ApoCanD

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	587226	Tumour	LARGE INTESTINE	ENST00000221132	c.844C>T	p.R282C	COSMIC	NP	NP
2	60T	Tumour	SKIN	ENST00000221132	c.378C>T	p.S126S	COSMIC	NP	NP
3	ESO-582	Tumour	OESOPHAGUS	ENST00000221132	c.702A>G	p.S234S	COSMIC	NP	NP
4	H441	Cell Line	LUNG	ENST00000221132	c.440G>T	p.R147L	COSMIC	NP	NP
5	LUAD-RT-S01702	Tumour	LUNG	ENST00000221132	c.914C>T	p.S305L	COSMIC	NP	NP
6	ME020T	Tumour	NS	ENST00000221132	c.751C>T	p.P251S	COSMIC	NP	NP
7	ME024T	Tumour	NS	ENST00000221132	c.464C>T	p.T155I	COSMIC	NP	NP
8	TCGA-02-0028-01	Tumour	CENTRAL NERVOUS SYSTEM	ENST00000221132	c.190C>T	p.P64S	COSMIC	NP	NP
9	TCGA-02-0083-01	Tumour	CENTRAL NERVOUS SYSTEM	ENST00000221132	c.1329G>C	p.K443N	COSMIC	NP	NP
10	TCGA-02-0114-01	Tumour	CENTRAL NERVOUS SYSTEM	ENST00000221132	c.208G>A	p.A70T	COSMIC	NP	NP
11	TCGA-22-5473-01	Tumour	LUNG	ENST00000221132	c.1177G>A	p.E393K	COSMIC	NP	NP
12	TCGA-24-1556-01	Tumour	OVARY	ENST00000221132	c.1122C>A	p.I374I	COSMIC	NP	NP
13	TCGA-24-2289-01	Tumour	OVARY	ENST00000221132	c.395G>T	p.C132F	COSMIC	NP	NP
14	TCGA-25-1329-01	Tumour	OVARY	ENST00000221132	c.440G>A	p.R147Q	COSMIC	NP	NP
15	TCGA-36-2530-01	Tumour	OVARY	ENST00000221132	c.570C>G	p.C190W	COSMIC	NP	NP
16	TCGA-A8-A076-01	Tumour	BREAST	ENST00000221132	c.309C>T	p.V103V	COSMIC	NP	NP
17	TCGA-AA-3870-01	Tumour	LARGE INTESTINE	ENST00000221132	c.969G>T	p.L323F	COSMIC	NP	NP
18	TCGA-AA-3947-01	Tumour	LARGE INTESTINE	ENST00000221132	c.645G>T	p.M215I	COSMIC	NP	NP
19	TCGA-AA-A010-01	Tumour	LARGE INTESTINE	ENST00000221132	c.337C>T	p.L113F	COSMIC	NP	NP
20	TCGA-AD-5900-01	Tumour	LARGE INTESTINE	ENST00000221132	c.1326_1327delGA	p.K443fs*>26	COSMIC	NP	NP
21	TCGA-AD-5900-01	Tumour	LARGE INTESTINE	ENST00000221132	c.1327A>G	p.K443E	COSMIC	NP	NP
22	TCGA-AU-3779-01	Tumour	LARGE INTESTINE	ENST00000221132	c.1328A>G	p.K443R	COSMIC	NP	NP
23	TCGA-AU-6004-01	Tumour	LARGE INTESTINE	ENST00000221132	c.933_934delTG	p.E312fs*32	COSMIC	NP	NP
24	TCGA-B5-A11V-01	Tumour	ENDOMETRIUM	ENST00000221132	c.295G>T	p.V99F	COSMIC	NP	NP
25	TCGA-BS-A0TJ-01	Tumour	ENDOMETRIUM	ENST00000221132	c.425C>A	p.P142H	COSMIC	NP	NP
26	TCGA-CF-A3MH-01	Tumour	URINARY TRACT	ENST00000221132	c.894G>C	p.E298D	COSMIC	NP	NP
27	TCGA-CK-4950-01	Tumour	LARGE INTESTINE	ENST00000221132	c.1122C>T	p.I374I	COSMIC	NP	NP
28	TCGA-CM-4743-01	Tumour	LARGE INTESTINE	ENST00000221132	c.1122C>T	p.I374I	COSMIC	NP	NP
29	TCGA-CM-6161-01	Tumour	LARGE INTESTINE	ENST00000221132	c.1328A>G	p.K443R	COSMIC	NP	NP
30	TCGA-CU-A3KJ-01	Tumour	URINARY TRACT	ENST00000221132	c.54G>C	p.P18P	COSMIC	NP	NP
