261	c.592G>A	p.E198K	COSMIC	NP	NP
24	86583	Tumour	LUNG	ENST00000241261	c.554A>G	p.Y185C	COSMIC	NP	NP
25	91T	Tumour	SKIN	ENST00000241261	c.754G>A	p.E252K	COSMIC	NP	NP
26	DU-145	Cell Line	PROSTATE	ENST00000241261	c.572G>T	p.R191L	COSMIC	NP	NP
27	HCC89T	Tumour	LIVER	ENST00000241261	c.208G>T	p.E70*	COSMIC	NP	NP
28	LUAD-CHTN-MAD06-00668	Tumour	LUNG	ENST00000241261	c.171C>A	p.F57L	COSMIC	NP	NP
29	LUAD-NYU282	Tumour	LUNG	ENST00000241261	c.525C>A	p.V175V	COSMIC	NP	NP
30	MZ7-mel	Cell Line	SKIN	ENST00000241261	c.693G>A	p.W231*	COSMIC	NP	NP
31	Malme-3M	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000241261	c.650C>T	p.P217L	COSMIC	NP	NP
32	PD3992a	Tumour	BREAST	ENST00000241261	c.538G>A	p.G180R	COSMIC	NP	NP
33	PD4119a	Tumour	BREAST	ENST00000241261	c.181G>A	p.D61N	COSMIC	NP	NP
34	RK051	Tumour	C01 LIVER	ENST00000241261	c.314-3T>C	p.?	COSMIC	NP	NP
35	TCGA-13-2061-01	Tumour	OVARY	ENST00000241261	c.607G>A	p.D203N	COSMIC	NP	NP
36	TCGA-43-6143-01	Tumour	LUNG	ENST00000241261	c.828G>T	p.G276G	COSMIC	NP	NP
37	TCGA-49-4490-01	Tumour	LUNG	ENST00000241261	c.807C>T	p.D269D	COSMIC	NP	NP
38	TCGA-51-4081-01	Tumour	LUNG	ENST00000241261	c.375C>T	p.H125H	COSMIC	NP	NP
39	TCGA-61-1998-01	Tumour	OVARY	ENST00000241261	c.36_37GG>AA	p.G13R	COSMIC	NP	NP
40	TCGA-67-6215-01	Tumour	LUNG	ENST00000241261	c.834T>G	p.F278L	COSMIC	NP	NP
41	TCGA-A8-A08L-01	Tumour	BREAST	ENST00000241261	c.33C>T	p.S11S	COSMIC	NP	NP
42	TCGA-AA-3833-01	Tumour	LARGE INTESTINE	ENST00000241261	c.340G>A	p.V114M	COSMIC	NP	NP
43	TCGA-AK-3447-01	Tumour	KIDNEY	ENST00000241261	c.418+2T>A	p.?	COSMIC	NP	NP
44	TCGA-AQ-A04H-01	Tumour	BREAST	ENST00000241261	c.687T>C	p.S229S	COSMIC	NP	NP
45	TCGA-AS-3778-01	Tumour	KIDNEY	ENST00000241261	c.418+2T>A	p.?	COSMIC	NP	NP
46	TCGA-AX-A0J0-01	Tumour	ENDOMETRIUM	ENST00000241261	c.178G>T	p.E60*	COSMIC	NP	NP
47	TCGA-AZ-6608-01	Tumour	LARGE INTESTINE	ENST00000241261	c.693G>A	p.W231*	COSMIC	NP	NP
48	TCGA-EI-6508-01	Tumour	LARGE INTESTINE	ENST00000241261	c.693G>A	p.W231*	COSMIC	NP	NP
49	TCGA-FD-A3N5-01	Tumour	URINARY TRACT	ENST00000241261	c.412T>C	p.S138P	COSMIC	NP	NP
50	TCGA-GV-A3JX-01	Tumour	URINARY TRACT	ENST00000241261	c.279G>C	p.L93F	COSMIC	NP	NP
51	YUMER	Tumour	SKIN	ENST00000241261	c.821T>A	p.F274Y	COSMIC	NP	NP
52	COLO792	Cell Line	SKIN	ENST00000241261	c.419-7C>T	p.?	COSMIC	NP	NP
53	D566MG	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000241261	c.133-3C>A	p.?	COSMIC	NP	NP
54	DND41	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000241261	c.747G>A	p.E249E	COSMIC	NP	NP
55	DND41	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000241261	c.76C>A	p.L26M	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
56	DU145	Cell Line	PROSTATE	ENST00000241261	c.572G>T	p.R191L	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
57	ES8	Cell Line	BONE	ENST00000241261	c.7A>G	p.M3V	COSMIC	PASSENGER/OTHER	BENIGN
