ApoCanD

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	639V	Cell Line	URINARY TRACT	NP_127497	c.1370C>T	p.T457M	CCLE	PASSENGER/OTHER	Probably Damaging
2	BL70	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_127497	c.2320C>T	p.Q774*	CCLE	NP	NP
3	C32	Cell Line	SKIN	NP_127497	c.2170G>A	p.E724K	CCLE	PASSENGER/OTHER	Probably Damaging
4	COLO741	Cell Line	SKIN	NP_127497	c.883_883delC	p.L295fs	CCLE	NP	NP
5	EFO27	Cell Line	OVARY	NP_127497	c.439C>T	p.R147C	CCLE	PASSENGER/OTHER	Probably Damaging
6	FTC133	Cell Line	THYROID	NP_127497	c.104G>T	p.R35M	CCLE	PASSENGER/OTHER	Benign
7	HCC1359	Cell Line	LUNG	NP_127497	c.4269_4269delC	p.P1423fs	CCLE	NP	NP
8	HCT15	Cell Line	LARGE INTESTINE	NP_127497	c.2501G>T	p.R834L	CCLE	PASSENGER/OTHER	Benign
9	HEC108	Cell Line	ENDOMETRIUM	NP_127497	c.3041G>A	p.R1014K	CCLE	PASSENGER/OTHER	Probably Damaging
10	HEC151	Cell Line	ENDOMETRIUM	NP_127497	c.52_54delAAG	p.K18del	CCLE	NP	NP
11	HEC251	Cell Line	ENDOMETRIUM	NP_127497	c.3376G>T	p.E1126*	CCLE	NP	NP
12	HEC251	Cell Line	ENDOMETRIUM	NP_127497	c.3387C>A	p.F1129L	CCLE	PASSENGER/OTHER	Probably Damaging
13	HEC251	Cell Line	ENDOMETRIUM	NP_127497	c.3934C>T	p.R1312*	CCLE	NP	NP
14	HS840T	Cell Line	UPPER AERODIGESTIVE TRACT	NP_127497	c.1418C>T	p.A473V	CCLE	PASSENGER/OTHER	Possibly Damaging
15	HT	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_127497	c.2462G>T	p.S821I	CCLE	PASSENGER/OTHER	Probably Damaging
16	HT144	Cell Line	SKIN	NP_127497	c.1340C>T	p.T447I	CCLE	PASSENGER/OTHER	Possibly Damaging
17	IGROV1	Cell Line	OVARY	NP_127497	c.1461G>T	p.K487N	CCLE	PASSENGER/OTHER	Possibly Damaging
18	IPC298	Cell Line	SKIN	NP_127497	c.2531T>C	p.L844S	CCLE	PASSENGER/OTHER	Probably Damaging
19	ISHIKAWAHERAKLIO02ER	Cell Line	ENDOMETRIUM	NP_127497	c.2055_2056delGA	p.E685fs	CCLE	NP	NP
20	JK1	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_127497	c.2756G>A	p.S919N	CCLE	PASSENGER/OTHER	Possibly Damaging
21	KASUMI2	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_127497	c.2700_splice	p.Q900_splice	CCLE	NP	NP
22	KPL1	Cell Line	BREAST	NP_127497	c.725C>A	p.P242Q	CCLE	PASSENGER/OTHER	Benign
23	KYSE270	Cell Line	OESOPHAGUS	NP_127497	c.1199C>G	p.S400C	CCLE	PASSENGER/OTHER	Probably Damaging
24	KYSE450	Cell Line	OESOPHAGUS	NP_127497	c.3001G>A	p.G1001R	CCLE	PASSENGER/OTHER	Benign
25	L540	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_127497	c.361A>T	p.I121F	CCLE	PASSENGER/OTHER	Benign
26	LOVO	Cell Line	LARGE INTESTINE	NP_127497	c.120G>T	p.E40D	CCLE	PASSENGER/OTHER	Possibly Damaging
27	LS411N	Cell Line	LARGE INTESTINE	NP_127497	c.4279C>T	p.R1427W	CCLE	PASSENGER/OTHER	Probably Damaging
28	MALME3M	Cell Line	SKIN	NP_127497	c.4057_splice	p.G1353_splice	CCLE	NP	NP
29	MCF7	Cell Line	BREAST	NP_127497	c.725C>A	p.P242Q	CCLE	PASSENGER/OTHER	Benign
30	MFE319	Cell Line	ENDOMETRIUM	NP_127497	c.3046G>T	p.G1016*	CCLE	NP	NP
31	MFE319	Cell Line	ENDOMETRIUM	NP_127497	c.68A>G	p.E23G	CCLE	PASSENGER/OTHER	Probably Damaging
32	MOLM13	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_127497	c.2809G>A	p.V937I	CCLE	PASSENGER/OTHER	Benign
33	NCIH1339	Cell Line	LUNG	NP_127497	c.4321A>C	p.K1441Q	CCLE	PASSENGER/OTHER	Probably Damaging
34	NCIH1876	Cell Line	LUNG	NP_127497	c.1424G>A	p.W475*	CCLE	NP	NP
35	OVK18	Cell Line	OVARY	NP_127497	c.2639C>T	p.A880V	CCLE	PASSENGER/OTHER	Probably Damaging
36	RCHACV	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_127497	c.3785C>T	p.A1262V	CCLE	PASSENGER/OTHER	Probably Damaging
37	SKMEL1	Cell Line	SKIN	NP_127497	c.766G>A	p.E256K	CCLE	PASSENGER/OTHER	Benign
38	SNU1040	Cell Line	LARGE INTESTINE	NP_127497	c.3280G>A	p.E1094K	CCLE	PASSENGER/OTHER	Probably Damaging
39	SNU1040	Cell Line	LARGE INTESTINE	NP_127497	c.3365C>T	p.A1122V	CCLE	PASSENGER/OTHER	Probably Damaging
40	SNUC4	Cell Line	LARGE INTESTINE	NP_127497	c.1748_1749insA	p.K583fs	CCLE	NP	NP
41	SUPB15	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_127497	c.4193T>A	p.V1398D	CCLE	PASSENGER/OTHER	Benign
42	TOV21G	Cell Line	OVARY	NP_127497	c.1748_1748delA	p.K583fs	CCLE	NP	NP
43	WM115	Cell Line	SKIN	NP_127497	c.1708G>A	p.D570N	CCLE	PASSENGER/OTHER	Benign
44	WM2664	Cell Line	SKIN	NP_127497	c.1708G>A	p.D570N	CCLE	PASSENGER/OTHER	Benign
