ApoCanD

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	GP2D	Cell Line	LARGE INTESTINE	NP_000585	c.64_64delG	p.G22fs	CCLE	NP	NP
2	HEC6	Cell Line	ENDOMETRIUM	NP_000585	c.560C>T	p.A187V	CCLE	PASSENGER/OTHER	Benign
3	LS123	Cell Line	LARGE INTESTINE	NP_000585	c.407C>T	p.S136F	CCLE	PASSENGER/OTHER	Probably Damaging
4	NCIH684	Cell Line	LIVER	NP_000585	c.238T>C	p.S80P	CCLE	PASSENGER/OTHER	Probably Damaging
5	SKNDZ	Cell Line	AUTONOMIC GANGLIA	NP_000585	c.673C>A	p.Q225K	CCLE	PASSENGER/OTHER	Probably Damaging
6	UMUC3	Cell Line	URINARY TRACT	NP_000585	c.201C>G	p.L67L	CCLE	NP	NP
7	CP66-MEL	Cell Line	SKIN	ENST00000449264	c.437C>T	p.P146L	COSMIC	NP	NP
8	ESO-043	Tumour	OESOPHAGUS	ENST00000449264	c.565C>A	p.P189T	COSMIC	NP	NP
9	LAU165	Cell Line	SKIN	ENST00000449264	c.644C>T	p.P215L	COSMIC	NP	NP
10	LAU165	Cell Line	SKIN	ENST00000449264	c.645C>T	p.P215P	COSMIC	NP	NP
11	LUAD-S01467	Tumour	LUNG	ENST00000449264	c.160G>A	p.G54R	COSMIC	NP	NP
12	Pa03C	Cell Line	PANCREAS	ENST00000449264	c.619C>T	p.R207*	COSMIC	NP	NP
13	RK056	Tumour	C01 LIVER	ENST00000449264	c.123G>A	p.V41V	COSMIC	NP	NP
14	S01366	Tumour	LUNG	ENST00000449264	c.644_645CC>AA	p.P215>?	COSMIC	NP	NP
15	TCGA-23-1022-01	Tumour	OVARY	ENST00000449264	c.451C>T	p.L151F	COSMIC	NP	NP
16	TCGA-60-2722-01	Tumour	LUNG	ENST00000449264	c.361G>A	p.D121N	COSMIC	NP	NP
17	TCGA-78-7159-01	Tumour	LUNG	ENST00000449264	c.644C>A	p.P215H	COSMIC	NP	NP
18	TCGA-AA-A010-01	Tumour	LARGE INTESTINE	ENST00000449264	c.477C>T	p.I159I	COSMIC	NP	NP
19	TCGA-CM-4752-01	Tumour	LARGE INTESTINE	ENST00000449264	c.481G>A	p.V161I	COSMIC	NP	NP
20	TCGA-DY-A1DF-01	Tumour	LARGE INTESTINE	ENST00000449264	c.452T>C	p.L151P	COSMIC	NP	NP
21	TCGA-G4-6299-01	Tumour	LARGE INTESTINE	ENST00000449264	c.453C>T	p.L151L	COSMIC	NP	NP
22	ASH3	Cell Line	THYROID	ENST00000449264	c.195G>A	p.R65R	COSMIC	NP	NP
23	CP66MEL	Cell Line	SKIN	ENST00000449264	c.437C>T	p.P146L	COSMIC	PASSENGER/OTHER	BENIGN
24	CTV1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000449264	c.254G>C	p.S85T	COSMIC	PASSENGER/OTHER	BENIGN
25	GP5D	Cell Line	LARGE_INTESTINE	ENST00000449264	c.64delG	p.Q25fs*15	COSMIC	NP	NP
26	JURKAT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000449264	c.280+10C>T	p.?	COSMIC	NP	NP
27	JURKAT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000449264	c.478G>A	p.A160T	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
28	LS123	Cell Line	LARGE_INTESTINE	ENST00000449264	c.407C>T	p.S136F	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
29	MCC13	Cell Line	SKIN	ENST00000449264	c.695C>T	p.A232V	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
30	MEWO	Cell Line	SKIN	ENST00000449264	c.180G>A	p.R60R	COSMIC	NP	NP
31	MHHPREB1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000449264	c.626G>T	p.S209I	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
32	MOLT4	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000449264	c.454C>A	p.L152I	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
33	NCIH2347	Cell Line	LUNG	ENST00000449264	c.298G>C	p.G100R	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
34	OVTOKO	Cell Line	OVARY	ENST00000449264	c.69G>T	p.G23G	COSMIC	NP	NP
35	RF48	Cell Line	STOMACH	ENST00000449264	c.489C>T	p.Y163Y	COSMIC	NP	NP
36	SKNDZ	Cell Line	AUTONOMIC_GANGLIA	ENST00000449264	c.673C>A	p.Q225K	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
37	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000449264	c.657C>A	p.D219E	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
38	SUPT1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000449264	c.407C>T	p.S136F	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
39	SUPT1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000449264	c.499G>A	p.V167I	COSMIC	PASSENGER/OTHER	BENIGN
40	SW684	Cell Line	SOFT_TISSUE	ENST00000449264	c.236C>T	p.S79L	COSMIC	PASSENGER/OTHER	BENIGN
41	UMUC3	Cell Line	URINARY_TRACT	ENST00000449264	c.201C>G	p.L67L	COSMIC	NP	NP