31	TCGA-EJ-5514-01	Tumour	PROSTATE	ENST00000221132	c.862G>T	p.G288W	COSMIC	NP	NP
32	TCGA-G2-A2ES-01	Tumour	URINARY TRACT	ENST00000221132	c.874G>A	p.E292K	COSMIC	NP	NP
33	TCGA-G4-6321-01	Tumour	LARGE INTESTINE	ENST00000221132	c.439C>A	p.R147R	COSMIC	NP	NP
34	TCGA-G4-6628-01	Tumour	LARGE INTESTINE	ENST00000221132	c.799G>T	p.G267C	COSMIC	NP	NP
35	YURTHE	Tumour	SKIN	ENST00000221132	c.682G>T	p.E228*	COSMIC	NP	NP
36	YUWAND	Tumour	SKIN	ENST00000221132	c.1043G>A	p.R348K	COSMIC	NP	NP
37	ccRCC-5	Tumour	KIDNEY	ENST00000221132	c.352A>G	p.I118V	COSMIC	NP	NP
38	pfg008T	Tumour	STOMACH	ENST00000221132	c.498A>G	p.P166P	COSMIC	NP	NP
39	A388	Cell Line	SKIN	ENST00000221132	c.1084G>A	p.E362K	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
40	CL34	Cell Line	LARGE_INTESTINE	ENST00000221132	c.645G>T	p.M215I	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
41	COLO684	Cell Line	ENDOMETRIUM	ENST00000221132	c.630-6A>G	p.?	COSMIC	NP	NP
42	COLO783	Cell Line	SKIN	ENST00000221132	c.832-6C>T	p.?	COSMIC	NP	NP
43	CTV1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000221132	c.1234C>T	p.L412L	COSMIC	NP	NP
44	DND41	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000221132	c.594C>T	p.D198D	COSMIC	NP	NP
45	EW7	Cell Line	BONE	ENST00000221132	c.400C>T	p.P134S	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
46	GRST	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000221132	c.1361T>C	p.F454S	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
47	H2869	Cell Line	PLEURA	ENST00000221132	c.915G>A	p.S305S	COSMIC	NP	NP
48	JJN3	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000221132	c.520G>A	p.E174K	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
49	JSC1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000221132	c.346C>A	p.Q116K	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
50	LS411N	Cell Line	LARGE_INTESTINE	ENST00000221132	c.753G>A	p.P251P	COSMIC	NP	NP
51	LS411N	Cell Line	LARGE_INTESTINE	ENST00000221132	c.915G>A	p.S305S	COSMIC	NP	NP
52	NCIH1688	Cell Line	LUNG	ENST00000221132	c.389A>T	p.E130V	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
53	NCIH1836	Cell Line	LUNG	ENST00000221132	c.845G>A	p.R282H	COSMIC	PASSENGER/OTHER	BENIGN
54	NCIH441	Cell Line	LUNG	ENST00000221132	c.440G>T	p.R147L	COSMIC	PASSENGER/OTHER	BENIGN
55	PCI30	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000221132	c.880A>C	p.N294H	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
56	SARC9371	Cell Line	BONE	ENST00000221132	c.1181T>G	p.I394S	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
57	SKUT1	Cell Line	SOFT_TISSUE	ENST00000221132	c.831+8G>A	p.?	COSMIC	NP	NP
