ApoCanD

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	BN50T	Tumour	LIVER	ENST00000347755	c.1303-3C>T	p.?	COSMIC	NP	NP
2	ESO-139	Tumour	OESOPHAGUS	ENST00000347755	c.805G>A	p.D269N	COSMIC	NP	NP
3	HCC137T	Tumour	LIVER	ENST00000347755	c.478C>T	p.L160F	COSMIC	NP	NP
4	HCT-15	Cell Line	LARGE INTESTINE	ENST00000347755	c.319G>T	p.G107C	COSMIC	NP	NP
5	RK080	Tumour	C01 LIVER	ENST00000347755	c.214C>A	p.H72N	COSMIC	NP	NP
6	TARGET-30-PARASL	Tumour	AUTONOMIC GANGLIA	ENST00000347755	c.1542G>C	p.V514V	COSMIC	NP	NP
7	TCGA-44-2662-01	Tumour	LUNG	ENST00000347755	c.2013C>T	p.A671A	COSMIC	NP	NP
8	TCGA-78-7147-01	Tumour	LUNG	ENST00000347755	c.2393G>T	p.R798L	COSMIC	NP	NP
9	TCGA-A6-6781-01	Tumour	LARGE INTESTINE	ENST00000347755	c.853G>A	p.A285T	COSMIC	NP	NP
10	TCGA-AA-3492-01	Tumour	LARGE INTESTINE	ENST00000347755	c.208A>C	p.S70R	COSMIC	NP	NP
11	TCGA-AA-3663-01	Tumour	LARGE INTESTINE	ENST00000347755	c.1599C>T	p.T533T	COSMIC	NP	NP
12	TCGA-AD-6895-01	Tumour	LARGE INTESTINE	ENST00000347755	c.2238C>T	p.D746D	COSMIC	NP	NP
13	TCGA-AD-6965-01	Tumour	LARGE INTESTINE	ENST00000347755	c.2199C>T	p.P733P	COSMIC	NP	NP
14	TCGA-AN-A0FX-01	Tumour	BREAST	ENST00000347755	c.682_683insC	p.R228fs*31	COSMIC	NP	NP
15	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000347755	c.593G>A	p.R198H	COSMIC	NP	NP
16	TCGA-AP-A0LM-01	Tumour	ENDOMETRIUM	ENST00000347755	c.1208C>T	p.P403L	COSMIC	NP	NP
17	TCGA-BL-A3JM-01	Tumour	URINARY TRACT	ENST00000347755	c.1564C>A	p.Q522K	COSMIC	NP	NP
18	TCGA-CA-6717-01	Tumour	LARGE INTESTINE	ENST00000347755	c.1870C>T	p.R624C	COSMIC	NP	NP
19	TCGA-CA-6717-01	Tumour	LARGE INTESTINE	ENST00000347755	c.195A>C	p.E65D	COSMIC	NP	NP
20	TCGA-CM-5862-01	Tumour	LARGE INTESTINE	ENST00000347755	c.1826A>G	p.E609G	COSMIC	NP	NP
21	TCGA-D5-5538-01	Tumour	LARGE INTESTINE	ENST00000347755	c.2485G>A	p.D829N	COSMIC	NP	NP
22	TCGA-DK-A3IL-01	Tumour	URINARY TRACT	ENST00000347755	c.2184G>A	p.V728V	COSMIC	NP	NP
23	TCGA-G2-A2EJ-01	Tumour	URINARY TRACT	ENST00000347755	c.934C>A	p.P312T	COSMIC	NP	NP
24	YUBER	Tumour	SKIN	ENST00000347755	c.563C>T	p.P188L	COSMIC	NP	NP
25	YUKLAB	Tumour	SKIN	ENST00000347755	c.1069C>T	p.R357C	COSMIC	NP	NP
26	ccRCC-23	Tumour	KIDNEY	ENST00000347755	c.815A>G	p.D272G	COSMIC	NP	NP
27	CAL78	Cell Line	BONE	ENST00000347755	c.2187T>C	p.P729P	COSMIC	NP	NP
28	CORL279	Cell Line	LUNG	ENST00000347755	c.231G>T	p.L77L	COSMIC	NP	NP
29	CTV1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000347755	c.1578delC	p.S527fs*90	COSMIC	NP	NP
30	CW2	Cell Line	LARGE_INTESTINE	ENST00000347755	c.46G>A	p.A16T	COSMIC	PASSENGER/OTHER	BENIGN
31	D245MG	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000347755	c.1545C>T	p.S515S	COSMIC	NP	NP
32	DND41	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000347755	c.910A>G	p.S304G	COSMIC	PASSENGER/OTHER	BENIGN
33	H2795	Cell Line	PLEURA	ENST00000347755	c.135G>C	p.G45G	COSMIC	NP	NP
34	H290	Cell Line	PLEURA	ENST00000347755	c.308G>A	p.R103Q	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
35	HCC2998	Cell Line	LARGE_INTESTINE	ENST00000347755	c.598G>A	p.D200N	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
36	HEC1	Cell Line	ENDOMETRIUM	ENST00000347755	c.931A>G	p.I311V	COSMIC	PASSENGER/OTHER	BENIGN
