ApoCanD

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	CHL1	Cell Line	SKIN	NP_001056	c.739_splice	p.V247_splice	CCLE	NP	NP
2	COLO680N	Cell Line	OESOPHAGUS	NP_001056	c.762A>C	p.E254D	CCLE	PASSENGER/OTHER	Benign
3	DV90	Cell Line	LUNG	NP_001056	c.1144G>A	p.D382N	CCLE	CANCER	Probably Damaging
4	HT115	Cell Line	LARGE INTESTINE	NP_001056	c.167C>T	p.S56L	CCLE	PASSENGER/OTHER	Probably Damaging
5	JHUEM7	Cell Line	ENDOMETRIUM	NP_001056	c.167C>T	p.S56L	CCLE	PASSENGER/OTHER	Probably Damaging
6	ME1	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_001056	c.460G>A	p.V154M	CCLE	PASSENGER/OTHER	Probably Damaging
7	NCIH889	Cell Line	LUNG	NP_001056	c.1189C>T	p.R397C	CCLE	PASSENGER/OTHER	Probably Damaging
8	SNU1040	Cell Line	LARGE INTESTINE	NP_001056	c.1304A>T	p.E435V	CCLE	CANCER	Probably Damaging
9	SNU601	Cell Line	STOMACH	NP_001056	c.1222A>T	p.R408W	CCLE	CANCER	Probably Damaging
10	587234	Tumour	LARGE INTESTINE	ENST00000162749	c.1026G>T	p.E342D	COSMIC	NP	NP
11	587256	Tumour	LARGE INTESTINE	ENST00000162749	c.961G>A	p.A321T	COSMIC	NP	NP
12	587342	Tumour	LARGE INTESTINE	ENST00000162749	c.985C>A	p.L329I	COSMIC	NP	NP
13	86571	Tumour	LUNG	ENST00000162749	c.237G>A	p.T79T	COSMIC	NP	NP
14	86802	Tumour	LUNG	ENST00000162749	c.955C>T	p.Q319*	COSMIC	NP	NP
15	CLL023	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000162749	c.1275C>T	p.L425L	COSMIC	NP	NP
16	DLBCL-PatientI	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000162749	c.734C>T	p.S245F	COSMIC	NP	NP
17	GC3	Tumour	T STOMACH	ENST00000162749	c.625+5G>A	p.?	COSMIC	NP	NP
18	GC8	Tumour	T STOMACH	ENST00000162749	c.740-9T>C	p.?	COSMIC	NP	NP
19	HN	Tumour	62469 UPPER AERODIGESTIVE TRACT	ENST00000162749	c.236C>T	p.T79M	COSMIC	NP	NP
20	HN	Tumour	62832 UPPER AERODIGESTIVE TRACT	ENST00000162749	c.955C>T	p.Q319*	COSMIC	NP	NP
21	MZ7-mel	Cell Line	SKIN	ENST00000162749	c.760G>A	p.E254K	COSMIC	NP	NP
22	NB-0462	Tumour	AUTONOMIC GANGLIA	ENST00000162749	c.842_843insT	p.T282fs*22	COSMIC	NP	NP
23	PD6760a	Tumour	NS	ENST00000162749	c.147T>C	p.Y49Y	COSMIC	NP	NP
24	TCGA-04-1337-01	Tumour	OVARY	ENST00000162749	c.432C>G	p.F144L	COSMIC	NP	NP
25	TCGA-29-1770-01	Tumour	OVARY	ENST00000162749	c.1368A>T	p.*456C	COSMIC	NP	NP
26	TCGA-33-4566-01	Tumour	LUNG	ENST00000162749	c.1070C>T	p.A357V	COSMIC	NP	NP
27	TCGA-66-2792-01	Tumour	LUNG	ENST00000162749	c.567G>T	p.L189L	COSMIC	NP	NP
28	TCGA-66-2792-01	Tumour	LUNG	ENST00000162749	c.619G>A	p.D207N	COSMIC	NP	NP
29	TCGA-A8-A09Q-01	Tumour	BREAST	ENST00000162749	c.36A>G	p.P12P	COSMIC	NP	NP
30	TCGA-AA-3710-01	Tumour	LARGE INTESTINE	ENST00000162749	c.531C>T	p.N177N	COSMIC	NP	NP
31	TCGA-AA-A022-01	Tumour	LARGE INTESTINE	ENST00000162749	c.47T>C	p.L16P	COSMIC	NP	NP
