ApoCanD

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	COLO741	Cell Line	SKIN	NP_003795	c.1156C>T	p.L386F	CCLE	CANCER	Possibly Damaging
2	COLO792	Cell Line	SKIN	NP_003795	c.268C>T	p.L90L	CCLE	NP	NP
3	DU145	Cell Line	PROSTATE	NP_003795	c.1381G>A	p.V461I	CCLE	CANCER	Benign
4	HCC1195	Cell Line	LUNG	NP_003795	c.1808G>A	p.R603H	CCLE	PASSENGER/OTHER	Probably Damaging
5	HCC15	Cell Line	LUNG	NP_003795	c.976G>T	p.V326L	CCLE	CANCER	Benign
6	HCC1569	Cell Line	BREAST	NP_003795	c.829A>G	p.T277A	CCLE	CANCER	Probably Damaging
7	HEC251	Cell Line	ENDOMETRIUM	NP_003795	c.1290G>T	p.Q430H	CCLE	CANCER	Possibly Damaging
8	HEC251	Cell Line	ENDOMETRIUM	NP_003795	c.724A>C	p.K242Q	CCLE	PASSENGER/OTHER	Benign
9	HEC59	Cell Line	ENDOMETRIUM	NP_003795	c.623A>G	p.K208R	CCLE	CANCER	Probably Damaging
10	HEC6	Cell Line	ENDOMETRIUM	NP_003795	c.979G>A	p.A327T	CCLE	CANCER	Possibly Damaging
11	HT115	Cell Line	LARGE INTESTINE	NP_003795	c.725A>C	p.K242T	CCLE	PASSENGER/OTHER	Benign
12	KMBC2	Cell Line	URINARY TRACT	NP_003795	c.1335T>A	p.H445Q	CCLE	PASSENGER/OTHER	Benign
13	MEC1	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_003795	c.171C>T	p.N57N	CCLE	NP	NP
14	MHHCALL4	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_003795	c.160A>G	p.I54V	CCLE	PASSENGER/OTHER	Benign
15	NB1	Cell Line	AUTONOMIC GANGLIA	NP_003795	c.235C>G	p.L79V	CCLE	CANCER	Probably Damaging
16	NCIH510	Cell Line	LUNG	NP_003795	c.279G>T	p.E93D	CCLE	CANCER	Probably Damaging
17	NCIH810	Cell Line	LUNG	NP_003795	c.1558A>T	p.S520C	CCLE	PASSENGER/OTHER	Probably Damaging
18	SNU1077	Cell Line	ENDOMETRIUM	NP_003795	c.309G>A	p.V103V	CCLE	NP	NP
19	SNU81	Cell Line	LARGE INTESTINE	NP_003795	c.1271G>T	p.R424I	CCLE	CANCER	Benign
20	TE9	Cell Line	OESOPHAGUS	NP_003795	c.502C>A	p.L168M	CCLE	CANCER	Probably Damaging
21	16678	Tumour	LUNG	ENST00000259808	c.1135C>T	p.Q379*	COSMIC	NP	NP
22	1960034	Tumour	URINARY TRACT	ENST00000259808	c.781A>G	p.I261V	COSMIC	NP	NP
23	587376	Tumour	LARGE INTESTINE	ENST00000259808	c.715A>C	p.M239L	COSMIC	NP	NP
24	587394	Tumour	LARGE INTESTINE	ENST00000259808	c.378G>A	p.M126I	COSMIC	NP	NP
25	BN22T	Tumour	LIVER	ENST00000259808	c.1713G>A	p.K571K	COSMIC	NP	NP
26	CLL041	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000259808	c.1796A>G	p.K599R	COSMIC	NP	NP
27	CLL043	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000259808	c.1123C>T	p.Q375*	COSMIC	NP	NP
28	CLL090	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000259808	c.1807C>A	p.R603S	COSMIC	NP	NP
29	CLL133	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000259808	c.1343C>T	p.A448V	COSMIC	NP	NP
30	CP50-MEL-B	Cell Line	SKIN	ENST00000259808	c.1188A>G	p.K396K	COSMIC	NP	NP
31	ESO-075	Tumour	OESOPHAGUS	ENST00000259808	c.765C>T	p.Y255Y	COSMIC	NP	NP