37	HEP3B217	Cell Line	NS	ENST00000347755	c.1021G>A	p.V341I	COSMIC	PASSENGER/OTHER	BENIGN
38	JURKAT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000347755	c.1995C>T	p.G665G	COSMIC	NP	NP
39	JURKAT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000347755	c.2008G>A	p.A670T	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
40	KARPAS45	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000347755	c.624G>A	p.T208T	COSMIC	NP	NP
41	KYM1	Cell Line	SOFT_TISSUE	ENST00000347755	c.64G>A	p.D22N	COSMIC	PASSENGER/OTHER	BENIGN
42	LNCAPCLONEFGC	Cell Line	PROSTATE	ENST00000347755	c.2048C>A	p.P683H	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
43	LNCAPCLONEFGC	Cell Line	PROSTATE	ENST00000347755	c.2052C>A	p.D684E	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
44	LU135	Cell Line	LUNG	ENST00000347755	c.2178C>T	p.G726G	COSMIC	NP	NP
45	MEWO	Cell Line	SKIN	ENST00000347755	c.581C>T	p.S194F	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
46	MHHPREB1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000347755	c.229C>T	p.L77L	COSMIC	NP	NP
47	MOLT16	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000347755	c.2248A>G	p.M750V	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
48	MOLT16	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000347755	c.2519C>T	p.A840V	COSMIC	CANCER	PROBABLY DAMAGING
49	MOLT4	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000347755	c.1612C>T	p.L538L	COSMIC	NP	NP
50	MOLT4	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000347755	c.2041+7A>T	p.?	COSMIC	NP	NP
51	MOLT4	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000347755	c.2608C>T	p.R870C	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
52	MOLT4	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000347755	c.483T>C	p.S161S	COSMIC	NP	NP
53	NB6	Cell Line	AUTONOMIC_GANGLIA	ENST00000347755	c.563C>A	p.P188Q	COSMIC	PASSENGER/OTHER	BENIGN
54	NCIH647	Cell Line	LUNG	ENST00000347755	c.2625C>T	p.L875L	COSMIC	NP	NP
55	NCIH748	Cell Line	LUNG	ENST00000347755	c.172C>T	p.P58S	COSMIC	PASSENGER/OTHER	BENIGN
56	NK92MI	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000347755	c.1016G>A	p.C339Y	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
57	PC3[JPC3]	Cell Line	LUNG	ENST00000347755	c.598G>A	p.D200N	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
58	PSN1	Cell Line	PANCREAS	ENST00000347755	c.2178C>T	p.G726G	COSMIC	NP	NP
59	PWR1E	Cell Line	PROSTATE	ENST00000347755	c.2022C>T	p.R674R	COSMIC	NP	NP
60	SJSA1	Cell Line	BONE	ENST00000347755	c.2326C>A	p.P776T	COSMIC	CANCER	POSSIBLY DAMAGING
61	SKMEL3	Cell Line	SKIN	ENST00000347755	c.2639A>G	p.Y880C	COSMIC	CANCER	PROBABLY DAMAGING
62	SKMEL31	Cell Line	SKIN	ENST00000347755	c.2632C>T	p.R878C	COSMIC	CANCER	PROBABLY DAMAGING
63	SNU175	Cell Line	LARGE_INTESTINE	ENST00000347755	c.2593G>A	p.V865M	COSMIC	PASSENGER/OTHER	BENIGN
64	T84	Cell Line	LARGE_INTESTINE	ENST00000347755	c.2168_2170delTCT	p.F723delF	COSMIC	NP	NP
65	TT	Cell Line	THYROID	ENST00000347755	c.394C>G	p.L132V	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
66	ZR7530	Cell Line	BREAST	ENST00000347755	c.75_78AGGG>T	p.G26delG	COSMIC	NP	NP
