ApoCanD

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	113368	Tumour	LUNG	ENST00000361510	c.2854C>A	p.Q952K	COSMIC	NP	NP
2	587228	Tumour	LARGE INTESTINE	ENST00000361510	c.2296C>T	p.R766*	COSMIC	NP	NP
3	587284	Tumour	LARGE INTESTINE	ENST00000361510	c.2813T>C	p.I938T	COSMIC	NP	NP
4	587342	Tumour	LARGE INTESTINE	ENST00000361510	c.449-2A>G	p.?	COSMIC	NP	NP
5	8015299	Tumour	PANCREAS	ENST00000361510	c.212G>A	p.R71H	COSMIC	NP	NP
6	CA3	Tumour	LARGE INTESTINE	ENST00000361510	c.1497A>G	p.E499E	COSMIC	NP	NP
7	H2009	Cell Line	LUNG	ENST00000361510	c.655G>A	p.E219K	COSMIC	NP	NP
8	HCC105T	Tumour	LIVER	ENST00000361510	c.818T>G	p.L273R	COSMIC	NP	NP
9	HCC115T	Tumour	LIVER	ENST00000361510	c.444T>G	p.D148E	COSMIC	NP	NP
10	HCC2998	Cell Line	LARGE INTESTINE	ENST00000361510	c.1498C>T	p.R500C	COSMIC	NP	NP
11	HCC41T	Tumour	LIVER	ENST00000361510	c.2370A>G	p.I790M	COSMIC	NP	NP
12	HCT-116	Cell Line	LARGE INTESTINE	ENST00000361510	c.1312T>A	p.S438T	COSMIC	NP	NP
13	HN	Tumour	62624 UPPER AERODIGESTIVE TRACT	ENST00000361510	c.1752A>G	p.L584L	COSMIC	NP	NP
14	LC	Tumour	C32 LUNG	ENST00000361510	c.211C>T	p.R71C	COSMIC	NP	NP
15	LUAD-B00523	Tumour	LUNG	ENST00000361510	c.967T>G	p.Y323D	COSMIC	NP	NP
16	LUAD-RT-S01477	Tumour	LUNG	ENST00000361510	c.1726G>C	p.E576Q	COSMIC	NP	NP
17	LUAD-S01341	Tumour	LUNG	ENST00000361510	c.111A>G	p.S37S	COSMIC	NP	NP
18	PD4002a	Tumour	BREAST	ENST00000361510	c.762C>G	p.S254R	COSMIC	NP	NP
19	PD6746a	Tumour	NS	ENST00000361510	c.412G>A	p.D138N	COSMIC	NP	NP
20	RK047	Tumour	C01 LIVER	ENST00000361510	c.433G>T	p.E145*	COSMIC	NP	NP
21	TARGET-30-PANUIF	Tumour	AUTONOMIC GANGLIA	ENST00000361510	c.526C>T	p.L176F	COSMIC	NP	NP
22	TCGA-05-4427-01	Tumour	LUNG	ENST00000361510	c.2472A>T	p.P824P	COSMIC	NP	NP
23	TCGA-18-3416-01	Tumour	LUNG	ENST00000361510	c.790-1G>T	p.?	COSMIC	NP	NP
24	TCGA-20-1683-01	Tumour	OVARY	ENST00000361510	c.2617C>T	p.R873W	COSMIC	NP	NP
25	TCGA-34-2596-01	Tumour	LUNG	ENST00000361510	c.380C>T	p.P127L	COSMIC	NP	NP
26	TCGA-34-5928-01	Tumour	LUNG	ENST00000361510	c.110C>T	p.S37L	COSMIC	NP	NP
27	TCGA-39-5022-01	Tumour	LUNG	ENST00000361510	c.1446G>C	p.Q482H	COSMIC	NP	NP
28	TCGA-43-2578-01	Tumour	LUNG	ENST00000361510	c.2088G>T	p.A696A	COSMIC	NP	NP
29	TCGA-49-6743-01	Tumour	LUNG	ENST00000361510	c.1211A>T	p.D404V	COSMIC	NP	NP
30	TCGA-55-7283-01	Tumour	LUNG	ENST00000361510	c.2103A>T	p.S701S	COSMIC	NP	NP
31	TCGA-67-3771-01	Tumour	LUNG	ENST00000361510	c.1767A>G	p.L589L	COSMIC	NP	NP
32	TCGA-69-7978-01	Tumour	LUNG	ENST00000361510	c.647G>A	p.R216H	COSMIC	NP	NP
33	TCGA-78-7220-01	Tumour	LUNG	ENST00000361510	c.1278G>A	p.V426V	COSMIC	NP	NP
34	TCGA-85-6561-01	Tumour	LUNG	ENST00000361510	c.802G>T	p.E268*	COSMIC	NP	NP
35	TCGA-A3-3357-01	Tumour	KIDNEY	ENST00000361510	c.1988T>C	p.L663P	COSMIC	NP	NP
36	TCGA-A6-3809-01	Tumour	LARGE INTESTINE	ENST00000361510	c.2795T>A	p.V932E	COSMIC	NP	NP
37	TCGA-A8-A090-01	Tumour	BREAST	ENST00000361510	c.1915C>T	p.R639C	COSMIC	NP	NP
38	TCGA-A8-A09V-01	Tumour	BREAST	ENST00000361510	c.878_880delAGG	p.E294delE	COSMIC	NP	NP
39	TCGA-AA-3492-01	Tumour	LARGE INTESTINE	ENST00000361510	c.1906A>G	p.N636D	COSMIC	NP	NP
40	TCGA-AA-3663-01	Tumour	LARGE INTESTINE	ENST00000361510	c.1969C>T	p.L657F	COSMIC	NP	NP
41	TCGA-AA-3715-01	Tumour	LARGE INTESTINE	ENST00000361510	c.2569A>G	p.N857D	COSMIC	NP	NP
