ApoCanD

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	ESO-838	Tumour	OESOPHAGUS	ENST00000312584	c.585G>A	p.A195A	COSMIC	NP	NP
2	HN	Tumour	00338 UPPER AERODIGESTIVE TRACT	ENST00000312584	c.411C>T	p.T137T	COSMIC	NP	NP
3	PR-00-1165	Tumour	PROSTATE	ENST00000312584	c.466C>T	p.R156W	COSMIC	NP	NP
4	RK027	Tumour	C01 LIVER	ENST00000312584	c.702G>T	p.K234N	COSMIC	NP	NP
5	TCGA-63-5128-01	Tumour	LUNG	ENST00000312584	c.870C>T	p.V290V	COSMIC	NP	NP
6	TCGA-66-2767-01	Tumour	LUNG	ENST00000312584	c.702G>A	p.K234K	COSMIC	NP	NP
7	TCGA-AG-3601-01	Tumour	LARGE INTESTINE	ENST00000312584	c.556G>T	p.A186S	COSMIC	NP	NP
8	TCGA-AG-A002-01	Tumour	LARGE INTESTINE	ENST00000312584	c.870C>A	p.V290V	COSMIC	NP	NP
9	TCGA-AN-A0AT-01	Tumour	BREAST	ENST00000312584	c.444_448delTAAAA	p.D148fs*4	COSMIC	NP	NP
10	TCGA-AP-A056-01	Tumour	ENDOMETRIUM	ENST00000312584	c.818A>G	p.D273G	COSMIC	NP	NP
11	TCGA-AP-A0LG-01	Tumour	ENDOMETRIUM	ENST00000312584	c.179G>A	p.R60Q	COSMIC	NP	NP
12	TCGA-AZ-6601-01	Tumour	LARGE INTESTINE	ENST00000312584	c.1148C>T	p.T383M	COSMIC	NP	NP
13	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000312584	c.373C>A	p.Q125K	COSMIC	NP	NP
14	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000312584	c.459G>T	p.E153D	COSMIC	NP	NP
15	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000312584	c.94C>T	p.L32F	COSMIC	NP	NP
16	TCGA-D1-A103-01	Tumour	ENDOMETRIUM	ENST00000312584	c.945G>A	p.Q315Q	COSMIC	NP	NP
17	TCGA-D1-A15X-01	Tumour	ENDOMETRIUM	ENST00000312584	c.884T>C	p.I295T	COSMIC	NP	NP
18	TCGA-DK-A3IL-01	Tumour	URINARY TRACT	ENST00000312584	c.467G>A	p.R156Q	COSMIC	NP	NP
19	cSCCP7	Tumour	SKIN	ENST00000312584	c.577C>T	p.P193S	COSMIC	NP	NP
20	2313287	Cell Line	STOMACH	ENST00000312584	c.990_991insAGG	p.R330	COSMIC	NP	NP
21	ALLPO	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000312584	c.771C>G	p.V257V	COSMIC	NP	NP
22	CAL54	Cell Line	KIDNEY	ENST00000312584	c.330C>G	p.N110K	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
23	DJM1	Cell Line	SKIN	ENST00000312584	c.930G>T	p.L310F	COSMIC	NP	NP
24	EFO27	Cell Line	OVARY	ENST00000312584	c.329_330insA	p.N110fs*13	COSMIC	NP	NP
25	HEMCSS	Cell Line	BONE	ENST00000312584	c.930G>T	p.L310F	COSMIC	NP	NP
26	HH	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000312584	c.737-4C>T	p.?	COSMIC	NP	NP
27	IPC298	Cell Line	SKIN	ENST00000312584	c.1028-8C>A	p.?	COSMIC	NP	NP
28	KATOIII	Cell Line	STOMACH	ENST00000312584	c.679G>T	p.V227L	COSMIC	PASSENGER/OTHER	BENIGN
29	KGN	Cell Line	OVARY	ENST00000312584	c.930G>T	p.L310F	COSMIC	NP	NP
30	LNCAPCLONEFGC	Cell Line	PROSTATE	ENST00000312584	c.965A>T	p.E322V	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
31	MC1010	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000312584	c.257-8C>T	p.?	COSMIC	NP	NP
32	MDAMB468	Cell Line	BREAST	ENST00000312584	c.781C>T	p.R261W	COSMIC	PASSENGER/OTHER	BENIGN
33	ML2	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000312584	c.611G>T	p.G204V	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
34	MMACSF	Cell Line	SKIN	ENST00000312584	c.930G>T	p.L310F	COSMIC	NP	NP
35	NCIH510A	Cell Line	LUNG	ENST00000312584	c.658G>A	p.V220I	COSMIC	PASSENGER/OTHER	BENIGN
36	NCIH630	Cell Line	LARGE_INTESTINE	ENST00000312584	c.519G>A	p.T173T	COSMIC	NP	NP
37	OVK18	Cell Line	OVARY	ENST00000312584	c.20G>T	p.S7I	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
38	RCHACV	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000312584	c.1020C>T	p.S340S	COSMIC	NP	NP
39	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000312584	c.355A>G	p.T119A	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
40	SNU407	Cell Line	LARGE_INTESTINE	ENST00000312584	c.294G>A	p.P98P	COSMIC	NP	NP
41	SNU81	Cell Line	LARGE_INTESTINE	ENST00000312584	c.780G>A	p.R260R	COSMIC	NP	NP