32	TCGA-AP-A056-01	Tumour	ENDOMETRIUM	ENST00000162749	c.167C>T	p.S56L	COSMIC	NP	NP
33	TCGA-AP-A0LM-01	Tumour	ENDOMETRIUM	ENST00000162749	c.457A>G	p.T153A	COSMIC	NP	NP
34	TCGA-AX-A0J1-01	Tumour	ENDOMETRIUM	ENST00000162749	c.213C>T	p.D71D	COSMIC	NP	NP
35	TCGA-AZ-4315-01	Tumour	LARGE INTESTINE	ENST00000162749	c.167C>T	p.S56L	COSMIC	NP	NP
36	TCGA-B0-5702-01	Tumour	KIDNEY	ENST00000162749	c.46C>T	p.L16L	COSMIC	NP	NP
37	TCGA-B5-A0JV-01	Tumour	ENDOMETRIUM	ENST00000162749	c.841C>A	p.P281T	COSMIC	NP	NP
38	TCGA-B5-A0JY-01	Tumour	ENDOMETRIUM	ENST00000162749	c.212A>G	p.D71G	COSMIC	NP	NP
39	TCGA-B6-A0RN-01	Tumour	BREAST	ENST00000162749	c.362G>A	p.R121Q	COSMIC	NP	NP
40	TCGA-BP-5185-01	Tumour	KIDNEY	ENST00000162749	c.623C>T	p.S208L	COSMIC	NP	NP
41	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000162749	c.168G>A	p.S56S	COSMIC	NP	NP
42	TCGA-C8-A274-01	Tumour	BREAST	ENST00000162749	c.74C>T	p.S25L	COSMIC	NP	NP
43	TCGA-CJ-5679-01	Tumour	KIDNEY	ENST00000162749	c.106G>T	p.D36Y	COSMIC	NP	NP
44	TCGA-CZ-5451-01	Tumour	KIDNEY	ENST00000162749	c.681C>A	p.L227L	COSMIC	NP	NP
45	TCGA-D1-A17Q-01	Tumour	ENDOMETRIUM	ENST00000162749	c.526G>T	p.E176*	COSMIC	NP	NP
46	TCGA-F4-6570-01	Tumour	LARGE INTESTINE	ENST00000162749	c.79delG	p.V27fs*8	COSMIC	NP	NP
47	TCGA-G4-6309-01	Tumour	LARGE INTESTINE	ENST00000162749	c.68A>G	p.Y23C	COSMIC	NP	NP
48	YUKLAB	Tumour	SKIN	ENST00000162749	c.217C>T	p.P73S	COSMIC	NP	NP
49	BE13	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000162749	c.862G>A	p.V288M	COSMIC	PASSENGER/OTHER	BENIGN
50	CHL1	Cell Line	SKIN	ENST00000162749	c.739+1G>A	p.?	COSMIC	NP	NP
51	COLO680N	Cell Line	OESOPHAGUS	ENST00000162749	c.762A>C	p.E254D	COSMIC	PASSENGER/OTHER	BENIGN
52	CP67MEL	Cell Line	SKIN	ENST00000162749	c.193G>A	p.G65R	COSMIC	CANCER	PROBABLY DAMAGING
53	CROAP2	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000162749	c.1075C>T	p.L359L	COSMIC	NP	NP
54	EW3	Cell Line	BONE	ENST00000162749	c.1354A>G	p.S452G	COSMIC	PASSENGER/OTHER	BENIGN
55	HPAC	Cell Line	PANCREAS	ENST00000162749	c.1075C>T	p.L359L	COSMIC	NP	NP
56	HT115	Cell Line	LARGE_INTESTINE	ENST00000162749	c.167C>T	p.S56L	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
57	MDST8	Cell Line	LARGE_INTESTINE	ENST00000162749	c.793A>T	p.K265*	COSMIC	NP	NP
58	ME1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000162749	c.460G>A	p.V154M	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
59	MOLT4	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000162749	c.771G>A	p.G257G	COSMIC	NP	NP
60	MZ7MEL	Cell Line	SKIN	ENST00000162749	c.760G>A	p.E254K	COSMIC	PASSENGER/OTHER	BENIGN
61	NCIH740	Cell Line	LUNG	ENST00000162749	c.823C>T	p.P275S	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