42	GP2D	Cell Line	LARGE INTESTINE	NP_000585	c.64_64delG	p.G22fs	CCLE	NP	NP
43	HEC6	Cell Line	ENDOMETRIUM	NP_000585	c.560C>T	p.A187V	CCLE	PASSENGER/OTHER	Benign
44	LS123	Cell Line	LARGE INTESTINE	NP_000585	c.407C>T	p.S136F	CCLE	PASSENGER/OTHER	Probably Damaging
45	NCIH684	Cell Line	LIVER	NP_000585	c.238T>C	p.S80P	CCLE	PASSENGER/OTHER	Probably Damaging
46	SKNDZ	Cell Line	AUTONOMIC GANGLIA	NP_000585	c.673C>A	p.Q225K	CCLE	PASSENGER/OTHER	Probably Damaging
47	UMUC3	Cell Line	URINARY TRACT	NP_000585	c.201C>G	p.L67L	CCLE	NP	NP
48	CP66-MEL	Cell Line	SKIN	ENST00000449264	c.437C>T	p.P146L	COSMIC	NP	NP
49	ESO-043	Tumour	OESOPHAGUS	ENST00000449264	c.565C>A	p.P189T	COSMIC	NP	NP
50	LAU165	Cell Line	SKIN	ENST00000449264	c.644C>T	p.P215L	COSMIC	NP	NP
51	LAU165	Cell Line	SKIN	ENST00000449264	c.645C>T	p.P215P	COSMIC	NP	NP
52	LUAD-S01467	Tumour	LUNG	ENST00000449264	c.160G>A	p.G54R	COSMIC	NP	NP
53	Pa03C	Cell Line	PANCREAS	ENST00000449264	c.619C>T	p.R207*	COSMIC	NP	NP
54	RK056	Tumour	C01 LIVER	ENST00000449264	c.123G>A	p.V41V	COSMIC	NP	NP
55	S01366	Tumour	LUNG	ENST00000449264	c.644_645CC>AA	p.P215>?	COSMIC	NP	NP
56	TCGA-23-1022-01	Tumour	OVARY	ENST00000449264	c.451C>T	p.L151F	COSMIC	NP	NP
57	TCGA-60-2722-01	Tumour	LUNG	ENST00000449264	c.361G>A	p.D121N	COSMIC	NP	NP
58	TCGA-78-7159-01	Tumour	LUNG	ENST00000449264	c.644C>A	p.P215H	COSMIC	NP	NP
59	TCGA-AA-A010-01	Tumour	LARGE INTESTINE	ENST00000449264	c.477C>T	p.I159I	COSMIC	NP	NP
60	TCGA-CM-4752-01	Tumour	LARGE INTESTINE	ENST00000449264	c.481G>A	p.V161I	COSMIC	NP	NP
61	TCGA-DY-A1DF-01	Tumour	LARGE INTESTINE	ENST00000449264	c.452T>C	p.L151P	COSMIC	NP	NP
62	TCGA-G4-6299-01	Tumour	LARGE INTESTINE	ENST00000449264	c.453C>T	p.L151L	COSMIC	NP	NP
63	ASH3	Cell Line	THYROID	ENST00000449264	c.195G>A	p.R65R	COSMIC	NP	NP
64	CP66MEL	Cell Line	SKIN	ENST00000449264	c.437C>T	p.P146L	COSMIC	PASSENGER/OTHER	BENIGN
65	CTV1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000449264	c.254G>C	p.S85T	COSMIC	PASSENGER/OTHER	BENIGN
66	GP5D	Cell Line	LARGE_INTESTINE	ENST00000449264	c.64delG	p.Q25fs*15	COSMIC	NP	NP
67	JURKAT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000449264	c.280+10C>T	p.?	COSMIC	NP	NP
68	JURKAT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000449264	c.478G>A	p.A160T	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
69	LS123	Cell Line	LARGE_INTESTINE	ENST00000449264	c.407C>T	p.S136F	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
70	MCC13	Cell Line	SKIN	ENST00000449264	c.695C>T	p.A232V	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
71	MEWO	Cell Line	SKIN	ENST00000449264	c.180G>A	p.R60R	COSMIC	NP	NP
72	MHHPREB1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000449264	c.626G>T	p.S209I	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
73	MOLT4	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000449264	c.454C>A	p.L152I	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
74	NCIH2347	Cell Line	LUNG	ENST00000449264	c.298G>C	p.G100R	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
75	OVTOKO	Cell Line	OVARY	ENST00000449264	c.69G>T	p.G23G	COSMIC	NP	NP
76	RF48	Cell Line	STOMACH	ENST00000449264	c.489C>T	p.Y163Y	COSMIC	NP	NP
77	SKNDZ	Cell Line	AUTONOMIC_GANGLIA	ENST00000449264	c.673C>A	p.Q225K	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
78	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000449264	c.657C>A	p.D219E	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
79	SUPT1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000449264	c.407C>T	p.S136F	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
80	SUPT1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000449264	c.499G>A	p.V167I	COSMIC	PASSENGER/OTHER	BENIGN
81	SW684	Cell Line	SOFT_TISSUE	ENST00000449264	c.236C>T	p.S79L	COSMIC	PASSENGER/OTHER	BENIGN
82	UMUC3	Cell Line	URINARY_TRACT	ENST00000449264	c.201C>G	p.L67L	COSMIC	NP	NP

