ApoCanD

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	587228	Tumour	LARGE INTESTINE	ENST00000356864	c.580G>A	p.A194T	COSMIC	NP	NP
2	HN	Tumour	62374 UPPER AERODIGESTIVE TRACT	ENST00000356864	c.232G>A	p.A78T	COSMIC	NP	NP
3	HN	Tumour	62857 2 UPPER AERODIGESTIVE TRACT	ENST00000356864	c.736G>A	p.V246I	COSMIC	NP	NP
4	LAU63	Cell Line	SKIN	ENST00000356864	c.4G>A	p.A2T	COSMIC	NP	NP
5	LUAD-NYU408	Tumour	LUNG	ENST00000356864	c.253T>G	p.C85G	COSMIC	NP	NP
6	ME029T	Tumour	SKIN	ENST00000356864	c.551A>C	p.N184T	COSMIC	NP	NP
7	RK099	Tumour	C01 LIVER	ENST00000356864	c.606G>A	p.P202P	COSMIC	NP	NP
8	TCGA-44-2659-01	Tumour	LUNG	ENST00000356864	c.148G>A	p.G50R	COSMIC	NP	NP
9	TCGA-A3-3316-01	Tumour	KIDNEY	ENST00000356864	c.113C>A	p.T38K	COSMIC	NP	NP
10	TCGA-AA-3663-01	Tumour	LARGE INTESTINE	ENST00000356864	c.248C>T	p.P83L	COSMIC	NP	NP
11	TCGA-AA-3844-01	Tumour	LARGE INTESTINE	ENST00000356864	c.596C>A	p.T199N	COSMIC	NP	NP
12	TCGA-AA-3855-01	Tumour	LARGE INTESTINE	ENST00000356864	c.641C>A	p.T214N	COSMIC	NP	NP
13	TCGA-AA-3866-01	Tumour	LARGE INTESTINE	ENST00000356864	c.596C>A	p.T199N	COSMIC	NP	NP
14	TCGA-AA-3869-01	Tumour	LARGE INTESTINE	ENST00000356864	c.641C>A	p.T214N	COSMIC	NP	NP
15	TCGA-AA-3872-01	Tumour	LARGE INTESTINE	ENST00000356864	c.596C>A	p.T199N	COSMIC	NP	NP
16	TCGA-AA-3950-01	Tumour	LARGE INTESTINE	ENST00000356864	c.606G>A	p.P202P	COSMIC	NP	NP
17	TCGA-AA-3972-01	Tumour	LARGE INTESTINE	ENST00000356864	c.641C>A	p.T214N	COSMIC	NP	NP
18	TCGA-AD-6895-01	Tumour	LARGE INTESTINE	ENST00000356864	c.467A>G	p.N156S	COSMIC	NP	NP
19	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000356864	c.31G>A	p.V11I	COSMIC	NP	NP
20	TCGA-BG-A0M9-01	Tumour	ENDOMETRIUM	ENST00000356864	c.363C>T	p.S121S	COSMIC	NP	NP
21	TCGA-BH-A0C3-01	Tumour	BREAST	ENST00000356864	c.384T>C	p.C128C	COSMIC	NP	NP
22	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000356864	c.295A>C	p.S99R	COSMIC	NP	NP
23	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000356864	c.51C>T	p.V17V	COSMIC	NP	NP
24	TCGA-CH-5746-01	Tumour	PROSTATE	ENST00000356864	c.641C>A	p.T214N	COSMIC	NP	NP
25	TCGA-CH-5746-01	Tumour	PROSTATE	ENST00000356864	c.651G>A	p.P217P	COSMIC	NP	NP
26	TCGA-CM-4743-01	Tumour	LARGE INTESTINE	ENST00000356864	c.147G>T	p.K49N	COSMIC	NP	NP
27	TCGA-D1-A103-01	Tumour	ENDOMETRIUM	ENST00000356864	c.458T>G	p.F153C	COSMIC	NP	NP
28	TCGA-D1-A17Q-01	Tumour	ENDOMETRIUM	ENST00000356864	c.103C>T	p.P35S	COSMIC	NP	NP
29	TCGA-G2-A2EL-01	Tumour	URINARY TRACT	ENST00000356864	c.777T>C	p.V259V	COSMIC	NP	NP
30	TCGA-G9-6494-01	Tumour	PROSTATE	ENST00000356864	c.641C>A	p.T214N	COSMIC	NP	NP
31	HCC2998	Cell Line	LARGE_INTESTINE	ENST00000356864	c.454G>T	p.E152*	COSMIC	NP	NP
32	IM95	Cell Line	STOMACH	ENST00000356864	c.105C>T	p.P35P	COSMIC	NP	NP
33	NCIH1155	Cell Line	LUNG	ENST00000356864	c.345C>A	p.T115T	COSMIC	NP	NP
34	SCC90	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000356864	c.172C>T	p.H58Y	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
35	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000356864	c.232G>A	p.A78T	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
36	SW626	Cell Line	OVARY	ENST00000356864	c.647G>T	p.S216I	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