42	TCGA-AA-A00A-01	Tumour	LARGE INTESTINE	ENST00000361510	c.1538A>G	p.H513R	COSMIC	NP	NP
43	TCGA-AA-A00N-01	Tumour	LARGE INTESTINE	ENST00000361510	c.113G>A	p.R38Q	COSMIC	NP	NP
44	TCGA-AD-6890-01	Tumour	LARGE INTESTINE	ENST00000361510	c.2047G>T	p.V683L	COSMIC	NP	NP
45	TCGA-AG-3892-01	Tumour	LARGE INTESTINE	ENST00000361510	c.2208T>G	p.F736L	COSMIC	NP	NP
46	TCGA-AK-3430-01	Tumour	KIDNEY	ENST00000361510	c.2946G>A	p.L982L	COSMIC	NP	NP
47	TCGA-AN-A0XO-01	Tumour	BREAST	ENST00000361510	c.473G>A	p.S158N	COSMIC	NP	NP
48	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000361510	c.979C>A	p.L327I	COSMIC	NP	NP
49	TCGA-AP-A0LF-01	Tumour	ENDOMETRIUM	ENST00000361510	c.2920G>A	p.E974K	COSMIC	NP	NP
50	TCGA-AP-A0LM-01	Tumour	ENDOMETRIUM	ENST00000361510	c.2033C>A	p.S678Y	COSMIC	NP	NP
51	TCGA-AX-A05Z-01	Tumour	ENDOMETRIUM	ENST00000361510	c.191C>A	p.S64Y	COSMIC	NP	NP
52	TCGA-AX-A05Z-01	Tumour	ENDOMETRIUM	ENST00000361510	c.301C>T	p.R101C	COSMIC	NP	NP
53	TCGA-AX-A05Z-01	Tumour	ENDOMETRIUM	ENST00000361510	c.953C>T	p.S318F	COSMIC	NP	NP
54	TCGA-AZ-6601-01	Tumour	LARGE INTESTINE	ENST00000361510	c.470C>T	p.P157L	COSMIC	NP	NP
55	TCGA-B0-5096-01	Tumour	KIDNEY	ENST00000361510	c.1092C>G	p.A364A	COSMIC	NP	NP
56	TCGA-B0-5117-01	Tumour	KIDNEY	ENST00000361510	c.2810G>A	p.R937H	COSMIC	NP	NP
57	TCGA-B5-A0JY-01	Tumour	ENDOMETRIUM	ENST00000361510	c.1866C>A	p.F622L	COSMIC	NP	NP
58	TCGA-B5-A0JY-01	Tumour	ENDOMETRIUM	ENST00000361510	c.2431C>T	p.L811F	COSMIC	NP	NP
59	TCGA-B5-A11E-01	Tumour	ENDOMETRIUM	ENST00000361510	c.2228C>T	p.P743L	COSMIC	NP	NP
60	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000361510	c.1099C>T	p.R367*	COSMIC	NP	NP
61	TCGA-BS-A0UJ-01	Tumour	ENDOMETRIUM	ENST00000361510	c.2063T>C	p.I688T	COSMIC	NP	NP
62	TCGA-BS-A0UM-01	Tumour	ENDOMETRIUM	ENST00000361510	c.294A>G	p.L98L	COSMIC	NP	NP
63	TCGA-BT-A0YX-01	Tumour	URINARY TRACT	ENST00000361510	c.1837G>C	p.E613Q	COSMIC	NP	NP
64	TCGA-BT-A0YX-01	Tumour	URINARY TRACT	ENST00000361510	c.865G>A	p.E289K	COSMIC	NP	NP
65	TCGA-CA-6717-01	Tumour	LARGE INTESTINE	ENST00000361510	c.225C>A	p.F75L	COSMIC	NP	NP
66	TCGA-CA-6717-01	Tumour	LARGE INTESTINE	ENST00000361510	c.850T>G	p.Y284D	COSMIC	NP	NP
67	TCGA-CU-A3KJ-01	Tumour	URINARY TRACT	ENST00000361510	c.2786G>C	p.C929S	COSMIC	NP	NP
68	TCGA-D1-A17Q-01	Tumour	ENDOMETRIUM	ENST00000361510	c.1261C>A	p.R421R	COSMIC	NP	NP
69	TCGA-DR-A0ZM-01	Tumour	CERVIX	ENST00000361510	c.1837G>C	p.E613Q	COSMIC	NP	NP
70	TCGA-EI-6507-01	Tumour	LARGE INTESTINE	ENST00000361510	c.1504A>G	p.I502V	COSMIC	NP	NP
71	TCGA-F5-6465-01	Tumour	LARGE INTESTINE	ENST00000361510	c.113G>A	p.R38Q	COSMIC	NP	NP
72	TCGA-FU-A23L-01	Tumour	CERVIX	ENST00000361510	c.2320G>A	p.E774K	COSMIC	NP	NP
73	TCGA-G4-6307-01	Tumour	LARGE INTESTINE	ENST00000361510	c.2666A>C	p.K889T	COSMIC	NP	NP
74	TCGA-G4-6307-01	Tumour	LARGE INTESTINE	ENST00000361510	c.2702T>G	p.L901*	COSMIC	NP	NP
75	TCGA-G4-6307-01	Tumour	LARGE INTESTINE	ENST00000361510	c.2746T>C	p.Y916H	COSMIC	NP	NP
76	TCGA-G4-6628-01	Tumour	LARGE INTESTINE	ENST00000361510	c.253C>T	p.R85C	COSMIC	NP	NP
77	ccRCC-77	Tumour	KIDNEY	ENST00000361510	c.1342A>G	p.R448G	COSMIC	NP	NP
78	22RV1	Cell Line	PROSTATE	ENST00000361510	c.2444delA	p.N816fs*39	COSMIC	NP	NP
79	A3KAW	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000361510	c.668A>G	p.H223R	COSMIC	NP	NP