32	HCC4T	Tumour	LIVER	ENST00000259808	c.466G>A	p.D156N	COSMIC	NP	NP
33	HCC53T	Tumour	LIVER	ENST00000259808	c.1337G>C	p.G446A	COSMIC	NP	NP
34	HN	Tumour	62814 UPPER AERODIGESTIVE TRACT	ENST00000259808	c.1808G>A	p.R603H	COSMIC	NP	NP
35	HN	Tumour	63021 UPPER AERODIGESTIVE TRACT	ENST00000259808	c.1139A>T	p.D380V	COSMIC	NP	NP
36	HX13T	Tumour	LIVER	ENST00000259808	c.466G>A	p.D156N	COSMIC	NP	NP
37	LC	Tumour	C9 LUNG	ENST00000259808	c.466G>C	p.D156H	COSMIC	NP	NP
38	PACA44	Tumour	PANCREAS	ENST00000259808	c.1899A>C	p.Q633H	COSMIC	NP	NP
39	PD1520a	Tumour	LARGE INTESTINE	ENST00000259808	c.191C>T	p.A64V	COSMIC	NP	NP
40	PD2060a	Tumour	LARGE INTESTINE	ENST00000259808	c.241G>A	p.V81I	COSMIC	NP	NP
41	PD2064a	Tumour	LARGE INTESTINE	ENST00000259808	c.659C>T	p.A220V	COSMIC	NP	NP
42	TCGA-05-4390-01	Tumour	LUNG	ENST00000259808	c.1057C>G	p.P353A	COSMIC	NP	NP
43	TCGA-35-4122-01	Tumour	LUNG	ENST00000259808	c.715A>G	p.M239V	COSMIC	NP	NP
44	TCGA-44-2655-01	Tumour	LUNG	ENST00000259808	c.1053G>T	p.M351I	COSMIC	NP	NP
45	TCGA-55-7574-01	Tumour	LUNG	ENST00000259808	c.447C>T	p.D149D	COSMIC	NP	NP
46	TCGA-55-7911-01	Tumour	LUNG	ENST00000259808	c.566C>T	p.T189I	COSMIC	NP	NP
47	TCGA-64-5781-01	Tumour	LUNG	ENST00000259808	c.1241G>T	p.R414M	COSMIC	NP	NP
48	TCGA-A5-A0GB-01	Tumour	ENDOMETRIUM	ENST00000259808	c.586G>A	p.E196K	COSMIC	NP	NP
49	TCGA-A8-A09B-01	Tumour	BREAST	ENST00000259808	c.366C>T	p.I122I	COSMIC	NP	NP
50	TCGA-AA-3660-01	Tumour	LARGE INTESTINE	ENST00000259808	c.1188A>G	p.K396K	COSMIC	NP	NP
51	TCGA-AA-3811-01	Tumour	LARGE INTESTINE	ENST00000259808	c.683A>G	p.Y228C	COSMIC	NP	NP
52	TCGA-AA-A01P-01	Tumour	LARGE INTESTINE	ENST00000259808	c.1685C>T	p.T562M	COSMIC	NP	NP
53	TCGA-AA-A01Q-01	Tumour	LARGE INTESTINE	ENST00000259808	c.585C>A	p.P195P	COSMIC	NP	NP
54	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000259808	c.1765C>A	p.P589T	COSMIC	NP	NP
55	TCGA-AP-A0LM-01	Tumour	ENDOMETRIUM	ENST00000259808	c.1462G>T	p.V488F	COSMIC	NP	NP
56	TCGA-AP-A1DQ-01	Tumour	ENDOMETRIUM	ENST00000259808	c.278A>T	p.E93V	COSMIC	NP	NP
57	TCGA-AZ-4315-01	Tumour	LARGE INTESTINE	ENST00000259808	c.1579G>T	p.E527*	COSMIC	NP	NP
58	TCGA-AZ-4315-01	Tumour	LARGE INTESTINE	ENST00000259808	c.1686G>A	p.T562T	COSMIC	NP	NP
59	TCGA-B5-A11E-01	Tumour	ENDOMETRIUM	ENST00000259808	c.1930G>A	p.A644T	COSMIC	NP	NP
60	TCGA-B8-5165-01	Tumour	KIDNEY	ENST00000259808	c.1994T>A	p.L665*	COSMIC	NP	NP
61	TCGA-BH-A0HP-01	Tumour	BREAST	ENST00000259808	c.808G>T	p.A270S	COSMIC	NP	NP
62	TCGA-BK-A13C-01	Tumour	ENDOMETRIUM	ENST00000259808	c.827C>T	p.P276L	COSMIC	NP	NP
63	TCGA-BL-A0C8-01	Tumour	URINARY TRACT	ENST00000259808	c.950G>C	p.R317T	COSMIC	NP	NP
64	TCGA-BP-4161-01	Tumour	KIDNEY	ENST00000259808	c.405A>G	p.I135M	COSMIC	NP	NP
65	TCGA-BS-A0TC-01	Tumour	ENDOMETRIUM	ENST00000259808	c.1579G>T	p.E527*	COSMIC	NP	NP