45	A498	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000572272	c.3811C>G	p.Q1271E	COSMIC	NP	NP
46	Br27P	Tumour	CENTRAL NERVOUS SYSTEM	ENST00000572272	c.1180C>T	p.P394S	COSMIC	NP	NP
47	ESO-0015	Tumour	OESOPHAGUS	ENST00000572272	c.3517C>G	p.Q1173E	COSMIC	NP	NP
48	ESO-1670	Tumour	OESOPHAGUS	ENST00000572272	c.2186C>T	p.T729M	COSMIC	NP	NP
49	ESO-K08	Tumour	OESOPHAGUS	ENST00000572272	c.2031G>C	p.L677L	COSMIC	NP	NP
50	GC1	Tumour	T STOMACH	ENST00000572272	c.2942T>G	p.L981R	COSMIC	NP	NP
51	HCC03T	Tumour	LIVER	ENST00000572272	c.1745A>C	p.K582T	COSMIC	NP	NP
52	HCC07T	Tumour	LIVER	ENST00000572272	c.3229G>A	p.D1077N	COSMIC	NP	NP
53	HCC1143	Cell Line	BREAST	ENST00000572272	c.2669G>A	p.R890K	COSMIC	PASSENGER/OTHER	Benign
54	HCC17T	Tumour	LIVER	ENST00000572272	c.1607G>A	p.R536Q	COSMIC	NP	NP
55	HCC207T	Tumour	LIVER	ENST00000572272	c.1593G>A	p.M531I	COSMIC	NP	NP
56	HCC207T	Tumour	LIVER	ENST00000572272	c.1594C>A	p.Q532K	COSMIC	NP	NP
57	HCC208T	Tumour	LIVER	ENST00000572272	c.2792A>T	p.Q931L	COSMIC	NP	NP
58	HCC2998	Cell Line	LARGE INTESTINE	ENST00000572272	c.3383A>C	p.E1128A	COSMIC	NP	NP
59	HN	Tumour	63115 UPPER AERODIGESTIVE TRACT	ENST00000572272	c.4152G>T	p.Q1384H	COSMIC	NP	NP
60	LC	Tumour	C9 LUNG	ENST00000572272	c.1416G>T	p.Q472H	COSMIC	NP	NP
61	LUAD	Tumour	E00623 LUNG	ENST00000572272	c.3784-2A>T	p.?	COSMIC	NP	NP
62	LUAD-5V8LT	Tumour	LUNG	ENST00000572272	c.1720C>A	p.L574M	COSMIC	NP	NP
63	LUAD-B00859	Tumour	LUNG	ENST00000572272	c.3783G>T	p.K1261N	COSMIC	NP	NP
64	LUAD-B01811	Tumour	LUNG	ENST00000572272	c.3264T>A	p.T1088T	COSMIC	NP	NP
65	LUAD-B02515	Tumour	LUNG	ENST00000572272	c.3241G>T	p.G1081C	COSMIC	NP	NP
66	LUAD-E00897	Tumour	LUNG	ENST00000572272	c.1648C>A	p.L550I	COSMIC	NP	NP
67	LUAD-F00368	Tumour	LUNG	ENST00000572272	c.2557G>T	p.D853Y	COSMIC	NP	NP
68	LUAD-NYU1128	Tumour	LUNG	ENST00000572272	c.2320C>T	p.Q774*	COSMIC	NP	NP
69	LUAD-RT-S01813	Tumour	LUNG	ENST00000572272	c.415C>A	p.Q139K	COSMIC	NP	NP
70	LUAD-RT-S01818	Tumour	LUNG	ENST00000572272	c.2986G>T	p.E996*	COSMIC	NP	NP
71	LUAD-RT-S01866	Tumour	LUNG	ENST00000572272	c.3313G>T	p.A1105S	COSMIC	NP	NP
72	LUAD-S00486	Tumour	LUNG	ENST00000572272	c.961G>A	p.G321S	COSMIC	NP	NP
73	LUAD-S01315	Tumour	LUNG	ENST00000572272	c.4360C>T	p.H1454Y	COSMIC	NP	NP
74	LUAD-S01413	Tumour	LUNG	ENST00000572272	c.3145C>T	p.P1049S	COSMIC	NP	NP
75	LUAD-YINHD	Tumour	LUNG	ENST00000572272	c.3524G>T	p.G1175V	COSMIC	NP	NP
76	LUAD-YINHD	Tumour	LUNG	ENST00000572272	c.4377C>G	p.L1459L	COSMIC	NP	NP
77	ME002T	Tumour	SKIN	ENST00000572272	c.2908G>A	p.E970K	COSMIC	NP	NP
78	ME011T	Tumour	SKIN	ENST00000572272	c.807G>A	p.W269*	COSMIC	NP	NP
79	ME041T	Tumour	SKIN	ENST00000572272	c.2215G>A	p.E739K	COSMIC	NP	NP
80	MOLT-4	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000572272	c.922C>T	p.R308*	COSMIC	NP	NP
81	MZ7-mel	Cell Line	SKIN	ENST00000572272	c.489C>T	p.S163S	COSMIC	NP	NP
82	NB-1942	Tumour	AUTONOMIC GANGLIA	ENST00000572272	c.1470C>A	p.F490L	COSMIC	NP	NP
83	NB1940T	Tumour	AUTONOMIC GANGLIA	ENST00000572272	c.2270G>T	p.C757F	COSMIC	NP	NP
84	NCI-H128	Cell Line	LUNG	ENST00000572272	c.3453G>T	p.L1151L	COSMIC	NP	NP
85	NCI-H1395	Cell Line	LUNG	ENST00000572272	c.1963A>T	p.K655*	COSMIC	NP	NP
86	NCI-H1395	Cell Line	LUNG	ENST00000572272	c.808A>T	p.K270*	COSMIC	NP	NP
87	NCI-H1437	Cell Line	LUNG	ENST00000572272	c.2389T>A	p.W797R	COSMIC	NP	NP
88	P08-2516	Tumour	PROSTATE	ENST00000572272	c.2999C>T	p.T1000M	COSMIC	NP	NP
89	PD4107a	Tumour	BREAST	ENST00000572272	c.1847C>G	p.P616R	COSMIC	NP	NP
90	PD6367a	Tumour	NS	ENST00000572272	c.436C>T	p.R146C	COSMIC	NP	NP
91	Patient1	Tumour	OVARY	ENST00000572272	c.3414G>C	p.E1138D	COSMIC	NP	NP
92	SWE-28	Tumour	PROSTATE	ENST00000572272	c.2818C>T	p.R940*	COSMIC	NP	NP
93	TCGA-05-4427-01	Tumour	LUNG	ENST00000572272	c.701G>A	p.W234*	COSMIC	NP	NP
94	TCGA-09-2056-01	Tumour	OVARY	ENST00000572272	c.1308G>A	p.A436A	COSMIC	NP	NP
95	TCGA-22-4601-01	Tumour	LUNG	ENST00000572272	c.3423A>G	p.P1141P	COSMIC	NP	NP
96	TCGA-22-5473-01	Tumour	LUNG	ENST00000572272	c.4268C>A	p.P1423H	COSMIC	NP	NP
97	TCGA-33-6737-01	Tumour	LUNG	ENST00000572272	c.4039G>A	p.E1347K	COSMIC	NP	NP
98	TCGA-44-2659-01	Tumour	LUNG	ENST00000572272	c.1418C>T	p.A473V	COSMIC	NP	NP
99	TCGA-50-5939-01	Tumour	LUNG	ENST00000572272	c.3214C>T	p.P1072S	COSMIC	NP	NP
