ApoCanD

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	587338	Tumour	LARGE INTESTINE	ENST00000212369	c.805A>G	p.T269A	COSMIC	NP	NP
2	GC8	Tumour	T STOMACH	ENST00000212369	c.522T>C	p.A174A	COSMIC	NP	NP
3	LUAD-5V8LT	Tumour	LUNG	ENST00000212369	c.931A>T	p.R311W	COSMIC	NP	NP
4	LUAD-D01278	Tumour	LUNG	ENST00000212369	c.771C>T	p.S257S	COSMIC	NP	NP
5	LUAD-YINHD	Tumour	LUNG	ENST00000212369	c.414G>A	p.T138T	COSMIC	NP	NP
6	LUAD-YINHD	Tumour	LUNG	ENST00000212369	c.607G>T	p.D203Y	COSMIC	NP	NP
7	RK006	Tumour	C02 LIVER	ENST00000212369	c.850A>G	p.M284V	COSMIC	NP	NP
8	TCGA-37-3783-01	Tumour	LUNG	ENST00000212369	c.818C>G	p.S273*	COSMIC	NP	NP
9	TCGA-37-3783-01	Tumour	LUNG	ENST00000212369	c.979C>T	p.L327L	COSMIC	NP	NP
10	TCGA-61-1910-01	Tumour	OVARY	ENST00000212369	c.235G>C	p.V79L	COSMIC	NP	NP
11	TCGA-AA-3510-01	Tumour	LARGE INTESTINE	ENST00000212369	c.229G>T	p.E77*	COSMIC	NP	NP
12	TCGA-AA-3852-01	Tumour	LARGE INTESTINE	ENST00000212369	c.839G>A	p.G280D	COSMIC	NP	NP
13	TCGA-AA-3947-01	Tumour	LARGE INTESTINE	ENST00000212369	c.579G>T	p.Q193H	COSMIC	NP	NP
14	TCGA-AA-A00R-01	Tumour	LARGE INTESTINE	ENST00000212369	c.261T>C	p.A87A	COSMIC	NP	NP
15	TCGA-AG-A002-01	Tumour	LARGE INTESTINE	ENST00000212369	c.427T>G	p.F143V	COSMIC	NP	NP
16	TCGA-AP-A054-01	Tumour	ENDOMETRIUM	ENST00000212369	c.393A>G	p.A131A	COSMIC	NP	NP
17	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000212369	c.833C>T	p.A278V	COSMIC	NP	NP
18	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000212369	c.982G>T	p.A328S	COSMIC	NP	NP
19	TCGA-AX-A0J0-01	Tumour	ENDOMETRIUM	ENST00000212369	c.268C>T	p.R90C	COSMIC	NP	NP
20	TCGA-B5-A11E-01	Tumour	ENDOMETRIUM	ENST00000212369	c.418G>T	p.A140S	COSMIC	NP	NP
21	TCGA-BG-A0M4-01	Tumour	ENDOMETRIUM	ENST00000212369	c.997A>G	p.T333A	COSMIC	NP	NP
22	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000212369	c.229G>T	p.E77*	COSMIC	NP	NP
23	TCGA-BS-A0UV-01	Tumour	ENDOMETRIUM	ENST00000212369	c.674G>A	p.R225H	COSMIC	NP	NP
24	TCGA-C8-A26Z-01	Tumour	BREAST	ENST00000212369	c.791A>G	p.N264S	COSMIC	NP	NP
25	TCGA-CJ-6027-01	Tumour	KIDNEY	ENST00000212369	c.695A>T	p.E232V	COSMIC	NP	NP
26	TCGA-D1-A17A-01	Tumour	ENDOMETRIUM	ENST00000212369	c.201G>C	p.L67F	COSMIC	NP	NP
27	TCGA-DK-A3IT-01	Tumour	URINARY TRACT	ENST00000212369	c.876C>A	p.I292I	COSMIC	NP	NP
28	TCGA-G4-6625-01	Tumour	LARGE INTESTINE	ENST00000212369	c.1094A>G	p.N365S	COSMIC	NP	NP
29	TCGA-G4-6628-01	Tumour	LARGE INTESTINE	ENST00000212369	c.288T>G	p.L96L	COSMIC	NP	NP
30	YUGAFFE	Tumour	SKIN	ENST00000212369	c.883C>T	p.P295S	COSMIC	NP	NP
31	22RV1	Cell Line	PROSTATE	ENST00000212369	c.833C>T	p.A278V	COSMIC	PASSENGER/OTHER	BENIGN
32	451LU	Cell Line	SKIN	ENST00000212369	c.331G>C	p.G111R	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
33	DND41	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000212369	c.95A>G	p.Q32R	COSMIC	PASSENGER/OTHER	BENIGN
34	FADU	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000212369	c.846T>C	p.S282S	COSMIC	NP	NP
35	HCC2998	Cell Line	LARGE_INTESTINE	ENST00000212369	c.571-10C>T	p.?	COSMIC	NP	NP
36	HCT116	Cell Line	LARGE_INTESTINE	ENST00000212369	c.716C>T	p.A239V	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
37	KM12	Cell Line	LARGE_INTESTINE	ENST00000212369	c.1006A>C	p.S336R	COSMIC	PASSENGER/OTHER	BENIGN
38	MC1010	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000212369	c.476C>T	p.A159V	COSMIC	PASSENGER/OTHER	BENIGN
39	MHHES1	Cell Line	BONE	ENST00000212369	c.570+8A>G	p.?	COSMIC	NP	NP
40	NCIH2405	Cell Line	LUNG	ENST00000212369	c.990+1G>A	p.?	COSMIC	NP	NP
41	NCIH250	Cell Line	LUNG	ENST00000212369	c.570+8A>G	p.?	COSMIC	NP	NP
42	RL	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000212369	c.331G>C	p.G111R	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
43	SAOS2	Cell Line	BONE	ENST00000212369	c.73-5A>G	p.?	COSMIC	NP	NP
44	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000212369	c.344-3C>T	p.?	COSMIC	NP	NP
45	TGBC11TKB	Cell Line	STOMACH	ENST00000212369	c.130A>G	p.N44D	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