66	TCGA-C8-A1HM-01	Tumour	BREAST	ENST00000259808	c.1577-1G>A	p.?	COSMIC	NP	NP
67	TCGA-CA-6717-01	Tumour	LARGE INTESTINE	ENST00000259808	c.931G>A	p.E311K	COSMIC	NP	NP
68	TCGA-CK-5916-01	Tumour	LARGE INTESTINE	ENST00000259808	c.606C>T	p.N202N	COSMIC	NP	NP
69	TCGA-D1-A0ZS-01	Tumour	ENDOMETRIUM	ENST00000259808	c.1191G>A	p.Q397Q	COSMIC	NP	NP
70	TCGA-D1-A17D-01	Tumour	ENDOMETRIUM	ENST00000259808	c.863_866delTTTA	p.Y289fs*1	COSMIC	NP	NP
71	TCGA-D1-A17Q-01	Tumour	ENDOMETRIUM	ENST00000259808	c.1729+1G>A	p.?	COSMIC	NP	NP
72	TCGA-D5-5538-01	Tumour	LARGE INTESTINE	ENST00000259808	c.955C>T	p.Q319*	COSMIC	NP	NP
73	TCGA-D5-6539-01	Tumour	LARGE INTESTINE	ENST00000259808	c.1136A>G	p.Q379R	COSMIC	NP	NP
74	TCGA-DI-A0WH-01	Tumour	ENDOMETRIUM	ENST00000259808	c.401T>C	p.V134A	COSMIC	NP	NP
75	TCGA-E2-A152-01	Tumour	BREAST	ENST00000259808	c.439G>A	p.D147N	COSMIC	NP	NP
76	TCGA-G9-6332-01	Tumour	PROSTATE	ENST00000259808	c.71A>G	p.D24G	COSMIC	NP	NP
77	201T	Cell Line	LUNG	ENST00000259808	c.1586T>G	p.I529R	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
78	A2058	Cell Line	SKIN	ENST00000259808	c.502C>T	p.L168L	COSMIC	NP	NP
79	ALLPO	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000259808	c.662T>A	p.I221K	COSMIC	CANCER	PROBABLY DAMAGING
80	C3A	Cell Line	LIVER	ENST00000259808	c.689-10T>C	p.?	COSMIC	NP	NP
81	COLO205	Cell Line	LARGE_INTESTINE	ENST00000259808	c.1782G>C	p.L594L	COSMIC	NP	NP
82	COLO741	Cell Line	LARGE_INTESTINE	ENST00000259808	c.1156C>T	p.L386F	COSMIC	CANCER	POSSIBLY DAMAGING
83	COLO792	Cell Line	SKIN	ENST00000259808	c.268C>T	p.L90L	COSMIC	NP	NP
84	CP50MELB	Cell Line	SKIN	ENST00000259808	c.1188A>G	p.K396K	COSMIC	NP	NP
85	DU145	Cell Line	PROSTATE	ENST00000259808	c.1381G>A	p.V461I	COSMIC	CANCER	BENIGN
86	HCC15	Cell Line	LUNG	ENST00000259808	c.976G>T	p.V326L	COSMIC	CANCER	BENIGN
87	HCC1569	Cell Line	BREAST	ENST00000259808	c.829A>G	p.T277A	COSMIC	CANCER	PROBABLY DAMAGING
88	HCC70	Cell Line	BREAST	ENST00000259808	c.1671A>G	p.L557L	COSMIC	NP	NP
89	HEC1	Cell Line	ENDOMETRIUM	ENST00000259808	c.1844T>C	p.I615T	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
90	HT115	Cell Line	LARGE_INTESTINE	ENST00000259808	c.725A>C	p.K242T	COSMIC	PASSENGER/OTHER	BENIGN
91	KARPAS45	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000259808	c.404T>C	p.I135T	COSMIC	CANCER	PROBABLY DAMAGING
92	KGN	Cell Line	OVARY	ENST00000259808	c.1335T>A	p.H445Q	COSMIC	PASSENGER/OTHER	BENIGN
93	MHHCALL4	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000259808	c.160A>G	p.I54V	COSMIC	PASSENGER/OTHER	BENIGN
94	MPP89	Cell Line	PLEURA	ENST00000259808	c.399C>G	p.G133G	COSMIC	NP	NP
95	NCIH187	Cell Line	LUNG	ENST00000259808	c.575A>G	p.Y192C	COSMIC	CANCER	PROBABLY DAMAGING