100	TCGA-53-7624-01	Tumour	LUNG	ENST00000572272	c.51G>A	p.K17K	COSMIC	NP	NP
101	TCGA-55-8089-01	Tumour	LUNG	ENST00000572272	c.1437G>T	p.L479L	COSMIC	NP	NP
102	TCGA-60-2721-01	Tumour	LUNG	ENST00000572272	c.3860G>A	p.G1287D	COSMIC	NP	NP
103	TCGA-66-2744-01	Tumour	LUNG	ENST00000572272	c.4055C>A	p.P1352Q	COSMIC	NP	NP
104	TCGA-67-3771-01	Tumour	LUNG	ENST00000572272	c.256G>A	p.A86T	COSMIC	NP	NP
105	TCGA-67-3771-01	Tumour	LUNG	ENST00000572272	c.684G>A	p.E228E	COSMIC	NP	NP
106	TCGA-69-7980-01	Tumour	LUNG	ENST00000572272	c.1391A>C	p.Q464P	COSMIC	NP	NP
107	TCGA-78-7149-01	Tumour	LUNG	ENST00000572272	c.3265G>A	p.E1089K	COSMIC	NP	NP
108	TCGA-95-7043-01	Tumour	LUNG	ENST00000572272	c.598G>T	p.E200*	COSMIC	NP	NP
109	TCGA-99-8032-01	Tumour	LUNG	ENST00000572272	c.3974T>C	p.V1325A	COSMIC	NP	NP
110	TCGA-A5-A0GP-01	Tumour	ENDOMETRIUM	ENST00000572272	c.1661A>G	p.Y554C	COSMIC	NP	NP
111	TCGA-A8-A097-01	Tumour	BREAST	ENST00000572272	c.3118A>G	p.I1040V	COSMIC	NP	NP
112	TCGA-AA-3510-01	Tumour	LARGE INTESTINE	ENST00000572272	c.3946G>T	p.E1316*	COSMIC	NP	NP
113	TCGA-AA-3525-01	Tumour	LARGE INTESTINE	ENST00000572272	c.1542G>T	p.W514C	COSMIC	NP	NP
114	TCGA-AA-3525-01	Tumour	LARGE INTESTINE	ENST00000572272	c.3673G>A	p.A1225T	COSMIC	NP	NP
115	TCGA-AA-3534-01	Tumour	LARGE INTESTINE	ENST00000572272	c.2959C>T	p.R987W	COSMIC	NP	NP
116	TCGA-AA-3715-01	Tumour	LARGE INTESTINE	ENST00000572272	c.4143T>C	p.F1381F	COSMIC	NP	NP
117	TCGA-AA-3821-01	Tumour	LARGE INTESTINE	ENST00000572272	c.3914A>G	p.K1305R	COSMIC	NP	NP
118	TCGA-AA-3833-01	Tumour	LARGE INTESTINE	ENST00000572272	c.3638C>T	p.S1213F	COSMIC	NP	NP
119	TCGA-AA-3864-01	Tumour	LARGE INTESTINE	ENST00000572272	c.3339G>A	p.T1113T	COSMIC	NP	NP
120	TCGA-AA-3977-01	Tumour	LARGE INTESTINE	ENST00000572272	c.2186C>T	p.T729M	COSMIC	NP	NP
121	TCGA-AA-3977-01	Tumour	LARGE INTESTINE	ENST00000572272	c.510C>T	p.S170S	COSMIC	NP	NP
122	TCGA-AA-3982-01	Tumour	LARGE INTESTINE	ENST00000572272	c.1371G>A	p.T457T	COSMIC	NP	NP
123	TCGA-AA-A00D-01	Tumour	LARGE INTESTINE	ENST00000572272	c.2809G>A	p.V937I	COSMIC	NP	NP
124	TCGA-AA-A00N-01	Tumour	LARGE INTESTINE	ENST00000572272	c.2266T>G	p.F756V	COSMIC	NP	NP
125	TCGA-AA-A010-01	Tumour	LARGE INTESTINE	ENST00000572272	c.373C>T	p.P125S	COSMIC	NP	NP
126	TCGA-AD-6889-01	Tumour	LARGE INTESTINE	ENST00000572272	c.2818C>T	p.R940*	COSMIC	NP	NP
127	TCGA-AG-3731-01	Tumour	LARGE INTESTINE	ENST00000572272	c.2668A>G	p.R890G	COSMIC	NP	NP
128	TCGA-AG-3892-01	Tumour	LARGE INTESTINE	ENST00000572272	c.1887C>A	p.F629L	COSMIC	NP	NP
129	TCGA-AG-3892-01	Tumour	LARGE INTESTINE	ENST00000572272	c.2214C>T	p.F738F	COSMIC	NP	NP
130	TCGA-AG-4007-01	Tumour	LARGE INTESTINE	ENST00000572272	c.3373G>A	p.V1125I	COSMIC	NP	NP
131	TCGA-AG-A011-01	Tumour	LARGE INTESTINE	ENST00000572272	c.4271G>T	p.S1424I	COSMIC	NP	NP
132	TCGA-AP-A056-01	Tumour	ENDOMETRIUM	ENST00000572272	c.2784C>T	p.D928D	COSMIC	NP	NP
133	TCGA-AP-A056-01	Tumour	ENDOMETRIUM	ENST00000572272	c.3387C>A	p.F1129L	COSMIC	NP	NP
134	TCGA-AP-A056-01	Tumour	ENDOMETRIUM	ENST00000572272	c.3865C>T	p.R1289C	COSMIC	NP	NP
135	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000572272	c.4184C>T	p.S1395L	COSMIC	NP	NP
136	TCGA-AP-A0L8-01	Tumour	ENDOMETRIUM	ENST00000572272	c.1212G>A	p.R404R	COSMIC	NP	NP
137	TCGA-AP-A0LD-01	Tumour	ENDOMETRIUM	ENST00000572272	c.2698C>T	p.Q900*	COSMIC	NP	NP
138	TCGA-AP-A0LE-01	Tumour	ENDOMETRIUM	ENST00000572272	c.3669T>C	p.H1223H	COSMIC	NP	NP
139	TCGA-AP-A0LM-01	Tumour	ENDOMETRIUM	ENST00000572272	c.377C>T	p.A126V	COSMIC	NP	NP
140	TCGA-AX-A05Z-01	Tumour	ENDOMETRIUM	ENST00000572272	c.3720C>T	p.R1240R	COSMIC	NP	NP
141	TCGA-AX-A05Z-01	Tumour	ENDOMETRIUM	ENST00000572272	c.3962C>T	p.S1321L	COSMIC	NP	NP
142	TCGA-AX-A0J0-01	Tumour	ENDOMETRIUM	ENST00000572272	c.850C>A	p.L284I	COSMIC	NP	NP
143	TCGA-AZ-4315-01	Tumour	LARGE INTESTINE	ENST00000572272	c.2194A>G	p.T732A	COSMIC	NP	NP
144	TCGA-B0-4810-01	Tumour	KIDNEY	ENST00000572272	c.1542G>A	p.W514*	COSMIC	NP	NP
145	TCGA-B0-5094-01	Tumour	KIDNEY	ENST00000572272	c.3521-1G>T	p.?	COSMIC	NP	NP
146	TCGA-B5-A0JY-01	Tumour	ENDOMETRIUM	ENST00000572272	c.763T>C	p.W255R	COSMIC	NP	NP
147	TCGA-B5-A0JY-01	Tumour	ENDOMETRIUM	ENST00000572272	c.880C>T	p.P294S	COSMIC	NP	NP