42	ESO-838	Tumour	OESOPHAGUS	ENST00000312584	c.585G>A	p.A195A	COSMIC	NP	NP
43	HN	Tumour	00338 UPPER AERODIGESTIVE TRACT	ENST00000312584	c.411C>T	p.T137T	COSMIC	NP	NP
44	PR-00-1165	Tumour	PROSTATE	ENST00000312584	c.466C>T	p.R156W	COSMIC	NP	NP
45	RK027	Tumour	C01 LIVER	ENST00000312584	c.702G>T	p.K234N	COSMIC	NP	NP
46	TCGA-63-5128-01	Tumour	LUNG	ENST00000312584	c.870C>T	p.V290V	COSMIC	NP	NP
47	TCGA-66-2767-01	Tumour	LUNG	ENST00000312584	c.702G>A	p.K234K	COSMIC	NP	NP
48	TCGA-AG-3601-01	Tumour	LARGE INTESTINE	ENST00000312584	c.556G>T	p.A186S	COSMIC	NP	NP
49	TCGA-AG-A002-01	Tumour	LARGE INTESTINE	ENST00000312584	c.870C>A	p.V290V	COSMIC	NP	NP
50	TCGA-AN-A0AT-01	Tumour	BREAST	ENST00000312584	c.444_448delTAAAA	p.D148fs*4	COSMIC	NP	NP
51	TCGA-AP-A056-01	Tumour	ENDOMETRIUM	ENST00000312584	c.818A>G	p.D273G	COSMIC	NP	NP
52	TCGA-AP-A0LG-01	Tumour	ENDOMETRIUM	ENST00000312584	c.179G>A	p.R60Q	COSMIC	NP	NP
53	TCGA-AZ-6601-01	Tumour	LARGE INTESTINE	ENST00000312584	c.1148C>T	p.T383M	COSMIC	NP	NP
54	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000312584	c.373C>A	p.Q125K	COSMIC	NP	NP
55	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000312584	c.459G>T	p.E153D	COSMIC	NP	NP
56	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000312584	c.94C>T	p.L32F	COSMIC	NP	NP
57	TCGA-D1-A103-01	Tumour	ENDOMETRIUM	ENST00000312584	c.945G>A	p.Q315Q	COSMIC	NP	NP
58	TCGA-D1-A15X-01	Tumour	ENDOMETRIUM	ENST00000312584	c.884T>C	p.I295T	COSMIC	NP	NP
59	TCGA-DK-A3IL-01	Tumour	URINARY TRACT	ENST00000312584	c.467G>A	p.R156Q	COSMIC	NP	NP
60	cSCCP7	Tumour	SKIN	ENST00000312584	c.577C>T	p.P193S	COSMIC	NP	NP
61	2313287	Cell Line	STOMACH	ENST00000312584	c.990_991insAGG	p.R330	COSMIC	NP	NP
62	ALLPO	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000312584	c.771C>G	p.V257V	COSMIC	NP	NP
63	CAL54	Cell Line	KIDNEY	ENST00000312584	c.330C>G	p.N110K	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
64	DJM1	Cell Line	SKIN	ENST00000312584	c.930G>T	p.L310F	COSMIC	NP	NP
65	EFO27	Cell Line	OVARY	ENST00000312584	c.329_330insA	p.N110fs*13	COSMIC	NP	NP
66	HEMCSS	Cell Line	BONE	ENST00000312584	c.930G>T	p.L310F	COSMIC	NP	NP
67	HH	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000312584	c.737-4C>T	p.?	COSMIC	NP	NP
68	IPC298	Cell Line	SKIN	ENST00000312584	c.1028-8C>A	p.?	COSMIC	NP	NP
69	KATOIII	Cell Line	STOMACH	ENST00000312584	c.679G>T	p.V227L	COSMIC	PASSENGER/OTHER	BENIGN
70	KGN	Cell Line	OVARY	ENST00000312584	c.930G>T	p.L310F	COSMIC	NP	NP
71	LNCAPCLONEFGC	Cell Line	PROSTATE	ENST00000312584	c.965A>T	p.E322V	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
72	MC1010	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000312584	c.257-8C>T	p.?	COSMIC	NP	NP
73	MDAMB468	Cell Line	BREAST	ENST00000312584	c.781C>T	p.R261W	COSMIC	PASSENGER/OTHER	BENIGN
74	ML2	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000312584	c.611G>T	p.G204V	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
75	MMACSF	Cell Line	SKIN	ENST00000312584	c.930G>T	p.L310F	COSMIC	NP	NP
76	NCIH510A	Cell Line	LUNG	ENST00000312584	c.658G>A	p.V220I	COSMIC	PASSENGER/OTHER	BENIGN
77	NCIH630	Cell Line	LARGE_INTESTINE	ENST00000312584	c.519G>A	p.T173T	COSMIC	NP	NP
78	OVK18	Cell Line	OVARY	ENST00000312584	c.20G>T	p.S7I	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
79	RCHACV	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000312584	c.1020C>T	p.S340S	COSMIC	NP	NP
80	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000312584	c.355A>G	p.T119A	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
81	SNU407	Cell Line	LARGE_INTESTINE	ENST00000312584	c.294G>A	p.P98P	COSMIC	NP	NP
82	SNU81	Cell Line	LARGE_INTESTINE	ENST00000312584	c.780G>A	p.R260R	COSMIC	NP	NP