96	NCIH510A	Cell Line	LUNG	ENST00000259808	c.279G>T	p.E93D	COSMIC	CANCER	PROBABLY DAMAGING
97	NCIH810	Cell Line	LUNG	ENST00000259808	c.1558A>T	p.S520C	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
98	PF382	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000259808	c.810G>A	p.A270A	COSMIC	NP	NP
99	RCCER	Cell Line	KIDNEY	ENST00000259808	c.1591T>C	p.Y531H	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
100	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000259808	c.1238G>A	p.R413H	COSMIC	CANCER	PROBABLY DAMAGING
101	SNU407	Cell Line	LARGE_INTESTINE	ENST00000259808	c.557A>G	p.N186S	COSMIC	CANCER	BENIGN
102	SNU81	Cell Line	LARGE_INTESTINE	ENST00000259808	c.1271G>T	p.R424I	COSMIC	CANCER	BENIGN
103	TE9	Cell Line	OESOPHAGUS	ENST00000259808	c.502C>A	p.L168M	COSMIC	CANCER	PROBABLY DAMAGING
104	COLO741	Cell Line	SKIN	NP_003795	c.1156C>T	p.L386F	CCLE	CANCER	Possibly Damaging
105	COLO792	Cell Line	SKIN	NP_003795	c.268C>T	p.L90L	CCLE	NP	NP
106	DU145	Cell Line	PROSTATE	NP_003795	c.1381G>A	p.V461I	CCLE	CANCER	Benign
107	HCC1195	Cell Line	LUNG	NP_003795	c.1808G>A	p.R603H	CCLE	PASSENGER/OTHER	Probably Damaging
108	HCC15	Cell Line	LUNG	NP_003795	c.976G>T	p.V326L	CCLE	CANCER	Benign
109	HCC1569	Cell Line	BREAST	NP_003795	c.829A>G	p.T277A	CCLE	CANCER	Probably Damaging
110	HEC251	Cell Line	ENDOMETRIUM	NP_003795	c.1290G>T	p.Q430H	CCLE	CANCER	Possibly Damaging
111	HEC251	Cell Line	ENDOMETRIUM	NP_003795	c.724A>C	p.K242Q	CCLE	PASSENGER/OTHER	Benign
112	HEC59	Cell Line	ENDOMETRIUM	NP_003795	c.623A>G	p.K208R	CCLE	CANCER	Probably Damaging
113	HEC6	Cell Line	ENDOMETRIUM	NP_003795	c.979G>A	p.A327T	CCLE	CANCER	Possibly Damaging
114	HT115	Cell Line	LARGE INTESTINE	NP_003795	c.725A>C	p.K242T	CCLE	PASSENGER/OTHER	Benign
115	KMBC2	Cell Line	URINARY TRACT	NP_003795	c.1335T>A	p.H445Q	CCLE	PASSENGER/OTHER	Benign
116	MEC1	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_003795	c.171C>T	p.N57N	CCLE	NP	NP
117	MHHCALL4	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_003795	c.160A>G	p.I54V	CCLE	PASSENGER/OTHER	Benign
118	NB1	Cell Line	AUTONOMIC GANGLIA	NP_003795	c.235C>G	p.L79V	CCLE	CANCER	Probably Damaging
119	NCIH510	Cell Line	LUNG	NP_003795	c.279G>T	p.E93D	CCLE	CANCER	Probably Damaging
120	NCIH810	Cell Line	LUNG	NP_003795	c.1558A>T	p.S520C	CCLE	PASSENGER/OTHER	Probably Damaging
121	SNU1077	Cell Line	ENDOMETRIUM	NP_003795	c.309G>A	p.V103V	CCLE	NP	NP
122	SNU81	Cell Line	LARGE INTESTINE	NP_003795	c.1271G>T	p.R424I	CCLE	CANCER	Benign
123	TE9	Cell Line	OESOPHAGUS	NP_003795	c.502C>A	p.L168M	CCLE	CANCER	Probably Damaging
124	16678	Tumour	LUNG	ENST00000259808	c.1135C>T	p.Q379*	COSMIC	NP	NP
125	1960034	Tumour	URINARY TRACT	ENST00000259808	c.781A>G	p.I261V	COSMIC	NP	NP