148	TCGA-B5-A11E-01	Tumour	ENDOMETRIUM	ENST00000572272	c.3034C>T	p.R1012W	COSMIC	NP	NP
149	TCGA-BG-A0LX-01	Tumour	ENDOMETRIUM	ENST00000572272	c.3601G>T	p.E1201*	COSMIC	NP	NP
150	TCGA-BG-A0M4-01	Tumour	ENDOMETRIUM	ENST00000572272	c.784A>C	p.S262R	COSMIC	NP	NP
151	TCGA-BH-A0BV-01	Tumour	BREAST	ENST00000572272	c.1637C>T	p.T546I	COSMIC	NP	NP
152	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000572272	c.1887C>A	p.F629L	COSMIC	NP	NP
153	TCGA-CA-6717-01	Tumour	LARGE INTESTINE	ENST00000572272	c.3133+8C>T	p.?	COSMIC	NP	NP
154	TCGA-CA-6717-01	Tumour	LARGE INTESTINE	ENST00000572272	c.377C>T	p.A126V	COSMIC	NP	NP
155	TCGA-CA-6717-01	Tumour	LARGE INTESTINE	ENST00000572272	c.3865C>T	p.R1289C	COSMIC	NP	NP
156	TCGA-CA-6717-01	Tumour	LARGE INTESTINE	ENST00000572272	c.3870C>T	p.Y1290Y	COSMIC	NP	NP
157	TCGA-CA-6717-01	Tumour	LARGE INTESTINE	ENST00000572272	c.3878C>T	p.S1293F	COSMIC	NP	NP
158	TCGA-CA-6719-01	Tumour	LARGE INTESTINE	ENST00000572272	c.808A>G	p.K270E	COSMIC	NP	NP
159	TCGA-CH-5741-01	Tumour	PROSTATE	ENST00000572272	c.4169T>C	p.I1390T	COSMIC	NP	NP
160	TCGA-CK-5914-01	Tumour	LARGE INTESTINE	ENST00000572272	c.2390G>A	p.W797*	COSMIC	NP	NP
161	TCGA-CK-5916-01	Tumour	LARGE INTESTINE	ENST00000572272	c.1748delA	p.K583fs*14	COSMIC	NP	NP
162	TCGA-CK-6747-01	Tumour	LARGE INTESTINE	ENST00000572272	c.1142C>A	p.A381D	COSMIC	NP	NP
163	TCGA-CL-5917-01	Tumour	LARGE INTESTINE	ENST00000572272	c.1964A>G	p.K655R	COSMIC	NP	NP
164	TCGA-CM-4747-01	Tumour	LARGE INTESTINE	ENST00000572272	c.3174C>T	p.C1058C	COSMIC	NP	NP
165	TCGA-CM-5861-01	Tumour	LARGE INTESTINE	ENST00000572272	c.1330C>T	p.L444L	COSMIC	NP	NP
166	TCGA-CM-6162-01	Tumour	LARGE INTESTINE	ENST00000572272	c.226C>T	p.Q76*	COSMIC	NP	NP
167	TCGA-CM-6171-01	Tumour	LARGE INTESTINE	ENST00000572272	c.2529-1G>T	p.?	COSMIC	NP	NP
168	TCGA-D1-A167-01	Tumour	ENDOMETRIUM	ENST00000572272	c.436C>T	p.R146C	COSMIC	NP	NP
169	TCGA-D1-A16R-01	Tumour	ENDOMETRIUM	ENST00000572272	c.1399A>G	p.I467V	COSMIC	NP	NP
170	TCGA-D1-A17D-01	Tumour	ENDOMETRIUM	ENST00000572272	c.3778C>T	p.R1260W	COSMIC	NP	NP
171	TCGA-D1-A17Q-01	Tumour	ENDOMETRIUM	ENST00000572272	c.3275A>G	p.D1092G	COSMIC	NP	NP
172	TCGA-D1-A17Q-01	Tumour	ENDOMETRIUM	ENST00000572272	c.3934C>T	p.R1312*	COSMIC	NP	NP
173	TCGA-D5-5538-01	Tumour	LARGE INTESTINE	ENST00000572272	c.3200A>T	p.D1067V	COSMIC	NP	NP
174	TCGA-D8-A1XL-01	Tumour	BREAST	ENST00000572272	c.2142C>T	p.H714H	COSMIC	NP	NP
175	TCGA-DC-5337-01	Tumour	LARGE INTESTINE	ENST00000572272	c.1964A>G	p.K655R	COSMIC	NP	NP
176	TCGA-DK-A1A3-01	Tumour	URINARY TRACT	ENST00000572272	c.1194C>T	p.I398I	COSMIC	NP	NP
177	TCGA-DR-A0ZM-01	Tumour	CERVIX	ENST00000572272	c.3009G>C	p.M1003I	COSMIC	NP	NP
178	TCGA-DY-A0XA-01	Tumour	LARGE INTESTINE	ENST00000572272	c.809A>G	p.K270R	COSMIC	NP	NP
179	TCGA-G4-6293-01	Tumour	LARGE INTESTINE	ENST00000572272	c.2668A>G	p.R890G	COSMIC	NP	NP
180	TCGA-G9-6367-01	Tumour	PROSTATE	ENST00000572272	c.464T>A	p.L155H	COSMIC	NP	NP
181	YUAKER	Tumour	SKIN	ENST00000572272	c.3804G>A	p.M1268I	COSMIC	NP	NP
182	YUKLAB	Tumour	SKIN	ENST00000572272	c.1376_1377GG>AA	p.R459Q	COSMIC	NP	NP
183	YUKLAB	Tumour	SKIN	ENST00000572272	c.2251C>T	p.L751F	COSMIC	NP	NP
184	YUKLAB	Tumour	SKIN	ENST00000572272	c.3163G>A	p.E1055K	COSMIC	NP	NP
185	YULAN	Tumour	SKIN	ENST00000572272	c.4024G>A	p.E1342K	COSMIC	NP	NP
186	YUMUT	Tumour	SKIN	ENST00000572272	c.2302C>T	p.Q768*	COSMIC	NP	NP
187	YURIF	Cell Line	SKIN	ENST00000572272	c.1384G>A	p.A462T	COSMIC	NP	NP
188	YURTHE	Tumour	SKIN	ENST00000572272	c.1441T>C	p.F481L	COSMIC	NP	NP
189	YUVAIL	Tumour	SKIN	ENST00000572272	c.367G>A	p.E123K	COSMIC	NP	NP
190	ccRCC-77	Tumour	KIDNEY	ENST00000572272	c.491C>A	p.P164Q	COSMIC	NP	NP
191	pfg008T	Tumour	STOMACH	ENST00000572272	c.3396G>T	p.W1132C	COSMIC	NP	NP
192	451LU	Cell Line	SKIN	ENST00000572272	c.3706T>C	p.L1236L	COSMIC	NP	NP
193	639V	Cell Line	URINARY_TRACT	ENST00000572272	c.1370C>T	p.T457M	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
194	A498	Cell Line	KIDNEY	ENST00000572272	c.3811C>G	p.Q1271E	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
195	A4FUK	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000572272	c.2369T>C	p.V790A	COSMIC	PASSENGER/OTHER	BENIGN
196	BL70	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000572272	c.2320C>T	p.Q774*	COSMIC	NP	NP