62	OVCA420	Cell Line	OVARY	ENST00000162749	c.32_34delTGC	p.L11delL	COSMIC	NP	NP
63	PANC0327	Cell Line	PANCREAS	ENST00000162749	c.123T>G	p.D41E	COSMIC	PASSENGER/OTHER	BENIGN
64	SKUT1	Cell Line	SOFT_TISSUE	ENST00000162749	c.398G>A	p.R133Q	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
65	TT2609C02	Cell Line	THYROID	ENST00000162749	c.1332C>T	p.P444P	COSMIC	NP	NP
66	CHL1	Cell Line	SKIN	NP_001056	c.739_splice	p.V247_splice	CCLE	NP	NP
67	COLO680N	Cell Line	OESOPHAGUS	NP_001056	c.762A>C	p.E254D	CCLE	PASSENGER/OTHER	Benign
68	DV90	Cell Line	LUNG	NP_001056	c.1144G>A	p.D382N	CCLE	CANCER	Probably Damaging
69	HT115	Cell Line	LARGE INTESTINE	NP_001056	c.167C>T	p.S56L	CCLE	PASSENGER/OTHER	Probably Damaging
70	JHUEM7	Cell Line	ENDOMETRIUM	NP_001056	c.167C>T	p.S56L	CCLE	PASSENGER/OTHER	Probably Damaging
71	ME1	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_001056	c.460G>A	p.V154M	CCLE	PASSENGER/OTHER	Probably Damaging
72	NCIH889	Cell Line	LUNG	NP_001056	c.1189C>T	p.R397C	CCLE	PASSENGER/OTHER	Probably Damaging
73	SNU1040	Cell Line	LARGE INTESTINE	NP_001056	c.1304A>T	p.E435V	CCLE	CANCER	Probably Damaging
74	SNU601	Cell Line	STOMACH	NP_001056	c.1222A>T	p.R408W	CCLE	CANCER	Probably Damaging
75	587234	Tumour	LARGE INTESTINE	ENST00000162749	c.1026G>T	p.E342D	COSMIC	NP	NP
76	587256	Tumour	LARGE INTESTINE	ENST00000162749	c.961G>A	p.A321T	COSMIC	NP	NP
77	587342	Tumour	LARGE INTESTINE	ENST00000162749	c.985C>A	p.L329I	COSMIC	NP	NP
78	86571	Tumour	LUNG	ENST00000162749	c.237G>A	p.T79T	COSMIC	NP	NP
79	86802	Tumour	LUNG	ENST00000162749	c.955C>T	p.Q319*	COSMIC	NP	NP
80	CLL023	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000162749	c.1275C>T	p.L425L	COSMIC	NP	NP
81	DLBCL-PatientI	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000162749	c.734C>T	p.S245F	COSMIC	NP	NP
82	GC3	Tumour	T STOMACH	ENST00000162749	c.625+5G>A	p.?	COSMIC	NP	NP
83	GC8	Tumour	T STOMACH	ENST00000162749	c.740-9T>C	p.?	COSMIC	NP	NP
84	HN	Tumour	62469 UPPER AERODIGESTIVE TRACT	ENST00000162749	c.236C>T	p.T79M	COSMIC	NP	NP
85	HN	Tumour	62832 UPPER AERODIGESTIVE TRACT	ENST00000162749	c.955C>T	p.Q319*	COSMIC	NP	NP
86	MZ7-mel	Cell Line	SKIN	ENST00000162749	c.760G>A	p.E254K	COSMIC	NP	NP
87	NB-0462	Tumour	AUTONOMIC GANGLIA	ENST00000162749	c.842_843insT	p.T282fs*22	COSMIC	NP	NP
88	PD6760a	Tumour	NS	ENST00000162749	c.147T>C	p.Y49Y	COSMIC	NP	NP
89	TCGA-04-1337-01	Tumour	OVARY	ENST00000162749	c.432C>G	p.F144L	COSMIC	NP	NP
90	TCGA-29-1770-01	Tumour	OVARY	ENST00000162749	c.1368A>T	p.*456C	COSMIC	NP	NP
91	TCGA-33-4566-01	Tumour	LUNG	ENST00000162749	c.1070C>T	p.A357V	COSMIC	NP	NP
92	TCGA-66-2792-01	Tumour	LUNG	ENST00000162749	c.567G>T	p.L189L	COSMIC	NP	NP