58	SW1463	Cell Line	LARGE_INTESTINE	ENST00000221132	c.801T>C	p.G267G	COSMIC	NP	NP
59	SW1783	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000221132	c.1020G>A	p.P340P	COSMIC	NP	NP
60	SW982	Cell Line	SOFT_TISSUE	ENST00000221132	c.614G>A	p.R205Q	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
61	WIL2NS	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000221132	c.1098G>A	p.L366L	COSMIC	NP	NP
62	587226	Tumour	LARGE INTESTINE	ENST00000221132	c.844C>T	p.R282C	COSMIC	NP	NP
63	60T	Tumour	SKIN	ENST00000221132	c.378C>T	p.S126S	COSMIC	NP	NP
64	ESO-582	Tumour	OESOPHAGUS	ENST00000221132	c.702A>G	p.S234S	COSMIC	NP	NP
65	H441	Cell Line	LUNG	ENST00000221132	c.440G>T	p.R147L	COSMIC	NP	NP
66	LUAD-RT-S01702	Tumour	LUNG	ENST00000221132	c.914C>T	p.S305L	COSMIC	NP	NP
67	ME020T	Tumour	NS	ENST00000221132	c.751C>T	p.P251S	COSMIC	NP	NP
68	ME024T	Tumour	NS	ENST00000221132	c.464C>T	p.T155I	COSMIC	NP	NP
69	TCGA-02-0028-01	Tumour	CENTRAL NERVOUS SYSTEM	ENST00000221132	c.190C>T	p.P64S	COSMIC	NP	NP
70	TCGA-02-0083-01	Tumour	CENTRAL NERVOUS SYSTEM	ENST00000221132	c.1329G>C	p.K443N	COSMIC	NP	NP
71	TCGA-02-0114-01	Tumour	CENTRAL NERVOUS SYSTEM	ENST00000221132	c.208G>A	p.A70T	COSMIC	NP	NP
72	TCGA-22-5473-01	Tumour	LUNG	ENST00000221132	c.1177G>A	p.E393K	COSMIC	NP	NP
73	TCGA-24-1556-01	Tumour	OVARY	ENST00000221132	c.1122C>A	p.I374I	COSMIC	NP	NP
74	TCGA-24-2289-01	Tumour	OVARY	ENST00000221132	c.395G>T	p.C132F	COSMIC	NP	NP
75	TCGA-25-1329-01	Tumour	OVARY	ENST00000221132	c.440G>A	p.R147Q	COSMIC	NP	NP
76	TCGA-36-2530-01	Tumour	OVARY	ENST00000221132	c.570C>G	p.C190W	COSMIC	NP	NP
77	TCGA-A8-A076-01	Tumour	BREAST	ENST00000221132	c.309C>T	p.V103V	COSMIC	NP	NP
78	TCGA-AA-3870-01	Tumour	LARGE INTESTINE	ENST00000221132	c.969G>T	p.L323F	COSMIC	NP	NP
79	TCGA-AA-3947-01	Tumour	LARGE INTESTINE	ENST00000221132	c.645G>T	p.M215I	COSMIC	NP	NP
80	TCGA-AA-A010-01	Tumour	LARGE INTESTINE	ENST00000221132	c.337C>T	p.L113F	COSMIC	NP	NP
81	TCGA-AD-5900-01	Tumour	LARGE INTESTINE	ENST00000221132	c.1326_1327delGA	p.K443fs*>26	COSMIC	NP	NP
82	TCGA-AD-5900-01	Tumour	LARGE INTESTINE	ENST00000221132	c.1327A>G	p.K443E	COSMIC	NP	NP
83	TCGA-AU-3779-01	Tumour	LARGE INTESTINE	ENST00000221132	c.1328A>G	p.K443R	COSMIC	NP	NP
84	TCGA-AU-6004-01	Tumour	LARGE INTESTINE	ENST00000221132	c.933_934delTG	p.E312fs*32	COSMIC	NP	NP
85	TCGA-B5-A11V-01	Tumour	ENDOMETRIUM	ENST00000221132	c.295G>T	p.V99F	COSMIC	NP	NP
86	TCGA-BS-A0TJ-01	Tumour	ENDOMETRIUM	ENST00000221132	c.425C>A	p.P142H	COSMIC	NP	NP
87	TCGA-CF-A3MH-01	Tumour	URINARY TRACT	ENST00000221132	c.894G>C	p.E298D	COSMIC	NP	NP