197	BT20	Cell Line	BREAST	ENST00000572272	c.1746A>T	p.K582N	COSMIC	PASSENGER/OTHER	BENIGN
198	C32	Cell Line	SKIN	ENST00000572272	c.2170G>A	p.E724K	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
199	COLO741	Cell Line	LARGE_INTESTINE	ENST00000572272	c.883delC	p.L295fs*17	COSMIC	NP	NP
200	DG75	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000572272	c.524A>G	p.N175S	COSMIC	PASSENGER/OTHER	BENIGN
201	ECC10	Cell Line	STOMACH	ENST00000572272	c.525C>T	p.N175N	COSMIC	NP	NP
202	EN	Cell Line	ENDOMETRIUM	ENST00000572272	c.1399A>G	p.I467V	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
203	GRST	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000572272	c.3326G>A	p.R1109H	COSMIC	PASSENGER/OTHER	BENIGN
204	H2731	Cell Line	PLEURA	ENST00000572272	c.3355A>T	p.M1119L	COSMIC	PASSENGER/OTHER	BENIGN
205	H290	Cell Line	PLEURA	ENST00000572272	c.2077C>T	p.R693W	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
206	HCC1143	Cell Line	BREAST	ENST00000572272	c.2669G>A	p.R890K	COSMIC	PASSENGER/OTHER	BENIGN
207	HCC2998	Cell Line	LARGE_INTESTINE	ENST00000572272	c.1887C>T	p.F629F	COSMIC	NP	NP
208	HCC2998	Cell Line	LARGE_INTESTINE	ENST00000572272	c.3383A>C	p.E1128A	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
209	HCC2998	Cell Line	LARGE_INTESTINE	ENST00000572272	c.3521-9C>A	p.?	COSMIC	NP	NP
210	HCT15	Cell Line	LARGE_INTESTINE	ENST00000572272	c.3220G>A	p.G1074R	COSMIC	PASSENGER/OTHER	BENIGN
211	HS939T	Cell Line	SKIN	ENST00000572272	c.2394G>A	p.Q798Q	COSMIC	NP	NP
212	HT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000572272	c.2462G>T	p.S821I	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
213	HT115	Cell Line	LARGE_INTESTINE	ENST00000572272	c.4103-9C>T	p.?	COSMIC	NP	NP
214	HUTU80	Cell Line	SMALL_INTESTINE	ENST00000572272	c.3613A>G	p.I1205V	COSMIC	PASSENGER/OTHER	BENIGN
215	IGROV1	Cell Line	OVARY	ENST00000572272	c.1461G>T	p.K487N	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
216	IGROV1	Cell Line	OVARY	ENST00000572272	c.675G>A	p.E225E	COSMIC	NP	NP
217	IPC298	Cell Line	SKIN	ENST00000572272	c.2531T>C	p.L844S	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
218	JEG3	Cell Line	PLACENTA	ENST00000572272	c.2290G>A	p.V764M	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
219	JHH7	Cell Line	LIVER	ENST00000572272	c.525C>T	p.N175N	COSMIC	NP	NP
220	JHOS4	Cell Line	OVARY	ENST00000572272	c.1929A>G	p.R643R	COSMIC	NP	NP
221	JURKAT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000572272	c.2808C>T	p.D936D	COSMIC	NP	NP
222	KARPAS45	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000572272	c.1990G>T	p.G664C	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
223	KINGS1	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000572272	c.2002G>T	p.A668S	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
224	KYSE270	Cell Line	OESOPHAGUS	ENST00000572272	c.1199C>G	p.S400C	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
225	KYSE450	Cell Line	OESOPHAGUS	ENST00000572272	c.3001G>A	p.G1001R	COSMIC	PASSENGER/OTHER	BENIGN
226	L428	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000572272	c.3678G>A	p.L1226L	COSMIC	NP	NP
227	L540	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000572272	c.361A>T	p.I121F	COSMIC	PASSENGER/OTHER	BENIGN
228	LS411N	Cell Line	LARGE_INTESTINE	ENST00000572272	c.4279C>T	p.R1427W	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
229	MCC26	Cell Line	SKIN	ENST00000572272	c.2911C>A	p.L971M	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
230	MCF7	Cell Line	BREAST	ENST00000572272	c.725C>A	p.P242Q	COSMIC	PASSENGER/OTHER	BENIGN
231	MDAMB157	Cell Line	BREAST	ENST00000572272	c.343G>A	p.A115T	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
232	MEWO	Cell Line	SKIN	ENST00000572272	c.3732G>A	p.E1244E	COSMIC	NP	NP
233	MFE319	Cell Line	ENDOMETRIUM	ENST00000572272	c.3046G>T	p.G1016*	COSMIC	NP	NP
234	MFE319	Cell Line	ENDOMETRIUM	ENST00000572272	c.68A>G	p.E23G	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
235	MKN1	Cell Line	STOMACH	ENST00000572272	c.1555G>T	p.V519L	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
236	MOLM13	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000572272	c.2809G>A	p.V937I	COSMIC	PASSENGER/OTHER	BENIGN