80	ALLPO	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000361510	c.1016C>T	p.T339M	COSMIC	NP	NP
81	AN3CA	Cell Line	ENDOMETRIUM	ENST00000361510	c.2335G>T	p.V779F	COSMIC	NP	NP
82	BL41	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000361510	c.2012+1_2012+4delGTAA	p.?	COSMIC	NP	NP
83	C33A	Cell Line	CERVIX	ENST00000361510	c.381G>A	p.P127P	COSMIC	NP	NP
84	CAL33	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000361510	c.72A>G	p.I24M	COSMIC	NP	NP
85	EN	Cell Line	ENDOMETRIUM	ENST00000361510	c.1981A>G	p.I661V	COSMIC	NP	NP
86	EN	Cell Line	ENDOMETRIUM	ENST00000361510	c.431A>G	p.D144G	COSMIC	NP	NP
87	ES6	Cell Line	BONE	ENST00000361510	c.70A>G	p.I24V	COSMIC	NP	NP
88	ES6	Cell Line	BONE	ENST00000361510	c.843+6C>A	p.?	COSMIC	NP	NP
89	EVSAT	Cell Line	BREAST	ENST00000361510	c.100C>T	p.H34Y	COSMIC	NP	NP
90	FUOV1	Cell Line	OVARY	ENST00000361510	c.151C>T	p.Q51*	COSMIC	NP	NP
91	GP5D	Cell Line	LARGE_INTESTINE	ENST00000361510	c.748G>T	p.A250S	COSMIC	NP	NP
92	H2722	Cell Line	PLEURA	ENST00000361510	c.1231-1G>C	p.?	COSMIC	NP	NP
93	HCC2998	Cell Line	LARGE_INTESTINE	ENST00000361510	c.1498C>T	p.R500C	COSMIC	NP	NP
94	HCC366	Cell Line	LUNG	ENST00000361510	c.2390A>T	p.D797V	COSMIC	NP	NP
95	HCT116	Cell Line	LARGE_INTESTINE	ENST00000361510	c.1312T>A	p.S438T	COSMIC	NP	NP
96	HEC1	Cell Line	ENDOMETRIUM	ENST00000361510	c.1319A>G	p.N440S	COSMIC	NP	NP
97	HEL	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000361510	c.71T>C	p.I24T	COSMIC	NP	NP
98	HT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000361510	c.544delT	p.F183fs*12	COSMIC	NP	NP
99	HT115	Cell Line	LARGE_INTESTINE	ENST00000361510	c.509A>G	p.D170G	COSMIC	NP	NP
100	IGROV1	Cell Line	OVARY	ENST00000361510	c.2735G>A	p.R912Q	COSMIC	NP	NP
101	JHH2	Cell Line	LIVER	ENST00000361510	c.382G>A	p.D128N	COSMIC	NP	NP
102	JURKAT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000361510	c.1477G>T	p.D493Y	COSMIC	NP	NP
103	KELLY	Cell Line	AUTONOMIC_GANGLIA	ENST00000361510	c.1136G>A	p.R379H	COSMIC	NP	NP
104	KMH2	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000361510	c.744A>G	p.R248R	COSMIC	NP	NP
105	KNS42	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000361510	c.1308C>A	p.T436T	COSMIC	NP	NP
106	KURAMOCHI	Cell Line	OVARY	ENST00000361510	c.1875A>G	p.T625T	COSMIC	NP	NP
107	KYSE450	Cell Line	OESOPHAGUS	ENST00000361510	c.704T>C	p.L235S	COSMIC	NP	NP
108	LAN6	Cell Line	AUTONOMIC_GANGLIA	ENST00000361510	c.1377+10T>C	p.?	COSMIC	NP	NP
109	LN229	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000361510	c.2612C>G	p.T871R	COSMIC	NP	NP
110	LOVO	Cell Line	LARGE_INTESTINE	ENST00000361510	c.2478_2479insA	p.R829fs*17	COSMIC	NP	NP
111	MC116	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000361510	c.212G>A	p.R71H	COSMIC	NP	NP
112	NALM6	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000361510	c.2850G>A	p.R950R	COSMIC	NP	NP
113	NCIH1573	Cell Line	LUNG	ENST00000361510	c.679-6T>C	p.?	COSMIC	NP	NP
114	NCIH1693	Cell Line	LUNG	ENST00000361510	c.2647G>A	p.V883I	COSMIC	NP	NP
115	NCIH196	Cell Line	LUNG	ENST00000361510	c.495A>G	p.L165L	COSMIC	NP	NP
116	NCIH2009	Cell Line	LUNG	ENST00000361510	c.655G>A	p.E219K	COSMIC	NP	NP
117	NCIH2228	Cell Line	LUNG	ENST00000361510	c.344C>T	p.A115V	COSMIC	NP	NP
118	NCIH2342	Cell Line	LUNG	ENST00000361510	c.1608+5G>T	p.?	COSMIC	NP	NP