93	TCGA-66-2792-01	Tumour	LUNG	ENST00000162749	c.619G>A	p.D207N	COSMIC	NP	NP
94	TCGA-A8-A09Q-01	Tumour	BREAST	ENST00000162749	c.36A>G	p.P12P	COSMIC	NP	NP
95	TCGA-AA-3710-01	Tumour	LARGE INTESTINE	ENST00000162749	c.531C>T	p.N177N	COSMIC	NP	NP
96	TCGA-AA-A022-01	Tumour	LARGE INTESTINE	ENST00000162749	c.47T>C	p.L16P	COSMIC	NP	NP
97	TCGA-AP-A056-01	Tumour	ENDOMETRIUM	ENST00000162749	c.167C>T	p.S56L	COSMIC	NP	NP
98	TCGA-AP-A0LM-01	Tumour	ENDOMETRIUM	ENST00000162749	c.457A>G	p.T153A	COSMIC	NP	NP
99	TCGA-AX-A0J1-01	Tumour	ENDOMETRIUM	ENST00000162749	c.213C>T	p.D71D	COSMIC	NP	NP
100	TCGA-AZ-4315-01	Tumour	LARGE INTESTINE	ENST00000162749	c.167C>T	p.S56L	COSMIC	NP	NP
101	TCGA-B0-5702-01	Tumour	KIDNEY	ENST00000162749	c.46C>T	p.L16L	COSMIC	NP	NP
102	TCGA-B5-A0JV-01	Tumour	ENDOMETRIUM	ENST00000162749	c.841C>A	p.P281T	COSMIC	NP	NP
103	TCGA-B5-A0JY-01	Tumour	ENDOMETRIUM	ENST00000162749	c.212A>G	p.D71G	COSMIC	NP	NP
104	TCGA-B6-A0RN-01	Tumour	BREAST	ENST00000162749	c.362G>A	p.R121Q	COSMIC	NP	NP
105	TCGA-BP-5185-01	Tumour	KIDNEY	ENST00000162749	c.623C>T	p.S208L	COSMIC	NP	NP
106	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000162749	c.168G>A	p.S56S	COSMIC	NP	NP
107	TCGA-C8-A274-01	Tumour	BREAST	ENST00000162749	c.74C>T	p.S25L	COSMIC	NP	NP
108	TCGA-CJ-5679-01	Tumour	KIDNEY	ENST00000162749	c.106G>T	p.D36Y	COSMIC	NP	NP
109	TCGA-CZ-5451-01	Tumour	KIDNEY	ENST00000162749	c.681C>A	p.L227L	COSMIC	NP	NP
110	TCGA-D1-A17Q-01	Tumour	ENDOMETRIUM	ENST00000162749	c.526G>T	p.E176*	COSMIC	NP	NP
111	TCGA-F4-6570-01	Tumour	LARGE INTESTINE	ENST00000162749	c.79delG	p.V27fs*8	COSMIC	NP	NP
112	TCGA-G4-6309-01	Tumour	LARGE INTESTINE	ENST00000162749	c.68A>G	p.Y23C	COSMIC	NP	NP
113	YUKLAB	Tumour	SKIN	ENST00000162749	c.217C>T	p.P73S	COSMIC	NP	NP
114	BE13	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000162749	c.862G>A	p.V288M	COSMIC	PASSENGER/OTHER	BENIGN
115	CHL1	Cell Line	SKIN	ENST00000162749	c.739+1G>A	p.?	COSMIC	NP	NP
116	COLO680N	Cell Line	OESOPHAGUS	ENST00000162749	c.762A>C	p.E254D	COSMIC	PASSENGER/OTHER	BENIGN
117	CP67MEL	Cell Line	SKIN	ENST00000162749	c.193G>A	p.G65R	COSMIC	CANCER	PROBABLY DAMAGING
118	CROAP2	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000162749	c.1075C>T	p.L359L	COSMIC	NP	NP
119	EW3	Cell Line	BONE	ENST00000162749	c.1354A>G	p.S452G	COSMIC	PASSENGER/OTHER	BENIGN
120	HPAC	Cell Line	PANCREAS	ENST00000162749	c.1075C>T	p.L359L	COSMIC	NP	NP
121	HT115	Cell Line	LARGE_INTESTINE	ENST00000162749	c.167C>T	p.S56L	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
122	MDST8	Cell Line	LARGE_INTESTINE	ENST00000162749	c.793A>T	p.K265*	COSMIC	NP	NP