67	BN50T	Tumour	LIVER	ENST00000347755	c.1303-3C>T	p.?	COSMIC	NP	NP
68	ESO-139	Tumour	OESOPHAGUS	ENST00000347755	c.805G>A	p.D269N	COSMIC	NP	NP
69	HCC137T	Tumour	LIVER	ENST00000347755	c.478C>T	p.L160F	COSMIC	NP	NP
70	HCT-15	Cell Line	LARGE INTESTINE	ENST00000347755	c.319G>T	p.G107C	COSMIC	NP	NP
71	RK080	Tumour	C01 LIVER	ENST00000347755	c.214C>A	p.H72N	COSMIC	NP	NP
72	TARGET-30-PARASL	Tumour	AUTONOMIC GANGLIA	ENST00000347755	c.1542G>C	p.V514V	COSMIC	NP	NP
73	TCGA-44-2662-01	Tumour	LUNG	ENST00000347755	c.2013C>T	p.A671A	COSMIC	NP	NP
74	TCGA-78-7147-01	Tumour	LUNG	ENST00000347755	c.2393G>T	p.R798L	COSMIC	NP	NP
75	TCGA-A6-6781-01	Tumour	LARGE INTESTINE	ENST00000347755	c.853G>A	p.A285T	COSMIC	NP	NP
76	TCGA-AA-3492-01	Tumour	LARGE INTESTINE	ENST00000347755	c.208A>C	p.S70R	COSMIC	NP	NP
77	TCGA-AA-3663-01	Tumour	LARGE INTESTINE	ENST00000347755	c.1599C>T	p.T533T	COSMIC	NP	NP
78	TCGA-AD-6895-01	Tumour	LARGE INTESTINE	ENST00000347755	c.2238C>T	p.D746D	COSMIC	NP	NP
79	TCGA-AD-6965-01	Tumour	LARGE INTESTINE	ENST00000347755	c.2199C>T	p.P733P	COSMIC	NP	NP
80	TCGA-AN-A0FX-01	Tumour	BREAST	ENST00000347755	c.682_683insC	p.R228fs*31	COSMIC	NP	NP
81	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000347755	c.593G>A	p.R198H	COSMIC	NP	NP
82	TCGA-AP-A0LM-01	Tumour	ENDOMETRIUM	ENST00000347755	c.1208C>T	p.P403L	COSMIC	NP	NP
83	TCGA-BL-A3JM-01	Tumour	URINARY TRACT	ENST00000347755	c.1564C>A	p.Q522K	COSMIC	NP	NP
84	TCGA-CA-6717-01	Tumour	LARGE INTESTINE	ENST00000347755	c.1870C>T	p.R624C	COSMIC	NP	NP
85	TCGA-CA-6717-01	Tumour	LARGE INTESTINE	ENST00000347755	c.195A>C	p.E65D	COSMIC	NP	NP
86	TCGA-CM-5862-01	Tumour	LARGE INTESTINE	ENST00000347755	c.1826A>G	p.E609G	COSMIC	NP	NP
87	TCGA-D5-5538-01	Tumour	LARGE INTESTINE	ENST00000347755	c.2485G>A	p.D829N	COSMIC	NP	NP
88	TCGA-DK-A3IL-01	Tumour	URINARY TRACT	ENST00000347755	c.2184G>A	p.V728V	COSMIC	NP	NP
89	TCGA-G2-A2EJ-01	Tumour	URINARY TRACT	ENST00000347755	c.934C>A	p.P312T	COSMIC	NP	NP
90	YUBER	Tumour	SKIN	ENST00000347755	c.563C>T	p.P188L	COSMIC	NP	NP
91	YUKLAB	Tumour	SKIN	ENST00000347755	c.1069C>T	p.R357C	COSMIC	NP	NP
92	ccRCC-23	Tumour	KIDNEY	ENST00000347755	c.815A>G	p.D272G	COSMIC	NP	NP
93	CAL78	Cell Line	BONE	ENST00000347755	c.2187T>C	p.P729P	COSMIC	NP	NP
94	CORL279	Cell Line	LUNG	ENST00000347755	c.231G>T	p.L77L	COSMIC	NP	NP
95	CTV1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000347755	c.1578delC	p.S527fs*90	COSMIC	NP	NP
96	CW2	Cell Line	LARGE_INTESTINE	ENST00000347755	c.46G>A	p.A16T	COSMIC	PASSENGER/OTHER	BENIGN
97	D245MG	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000347755	c.1545C>T	p.S515S	COSMIC	NP	NP
98	DND41	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000347755	c.910A>G	p.S304G	COSMIC	PASSENGER/OTHER	BENIGN
99	H2795	Cell Line	PLEURA	ENST00000347755	c.135G>C	p.G45G	COSMIC	NP	NP
100	H290	Cell Line	PLEURA	ENST00000347755	c.308G>A	p.R103Q	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
101	HCC2998	Cell Line	LARGE_INTESTINE	ENST00000347755	c.598G>A	p.D200N	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
102	HEC1	Cell Line	ENDOMETRIUM	ENST00000347755	c.931A>G	p.I311V	COSMIC	PASSENGER/OTHER	BENIGN