*NP: Not Predicted

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	4.4949	4.2607	0.0821	0.07934
BILIARY TRACT	7.0831	7.1271	-0.3660	-0.3367
BONE	6.9147	7.3606	0.0938	0.0328
BREAST	5.4913	4.67505	-0.6225	-0.59535
CENTRAL NERVOUS SYSTEM	4.9013	4.4438	-0.0482	0.0273
ENDOMETRIUM	6.9533	7.4526	0.0026	0.0214
HAEMATOPOIETIC AND LYMPHOID TISSUE	5.6438	5.2897	0.0486	0.0511
KIDNEY	7.5483	7.3866	-0.2463	-0.0994
LARGE INTESTINE	6.7215	6.88435	-0.3023	-0.056065
LIVER	7.0144	6.9157	-0.3497	-0.331
LUNG	5.9682	5.81185	-0.3039	-0.33525
OESOPHAGUS	6.4029	6.8364	-0.1775	-0.10215
OVARY	6.2969	6.0436	-0.2618	-0.2519
PANCREAS	6.8304	6.9087	-0.5878	-0.5382
PLEURA	6.0149	6.1496	-0.2241	-0.1332
PROSTATE	6.1063	5.4083	-0.1334	-0.1648
SALIVARY GLAND	7.6494	7.6494	0.4381	0.4381
SKIN	5.0405	4.2656	-0.0515	0.037
SMALL INTESTINE	8.2393	8.2393	0.0403	0.0403
SOFT TISSUE	5.9748	5.94845	-0.0076	0.0203
STOMACH	6.8124	6.996	-0.1793	-0.12495
THYROID	7.5091	7.90475	-0.2775	-0.28845
UPPER AERODIGESTIVE TRACT	6.4113	6.09255	-0.6853	-0.4713
URINARY TRACT	5.9993	5.41075	-0.3087	-0.3238

Domain ID	Domain Name	Start Site	End Site	E-value
PF00020	TNFR_c6	99	139	1.2e-07
PF00020	TNFR_c6	141	180	5e-05
PF10717	ODV-E18	191	229	0.66
PF05568	ASFV_J13L	210	235	0.57
PF00020	TNFR_c6	99	139	1.2e-07
PF00020	TNFR_c6	141	180	5e-05
PF10717	ODV-E18	191	229	0.66
PF05568	ASFV_J13L	210	235	0.57

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
TNFRSF10D	TNFRSF10D	TNFRSF10D	ENSP00000310263	Q9UBN6
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
Q9UBN6	TNFRSF10D	ENSP00000310263	TNFRSF10D	Q9UBN6
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
TNFRSF10D	ENSP00000310263	603614	Q9UBN6	PA36600

Protein: TNFRSF10D

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)

Modelled Structure	Structures available in PDB
	Structure is not available in PDB