119	NCIH2342	Cell Line	LUNG	ENST00000361510	c.619G>T	p.E207*	COSMIC	NP	NP
120	NCIH2405	Cell Line	LUNG	ENST00000361510	c.1621A>T	p.I541F	COSMIC	NP	NP
121	NCIH345	Cell Line	LUNG	ENST00000361510	c.630G>A	p.A210A	COSMIC	NP	NP
122	NCIH64	Cell Line	LUNG	ENST00000361510	c.790-4T>A	p.?	COSMIC	NP	NP
123	NCIH647	Cell Line	LUNG	ENST00000361510	c.448+2T>G	p.?	COSMIC	NP	NP
124	OUMS23	Cell Line	LARGE_INTESTINE	ENST00000361510	c.980T>C	p.L327P	COSMIC	NP	NP
125	OVK18	Cell Line	OVARY	ENST00000361510	c.1493C>T	p.A498V	COSMIC	NP	NP
126	PC14	Cell Line	LUNG	ENST00000361510	c.1829T>C	p.M610T	COSMIC	NP	NP
127	RPMI8866	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000361510	c.1934G>T	p.R645L	COSMIC	NP	NP
128	SKOV3	Cell Line	OVARY	ENST00000361510	c.1074T>C	p.S358S	COSMIC	NP	NP
129	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000361510	c.2087C>T	p.A696V	COSMIC	NP	NP
130	SNU407	Cell Line	LARGE_INTESTINE	ENST00000361510	c.2702_2703insT	p.L901fs*9	COSMIC	NP	NP
131	SNU423	Cell Line	LIVER	ENST00000361510	c.1293C>T	p.T431T	COSMIC	NP	NP
132	SNU81	Cell Line	LARGE_INTESTINE	ENST00000361510	c.1261C>T	p.R421*	COSMIC	NP	NP
133	SNU81	Cell Line	LARGE_INTESTINE	ENST00000361510	c.301C>T	p.R101C	COSMIC	NP	NP
134	SNUC2B	Cell Line	LARGE_INTESTINE	ENST00000361510	c.1035+3A>G	p.?	COSMIC	NP	NP
135	SNUC2B	Cell Line	LARGE_INTESTINE	ENST00000361510	c.1035+5G>A	p.?	COSMIC	NP	NP
136	SNUC2B	Cell Line	LARGE_INTESTINE	ENST00000361510	c.2271G>T	p.E757D	COSMIC	NP	NP
137	SUPT1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000361510	c.785G>A	p.R262H	COSMIC	NP	NP
138	113368	Tumour	LUNG	ENST00000361510	c.2854C>A	p.Q952K	COSMIC	NP	NP
139	587228	Tumour	LARGE INTESTINE	ENST00000361510	c.2296C>T	p.R766*	COSMIC	NP	NP
140	587284	Tumour	LARGE INTESTINE	ENST00000361510	c.2813T>C	p.I938T	COSMIC	NP	NP
141	587342	Tumour	LARGE INTESTINE	ENST00000361510	c.449-2A>G	p.?	COSMIC	NP	NP
142	8015299	Tumour	PANCREAS	ENST00000361510	c.212G>A	p.R71H	COSMIC	NP	NP
143	CA3	Tumour	LARGE INTESTINE	ENST00000361510	c.1497A>G	p.E499E	COSMIC	NP	NP
144	H2009	Cell Line	LUNG	ENST00000361510	c.655G>A	p.E219K	COSMIC	NP	NP
145	HCC105T	Tumour	LIVER	ENST00000361510	c.818T>G	p.L273R	COSMIC	NP	NP
146	HCC115T	Tumour	LIVER	ENST00000361510	c.444T>G	p.D148E	COSMIC	NP	NP
147	HCC2998	Cell Line	LARGE INTESTINE	ENST00000361510	c.1498C>T	p.R500C	COSMIC	NP	NP
148	HCC41T	Tumour	LIVER	ENST00000361510	c.2370A>G	p.I790M	COSMIC	NP	NP
149	HCT-116	Cell Line	LARGE INTESTINE	ENST00000361510	c.1312T>A	p.S438T	COSMIC	NP	NP
150	HN	Tumour	62624 UPPER AERODIGESTIVE TRACT	ENST00000361510	c.1752A>G	p.L584L	COSMIC	NP	NP
151	LC	Tumour	C32 LUNG	ENST00000361510	c.211C>T	p.R71C	COSMIC	NP	NP
152	LUAD-B00523	Tumour	LUNG	ENST00000361510	c.967T>G	p.Y323D	COSMIC	NP	NP
153	LUAD-RT-S01477	Tumour	LUNG	ENST00000361510	c.1726G>C	p.E576Q	COSMIC	NP	NP
154	LUAD-S01341	Tumour	LUNG	ENST00000361510	c.111A>G	p.S37S	COSMIC	NP	NP
155	PD4002a	Tumour	BREAST	ENST00000361510	c.762C>G	p.S254R	COSMIC	NP	NP
156	PD6746a	Tumour	NS	ENST00000361510	c.412G>A	p.D138N	COSMIC	NP	NP
157	RK047	Tumour	C01 LIVER	ENST00000361510	c.433G>T	p.E145*	COSMIC	NP	NP
158	TARGET-30-PANUIF	Tumour	AUTONOMIC GANGLIA	ENST00000361510	c.526C>T	p.L176F	COSMIC	NP	NP
159	TCGA-05-4427-01	Tumour	LUNG	ENST00000361510	c.2472A>T	p.P824P	COSMIC	NP	NP