237	MOLT4	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000572272	c.922C>T	p.R308*	COSMIC	NP	NP
238	MZ7MEL	Cell Line	SKIN	ENST00000572272	c.489C>T	p.S163S	COSMIC	NP	NP
239	NCIH128	Cell Line	LUNG	ENST00000572272	c.3453G>T	p.L1151L	COSMIC	NP	NP
240	NCIH1437	Cell Line	LUNG	ENST00000572272	c.2389T>A	p.W797R	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
241	NCIH1792	Cell Line	LUNG	ENST00000572272	c.2056A>G	p.M686V	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
242	NCIH1792	Cell Line	LUNG	ENST00000572272	c.3721G>A	p.V1241I	COSMIC	PASSENGER/OTHER	BENIGN
243	NCIH1876	Cell Line	LUNG	ENST00000572272	c.1424G>A	p.W475*	COSMIC	NP	NP
244	NCIH2170	Cell Line	LUNG	ENST00000572272	c.2864G>T	p.R955L	COSMIC	PASSENGER/OTHER	BENIGN
245	NCIH630	Cell Line	LARGE_INTESTINE	ENST00000572272	c.4058-3C>T	p.?	COSMIC	NP	NP
246	NCIH660	Cell Line	PROSTATE	ENST00000572272	c.302G>T	p.S101I	COSMIC	PASSENGER/OTHER	BENIGN
247	NCIH661	Cell Line	LUNG	ENST00000572272	c.4095C>A	p.A1365A	COSMIC	NP	NP
248	NCIH748	Cell Line	LUNG	ENST00000572272	c.2720C>T	p.T907M	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
249	OVK18	Cell Line	OVARY	ENST00000572272	c.2639C>T	p.A880V	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
250	OVMIU	Cell Line	OVARY	ENST00000572272	c.994C>G	p.L332V	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
251	SARC9371	Cell Line	BONE	ENST00000572272	c.3804G>A	p.M1268I	COSMIC	PASSENGER/OTHER	BENIGN
252	SH4	Cell Line	SKIN	ENST00000572272	c.3296+8A>C	p.?	COSMIC	NP	NP
253	SKMEL1	Cell Line	SKIN	ENST00000572272	c.1607G>A	p.R536Q	COSMIC	PASSENGER/OTHER	BENIGN
254	SKMEL1	Cell Line	SKIN	ENST00000572272	c.766G>A	p.E256K	COSMIC	PASSENGER/OTHER	BENIGN
255	SKMEL1	Cell Line	SKIN	ENST00000572272	c.768G>A	p.E256E	COSMIC	NP	NP
256	SKMEL31	Cell Line	SKIN	ENST00000572272	c.1346T>C	p.L449P	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
257	SKMEL31	Cell Line	SKIN	ENST00000572272	c.1349C>T	p.P450L	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
258	SKMEL31	Cell Line	SKIN	ENST00000572272	c.1350C>A	p.P450P	COSMIC	NP	NP
259	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000572272	c.2154C>T	p.S718S	COSMIC	NP	NP
260	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000572272	c.2356C>A	p.L786M	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
261	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000572272	c.3365C>T	p.A1122V	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
262	SNU175	Cell Line	LARGE_INTESTINE	ENST00000572272	c.3720C>T	p.R1240R	COSMIC	NP	NP
263	SNU81	Cell Line	LARGE_INTESTINE	ENST00000572272	c.4356T>C	p.H1452H	COSMIC	NP	NP
264	SNUC2B	Cell Line	LARGE_INTESTINE	ENST00000572272	c.983G>A	p.R328H	COSMIC	PASSENGER/OTHER	BENIGN
265	SUPB15	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000572272	c.4193T>A	p.V1398D	COSMIC	PASSENGER/OTHER	BENIGN
266	SW13	Cell Line	ADRENAL_GLAND	ENST00000572272	c.331C>T	p.P111S	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
267	SW684	Cell Line	SOFT_TISSUE	ENST00000572272	c.665G>A	p.R222K	COSMIC	PASSENGER/OTHER	BENIGN
268	SW756	Cell Line	CERVIX	ENST00000572272	c.1828C>G	p.L610V	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
269	TCYIK	Cell Line	CERVIX	ENST00000572272	c.1310A>G	p.D437G	COSMIC	PASSENGER/OTHER	BENIGN
270	TE4	Cell Line	OESOPHAGUS	ENST00000572272	c.1740G>T	p.W580C	COSMIC	PASSENGER/OTHER	BENIGN
271	TOV21G	Cell Line	OVARY	ENST00000572272	c.1748delA	p.K583fs*14	COSMIC	NP	NP
272	WM115	Cell Line	SKIN	ENST00000572272	c.1708G>A	p.D570N	COSMIC	PASSENGER/OTHER	BENIGN
273	YT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000572272	c.525C>T	p.N175N	COSMIC	NP	NP
274	ZR7530	Cell Line	BREAST	ENST00000572272	c.4167G>A	p.L1389L	COSMIC	NP	NP
275	639V	Cell Line	URINARY TRACT	NP_127497	c.1370C>T	p.T457M	CCLE	PASSENGER/OTHER	Probably Damaging
276	BL70	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_127497	c.2320C>T	p.Q774*	CCLE	NP	NP
277	C32	Cell Line	SKIN	NP_127497	c.2170G>A	p.E724K	CCLE	PASSENGER/OTHER	Probably Damaging
278	COLO741	Cell Line	SKIN	NP_127497	c.883_883delC	p.L295fs	CCLE	NP	NP
279	EFO27	Cell Line	OVARY	NP_127497	c.439C>T	p.R147C	CCLE	PASSENGER/OTHER	Probably Damaging
280	FTC133	Cell Line	THYROID	NP_127497	c.104G>T	p.R35M	CCLE	PASSENGER/OTHER	Benign