58	HCT15	Cell Line	LARGE_INTESTINE	ENST00000241261	c.657T>C	p.P219P	COSMIC	NP	NP
59	HGC27	Cell Line	STOMACH	ENST00000241261	c.517G>A	p.E173K	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
60	HT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000241261	c.681A>G	p.R227R	COSMIC	NP	NP
61	HT55	Cell Line	LARGE_INTESTINE	ENST00000241261	c.433A>T	p.K145*	COSMIC	NP	NP
62	IM95	Cell Line	STOMACH	ENST00000241261	c.208G>A	p.E70K	COSMIC	PASSENGER/OTHER	BENIGN
63	JURLMK1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000241261	c.448A>G	p.K150E	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
64	LS513	Cell Line	LARGE_INTESTINE	ENST00000241261	c.726C>T	p.I242I	COSMIC	NP	NP
65	LU135	Cell Line	LUNG	ENST00000241261	c.448A>C	p.K150Q	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
66	MHHCALL4	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000241261	c.163G>A	p.A55T	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
67	MZ7MEL	Cell Line	SKIN	ENST00000241261	c.693G>A	p.W231*	COSMIC	NP	NP
68	NCIH650	Cell Line	LUNG	ENST00000241261	c.517G>T	p.E173*	COSMIC	NP	NP
69	NCISNU1	Cell Line	STOMACH	ENST00000241261	c.537delA	p.Y182fs*15	COSMIC	NP	NP
70	SW684	Cell Line	SOFT_TISSUE	ENST00000241261	c.517G>A	p.E173K	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
71	SW684	Cell Line	SOFT_TISSUE	ENST00000241261	c.583G>A	p.E195K	COSMIC	PASSENGER/OTHER	BENIGN
72	TGBC11TKB	Cell Line	STOMACH	ENST00000241261	c.296C>T	p.T99I	COSMIC	PASSENGER/OTHER	BENIGN
73	DND41	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_003801	c.747G>A	p.E249E	CCLE	NP	NP
74	DND41	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_003801	c.76C>A	p.L26M	CCLE	PASSENGER/OTHER	Probably Damaging
75	HCC1588	Cell Line	LUNG	NP_003801	c.726C>T	p.I242I	CCLE	NP	NP
76	HCT15	Cell Line	LARGE INTESTINE	NP_003801	c.657T>C	p.P219P	CCLE	NP	NP
77	HEC59	Cell Line	ENDOMETRIUM	NP_003801	c.230G>A	p.C77Y	CCLE	PASSENGER/OTHER	Probably Damaging
78	HGC27	Cell Line	STOMACH	NP_003801	c.517G>A	p.E173K	CCLE	PASSENGER/OTHER	Probably Damaging
79	HMC18	Cell Line	BREAST	NP_003801	c.706G>T	p.E236*	CCLE	NP	NP
80	HS944T	Cell Line	SKIN	NP_003801	c.708A>C	p.E236D	CCLE	PASSENGER/OTHER	Benign
81	HT	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_003801	c.681A>G	p.R227R	CCLE	NP	NP
82	HT55	Cell Line	LARGE INTESTINE	NP_003801	c.433A>T	p.K145*	CCLE	NP	NP
83	K029AX	Cell Line	SKIN	NP_003801	c.196G>A	p.D66N	CCLE	PASSENGER/OTHER	Probably Damaging
84	KMM1	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_003801	c.721T>G	p.S241A	CCLE	PASSENGER/OTHER	Probably Damaging
85	LS513	Cell Line	LARGE INTESTINE	NP_003801	c.726C>T	p.I242I	CCLE	NP	NP
86	MALME3M	Cell Line	SKIN	NP_003801	c.753G>A	p.K251K	CCLE	NP	NP
87	MHHCALL4	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_003801	c.163G>A	p.A55T	CCLE	PASSENGER/OTHER	Probably Damaging