160	TCGA-18-3416-01	Tumour	LUNG	ENST00000361510	c.790-1G>T	p.?	COSMIC	NP	NP
161	TCGA-20-1683-01	Tumour	OVARY	ENST00000361510	c.2617C>T	p.R873W	COSMIC	NP	NP
162	TCGA-34-2596-01	Tumour	LUNG	ENST00000361510	c.380C>T	p.P127L	COSMIC	NP	NP
163	TCGA-34-5928-01	Tumour	LUNG	ENST00000361510	c.110C>T	p.S37L	COSMIC	NP	NP
164	TCGA-39-5022-01	Tumour	LUNG	ENST00000361510	c.1446G>C	p.Q482H	COSMIC	NP	NP
165	TCGA-43-2578-01	Tumour	LUNG	ENST00000361510	c.2088G>T	p.A696A	COSMIC	NP	NP
166	TCGA-49-6743-01	Tumour	LUNG	ENST00000361510	c.1211A>T	p.D404V	COSMIC	NP	NP
167	TCGA-55-7283-01	Tumour	LUNG	ENST00000361510	c.2103A>T	p.S701S	COSMIC	NP	NP
168	TCGA-67-3771-01	Tumour	LUNG	ENST00000361510	c.1767A>G	p.L589L	COSMIC	NP	NP
169	TCGA-69-7978-01	Tumour	LUNG	ENST00000361510	c.647G>A	p.R216H	COSMIC	NP	NP
170	TCGA-78-7220-01	Tumour	LUNG	ENST00000361510	c.1278G>A	p.V426V	COSMIC	NP	NP
171	TCGA-85-6561-01	Tumour	LUNG	ENST00000361510	c.802G>T	p.E268*	COSMIC	NP	NP
172	TCGA-A3-3357-01	Tumour	KIDNEY	ENST00000361510	c.1988T>C	p.L663P	COSMIC	NP	NP
173	TCGA-A6-3809-01	Tumour	LARGE INTESTINE	ENST00000361510	c.2795T>A	p.V932E	COSMIC	NP	NP
174	TCGA-A8-A090-01	Tumour	BREAST	ENST00000361510	c.1915C>T	p.R639C	COSMIC	NP	NP
175	TCGA-A8-A09V-01	Tumour	BREAST	ENST00000361510	c.878_880delAGG	p.E294delE	COSMIC	NP	NP
176	TCGA-AA-3492-01	Tumour	LARGE INTESTINE	ENST00000361510	c.1906A>G	p.N636D	COSMIC	NP	NP
177	TCGA-AA-3663-01	Tumour	LARGE INTESTINE	ENST00000361510	c.1969C>T	p.L657F	COSMIC	NP	NP
178	TCGA-AA-3715-01	Tumour	LARGE INTESTINE	ENST00000361510	c.2569A>G	p.N857D	COSMIC	NP	NP
179	TCGA-AA-A00A-01	Tumour	LARGE INTESTINE	ENST00000361510	c.1538A>G	p.H513R	COSMIC	NP	NP
180	TCGA-AA-A00N-01	Tumour	LARGE INTESTINE	ENST00000361510	c.113G>A	p.R38Q	COSMIC	NP	NP
181	TCGA-AD-6890-01	Tumour	LARGE INTESTINE	ENST00000361510	c.2047G>T	p.V683L	COSMIC	NP	NP
182	TCGA-AG-3892-01	Tumour	LARGE INTESTINE	ENST00000361510	c.2208T>G	p.F736L	COSMIC	NP	NP
183	TCGA-AK-3430-01	Tumour	KIDNEY	ENST00000361510	c.2946G>A	p.L982L	COSMIC	NP	NP
184	TCGA-AN-A0XO-01	Tumour	BREAST	ENST00000361510	c.473G>A	p.S158N	COSMIC	NP	NP
185	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000361510	c.979C>A	p.L327I	COSMIC	NP	NP
186	TCGA-AP-A0LF-01	Tumour	ENDOMETRIUM	ENST00000361510	c.2920G>A	p.E974K	COSMIC	NP	NP
187	TCGA-AP-A0LM-01	Tumour	ENDOMETRIUM	ENST00000361510	c.2033C>A	p.S678Y	COSMIC	NP	NP
188	TCGA-AX-A05Z-01	Tumour	ENDOMETRIUM	ENST00000361510	c.191C>A	p.S64Y	COSMIC	NP	NP
189	TCGA-AX-A05Z-01	Tumour	ENDOMETRIUM	ENST00000361510	c.301C>T	p.R101C	COSMIC	NP	NP
190	TCGA-AX-A05Z-01	Tumour	ENDOMETRIUM	ENST00000361510	c.953C>T	p.S318F	COSMIC	NP	NP
191	TCGA-AZ-6601-01	Tumour	LARGE INTESTINE	ENST00000361510	c.470C>T	p.P157L	COSMIC	NP	NP
192	TCGA-B0-5096-01	Tumour	KIDNEY	ENST00000361510	c.1092C>G	p.A364A	COSMIC	NP	NP
193	TCGA-B0-5117-01	Tumour	KIDNEY	ENST00000361510	c.2810G>A	p.R937H	COSMIC	NP	NP
194	TCGA-B5-A0JY-01	Tumour	ENDOMETRIUM	ENST00000361510	c.1866C>A	p.F622L	COSMIC	NP	NP
195	TCGA-B5-A0JY-01	Tumour	ENDOMETRIUM	ENST00000361510	c.2431C>T	p.L811F	COSMIC	NP	NP
196	TCGA-B5-A11E-01	Tumour	ENDOMETRIUM	ENST00000361510	c.2228C>T	p.P743L	COSMIC	NP	NP
197	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000361510	c.1099C>T	p.R367*	COSMIC	NP	NP
