ApoCanD

Mutation Data (+)

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	LUAD-RT-S01769	Tumour	LUNG	ENST00000247470	c.585C>A	p.S195R	COSMIC	NP	NP
2	PD4203a	Tumour	NS	ENST00000247470	c.100G>A	p.E34K	COSMIC	NP	NP
3	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000247470	c.438C>T	p.Y146Y	COSMIC	NP	NP
4	TCGA-AZ-6598-01	Tumour	LARGE INTESTINE	ENST00000247470	c.237G>T	p.Q79H	COSMIC	NP	NP
5	TCGA-BP-5199-01	Tumour	KIDNEY	ENST00000247470	c.474G>C	p.K158N	COSMIC	NP	NP
6	TCGA-E2-A15J-01	Tumour	BREAST	ENST00000247470	c.433C>T	p.Q145*	COSMIC	NP	NP
7	ccRCC-41	Tumour	KIDNEY	ENST00000247470	c.349C>A	p.Q117K	COSMIC	NP	NP
8	CTB1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000247470	c.580C>T	p.R194W	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
9	HEP3B217	Cell Line	NS	ENST00000247470	c.332-6C>A	p.?	COSMIC	NP	NP
10	HTCC3	Cell Line	THYROID	ENST00000247470	c.9C>A	p.R3R	COSMIC	NP	NP
11	MFE319	Cell Line	ENDOMETRIUM	ENST00000247470	c.515C>T	p.T172I	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
12	MN60	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000247470	c.20_27delCCATCCTG	p.A7fs*62	COSMIC	NP	NP
13	MZ7MEL	Cell Line	SKIN	ENST00000247470	c.450G>A	p.R150R	COSMIC	NP	NP
14	NCIH460	Cell Line	LUNG	ENST00000247470	c.414G>T	p.G138G	COSMIC	NP	NP
15	REH	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000247470	c.384C>T	p.N128N	COSMIC	NP	NP
16	SKOV3	Cell Line	OVARY	ENST00000247470	c.587G>T	p.*196L	COSMIC	NP	NP
17	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000247470	c.396G>A	p.L132L	COSMIC	NP	NP
18	TT	Cell Line	THYROID	ENST00000247470	c.426G>T	p.T142T	COSMIC	NP	NP
19	LUAD-RT-S01769	Tumour	LUNG	ENST00000247470	c.585C>A	p.S195R	COSMIC	NP	NP
20	PD4203a	Tumour	NS	ENST00000247470	c.100G>A	p.E34K	COSMIC	NP	NP
21	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000247470	c.438C>T	p.Y146Y	COSMIC	NP	NP
22	TCGA-AZ-6598-01	Tumour	LARGE INTESTINE	ENST00000247470	c.237G>T	p.Q79H	COSMIC	NP	NP
23	TCGA-BP-5199-01	Tumour	KIDNEY	ENST00000247470	c.474G>C	p.K158N	COSMIC	NP	NP
24	TCGA-E2-A15J-01	Tumour	BREAST	ENST00000247470	c.433C>T	p.Q145*	COSMIC	NP	NP
25	ccRCC-41	Tumour	KIDNEY	ENST00000247470	c.349C>A	p.Q117K	COSMIC	NP	NP
26	CTB1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000247470	c.580C>T	p.R194W	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
27	HEP3B217	Cell Line	NS	ENST00000247470	c.332-6C>A	p.?	COSMIC	NP	NP
28	HTCC3	Cell Line	THYROID	ENST00000247470	c.9C>A	p.R3R	COSMIC	NP	NP
29	MFE319	Cell Line	ENDOMETRIUM	ENST00000247470	c.515C>T	p.T172I	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
30	MN60	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000247470	c.20_27delCCATCCTG	p.A7fs*62	COSMIC	NP	NP
31	MZ7MEL	Cell Line	SKIN	ENST00000247470	c.450G>A	p.R150R	COSMIC	NP	NP
32	NCIH460	Cell Line	LUNG	ENST00000247470	c.414G>T	p.G138G	COSMIC	NP	NP
33	REH	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000247470	c.384C>T	p.N128N	COSMIC	NP	NP
34	SKOV3	Cell Line	OVARY	ENST00000247470	c.587G>T	p.*196L	COSMIC	NP	NP
35	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000247470	c.396G>A	p.L132L	COSMIC	NP	NP
36	TT	Cell Line	THYROID	ENST00000247470	c.426G>T	p.T142T	COSMIC	NP	NP