88	TCGA-CK-4950-01	Tumour	LARGE INTESTINE	ENST00000221132	c.1122C>T	p.I374I	COSMIC	NP	NP
89	TCGA-CM-4743-01	Tumour	LARGE INTESTINE	ENST00000221132	c.1122C>T	p.I374I	COSMIC	NP	NP
90	TCGA-CM-6161-01	Tumour	LARGE INTESTINE	ENST00000221132	c.1328A>G	p.K443R	COSMIC	NP	NP
91	TCGA-CU-A3KJ-01	Tumour	URINARY TRACT	ENST00000221132	c.54G>C	p.P18P	COSMIC	NP	NP
92	TCGA-EJ-5514-01	Tumour	PROSTATE	ENST00000221132	c.862G>T	p.G288W	COSMIC	NP	NP
93	TCGA-G2-A2ES-01	Tumour	URINARY TRACT	ENST00000221132	c.874G>A	p.E292K	COSMIC	NP	NP
94	TCGA-G4-6321-01	Tumour	LARGE INTESTINE	ENST00000221132	c.439C>A	p.R147R	COSMIC	NP	NP
95	TCGA-G4-6628-01	Tumour	LARGE INTESTINE	ENST00000221132	c.799G>T	p.G267C	COSMIC	NP	NP
96	YURTHE	Tumour	SKIN	ENST00000221132	c.682G>T	p.E228*	COSMIC	NP	NP
97	YUWAND	Tumour	SKIN	ENST00000221132	c.1043G>A	p.R348K	COSMIC	NP	NP
98	ccRCC-5	Tumour	KIDNEY	ENST00000221132	c.352A>G	p.I118V	COSMIC	NP	NP
99	pfg008T	Tumour	STOMACH	ENST00000221132	c.498A>G	p.P166P	COSMIC	NP	NP
100	A388	Cell Line	SKIN	ENST00000221132	c.1084G>A	p.E362K	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
101	CL34	Cell Line	LARGE_INTESTINE	ENST00000221132	c.645G>T	p.M215I	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
102	COLO684	Cell Line	ENDOMETRIUM	ENST00000221132	c.630-6A>G	p.?	COSMIC	NP	NP
103	COLO783	Cell Line	SKIN	ENST00000221132	c.832-6C>T	p.?	COSMIC	NP	NP
104	CTV1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000221132	c.1234C>T	p.L412L	COSMIC	NP	NP
105	DND41	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000221132	c.594C>T	p.D198D	COSMIC	NP	NP
106	EW7	Cell Line	BONE	ENST00000221132	c.400C>T	p.P134S	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
107	GRST	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000221132	c.1361T>C	p.F454S	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
108	H2869	Cell Line	PLEURA	ENST00000221132	c.915G>A	p.S305S	COSMIC	NP	NP
109	JJN3	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000221132	c.520G>A	p.E174K	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
110	JSC1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000221132	c.346C>A	p.Q116K	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
111	LS411N	Cell Line	LARGE_INTESTINE	ENST00000221132	c.753G>A	p.P251P	COSMIC	NP	NP
112	LS411N	Cell Line	LARGE_INTESTINE	ENST00000221132	c.915G>A	p.S305S	COSMIC	NP	NP
113	NCIH1688	Cell Line	LUNG	ENST00000221132	c.389A>T	p.E130V	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
114	NCIH1836	Cell Line	LUNG	ENST00000221132	c.845G>A	p.R282H	COSMIC	PASSENGER/OTHER	BENIGN