198	TCGA-BS-A0UJ-01	Tumour	ENDOMETRIUM	ENST00000361510	c.2063T>C	p.I688T	COSMIC	NP	NP
199	TCGA-BS-A0UM-01	Tumour	ENDOMETRIUM	ENST00000361510	c.294A>G	p.L98L	COSMIC	NP	NP
200	TCGA-BT-A0YX-01	Tumour	URINARY TRACT	ENST00000361510	c.1837G>C	p.E613Q	COSMIC	NP	NP
201	TCGA-BT-A0YX-01	Tumour	URINARY TRACT	ENST00000361510	c.865G>A	p.E289K	COSMIC	NP	NP
202	TCGA-CA-6717-01	Tumour	LARGE INTESTINE	ENST00000361510	c.225C>A	p.F75L	COSMIC	NP	NP
203	TCGA-CA-6717-01	Tumour	LARGE INTESTINE	ENST00000361510	c.850T>G	p.Y284D	COSMIC	NP	NP
204	TCGA-CU-A3KJ-01	Tumour	URINARY TRACT	ENST00000361510	c.2786G>C	p.C929S	COSMIC	NP	NP
205	TCGA-D1-A17Q-01	Tumour	ENDOMETRIUM	ENST00000361510	c.1261C>A	p.R421R	COSMIC	NP	NP
206	TCGA-DR-A0ZM-01	Tumour	CERVIX	ENST00000361510	c.1837G>C	p.E613Q	COSMIC	NP	NP
207	TCGA-EI-6507-01	Tumour	LARGE INTESTINE	ENST00000361510	c.1504A>G	p.I502V	COSMIC	NP	NP
208	TCGA-F5-6465-01	Tumour	LARGE INTESTINE	ENST00000361510	c.113G>A	p.R38Q	COSMIC	NP	NP
209	TCGA-FU-A23L-01	Tumour	CERVIX	ENST00000361510	c.2320G>A	p.E774K	COSMIC	NP	NP
210	TCGA-G4-6307-01	Tumour	LARGE INTESTINE	ENST00000361510	c.2666A>C	p.K889T	COSMIC	NP	NP
211	TCGA-G4-6307-01	Tumour	LARGE INTESTINE	ENST00000361510	c.2702T>G	p.L901*	COSMIC	NP	NP
212	TCGA-G4-6307-01	Tumour	LARGE INTESTINE	ENST00000361510	c.2746T>C	p.Y916H	COSMIC	NP	NP
213	TCGA-G4-6628-01	Tumour	LARGE INTESTINE	ENST00000361510	c.253C>T	p.R85C	COSMIC	NP	NP
214	ccRCC-77	Tumour	KIDNEY	ENST00000361510	c.1342A>G	p.R448G	COSMIC	NP	NP
215	22RV1	Cell Line	PROSTATE	ENST00000361510	c.2444delA	p.N816fs*39	COSMIC	NP	NP
216	A3KAW	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000361510	c.668A>G	p.H223R	COSMIC	NP	NP
217	ALLPO	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000361510	c.1016C>T	p.T339M	COSMIC	NP	NP
218	AN3CA	Cell Line	ENDOMETRIUM	ENST00000361510	c.2335G>T	p.V779F	COSMIC	NP	NP
219	BL41	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000361510	c.2012+1_2012+4delGTAA	p.?	COSMIC	NP	NP
220	C33A	Cell Line	CERVIX	ENST00000361510	c.381G>A	p.P127P	COSMIC	NP	NP
221	CAL33	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000361510	c.72A>G	p.I24M	COSMIC	NP	NP
222	EN	Cell Line	ENDOMETRIUM	ENST00000361510	c.1981A>G	p.I661V	COSMIC	NP	NP
223	EN	Cell Line	ENDOMETRIUM	ENST00000361510	c.431A>G	p.D144G	COSMIC	NP	NP
224	ES6	Cell Line	BONE	ENST00000361510	c.70A>G	p.I24V	COSMIC	NP	NP
225	ES6	Cell Line	BONE	ENST00000361510	c.843+6C>A	p.?	COSMIC	NP	NP
226	EVSAT	Cell Line	BREAST	ENST00000361510	c.100C>T	p.H34Y	COSMIC	NP	NP
227	FUOV1	Cell Line	OVARY	ENST00000361510	c.151C>T	p.Q51*	COSMIC	NP	NP
228	GP5D	Cell Line	LARGE_INTESTINE	ENST00000361510	c.748G>T	p.A250S	COSMIC	NP	NP
229	H2722	Cell Line	PLEURA	ENST00000361510	c.1231-1G>C	p.?	COSMIC	NP	NP
230	HCC2998	Cell Line	LARGE_INTESTINE	ENST00000361510	c.1498C>T	p.R500C	COSMIC	NP	NP
231	HCC366	Cell Line	LUNG	ENST00000361510	c.2390A>T	p.D797V	COSMIC	NP	NP
232	HCT116	Cell Line	LARGE_INTESTINE	ENST00000361510	c.1312T>A	p.S438T	COSMIC	NP	NP
233	HEC1	Cell Line	ENDOMETRIUM	ENST00000361510	c.1319A>G	p.N440S	COSMIC	NP	NP
234	HEL	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000361510	c.71T>C	p.I24T	COSMIC	NP	NP
235	HT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000361510	c.544delT	p.F183fs*12	COSMIC	NP	NP
236	HT115	Cell Line	LARGE_INTESTINE	ENST00000361510	c.509A>G	p.D170G	COSMIC	NP	NP