123	ME1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000162749	c.460G>A	p.V154M	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
124	MOLT4	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000162749	c.771G>A	p.G257G	COSMIC	NP	NP
125	MZ7MEL	Cell Line	SKIN	ENST00000162749	c.760G>A	p.E254K	COSMIC	PASSENGER/OTHER	BENIGN
126	NCIH740	Cell Line	LUNG	ENST00000162749	c.823C>T	p.P275S	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
127	OVCA420	Cell Line	OVARY	ENST00000162749	c.32_34delTGC	p.L11delL	COSMIC	NP	NP
128	PANC0327	Cell Line	PANCREAS	ENST00000162749	c.123T>G	p.D41E	COSMIC	PASSENGER/OTHER	BENIGN
129	SKUT1	Cell Line	SOFT_TISSUE	ENST00000162749	c.398G>A	p.R133Q	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
130	TT2609C02	Cell Line	THYROID	ENST00000162749	c.1332C>T	p.P444P	COSMIC	NP	NP

*NP: Not Predicted

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	6.5354	6.9051	0.1062	0.0089
BILIARY TRACT	9.0952	9.0288	0.0947	0.0904
BONE	8.6767	9.039	0.0766	-0.0124
BREAST	8.7445	8.8717	-0.0071	-0.0043
CENTRAL NERVOUS SYSTEM	8.9654	9.1473	-0.0776	-0.0487
ENDOMETRIUM	8.4636	8.5246	-0.0554	-0.0226
HAEMATOPOIETIC AND LYMPHOID TISSUE	7.0507	7.2029	0.0011	0.015
KIDNEY	9.1754	9.0625	0.1917	0.1023
LARGE INTESTINE	8.2814	8.2084	0.1454	0.0489
LIVER	8.9157	8.9712	0.0257	0.1226
LUNG	7.9966	8.7694	0.0916	0.08347
OESOPHAGUS	9.1534	9.28175	0.2445	0.2498
OVARY	8.6830	8.8889	0.0415	0.0391
PANCREAS	9.1416	9.1056	0.1136	0.1961
PLEURA	9.4046	9.3638	0.0363	0.0089
PROSTATE	8.0009	7.8559	-0.1582	-0.18255
SALIVARY GLAND	8.5515	8.5515	-0.4107	-0.4107
SKIN	8.7510	8.6769	0.0048	-0.008317
SMALL INTESTINE	6.7164	6.7164	0.0223	0.0223
SOFT TISSUE	8.7817	9.0383	-0.0934	-0.0346
STOMACH	8.3303	8.4839	0.0516	-0.03067
THYROID	9.6037	9.4983	-0.0455	-0.055
UPPER AERODIGESTIVE TRACT	9.6086	9.532	0.1880	0.11905
URINARY TRACT	9.2321	9.12255	0.1404	0.20925

Domain ID	Domain Name	Start Site	End Site	E-value
PF00020	TNFR_c6	44	81	2.4e-08
PF00020	TNFR_c6	84	125	1.7e-11
PF00020	TNFR_c6	127	166	2.8e-08
PF00020	TNFR_c6	168	195	0.52
PF00531	Death	359	440	3.2e-18
PF00020	TNFR_c6	44	81	2.4e-08
PF00020	TNFR_c6	84	125	1.7e-11
PF00020	TNFR_c6	127	166	2.8e-08
PF00020	TNFR_c6	168	195	0.52
PF00531	Death	359	440	3.2e-18

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
TNFRSF1A	TNFRSF1A	TNFRSF1A	ENSP00000162749	P19438
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
P19438	TNFRSF1A	ENSP00000162749	TNFRSF1A	P19438
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
TNFRSF1A	ENSP00000162749	191190	P19438	PA36609

Protein: TNFRSF1A

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)

Modelled Structure	Structures available in PDB
	1EXT, 1FT4, 1ICH, 1NCF, 1TNR