103	HEP3B217	Cell Line	NS	ENST00000347755	c.1021G>A	p.V341I	COSMIC	PASSENGER/OTHER	BENIGN
104	JURKAT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000347755	c.1995C>T	p.G665G	COSMIC	NP	NP
105	JURKAT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000347755	c.2008G>A	p.A670T	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
106	KARPAS45	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000347755	c.624G>A	p.T208T	COSMIC	NP	NP
107	KYM1	Cell Line	SOFT_TISSUE	ENST00000347755	c.64G>A	p.D22N	COSMIC	PASSENGER/OTHER	BENIGN
108	LNCAPCLONEFGC	Cell Line	PROSTATE	ENST00000347755	c.2048C>A	p.P683H	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
109	LNCAPCLONEFGC	Cell Line	PROSTATE	ENST00000347755	c.2052C>A	p.D684E	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
110	LU135	Cell Line	LUNG	ENST00000347755	c.2178C>T	p.G726G	COSMIC	NP	NP
111	MEWO	Cell Line	SKIN	ENST00000347755	c.581C>T	p.S194F	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
112	MHHPREB1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000347755	c.229C>T	p.L77L	COSMIC	NP	NP
113	MOLT16	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000347755	c.2248A>G	p.M750V	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
114	MOLT16	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000347755	c.2519C>T	p.A840V	COSMIC	CANCER	PROBABLY DAMAGING
115	MOLT4	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000347755	c.1612C>T	p.L538L	COSMIC	NP	NP
116	MOLT4	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000347755	c.2041+7A>T	p.?	COSMIC	NP	NP
117	MOLT4	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000347755	c.2608C>T	p.R870C	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
118	MOLT4	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000347755	c.483T>C	p.S161S	COSMIC	NP	NP
119	NB6	Cell Line	AUTONOMIC_GANGLIA	ENST00000347755	c.563C>A	p.P188Q	COSMIC	PASSENGER/OTHER	BENIGN
120	NCIH647	Cell Line	LUNG	ENST00000347755	c.2625C>T	p.L875L	COSMIC	NP	NP
121	NCIH748	Cell Line	LUNG	ENST00000347755	c.172C>T	p.P58S	COSMIC	PASSENGER/OTHER	BENIGN
122	NK92MI	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000347755	c.1016G>A	p.C339Y	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
123	PC3[JPC3]	Cell Line	LUNG	ENST00000347755	c.598G>A	p.D200N	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
124	PSN1	Cell Line	PANCREAS	ENST00000347755	c.2178C>T	p.G726G	COSMIC	NP	NP
125	PWR1E	Cell Line	PROSTATE	ENST00000347755	c.2022C>T	p.R674R	COSMIC	NP	NP
126	SJSA1	Cell Line	BONE	ENST00000347755	c.2326C>A	p.P776T	COSMIC	CANCER	POSSIBLY DAMAGING
127	SKMEL3	Cell Line	SKIN	ENST00000347755	c.2639A>G	p.Y880C	COSMIC	CANCER	PROBABLY DAMAGING
128	SKMEL31	Cell Line	SKIN	ENST00000347755	c.2632C>T	p.R878C	COSMIC	CANCER	PROBABLY DAMAGING
129	SNU175	Cell Line	LARGE_INTESTINE	ENST00000347755	c.2593G>A	p.V865M	COSMIC	PASSENGER/OTHER	BENIGN
130	T84	Cell Line	LARGE_INTESTINE	ENST00000347755	c.2168_2170delTCT	p.F723delF	COSMIC	NP	NP
131	TT	Cell Line	THYROID	ENST00000347755	c.394C>G	p.L132V	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
132	ZR7530	Cell Line	BREAST	ENST00000347755	c.75_78AGGG>T	p.G26delG	COSMIC	NP	NP