126	587376	Tumour	LARGE INTESTINE	ENST00000259808	c.715A>C	p.M239L	COSMIC	NP	NP
127	587394	Tumour	LARGE INTESTINE	ENST00000259808	c.378G>A	p.M126I	COSMIC	NP	NP
128	BN22T	Tumour	LIVER	ENST00000259808	c.1713G>A	p.K571K	COSMIC	NP	NP
129	CLL041	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000259808	c.1796A>G	p.K599R	COSMIC	NP	NP
130	CLL043	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000259808	c.1123C>T	p.Q375*	COSMIC	NP	NP
131	CLL090	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000259808	c.1807C>A	p.R603S	COSMIC	NP	NP
132	CLL133	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000259808	c.1343C>T	p.A448V	COSMIC	NP	NP
133	CP50-MEL-B	Cell Line	SKIN	ENST00000259808	c.1188A>G	p.K396K	COSMIC	NP	NP
134	ESO-075	Tumour	OESOPHAGUS	ENST00000259808	c.765C>T	p.Y255Y	COSMIC	NP	NP
135	HCC4T	Tumour	LIVER	ENST00000259808	c.466G>A	p.D156N	COSMIC	NP	NP
136	HCC53T	Tumour	LIVER	ENST00000259808	c.1337G>C	p.G446A	COSMIC	NP	NP
137	HN	Tumour	62814 UPPER AERODIGESTIVE TRACT	ENST00000259808	c.1808G>A	p.R603H	COSMIC	NP	NP
138	HN	Tumour	63021 UPPER AERODIGESTIVE TRACT	ENST00000259808	c.1139A>T	p.D380V	COSMIC	NP	NP
139	HX13T	Tumour	LIVER	ENST00000259808	c.466G>A	p.D156N	COSMIC	NP	NP
140	LC	Tumour	C9 LUNG	ENST00000259808	c.466G>C	p.D156H	COSMIC	NP	NP
141	PACA44	Tumour	PANCREAS	ENST00000259808	c.1899A>C	p.Q633H	COSMIC	NP	NP
142	PD1520a	Tumour	LARGE INTESTINE	ENST00000259808	c.191C>T	p.A64V	COSMIC	NP	NP
143	PD2060a	Tumour	LARGE INTESTINE	ENST00000259808	c.241G>A	p.V81I	COSMIC	NP	NP
144	PD2064a	Tumour	LARGE INTESTINE	ENST00000259808	c.659C>T	p.A220V	COSMIC	NP	NP
145	TCGA-05-4390-01	Tumour	LUNG	ENST00000259808	c.1057C>G	p.P353A	COSMIC	NP	NP
146	TCGA-35-4122-01	Tumour	LUNG	ENST00000259808	c.715A>G	p.M239V	COSMIC	NP	NP
147	TCGA-44-2655-01	Tumour	LUNG	ENST00000259808	c.1053G>T	p.M351I	COSMIC	NP	NP
148	TCGA-55-7574-01	Tumour	LUNG	ENST00000259808	c.447C>T	p.D149D	COSMIC	NP	NP
149	TCGA-55-7911-01	Tumour	LUNG	ENST00000259808	c.566C>T	p.T189I	COSMIC	NP	NP
150	TCGA-64-5781-01	Tumour	LUNG	ENST00000259808	c.1241G>T	p.R414M	COSMIC	NP	NP
151	TCGA-A5-A0GB-01	Tumour	ENDOMETRIUM	ENST00000259808	c.586G>A	p.E196K	COSMIC	NP	NP
152	TCGA-A8-A09B-01	Tumour	BREAST	ENST00000259808	c.366C>T	p.I122I	COSMIC	NP	NP
153	TCGA-AA-3660-01	Tumour	LARGE INTESTINE	ENST00000259808	c.1188A>G	p.K396K	COSMIC	NP	NP
154	TCGA-AA-3811-01	Tumour	LARGE INTESTINE	ENST00000259808	c.683A>G	p.Y228C	COSMIC	NP	NP
155	TCGA-AA-A01P-01	Tumour	LARGE INTESTINE	ENST00000259808	c.1685C>T	p.T562M	COSMIC	NP	NP
156	TCGA-AA-A01Q-01	Tumour	LARGE INTESTINE	ENST00000259808	c.585C>A	p.P195P	COSMIC	NP	NP
157	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000259808	c.1765C>A	p.P589T	COSMIC	NP	NP
158	TCGA-AP-A0LM-01	Tumour	ENDOMETRIUM	ENST00000259808	c.1462G>T	p.V488F	COSMIC	NP	NP