46	587338	Tumour	LARGE INTESTINE	ENST00000212369	c.805A>G	p.T269A	COSMIC	NP	NP
47	GC8	Tumour	T STOMACH	ENST00000212369	c.522T>C	p.A174A	COSMIC	NP	NP
48	LUAD-5V8LT	Tumour	LUNG	ENST00000212369	c.931A>T	p.R311W	COSMIC	NP	NP
49	LUAD-D01278	Tumour	LUNG	ENST00000212369	c.771C>T	p.S257S	COSMIC	NP	NP
50	LUAD-YINHD	Tumour	LUNG	ENST00000212369	c.414G>A	p.T138T	COSMIC	NP	NP
51	LUAD-YINHD	Tumour	LUNG	ENST00000212369	c.607G>T	p.D203Y	COSMIC	NP	NP
52	RK006	Tumour	C02 LIVER	ENST00000212369	c.850A>G	p.M284V	COSMIC	NP	NP
53	TCGA-37-3783-01	Tumour	LUNG	ENST00000212369	c.818C>G	p.S273*	COSMIC	NP	NP
54	TCGA-37-3783-01	Tumour	LUNG	ENST00000212369	c.979C>T	p.L327L	COSMIC	NP	NP
55	TCGA-61-1910-01	Tumour	OVARY	ENST00000212369	c.235G>C	p.V79L	COSMIC	NP	NP
56	TCGA-AA-3510-01	Tumour	LARGE INTESTINE	ENST00000212369	c.229G>T	p.E77*	COSMIC	NP	NP
57	TCGA-AA-3852-01	Tumour	LARGE INTESTINE	ENST00000212369	c.839G>A	p.G280D	COSMIC	NP	NP
58	TCGA-AA-3947-01	Tumour	LARGE INTESTINE	ENST00000212369	c.579G>T	p.Q193H	COSMIC	NP	NP
59	TCGA-AA-A00R-01	Tumour	LARGE INTESTINE	ENST00000212369	c.261T>C	p.A87A	COSMIC	NP	NP
60	TCGA-AG-A002-01	Tumour	LARGE INTESTINE	ENST00000212369	c.427T>G	p.F143V	COSMIC	NP	NP
61	TCGA-AP-A054-01	Tumour	ENDOMETRIUM	ENST00000212369	c.393A>G	p.A131A	COSMIC	NP	NP
62	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000212369	c.833C>T	p.A278V	COSMIC	NP	NP
63	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000212369	c.982G>T	p.A328S	COSMIC	NP	NP
64	TCGA-AX-A0J0-01	Tumour	ENDOMETRIUM	ENST00000212369	c.268C>T	p.R90C	COSMIC	NP	NP
65	TCGA-B5-A11E-01	Tumour	ENDOMETRIUM	ENST00000212369	c.418G>T	p.A140S	COSMIC	NP	NP
66	TCGA-BG-A0M4-01	Tumour	ENDOMETRIUM	ENST00000212369	c.997A>G	p.T333A	COSMIC	NP	NP
67	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000212369	c.229G>T	p.E77*	COSMIC	NP	NP
68	TCGA-BS-A0UV-01	Tumour	ENDOMETRIUM	ENST00000212369	c.674G>A	p.R225H	COSMIC	NP	NP
69	TCGA-C8-A26Z-01	Tumour	BREAST	ENST00000212369	c.791A>G	p.N264S	COSMIC	NP	NP
70	TCGA-CJ-6027-01	Tumour	KIDNEY	ENST00000212369	c.695A>T	p.E232V	COSMIC	NP	NP
71	TCGA-D1-A17A-01	Tumour	ENDOMETRIUM	ENST00000212369	c.201G>C	p.L67F	COSMIC	NP	NP
72	TCGA-DK-A3IT-01	Tumour	URINARY TRACT	ENST00000212369	c.876C>A	p.I292I	COSMIC	NP	NP
73	TCGA-G4-6625-01	Tumour	LARGE INTESTINE	ENST00000212369	c.1094A>G	p.N365S	COSMIC	NP	NP
74	TCGA-G4-6628-01	Tumour	LARGE INTESTINE	ENST00000212369	c.288T>G	p.L96L	COSMIC	NP	NP
75	YUGAFFE	Tumour	SKIN	ENST00000212369	c.883C>T	p.P295S	COSMIC	NP	NP
76	22RV1	Cell Line	PROSTATE	ENST00000212369	c.833C>T	p.A278V	COSMIC	PASSENGER/OTHER	BENIGN
77	451LU	Cell Line	SKIN	ENST00000212369	c.331G>C	p.G111R	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
78	DND41	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000212369	c.95A>G	p.Q32R	COSMIC	PASSENGER/OTHER	BENIGN
79	FADU	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000212369	c.846T>C	p.S282S	COSMIC	NP	NP
80	HCC2998	Cell Line	LARGE_INTESTINE	ENST00000212369	c.571-10C>T	p.?	COSMIC	NP	NP
81	HCT116	Cell Line	LARGE_INTESTINE	ENST00000212369	c.716C>T	p.A239V	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
82	KM12	Cell Line	LARGE_INTESTINE	ENST00000212369	c.1006A>C	p.S336R	COSMIC	PASSENGER/OTHER	BENIGN
83	MC1010	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000212369	c.476C>T	p.A159V	COSMIC	PASSENGER/OTHER	BENIGN
84	MHHES1	Cell Line	BONE	ENST00000212369	c.570+8A>G	p.?	COSMIC	NP	NP
85	NCIH2405	Cell Line	LUNG	ENST00000212369	c.990+1G>A	p.?	COSMIC	NP	NP
86	NCIH250	Cell Line	LUNG	ENST00000212369	c.570+8A>G	p.?	COSMIC	NP	NP
87	RL	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000212369	c.331G>C	p.G111R	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
88	SAOS2	Cell Line	BONE	ENST00000212369	c.73-5A>G	p.?	COSMIC	NP	NP
89	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000212369	c.344-3C>T	p.?	COSMIC	NP	NP
90	TGBC11TKB	Cell Line	STOMACH	ENST00000212369	c.130A>G	p.N44D	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING

*NP: Not Predicted

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	9.2515	9.2931	-0.0639	0.003516
BILIARY TRACT	9.7044	9.7857	-0.1833	-0.197
BONE	10.1801	10.645	0.0608	0.01806
BREAST	9.9714	9.9644	-0.0275	0.007197
CENTRAL NERVOUS SYSTEM	10.2625	10.286	0.0558	0.05827
ENDOMETRIUM	9.8465	9.8304	0.0084	-0.005595
HAEMATOPOIETIC AND LYMPHOID TISSUE	9.8393	9.8479	-0.0403	-0.0036
KIDNEY	10.2949	10.336	-0.0587	-0.0243
LARGE INTESTINE	9.7225	9.73105	-0.1315	-0.0371
LIVER	10.1280	10.157	0.0611	0.0788
LUNG	10.0217	9.9895	0.0550	0.0346
OESOPHAGUS	9.9562	9.91825	0.1019	0.076785
OVARY	10.0355	10.127	0.1199	0.1469
PANCREAS	10.2151	10.233	0.0017	0.01814
PLEURA	10.5523	10.469	-0.0227	0.0837
PROSTATE	9.2433	9.25815	-0.0231	0.00515
SALIVARY GLAND	9.9984	9.9984	0.1260	0.126
SKIN	10.0597	10.059	-0.0149	0.007198
SMALL INTESTINE	9.6182	9.6182	0.0140	0.014
SOFT TISSUE	10.3117	10.4215	0.1404	0.077085
STOMACH	9.8824	9.7365	0.0205	0.00861
THYROID	10.2002	10.205	0.2079	0.20565
UPPER AERODIGESTIVE TRACT	10.0590	10.00475	-0.0658	0.035115
URINARY TRACT	10.1217	10.2245	0.1232	0.0941

Domain ID	Domain Name	Start Site	End Site	E-value
PF03114	BAR	19	253	4.4e-70
PF14604	SH3_9	312	362	1.4e-10
PF03114	BAR	19	253	4.4e-70
PF14604	SH3_9	312	362	1.4e-10

Domain ID	Start Site	End Site	E-value
0052378	20	252	3.27e-69
0049867	244	276	2.50e-18
0052378	20	252	3.27e-69
0049867	244	276	2.50e-18

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
SH3GLB1	SH3GLB1	SH3GLB1	ENSP00000473267	Q9Y371
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
Q9Y371	SH3GLB1	ENSP00000473267	SH3GLB1	Q9Y371
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
SH3GLB1	ENSP00000473267	609287	Q9Y371	PA35739

Protein: SH3GLB1

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)

Modelled Structure	Structures available in PDB
	Structure is not available in PDB