237	IGROV1	Cell Line	OVARY	ENST00000361510	c.2735G>A	p.R912Q	COSMIC	NP	NP
238	JHH2	Cell Line	LIVER	ENST00000361510	c.382G>A	p.D128N	COSMIC	NP	NP
239	JURKAT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000361510	c.1477G>T	p.D493Y	COSMIC	NP	NP
240	KELLY	Cell Line	AUTONOMIC_GANGLIA	ENST00000361510	c.1136G>A	p.R379H	COSMIC	NP	NP
241	KMH2	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000361510	c.744A>G	p.R248R	COSMIC	NP	NP
242	KNS42	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000361510	c.1308C>A	p.T436T	COSMIC	NP	NP
243	KURAMOCHI	Cell Line	OVARY	ENST00000361510	c.1875A>G	p.T625T	COSMIC	NP	NP
244	KYSE450	Cell Line	OESOPHAGUS	ENST00000361510	c.704T>C	p.L235S	COSMIC	NP	NP
245	LAN6	Cell Line	AUTONOMIC_GANGLIA	ENST00000361510	c.1377+10T>C	p.?	COSMIC	NP	NP
246	LN229	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000361510	c.2612C>G	p.T871R	COSMIC	NP	NP
247	LOVO	Cell Line	LARGE_INTESTINE	ENST00000361510	c.2478_2479insA	p.R829fs*17	COSMIC	NP	NP
248	MC116	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000361510	c.212G>A	p.R71H	COSMIC	NP	NP
249	NALM6	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000361510	c.2850G>A	p.R950R	COSMIC	NP	NP
250	NCIH1573	Cell Line	LUNG	ENST00000361510	c.679-6T>C	p.?	COSMIC	NP	NP
251	NCIH1693	Cell Line	LUNG	ENST00000361510	c.2647G>A	p.V883I	COSMIC	NP	NP
252	NCIH196	Cell Line	LUNG	ENST00000361510	c.495A>G	p.L165L	COSMIC	NP	NP
253	NCIH2009	Cell Line	LUNG	ENST00000361510	c.655G>A	p.E219K	COSMIC	NP	NP
254	NCIH2228	Cell Line	LUNG	ENST00000361510	c.344C>T	p.A115V	COSMIC	NP	NP
255	NCIH2342	Cell Line	LUNG	ENST00000361510	c.1608+5G>T	p.?	COSMIC	NP	NP
256	NCIH2342	Cell Line	LUNG	ENST00000361510	c.619G>T	p.E207*	COSMIC	NP	NP
257	NCIH2405	Cell Line	LUNG	ENST00000361510	c.1621A>T	p.I541F	COSMIC	NP	NP
258	NCIH345	Cell Line	LUNG	ENST00000361510	c.630G>A	p.A210A	COSMIC	NP	NP
259	NCIH64	Cell Line	LUNG	ENST00000361510	c.790-4T>A	p.?	COSMIC	NP	NP
260	NCIH647	Cell Line	LUNG	ENST00000361510	c.448+2T>G	p.?	COSMIC	NP	NP
261	OUMS23	Cell Line	LARGE_INTESTINE	ENST00000361510	c.980T>C	p.L327P	COSMIC	NP	NP
262	OVK18	Cell Line	OVARY	ENST00000361510	c.1493C>T	p.A498V	COSMIC	NP	NP
263	PC14	Cell Line	LUNG	ENST00000361510	c.1829T>C	p.M610T	COSMIC	NP	NP
264	RPMI8866	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000361510	c.1934G>T	p.R645L	COSMIC	NP	NP
265	SKOV3	Cell Line	OVARY	ENST00000361510	c.1074T>C	p.S358S	COSMIC	NP	NP
266	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000361510	c.2087C>T	p.A696V	COSMIC	NP	NP
267	SNU407	Cell Line	LARGE_INTESTINE	ENST00000361510	c.2702_2703insT	p.L901fs*9	COSMIC	NP	NP
268	SNU423	Cell Line	LIVER	ENST00000361510	c.1293C>T	p.T431T	COSMIC	NP	NP
269	SNU81	Cell Line	LARGE_INTESTINE	ENST00000361510	c.1261C>T	p.R421*	COSMIC	NP	NP
270	SNU81	Cell Line	LARGE_INTESTINE	ENST00000361510	c.301C>T	p.R101C	COSMIC	NP	NP
271	SNUC2B	Cell Line	LARGE_INTESTINE	ENST00000361510	c.1035+3A>G	p.?	COSMIC	NP	NP
272	SNUC2B	Cell Line	LARGE_INTESTINE	ENST00000361510	c.1035+5G>A	p.?	COSMIC	NP	NP
273	SNUC2B	Cell Line	LARGE_INTESTINE	ENST00000361510	c.2271G>T	p.E757D	COSMIC	NP	NP
274	SUPT1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000361510	c.785G>A	p.R262H	COSMIC	NP	NP

*NP: Not Predicted