159	TCGA-AP-A1DQ-01	Tumour	ENDOMETRIUM	ENST00000259808	c.278A>T	p.E93V	COSMIC	NP	NP
160	TCGA-AZ-4315-01	Tumour	LARGE INTESTINE	ENST00000259808	c.1579G>T	p.E527*	COSMIC	NP	NP
161	TCGA-AZ-4315-01	Tumour	LARGE INTESTINE	ENST00000259808	c.1686G>A	p.T562T	COSMIC	NP	NP
162	TCGA-B5-A11E-01	Tumour	ENDOMETRIUM	ENST00000259808	c.1930G>A	p.A644T	COSMIC	NP	NP
163	TCGA-B8-5165-01	Tumour	KIDNEY	ENST00000259808	c.1994T>A	p.L665*	COSMIC	NP	NP
164	TCGA-BH-A0HP-01	Tumour	BREAST	ENST00000259808	c.808G>T	p.A270S	COSMIC	NP	NP
165	TCGA-BK-A13C-01	Tumour	ENDOMETRIUM	ENST00000259808	c.827C>T	p.P276L	COSMIC	NP	NP
166	TCGA-BL-A0C8-01	Tumour	URINARY TRACT	ENST00000259808	c.950G>C	p.R317T	COSMIC	NP	NP
167	TCGA-BP-4161-01	Tumour	KIDNEY	ENST00000259808	c.405A>G	p.I135M	COSMIC	NP	NP
168	TCGA-BS-A0TC-01	Tumour	ENDOMETRIUM	ENST00000259808	c.1579G>T	p.E527*	COSMIC	NP	NP
169	TCGA-C8-A1HM-01	Tumour	BREAST	ENST00000259808	c.1577-1G>A	p.?	COSMIC	NP	NP
170	TCGA-CA-6717-01	Tumour	LARGE INTESTINE	ENST00000259808	c.931G>A	p.E311K	COSMIC	NP	NP
171	TCGA-CK-5916-01	Tumour	LARGE INTESTINE	ENST00000259808	c.606C>T	p.N202N	COSMIC	NP	NP
172	TCGA-D1-A0ZS-01	Tumour	ENDOMETRIUM	ENST00000259808	c.1191G>A	p.Q397Q	COSMIC	NP	NP
173	TCGA-D1-A17D-01	Tumour	ENDOMETRIUM	ENST00000259808	c.863_866delTTTA	p.Y289fs*1	COSMIC	NP	NP
174	TCGA-D1-A17Q-01	Tumour	ENDOMETRIUM	ENST00000259808	c.1729+1G>A	p.?	COSMIC	NP	NP
175	TCGA-D5-5538-01	Tumour	LARGE INTESTINE	ENST00000259808	c.955C>T	p.Q319*	COSMIC	NP	NP
176	TCGA-D5-6539-01	Tumour	LARGE INTESTINE	ENST00000259808	c.1136A>G	p.Q379R	COSMIC	NP	NP
177	TCGA-DI-A0WH-01	Tumour	ENDOMETRIUM	ENST00000259808	c.401T>C	p.V134A	COSMIC	NP	NP
178	TCGA-E2-A152-01	Tumour	BREAST	ENST00000259808	c.439G>A	p.D147N	COSMIC	NP	NP
179	TCGA-G9-6332-01	Tumour	PROSTATE	ENST00000259808	c.71A>G	p.D24G	COSMIC	NP	NP
180	201T	Cell Line	LUNG	ENST00000259808	c.1586T>G	p.I529R	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
181	A2058	Cell Line	SKIN	ENST00000259808	c.502C>T	p.L168L	COSMIC	NP	NP
182	ALLPO	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000259808	c.662T>A	p.I221K	COSMIC	CANCER	PROBABLY DAMAGING
183	C3A	Cell Line	LIVER	ENST00000259808	c.689-10T>C	p.?	COSMIC	NP	NP
184	COLO205	Cell Line	LARGE_INTESTINE	ENST00000259808	c.1782G>C	p.L594L	COSMIC	NP	NP
185	COLO741	Cell Line	LARGE_INTESTINE	ENST00000259808	c.1156C>T	p.L386F	COSMIC	CANCER	POSSIBLY DAMAGING
186	COLO792	Cell Line	SKIN	ENST00000259808	c.268C>T	p.L90L	COSMIC	NP	NP
187	CP50MELB	Cell Line	SKIN	ENST00000259808	c.1188A>G	p.K396K	COSMIC	NP	NP
188	DU145	Cell Line	PROSTATE	ENST00000259808	c.1381G>A	p.V461I	COSMIC	CANCER	BENIGN
189	HCC15	Cell Line	LUNG	ENST00000259808	c.976G>T	p.V326L	COSMIC	CANCER	BENIGN