88	NCIH650	Cell Line	LUNG	NP_003801	c.517G>T	p.E173*	CCLE	NP	NP
89	NUGC4	Cell Line	STOMACH	NP_003801	c.708A>C	p.E236D	CCLE	PASSENGER/OTHER	Benign
90	RERFLCAD1	Cell Line	LUNG	NP_003801	c.253C>T	p.R85C	CCLE	PASSENGER/OTHER	Probably Damaging
91	SNU1	Cell Line	STOMACH	NP_003801	c.537_537delA	p.K179fs	CCLE	NP	NP
92	SW48	Cell Line	LARGE INTESTINE	NP_003801	c.606C>T	p.N202N	CCLE	NP	NP
93	TGBC11TKB	Cell Line	STOMACH	NP_003801	c.296C>T	p.T99I	CCLE	PASSENGER/OTHER	Benign
94	24T	Tumour	SKIN	ENST00000241261	c.587T>A	p.I196K	COSMIC	NP	NP
95	24T	Tumour	SKIN	ENST00000241261	c.592G>A	p.E198K	COSMIC	NP	NP
96	86583	Tumour	LUNG	ENST00000241261	c.554A>G	p.Y185C	COSMIC	NP	NP
97	91T	Tumour	SKIN	ENST00000241261	c.754G>A	p.E252K	COSMIC	NP	NP
98	DU-145	Cell Line	PROSTATE	ENST00000241261	c.572G>T	p.R191L	COSMIC	NP	NP
99	HCC89T	Tumour	LIVER	ENST00000241261	c.208G>T	p.E70*	COSMIC	NP	NP
100	LUAD-CHTN-MAD06-00668	Tumour	LUNG	ENST00000241261	c.171C>A	p.F57L	COSMIC	NP	NP
101	LUAD-NYU282	Tumour	LUNG	ENST00000241261	c.525C>A	p.V175V	COSMIC	NP	NP
102	MZ7-mel	Cell Line	SKIN	ENST00000241261	c.693G>A	p.W231*	COSMIC	NP	NP
103	Malme-3M	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000241261	c.650C>T	p.P217L	COSMIC	NP	NP
104	PD3992a	Tumour	BREAST	ENST00000241261	c.538G>A	p.G180R	COSMIC	NP	NP
105	PD4119a	Tumour	BREAST	ENST00000241261	c.181G>A	p.D61N	COSMIC	NP	NP
106	RK051	Tumour	C01 LIVER	ENST00000241261	c.314-3T>C	p.?	COSMIC	NP	NP
107	TCGA-13-2061-01	Tumour	OVARY	ENST00000241261	c.607G>A	p.D203N	COSMIC	NP	NP
108	TCGA-43-6143-01	Tumour	LUNG	ENST00000241261	c.828G>T	p.G276G	COSMIC	NP	NP
109	TCGA-49-4490-01	Tumour	LUNG	ENST00000241261	c.807C>T	p.D269D	COSMIC	NP	NP
110	TCGA-51-4081-01	Tumour	LUNG	ENST00000241261	c.375C>T	p.H125H	COSMIC	NP	NP
111	TCGA-61-1998-01	Tumour	OVARY	ENST00000241261	c.36_37GG>AA	p.G13R	COSMIC	NP	NP
112	TCGA-67-6215-01	Tumour	LUNG	ENST00000241261	c.834T>G	p.F278L	COSMIC	NP	NP
113	TCGA-A8-A08L-01	Tumour	BREAST	ENST00000241261	c.33C>T	p.S11S	COSMIC	NP	NP
114	TCGA-AA-3833-01	Tumour	LARGE INTESTINE	ENST00000241261	c.340G>A	p.V114M	COSMIC	NP	NP
115	TCGA-AK-3447-01	Tumour	KIDNEY	ENST00000241261	c.418+2T>A	p.?	COSMIC	NP	NP
116	TCGA-AQ-A04H-01	Tumour	BREAST	ENST00000241261	c.687T>C	p.S229S	COSMIC	NP	NP
117	TCGA-AS-3778-01	Tumour	KIDNEY	ENST00000241261	c.418+2T>A	p.?	COSMIC	NP	NP
118	TCGA-AX-A0J0-01	Tumour	ENDOMETRIUM	ENST00000241261	c.178G>T	p.E60*	COSMIC	NP	NP
119	TCGA-AZ-6608-01	Tumour	LARGE INTESTINE	ENST00000241261	c.693G>A	p.W231*	COSMIC	NP	NP
120	TCGA-EI-6508-01	Tumour	LARGE INTESTINE	ENST00000241261	c.693G>A	p.W231*	COSMIC	NP	NP
121	TCGA-FD-A3N5-01	Tumour	URINARY TRACT	ENST00000241261	c.412T>C	p.S138P	COSMIC	NP	NP
122	TCGA-GV-A3JX-01	Tumour	URINARY TRACT	ENST00000241261	c.279G>C	p.L93F	COSMIC	NP	NP
123	YUMER	Tumour	SKIN	ENST00000241261	c.821T>A	p.F274Y	COSMIC	NP	NP
