ApoCanD

Mutation Data (+)

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	NAMALWA	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_066950	c.101A>G	p.D34G	CCLE	NA	Probably Damaging
2	RAJI	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_066950	c.70G>T	p.E24*	CCLE	NA	NP
3	SNU201	Cell Line	CENTRAL NERVOUS SYSTEM	NP_066950	c.135G>C	p.L45L	CCLE	NA	NP
4	SUDHL5	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_066950	c.1A>C	p.M1L	CCLE	NA	Probably Damaging
5	PD4087a	Tumour	BREAST	ENST00000316660	c.88_90delAGG	p.R30delR	COSMIC	NP	NP
6	NAMALWA	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000316660	c.101A>G	p.D34G	COSMIC	no weights	PROBABLY DAMAGING
7	RAJI	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000316660	c.70G>T	p.E24*	COSMIC	NP	NP
8	RAMOS2G64C10	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000316660	c.70G>A	p.E24K	COSMIC	no weights	PROBABLY DAMAGING
9	NAMALWA	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_066950	c.101A>G	p.D34G	CCLE	NA	Probably Damaging
10	RAJI	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_066950	c.70G>T	p.E24*	CCLE	NA	NP
11	SNU201	Cell Line	CENTRAL NERVOUS SYSTEM	NP_066950	c.135G>C	p.L45L	CCLE	NA	NP
12	SUDHL5	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_066950	c.1A>C	p.M1L	CCLE	NA	Probably Damaging
13	PD4087a	Tumour	BREAST	ENST00000316660	c.88_90delAGG	p.R30delR	COSMIC	NP	NP
14	NAMALWA	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000316660	c.101A>G	p.D34G	COSMIC	no weights	PROBABLY DAMAGING
15	RAJI	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000316660	c.70G>T	p.E24*	COSMIC	NP	NP
16	RAMOS2G64C10	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000316660	c.70G>A	p.E24K	COSMIC	no weights	PROBABLY DAMAGING

*NP: Not Predicted

Copy number variation and expression profile (+)

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	10.0207	9.9454	-0.2566	-0.06286
BILIARY TRACT	8.8166	8.5474	-0.4255	-0.5693
BONE	9.1416	9.4984	-0.0669	-0.007939
BREAST	8.0899	8.2382	-0.3675	-0.3264
CENTRAL NERVOUS SYSTEM	9.1579	10.009	-0.1843	-0.0492
ENDOMETRIUM	9.1896	9.5056	-0.2093	-0.1007
HAEMATOPOIETIC AND LYMPHOID TISSUE	10.3261	10.536	0.0461	-6e-04
KIDNEY	9.5581	9.6149	-0.3031	-0.2195
LARGE INTESTINE	8.9240	9.05665	-0.5288	-0.34685
LIVER	8.0552	8.4958	-0.3573	-0.391
LUNG	9.8569	10.0235	-0.1972	-0.1702
OESOPHAGUS	9.0445	9.38735	-0.8949	-0.78505
OVARY	9.0879	9.5262	-0.4196	-0.4627
PANCREAS	9.7805	9.87	-0.6965	-0.69
PLEURA	9.7910	9.4342	-0.2252	-0.0912
PROSTATE	9.2263	9.43515	0.0102	0.02544
SALIVARY GLAND	9.4530	9.453	-1.0200	-1.02
SKIN	9.0984	8.9404	-0.1650	-0.0772
SMALL INTESTINE	5.6534	5.6534	-0.0043	-0.0043
SOFT TISSUE	8.2805	9.55565	-0.2033	-0.055995
STOMACH	8.7631	8.7903	-0.3758	-0.20425
THYROID	10.8178	10.813	-0.2321	-0.2403
UPPER AERODIGESTIVE TRACT	9.5403	9.73095	-0.6725	-0.63485
URINARY TRACT	9.9290	9.78575	-0.2755	-0.14945

Gene Essentiality Data (+)

Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.

test

Tertiary structure (+)

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Modelled Structure	Structures available in PDB
	3MQP

Structure Domains (+)

1. PFAM Domains:

Domain ID	Domain Name	Start Site	End Site	E-value
PF15150	PMAIP1	1	54	2.7e-33
PF15150	PMAIP1	1	54	2.7e-33

2. Superfaimly domains are not present!!

Sequence Alignment (+)

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1. Variants are not present in 1000 Genomes!!

2. Sequence alignment with CCLE mutants:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

4. Mutants are not present in COSMIC!!

4. Sequence alignment with homologus proteins:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

Sequence Profiles (+)

HMM
With Uniprot database	With Mutants	With 1000 Genome Variants

PSSM
With Uniprot database	With Mutants	With 1000 Genome Variant

Post Translational Modifications (+)

Post translational modifications are not found!!

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
PMAIP1	PMAIP1	PMAIP1	ENSP00000269518	Q13794
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
Q13794	PMAIP1	ENSP00000269518	PMAIP1	Q13794
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
PMAIP1	ENSP00000269518	604959	Q13794	PA33434

Protein: PMAIP1