37	587228	Tumour	LARGE INTESTINE	ENST00000356864	c.580G>A	p.A194T	COSMIC	NP	NP
38	HN	Tumour	62374 UPPER AERODIGESTIVE TRACT	ENST00000356864	c.232G>A	p.A78T	COSMIC	NP	NP
39	HN	Tumour	62857 2 UPPER AERODIGESTIVE TRACT	ENST00000356864	c.736G>A	p.V246I	COSMIC	NP	NP
40	LAU63	Cell Line	SKIN	ENST00000356864	c.4G>A	p.A2T	COSMIC	NP	NP
41	LUAD-NYU408	Tumour	LUNG	ENST00000356864	c.253T>G	p.C85G	COSMIC	NP	NP
42	ME029T	Tumour	SKIN	ENST00000356864	c.551A>C	p.N184T	COSMIC	NP	NP
43	RK099	Tumour	C01 LIVER	ENST00000356864	c.606G>A	p.P202P	COSMIC	NP	NP
44	TCGA-44-2659-01	Tumour	LUNG	ENST00000356864	c.148G>A	p.G50R	COSMIC	NP	NP
45	TCGA-A3-3316-01	Tumour	KIDNEY	ENST00000356864	c.113C>A	p.T38K	COSMIC	NP	NP
46	TCGA-AA-3663-01	Tumour	LARGE INTESTINE	ENST00000356864	c.248C>T	p.P83L	COSMIC	NP	NP
47	TCGA-AA-3844-01	Tumour	LARGE INTESTINE	ENST00000356864	c.596C>A	p.T199N	COSMIC	NP	NP
48	TCGA-AA-3855-01	Tumour	LARGE INTESTINE	ENST00000356864	c.641C>A	p.T214N	COSMIC	NP	NP
49	TCGA-AA-3866-01	Tumour	LARGE INTESTINE	ENST00000356864	c.596C>A	p.T199N	COSMIC	NP	NP
50	TCGA-AA-3869-01	Tumour	LARGE INTESTINE	ENST00000356864	c.641C>A	p.T214N	COSMIC	NP	NP
51	TCGA-AA-3872-01	Tumour	LARGE INTESTINE	ENST00000356864	c.596C>A	p.T199N	COSMIC	NP	NP
52	TCGA-AA-3950-01	Tumour	LARGE INTESTINE	ENST00000356864	c.606G>A	p.P202P	COSMIC	NP	NP
53	TCGA-AA-3972-01	Tumour	LARGE INTESTINE	ENST00000356864	c.641C>A	p.T214N	COSMIC	NP	NP
54	TCGA-AD-6895-01	Tumour	LARGE INTESTINE	ENST00000356864	c.467A>G	p.N156S	COSMIC	NP	NP
55	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000356864	c.31G>A	p.V11I	COSMIC	NP	NP
56	TCGA-BG-A0M9-01	Tumour	ENDOMETRIUM	ENST00000356864	c.363C>T	p.S121S	COSMIC	NP	NP
57	TCGA-BH-A0C3-01	Tumour	BREAST	ENST00000356864	c.384T>C	p.C128C	COSMIC	NP	NP
58	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000356864	c.295A>C	p.S99R	COSMIC	NP	NP
59	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000356864	c.51C>T	p.V17V	COSMIC	NP	NP
60	TCGA-CH-5746-01	Tumour	PROSTATE	ENST00000356864	c.641C>A	p.T214N	COSMIC	NP	NP
61	TCGA-CH-5746-01	Tumour	PROSTATE	ENST00000356864	c.651G>A	p.P217P	COSMIC	NP	NP
62	TCGA-CM-4743-01	Tumour	LARGE INTESTINE	ENST00000356864	c.147G>T	p.K49N	COSMIC	NP	NP
63	TCGA-D1-A103-01	Tumour	ENDOMETRIUM	ENST00000356864	c.458T>G	p.F153C	COSMIC	NP	NP
64	TCGA-D1-A17Q-01	Tumour	ENDOMETRIUM	ENST00000356864	c.103C>T	p.P35S	COSMIC	NP	NP
65	TCGA-G2-A2EL-01	Tumour	URINARY TRACT	ENST00000356864	c.777T>C	p.V259V	COSMIC	NP	NP
66	TCGA-G9-6494-01	Tumour	PROSTATE	ENST00000356864	c.641C>A	p.T214N	COSMIC	NP	NP
67	HCC2998	Cell Line	LARGE_INTESTINE	ENST00000356864	c.454G>T	p.E152*	COSMIC	NP	NP
68	IM95	Cell Line	STOMACH	ENST00000356864	c.105C>T	p.P35P	COSMIC	NP	NP
69	NCIH1155	Cell Line	LUNG	ENST00000356864	c.345C>A	p.T115T	COSMIC	NP	NP
70	SCC90	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000356864	c.172C>T	p.H58Y	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
71	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000356864	c.232G>A	p.A78T	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
72	SW626	Cell Line	OVARY	ENST00000356864	c.647G>T	p.S216I	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING

*NP: Not Predicted

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	3.9679	3.9601	0.0821	0.07934
BILIARY TRACT	4.1750	4.1455	-0.3660	-0.3367
BONE	4.0206	4.0029	0.0938	0.0328
BREAST	4.1830	4.0898	-0.6517	-0.5984
CENTRAL NERVOUS SYSTEM	4.1214	3.9878	-0.0482	0.0273
ENDOMETRIUM	4.1769	4.1153	0.0026	0.0214
HAEMATOPOIETIC AND LYMPHOID TISSUE	4.1450	4.0408	0.0486	0.0511
KIDNEY	4.1641	4.1415	-0.2463	-0.0994
LARGE INTESTINE	4.2104	4.04865	-0.3056	-0.056065
LIVER	4.3235	4.0723	-0.3497	-0.331
LUNG	4.1197	3.99325	-0.3039	-0.33525
OESOPHAGUS	4.0893	4.01565	-0.1775	-0.10215
OVARY	4.2356	4.0845	-0.2618	-0.2519
PANCREAS	4.2395	4.068	-0.5878	-0.5382
PLEURA	3.9480	3.9277	-0.2241	-0.1332
PROSTATE	4.1368	4.16745	-0.1334	-0.1648
SALIVARY GLAND	4.4395	4.4395	0.4381	0.4381
SKIN	4.0237	4.0157	-0.0515	0.037
SMALL INTESTINE	4.3407	4.3407	0.0403	0.0403
SOFT TISSUE	4.0441	4.0776	-0.0076	0.0203
STOMACH	4.2150	4.1063	-0.1793	-0.12495
THYROID	4.0125	3.94515	-0.2775	-0.28845
UPPER AERODIGESTIVE TRACT	4.0796	4.0246	-0.6853	-0.4713
URINARY TRACT	4.1868	3.97745	-0.3087	-0.3238

Domain ID	Domain Name	Start Site	End Site	E-value
PF00020	TNFR_c6	69	109	4.6e-08
PF00020	TNFR_c6	111	149	2.4e-07
PF00020	TNFR_c6	69	109	4.6e-08
PF00020	TNFR_c6	111	149	2.4e-07

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
TNFRSF10C	TNFRSF10C	TNFRSF10C	ENSP00000349324	O14798
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
O14798	TNFRSF10C	ENSP00000349324	TNFRSF10C	O14798
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
TNFRSF10C	ENSP00000349324	603613	O14798	PA36599

Protein: TNFRSF10C

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)

Modelled Structure	Structures available in PDB
	Structure is not available in PDB