*NP: Not Predicted

Copy number variation and expression profile (+)

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	3.9190	3.8708	-0.0367	-0.04475
BILIARY TRACT	7.0135	6.9664	-0.0399	-0.2072
BONE	5.8298	5.9582	-0.0125	-0.02
BREAST	6.9575	7.4688	0.0398	-0.01311
CENTRAL NERVOUS SYSTEM	4.4653	3.9833	-0.0438	-0.047
ENDOMETRIUM	4.6474	4.0443	0.0140	-0.0329
HAEMATOPOIETIC AND LYMPHOID TISSUE	7.8857	8.2288	-0.0041	6e-04
KIDNEY	6.8999	6.7143	0.1257	0.0819
LARGE INTESTINE	7.0872	7.71675	0.0322	-0.01845
LIVER	5.4532	4.7568	-0.0746	-0.1154
LUNG	5.7956	5.1879	0.0009	-0.0007
OESOPHAGUS	7.4749	8.42375	0.1537	0.1089
OVARY	5.4774	4.397	0.0509	0.0389
PANCREAS	7.8868	8.1795	0.0021	0.1097
PLEURA	8.1020	8.9298	0.0293	0.0292
PROSTATE	4.8258	4.2247	-0.1666	-0.0767
SALIVARY GLAND	10.6510	10.651	0.3182	0.3182
SKIN	7.4514	7.6083	-0.0439	-0.0312
SMALL INTESTINE	3.8760	3.876	0.0160	0.01602
SOFT TISSUE	5.5601	4.19135	-0.1178	-0.05191
STOMACH	6.8854	7.2232	0.0378	-0.000910999999999999
THYROID	5.2805	4.58665	-0.0056	-0.04485
UPPER AERODIGESTIVE TRACT	8.9919	8.92365	-0.0120	-0.0136
URINARY TRACT	7.3936	7.76405	-0.0263	-0.0357

Gene Essentiality Data (+)

Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.

test

Tertiary structure (+)

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Modelled Structure	Structures available in PDB
	1UCP, 2KN6, 3J63

Structure Domains (+)

1. PFAM Domains:

Domain ID	Domain Name	Start Site	End Site	E-value
PF02758	PYRIN	5	86	5.5e-21
PF00619	CARD	113	194	2.2e-21
PF02758	PYRIN	5	86	5.5e-21
PF00619	CARD	113	194	2.2e-21

2. Superfamily Domains:

Domain ID	Start Site	End Site	E-value
0044274	1	90	2.00e-23
0036193	109	193	2.92e-18
0044274	1	90	2.00e-23
0036193	109	193	2.92e-18

Sequence Alignment (+)

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1. Sequence alignment with 1000 genome variations:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

2. Mutants are not present in CCLE!!

3. Sequence alignment with COSMIC mutants:

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4. Sequence alignment with homologus proteins:

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Sequence Profiles (+)

HMM
With Uniprot database	With Mutants	With 1000 Genome Variants

PSSM
With Uniprot database	With Mutants	With 1000 Genome Variant

Post Translational Modifications (+)

Post translational modifications are not found!!

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
PYCARD	PYCARD	PYCARD	ENSP00000247470	Q9ULZ3
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
Q9ULZ3	PYCARD	ENSP00000247470	PYCARD	Q9ULZ3
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
PYCARD	ENSP00000247470	606838	Q9ULZ3	PA134950175

Protein: PYCARD

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)