*NP: Not Predicted

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	4.5249	4.5398	-0.0397	-0.0241
BILIARY TRACT	5.2746	4.8152	-0.0936	-0.1384
BONE	4.5220	4.5025	-0.0363	-0.0323
BREAST	4.8349	4.6755	0.1550	0.08917
CENTRAL NERVOUS SYSTEM	4.6264	4.6314	0.0841	0.09247
ENDOMETRIUM	5.4150	4.9652	0.0690	0.01649
HAEMATOPOIETIC AND LYMPHOID TISSUE	6.0620	5.2873	0.1291	0.0964
KIDNEY	5.2959	4.936	-0.0581	0.014
LARGE INTESTINE	4.6297	4.5783	-0.0789	-0.00305
LIVER	4.5471	4.5004	0.1657	0.1434
LUNG	4.6049	4.5193	0.0738	0.1083
OESOPHAGUS	4.6013	4.5336	-0.0371	0.068615
OVARY	5.3920	4.9664	0.0361	0.0684
PANCREAS	4.7067	4.6152	-0.0261	0.027
PLEURA	4.6150	4.6307	0.0841	0.1233
PROSTATE	4.3811	4.3725	0.0888	0.00404
SALIVARY GLAND	4.4860	4.486	-0.3434	-0.3434
SKIN	4.5824	4.5677	0.0728	0.0568
SMALL INTESTINE	4.4589	4.4589	0.0063	0.0063
SOFT TISSUE	4.7386	4.67895	0.0481	0.06352
STOMACH	4.6843	4.58125	0.0528	0.05259
THYROID	4.9870	4.7842	0.0409	0.05405
UPPER AERODIGESTIVE TRACT	5.2147	5.0236	-0.0364	0.048815
URINARY TRACT	4.7373	4.619	0.0402	-0.03301

Domain ID	Domain Name	Start Site	End Site	E-value
PF00229	TNF	102	233	2.6e-43
PF00229	TNF	102	233	2.6e-43

Domain ID	Start Site	End Site	E-value
0045607	86	233	7.91e-50
0045607	86	233	7.91e-50

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
TNF	TNF	TNF	ENSP00000365290	P01375
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
P01375	TNF	ENSP00000365290	TNF	P01375
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
TNF	ENSP00000365290	191160	P01375	PA435

Protein: TNF

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)

Modelled Structure	Structures available in PDB
	1A8M, 1TNF, 2AZ5, 2E7A, 2TUN, 2ZJC, 2ZPX, 3ALQ, 3IT8, 3L9J, 3WD5, 4G3Y, 4TSV, 5TSW