124	COLO792	Cell Line	SKIN	ENST00000241261	c.419-7C>T	p.?	COSMIC	NP	NP
125	D566MG	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000241261	c.133-3C>A	p.?	COSMIC	NP	NP
126	DND41	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000241261	c.747G>A	p.E249E	COSMIC	NP	NP
127	DND41	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000241261	c.76C>A	p.L26M	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
128	DU145	Cell Line	PROSTATE	ENST00000241261	c.572G>T	p.R191L	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
129	ES8	Cell Line	BONE	ENST00000241261	c.7A>G	p.M3V	COSMIC	PASSENGER/OTHER	BENIGN
130	HCT15	Cell Line	LARGE_INTESTINE	ENST00000241261	c.657T>C	p.P219P	COSMIC	NP	NP
131	HGC27	Cell Line	STOMACH	ENST00000241261	c.517G>A	p.E173K	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
132	HT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000241261	c.681A>G	p.R227R	COSMIC	NP	NP
133	HT55	Cell Line	LARGE_INTESTINE	ENST00000241261	c.433A>T	p.K145*	COSMIC	NP	NP
134	IM95	Cell Line	STOMACH	ENST00000241261	c.208G>A	p.E70K	COSMIC	PASSENGER/OTHER	BENIGN
135	JURLMK1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000241261	c.448A>G	p.K150E	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
136	LS513	Cell Line	LARGE_INTESTINE	ENST00000241261	c.726C>T	p.I242I	COSMIC	NP	NP
137	LU135	Cell Line	LUNG	ENST00000241261	c.448A>C	p.K150Q	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
138	MHHCALL4	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000241261	c.163G>A	p.A55T	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
139	MZ7MEL	Cell Line	SKIN	ENST00000241261	c.693G>A	p.W231*	COSMIC	NP	NP
140	NCIH650	Cell Line	LUNG	ENST00000241261	c.517G>T	p.E173*	COSMIC	NP	NP
141	NCISNU1	Cell Line	STOMACH	ENST00000241261	c.537delA	p.Y182fs*15	COSMIC	NP	NP
142	SW684	Cell Line	SOFT_TISSUE	ENST00000241261	c.517G>A	p.E173K	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
143	SW684	Cell Line	SOFT_TISSUE	ENST00000241261	c.583G>A	p.E195K	COSMIC	PASSENGER/OTHER	BENIGN
144	TGBC11TKB	Cell Line	STOMACH	ENST00000241261	c.296C>T	p.T99I	COSMIC	PASSENGER/OTHER	BENIGN

*NP: Not Predicted

Domain ID	Domain Name	Start Site	End Site	E-value
PF13800	Sigma_reg_N	16	48	0.62
PF00229	TNF	152	280	4.3e-43
PF13800	Sigma_reg_N	16	48	0.62
PF00229	TNF	152	280	4.3e-43

Domain ID	Start Site	End Site	E-value
0036412	120	281	3.02e-59
0036412	120	281	3.02e-59

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
TNFSF10	TNFSF10	TNFSF10	ENSP00000241261	P50591
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
P50591	TNFSF10	ENSP00000241261	TNFSF10	P50591
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
TNFSF10	ENSP00000241261	603598	P50591	PA36618

Protein: TNFSF10

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)

Modelled Structure	Structures available in PDB
	1D0G, 1D2Q, 1D4V, 1DG6, 1DU3