190	HCC1569	Cell Line	BREAST	ENST00000259808	c.829A>G	p.T277A	COSMIC	CANCER	PROBABLY DAMAGING
191	HCC70	Cell Line	BREAST	ENST00000259808	c.1671A>G	p.L557L	COSMIC	NP	NP
192	HEC1	Cell Line	ENDOMETRIUM	ENST00000259808	c.1844T>C	p.I615T	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
193	HT115	Cell Line	LARGE_INTESTINE	ENST00000259808	c.725A>C	p.K242T	COSMIC	PASSENGER/OTHER	BENIGN
194	KARPAS45	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000259808	c.404T>C	p.I135T	COSMIC	CANCER	PROBABLY DAMAGING
195	KGN	Cell Line	OVARY	ENST00000259808	c.1335T>A	p.H445Q	COSMIC	PASSENGER/OTHER	BENIGN
196	MHHCALL4	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000259808	c.160A>G	p.I54V	COSMIC	PASSENGER/OTHER	BENIGN
197	MPP89	Cell Line	PLEURA	ENST00000259808	c.399C>G	p.G133G	COSMIC	NP	NP
198	NCIH187	Cell Line	LUNG	ENST00000259808	c.575A>G	p.Y192C	COSMIC	CANCER	PROBABLY DAMAGING
199	NCIH510A	Cell Line	LUNG	ENST00000259808	c.279G>T	p.E93D	COSMIC	CANCER	PROBABLY DAMAGING
200	NCIH810	Cell Line	LUNG	ENST00000259808	c.1558A>T	p.S520C	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
201	PF382	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000259808	c.810G>A	p.A270A	COSMIC	NP	NP
202	RCCER	Cell Line	KIDNEY	ENST00000259808	c.1591T>C	p.Y531H	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
203	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000259808	c.1238G>A	p.R413H	COSMIC	CANCER	PROBABLY DAMAGING
204	SNU407	Cell Line	LARGE_INTESTINE	ENST00000259808	c.557A>G	p.N186S	COSMIC	CANCER	BENIGN
205	SNU81	Cell Line	LARGE_INTESTINE	ENST00000259808	c.1271G>T	p.R424I	COSMIC	CANCER	BENIGN
206	TE9	Cell Line	OESOPHAGUS	ENST00000259808	c.502C>A	p.L168M	COSMIC	CANCER	PROBABLY DAMAGING

*NP: Not Predicted

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	6.2767	6.3562	-0.0590	-0.06139
BILIARY TRACT	6.9045	6.9656	-0.1095	-0.1277
BONE	7.0196	7.0217	0.0243	-0.008649
BREAST	7.2379	7.25265	0.0049	0.000853
CENTRAL NERVOUS SYSTEM	7.2009	7.2285	0.0999	0.1021
ENDOMETRIUM	7.0003	7.0505	0.0821	0.02306
HAEMATOPOIETIC AND LYMPHOID TISSUE	7.1698	7.1737	0.0706	0.0167
KIDNEY	7.1316	7.1804	-0.0355	0.04317
LARGE INTESTINE	7.0365	7.0988	-0.1322	-0.03415
LIVER	7.0470	6.9692	0.1667	0.1484
LUNG	6.9801	6.9932	0.0441	0.08215
OESOPHAGUS	6.7982	6.89775	-0.1211	-0.14181
OVARY	6.9656	6.9596	0.0712	0.04532
PANCREAS	6.9839	7.0055	-0.2829	-0.2584
PLEURA	7.0528	7.094	0.1009	0.1143
PROSTATE	7.0273	7.12105	0.0468	0.02087
SALIVARY GLAND	5.7003	5.7003	-0.4060	-0.406
SKIN	7.3739	7.3522	0.1567	0.1327
SMALL INTESTINE	7.2721	7.2721	-0.0119	-0.01187
SOFT TISSUE	7.2507	7.24625	-0.0786	-0.02715
STOMACH	7.1747	7.21005	0.0201	0.060225
THYROID	7.1623	7.2179	-0.0821	-0.04575
UPPER AERODIGESTIVE TRACT	7.0001	7.04225	-0.0628	0.02772
URINARY TRACT	7.2023	7.26825	0.0787	-0.00095