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	8.8088	8.8029	0.0400	-0.0276
BILIARY TRACT	8.4276	8.2301	0.1596	0.1328
BONE	8.2248	8.3552	0.0588	0.002
BREAST	8.3117	8.27455	0.2248	0.14605
CENTRAL NERVOUS SYSTEM	8.1227	8.2184	0.1544	0.1384
ENDOMETRIUM	8.1342	7.988	0.2030	0.063
HAEMATOPOIETIC AND LYMPHOID TISSUE	8.6688	8.6753	0.0839	0.0454
KIDNEY	8.4817	8.338	0.1611	0.136
LARGE INTESTINE	8.3285	8.2986	0.1467	0.0535
LIVER	8.0997	8.0925	-0.0261	-0.1005
LUNG	8.4269	8.40665	0.2402	0.2267
OESOPHAGUS	8.5930	8.6002	0.5951	0.6397
OVARY	8.2742	8.3043	0.2831	0.1494
PANCREAS	8.2509	8.2111	0.2661	0.2783
PLEURA	8.3869	8.6313	-0.0074	0.049
PROSTATE	8.1342	8.28815	0.1493	0.1612
SALIVARY GLAND	9.4513	9.4513	0.6866	0.6866
SKIN	8.4539	8.4035	0.2280	0.2175
SMALL INTESTINE	7.9827	7.9827	0.0245	0.0245
SOFT TISSUE	8.2840	8.2635	0.0642	0.0417
STOMACH	8.3205	8.2951	0.2309	0.2088
THYROID	8.6429	8.753	0.2183	0.20815
UPPER AERODIGESTIVE TRACT	8.4713	8.4989	0.5338	0.6119
URINARY TRACT	8.3445	8.4704	0.3164	0.31595

Domain ID	Domain Name	Start Site	End Site	E-value
PF07632	DUF1593	255	303	0.015
PF00350	Dynamin_N	291	469	2.6e-36
PF07699	GCC2_GCC3	844	864	0.65
PF05531	NPV_P10	922	957	0.66
PF07632	DUF1593	255	303	0.015
PF00350	Dynamin_N	291	469	2.6e-36
PF07699	GCC2_GCC3	844	864	0.65
PF05531	NPV_P10	922	957	0.66

Domain ID	Start Site	End Site	E-value
0051784	259	561	2.62e-52
0051784	259	561	2.62e-52

S. No.	Position	Amino acid	Type	Description
1	107	S	Phosphorylation	Phosphoserine
2	114	T	Phosphorylation	Phosphothreonine
3	21	S	Phosphorylation	Phosphoserine
4	21	S	Phosphorylation	Phosphoserine.
5	22	S	Phosphorylation	Phosphoserine
6	22	S	Phosphorylation	Phosphoserine.
7	228	K	Acetylation	N6-acetyllysine
8	228	K	Acetylation	N6-acetyllysine.
9	228	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
10	344	S	Phosphorylation	Phosphoserine
11	345	S	Phosphorylation	Phosphoserine
12	351	T	Phosphorylation	Phosphothreonine
13	568	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
14	708	S	Phosphorylation	Phosphoserine
15	890	T	Phosphorylation	Phosphothreonine
16	893	T	Phosphorylation	Phosphothreonine
17	929	T	Phosphorylation	Phosphothreonine
18	107	S	Phosphorylation	Phosphoserine
19	114	T	Phosphorylation	Phosphothreonine
20	21	S	Phosphorylation	Phosphoserine
21	21	S	Phosphorylation	Phosphoserine.
22	22	S	Phosphorylation	Phosphoserine
23	22	S	Phosphorylation	Phosphoserine.
24	228	K	Acetylation	N6-acetyllysine
25	228	K	Acetylation	N6-acetyllysine.
26	228	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
27	344	S	Phosphorylation	Phosphoserine
28	345	S	Phosphorylation	Phosphoserine
29	351	T	Phosphorylation	Phosphothreonine
30	568	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
31	708	S	Phosphorylation	Phosphoserine
32	890	T	Phosphorylation	Phosphothreonine
33	893	T	Phosphorylation	Phosphothreonine
34	929	T	Phosphorylation	Phosphothreonine

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
OPA1	OPA1	OPA1	NA	O60313
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
O60313	OPA1	NA	OPA1	O60313
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
OPA1	NA	605290	O60313	PA31927

Protein: OPA1

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)

Modelled Structure	Structures available in PDB
	Structure is not available in PDB