281	HCC1359	Cell Line	LUNG	NP_127497	c.4269_4269delC	p.P1423fs	CCLE	NP	NP
282	HCT15	Cell Line	LARGE INTESTINE	NP_127497	c.2501G>T	p.R834L	CCLE	PASSENGER/OTHER	Benign
283	HEC108	Cell Line	ENDOMETRIUM	NP_127497	c.3041G>A	p.R1014K	CCLE	PASSENGER/OTHER	Probably Damaging
284	HEC151	Cell Line	ENDOMETRIUM	NP_127497	c.52_54delAAG	p.K18del	CCLE	NP	NP
285	HEC251	Cell Line	ENDOMETRIUM	NP_127497	c.3376G>T	p.E1126*	CCLE	NP	NP
286	HEC251	Cell Line	ENDOMETRIUM	NP_127497	c.3387C>A	p.F1129L	CCLE	PASSENGER/OTHER	Probably Damaging
287	HEC251	Cell Line	ENDOMETRIUM	NP_127497	c.3934C>T	p.R1312*	CCLE	NP	NP
288	HS840T	Cell Line	UPPER AERODIGESTIVE TRACT	NP_127497	c.1418C>T	p.A473V	CCLE	PASSENGER/OTHER	Possibly Damaging
289	HT	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_127497	c.2462G>T	p.S821I	CCLE	PASSENGER/OTHER	Probably Damaging
290	HT144	Cell Line	SKIN	NP_127497	c.1340C>T	p.T447I	CCLE	PASSENGER/OTHER	Possibly Damaging
291	IGROV1	Cell Line	OVARY	NP_127497	c.1461G>T	p.K487N	CCLE	PASSENGER/OTHER	Possibly Damaging
292	IPC298	Cell Line	SKIN	NP_127497	c.2531T>C	p.L844S	CCLE	PASSENGER/OTHER	Probably Damaging
293	ISHIKAWAHERAKLIO02ER	Cell Line	ENDOMETRIUM	NP_127497	c.2055_2056delGA	p.E685fs	CCLE	NP	NP
294	JK1	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_127497	c.2756G>A	p.S919N	CCLE	PASSENGER/OTHER	Possibly Damaging
295	KASUMI2	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_127497	c.2700_splice	p.Q900_splice	CCLE	NP	NP
296	KPL1	Cell Line	BREAST	NP_127497	c.725C>A	p.P242Q	CCLE	PASSENGER/OTHER	Benign
297	KYSE270	Cell Line	OESOPHAGUS	NP_127497	c.1199C>G	p.S400C	CCLE	PASSENGER/OTHER	Probably Damaging
298	KYSE450	Cell Line	OESOPHAGUS	NP_127497	c.3001G>A	p.G1001R	CCLE	PASSENGER/OTHER	Benign
299	L540	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_127497	c.361A>T	p.I121F	CCLE	PASSENGER/OTHER	Benign
300	LOVO	Cell Line	LARGE INTESTINE	NP_127497	c.120G>T	p.E40D	CCLE	PASSENGER/OTHER	Possibly Damaging
301	LS411N	Cell Line	LARGE INTESTINE	NP_127497	c.4279C>T	p.R1427W	CCLE	PASSENGER/OTHER	Probably Damaging
302	MALME3M	Cell Line	SKIN	NP_127497	c.4057_splice	p.G1353_splice	CCLE	NP	NP
303	MCF7	Cell Line	BREAST	NP_127497	c.725C>A	p.P242Q	CCLE	PASSENGER/OTHER	Benign
304	MFE319	Cell Line	ENDOMETRIUM	NP_127497	c.3046G>T	p.G1016*	CCLE	NP	NP
305	MFE319	Cell Line	ENDOMETRIUM	NP_127497	c.68A>G	p.E23G	CCLE	PASSENGER/OTHER	Probably Damaging
306	MOLM13	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_127497	c.2809G>A	p.V937I	CCLE	PASSENGER/OTHER	Benign
307	NCIH1339	Cell Line	LUNG	NP_127497	c.4321A>C	p.K1441Q	CCLE	PASSENGER/OTHER	Probably Damaging
308	NCIH1876	Cell Line	LUNG	NP_127497	c.1424G>A	p.W475*	CCLE	NP	NP
309	OVK18	Cell Line	OVARY	NP_127497	c.2639C>T	p.A880V	CCLE	PASSENGER/OTHER	Probably Damaging
310	RCHACV	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_127497	c.3785C>T	p.A1262V	CCLE	PASSENGER/OTHER	Probably Damaging
311	SKMEL1	Cell Line	SKIN	NP_127497	c.766G>A	p.E256K	CCLE	PASSENGER/OTHER	Benign
312	SNU1040	Cell Line	LARGE INTESTINE	NP_127497	c.3280G>A	p.E1094K	CCLE	PASSENGER/OTHER	Probably Damaging
313	SNU1040	Cell Line	LARGE INTESTINE	NP_127497	c.3365C>T	p.A1122V	CCLE	PASSENGER/OTHER	Probably Damaging
314	SNUC4	Cell Line	LARGE INTESTINE	NP_127497	c.1748_1749insA	p.K583fs	CCLE	NP	NP
315	SUPB15	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_127497	c.4193T>A	p.V1398D	CCLE	PASSENGER/OTHER	Benign
316	TOV21G	Cell Line	OVARY	NP_127497	c.1748_1748delA	p.K583fs	CCLE	NP	NP
317	WM115	Cell Line	SKIN	NP_127497	c.1708G>A	p.D570N	CCLE	PASSENGER/OTHER	Benign
318	WM2664	Cell Line	SKIN	NP_127497	c.1708G>A	p.D570N	CCLE	PASSENGER/OTHER	Benign
319	A498	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000572272	c.3811C>G	p.Q1271E	COSMIC	NP	NP
320	Br27P	Tumour	CENTRAL NERVOUS SYSTEM	ENST00000572272	c.1180C>T	p.P394S	COSMIC	NP	NP
321	ESO-0015	Tumour	OESOPHAGUS	ENST00000572272	c.3517C>G	p.Q1173E	COSMIC	NP	NP
322	ESO-1670	Tumour	OESOPHAGUS	ENST00000572272	c.2186C>T	p.T729M	COSMIC	NP	NP
323	ESO-K08	Tumour	OESOPHAGUS	ENST00000572272	c.2031G>C	p.L677L	COSMIC	NP	NP
324	GC1	Tumour	T STOMACH	ENST00000572272	c.2942T>G	p.L981R	COSMIC	NP	NP
325	HCC03T	Tumour	LIVER	ENST00000572272	c.1745A>C	p.K582T	COSMIC	NP	NP