*NP: Not Predicted

Domain ID	Domain Name	Start Site	End Site	E-value
PF13855	LRR_8	126	183	6.3e-09
PF13855	LRR_8	195	252	2.6e-09
PF00560	LRR_1	265	283	0.13
PF00791	ZU5	339	416	0.00011
PF10461	Peptidase_S68	421	454	8.7e-19
PF00791	ZU5	469	537	8.2e-06
PF10461	Peptidase_S68	577	590	0.08
PF00531	Death	796	871	1.9e-15
PF13855	LRR_8	126	183	6.3e-09
PF13855	LRR_8	195	252	2.6e-09
PF00560	LRR_1	265	283	0.13
PF00791	ZU5	339	416	0.00011
PF10461	Peptidase_S68	421	454	8.7e-19
PF00791	ZU5	469	537	8.2e-06
PF10461	Peptidase_S68	577	590	0.08
PF00531	Death	796	871	1.9e-15

Domain ID	Start Site	End Site	E-value
0047619	52	297	2.61e-36
0036368	774	893	2.62e-21
0047619	52	297	2.61e-36
0036368	774	893	2.62e-21

S. No.	Position	Amino acid	Type	Description
1	2	A	Acetylation	N-acetylalanine.
2	299	S	Phosphorylation	Phosphoserine.
3	305	S	Phosphorylation	Phosphoserine.
4	485	T	Phosphorylation	Phosphothreonine
5	2	A	Acetylation	N-acetylalanine.
6	299	S	Phosphorylation	Phosphoserine.
7	305	S	Phosphorylation	Phosphoserine.
8	485	T	Phosphorylation	Phosphothreonine

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
PIDD	PIDD	PIDD
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
	PIDD		PIDD
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
PIDD		605247		PA30445

Protein: PIDD

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)

Modelled Structure	Structures available in PDB
	Structure is not available in PDB