Domain ID	Domain Name	Start Site	End Site	E-value
PF00069	Pkinase	22	281	7.8e-54
PF12721	RHIM	504	550	9.3e-12
PF00531	Death	586	665	1.6e-20
PF00069	Pkinase	22	281	7.8e-54
PF12721	RHIM	504	550	9.3e-12
PF00531	Death	586	665	1.6e-20

Domain ID	Start Site	End Site	E-value
0040727	6	286	7.28e-68
0036756	578	666	2.80e-24
0040727	6	286	7.28e-68
0036756	578	666	2.80e-24

S. No.	Position	Amino acid	Type	Description
1	115	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
2	25	S	Phosphorylation	Phosphoserine.
3	303	S	Phosphorylation	Phosphoserine.
4	316	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
5	320	S	Phosphorylation	Phosphoserine
6	320	S	Phosphorylation	Phosphoserine.
7	324	D	Proteolytic Cleavage	none
8	333	S	Phosphorylation	Phosphoserine.
9	337	T	Phosphorylation	Phosphothreonine
10	346	S	Phosphorylation	Phosphoserine
11	377	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
12	384	Y	Phosphorylation	Phosphotyrosine
13	384	Y	Phosphorylation	Phosphotyrosine.
14	387	Y	Phosphorylation	Phosphotyrosine
15	387	Y	Phosphorylation	Phosphotyrosine.
16	389	S	Phosphorylation	Phosphoserine
17	389	S	Phosphorylation	Phosphoserine.
18	571	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
19	6	S	Phosphorylation	Phosphoserine.
20	604	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
21	627	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
22	115	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
23	25	S	Phosphorylation	Phosphoserine.
24	303	S	Phosphorylation	Phosphoserine.
25	316	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
26	320	S	Phosphorylation	Phosphoserine
27	320	S	Phosphorylation	Phosphoserine.
28	324	D	Proteolytic Cleavage	none
29	333	S	Phosphorylation	Phosphoserine.
30	337	T	Phosphorylation	Phosphothreonine
31	346	S	Phosphorylation	Phosphoserine
32	377	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
33	384	Y	Phosphorylation	Phosphotyrosine
34	384	Y	Phosphorylation	Phosphotyrosine.
35	387	Y	Phosphorylation	Phosphotyrosine
36	387	Y	Phosphorylation	Phosphotyrosine.
37	389	S	Phosphorylation	Phosphoserine
38	389	S	Phosphorylation	Phosphoserine.
39	571	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
40	6	S	Phosphorylation	Phosphoserine.
41	604	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
42	627	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
RIPK1	RIPK1	RIPK1	ENSP00000259808	Q13546
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
Q13546	RIPK1	ENSP00000259808	RIPK1	Q13546
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
RIPK1	ENSP00000259808	603453	Q13546	PA34394

Protein: RIPK1

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)

Modelled Structure	Structures available in PDB
	4ITH, 4ITI, 4ITJ, 4NEU