115	NCIH441	Cell Line	LUNG	ENST00000221132	c.440G>T	p.R147L	COSMIC	PASSENGER/OTHER	BENIGN
116	PCI30	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000221132	c.880A>C	p.N294H	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
117	SARC9371	Cell Line	BONE	ENST00000221132	c.1181T>G	p.I394S	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
118	SKUT1	Cell Line	SOFT_TISSUE	ENST00000221132	c.831+8G>A	p.?	COSMIC	NP	NP
119	SW1463	Cell Line	LARGE_INTESTINE	ENST00000221132	c.801T>C	p.G267G	COSMIC	NP	NP
120	SW1783	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000221132	c.1020G>A	p.P340P	COSMIC	NP	NP
121	SW982	Cell Line	SOFT_TISSUE	ENST00000221132	c.614G>A	p.R205Q	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
122	WIL2NS	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000221132	c.1098G>A	p.L366L	COSMIC	NP	NP

*NP: Not Predicted

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	5.0939	5.1157	0.0821	0.07934
BILIARY TRACT	7.5417	7.8555	-0.3660	-0.3367
BONE	5.6129	5.7513	0.0938	0.0328
BREAST	6.6853	6.6639	-0.6225	-0.59535
CENTRAL NERVOUS SYSTEM	5.1283	4.8167	-0.0482	0.0273
ENDOMETRIUM	7.3558	7.6413	0.0026	0.0214
HAEMATOPOIETIC AND LYMPHOID TISSUE	7.1811	7.3852	0.0622	0.05173
KIDNEY	7.3657	7.3398	-0.2463	-0.0994
LARGE INTESTINE	7.6644	7.9147	-0.3023	-0.056065
LIVER	6.6390	6.7314	-0.3497	-0.331
LUNG	6.8977	7.15335	-0.3244	-0.34085
OESOPHAGUS	7.3883	7.54965	-0.1775	-0.10215
OVARY	6.9028	6.9353	-0.2618	-0.2519
PANCREAS	7.8396	7.9656	-0.4634	-0.5382
PLEURA	6.8438	7.0223	-0.2241	-0.1332
PROSTATE	7.5381	7.5185	-0.1334	-0.1648
SALIVARY GLAND	7.6243	7.6243	0.4381	0.4381
SKIN	5.3430	4.9002	-0.0515	0.037
SMALL INTESTINE	5.3033	5.3033	0.0403	0.0403
SOFT TISSUE	5.8571	5.8673	-0.0076	0.0203
STOMACH	7.2792	7.3298	-0.1793	-0.12495
THYROID	6.9077	7.17515	-0.2775	-0.28845
UPPER AERODIGESTIVE TRACT	7.2236	7.1348	-0.6853	-0.4713
URINARY TRACT	7.4185	7.575	-0.3087	-0.3238

Domain ID	Domain Name	Start Site	End Site	E-value
PF00020	TNFR_c6	148	188	2.8e-06
PF00020	TNFR_c6	190	229	5.2e-05
PF00531	Death	370	447	1.6e-17
PF00020	TNFR_c6	148	188	2.8e-06
PF00020	TNFR_c6	190	229	5.2e-05
PF00531	Death	370	447	1.6e-17

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
TNFRSF10A	TNFRSF10A	TNFRSF10A	ENSP00000221132	O00220
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
O00220	TNFRSF10A	ENSP00000221132	TNFRSF10A	O00220
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
TNFRSF10A	ENSP00000221132	603611	O00220	PA36597

Protein: TNFRSF10A

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)

Modelled Structure	Structures available in PDB
	Structure is not available in PDB