326	HCC07T	Tumour	LIVER	ENST00000572272	c.3229G>A	p.D1077N	COSMIC	NP	NP
327	HCC1143	Cell Line	BREAST	ENST00000572272	c.2669G>A	p.R890K	COSMIC	PASSENGER/OTHER	Benign
328	HCC17T	Tumour	LIVER	ENST00000572272	c.1607G>A	p.R536Q	COSMIC	NP	NP
329	HCC207T	Tumour	LIVER	ENST00000572272	c.1593G>A	p.M531I	COSMIC	NP	NP
330	HCC207T	Tumour	LIVER	ENST00000572272	c.1594C>A	p.Q532K	COSMIC	NP	NP
331	HCC208T	Tumour	LIVER	ENST00000572272	c.2792A>T	p.Q931L	COSMIC	NP	NP
332	HCC2998	Cell Line	LARGE INTESTINE	ENST00000572272	c.3383A>C	p.E1128A	COSMIC	NP	NP
333	HN	Tumour	63115 UPPER AERODIGESTIVE TRACT	ENST00000572272	c.4152G>T	p.Q1384H	COSMIC	NP	NP
334	LC	Tumour	C9 LUNG	ENST00000572272	c.1416G>T	p.Q472H	COSMIC	NP	NP
335	LUAD	Tumour	E00623 LUNG	ENST00000572272	c.3784-2A>T	p.?	COSMIC	NP	NP
336	LUAD-5V8LT	Tumour	LUNG	ENST00000572272	c.1720C>A	p.L574M	COSMIC	NP	NP
337	LUAD-B00859	Tumour	LUNG	ENST00000572272	c.3783G>T	p.K1261N	COSMIC	NP	NP
338	LUAD-B01811	Tumour	LUNG	ENST00000572272	c.3264T>A	p.T1088T	COSMIC	NP	NP
339	LUAD-B02515	Tumour	LUNG	ENST00000572272	c.3241G>T	p.G1081C	COSMIC	NP	NP
340	LUAD-E00897	Tumour	LUNG	ENST00000572272	c.1648C>A	p.L550I	COSMIC	NP	NP
341	LUAD-F00368	Tumour	LUNG	ENST00000572272	c.2557G>T	p.D853Y	COSMIC	NP	NP
342	LUAD-NYU1128	Tumour	LUNG	ENST00000572272	c.2320C>T	p.Q774*	COSMIC	NP	NP
343	LUAD-RT-S01813	Tumour	LUNG	ENST00000572272	c.415C>A	p.Q139K	COSMIC	NP	NP
344	LUAD-RT-S01818	Tumour	LUNG	ENST00000572272	c.2986G>T	p.E996*	COSMIC	NP	NP
345	LUAD-RT-S01866	Tumour	LUNG	ENST00000572272	c.3313G>T	p.A1105S	COSMIC	NP	NP
346	LUAD-S00486	Tumour	LUNG	ENST00000572272	c.961G>A	p.G321S	COSMIC	NP	NP
347	LUAD-S01315	Tumour	LUNG	ENST00000572272	c.4360C>T	p.H1454Y	COSMIC	NP	NP
348	LUAD-S01413	Tumour	LUNG	ENST00000572272	c.3145C>T	p.P1049S	COSMIC	NP	NP
349	LUAD-YINHD	Tumour	LUNG	ENST00000572272	c.3524G>T	p.G1175V	COSMIC	NP	NP
350	LUAD-YINHD	Tumour	LUNG	ENST00000572272	c.4377C>G	p.L1459L	COSMIC	NP	NP
351	ME002T	Tumour	SKIN	ENST00000572272	c.2908G>A	p.E970K	COSMIC	NP	NP
352	ME011T	Tumour	SKIN	ENST00000572272	c.807G>A	p.W269*	COSMIC	NP	NP
353	ME041T	Tumour	SKIN	ENST00000572272	c.2215G>A	p.E739K	COSMIC	NP	NP
354	MOLT-4	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000572272	c.922C>T	p.R308*	COSMIC	NP	NP
355	MZ7-mel	Cell Line	SKIN	ENST00000572272	c.489C>T	p.S163S	COSMIC	NP	NP
356	NB-1942	Tumour	AUTONOMIC GANGLIA	ENST00000572272	c.1470C>A	p.F490L	COSMIC	NP	NP
357	NB1940T	Tumour	AUTONOMIC GANGLIA	ENST00000572272	c.2270G>T	p.C757F	COSMIC	NP	NP
358	NCI-H128	Cell Line	LUNG	ENST00000572272	c.3453G>T	p.L1151L	COSMIC	NP	NP
359	NCI-H1395	Cell Line	LUNG	ENST00000572272	c.1963A>T	p.K655*	COSMIC	NP	NP
360	NCI-H1395	Cell Line	LUNG	ENST00000572272	c.808A>T	p.K270*	COSMIC	NP	NP
361	NCI-H1437	Cell Line	LUNG	ENST00000572272	c.2389T>A	p.W797R	COSMIC	NP	NP
362	P08-2516	Tumour	PROSTATE	ENST00000572272	c.2999C>T	p.T1000M	COSMIC	NP	NP
363	PD4107a	Tumour	BREAST	ENST00000572272	c.1847C>G	p.P616R	COSMIC	NP	NP
364	PD6367a	Tumour	NS	ENST00000572272	c.436C>T	p.R146C	COSMIC	NP	NP
365	Patient1	Tumour	OVARY	ENST00000572272	c.3414G>C	p.E1138D	COSMIC	NP	NP
366	SWE-28	Tumour	PROSTATE	ENST00000572272	c.2818C>T	p.R940*	COSMIC	NP	NP
367	TCGA-05-4427-01	Tumour	LUNG	ENST00000572272	c.701G>A	p.W234*	COSMIC	NP	NP
368	TCGA-09-2056-01	Tumour	OVARY	ENST00000572272	c.1308G>A	p.A436A	COSMIC	NP	NP
369	TCGA-22-4601-01	Tumour	LUNG	ENST00000572272	c.3423A>G	p.P1141P	COSMIC	NP	NP
370	TCGA-22-5473-01	Tumour	LUNG	ENST00000572272	c.4268C>A	p.P1423H	COSMIC	NP	NP
371	TCGA-33-6737-01	Tumour	LUNG	ENST00000572272	c.4039G>A	p.E1347K	COSMIC	NP	NP
372	TCGA-44-2659-01	Tumour	LUNG	ENST00000572272	c.1418C>T	p.A473V	COSMIC	NP	NP
373	TCGA-50-5939-01	Tumour	LUNG	ENST00000572272	c.3214C>T	p.P1072S	COSMIC	NP	NP
374	TCGA-53-7624-01	Tumour	LUNG	ENST00000572272	c.51G>A	p.K17K	COSMIC	NP	NP
375	TCGA-55-8089-01	Tumour	LUNG	ENST00000572272	c.1437G>T	p.L479L	COSMIC	NP	NP
376	TCGA-60-2721-01	Tumour	LUNG	ENST00000572272	c.3860G>A	p.G1287D	COSMIC	NP	NP
377	TCGA-66-2744-01	Tumour	LUNG	ENST00000572272	c.4055C>A	p.P1352Q	COSMIC	NP	NP
378	TCGA-67-3771-01	Tumour	LUNG	ENST00000572272	c.256G>A	p.A86T	COSMIC	NP	NP
379	TCGA-67-3771-01	Tumour	LUNG	ENST00000572272	c.684G>A	p.E228E	COSMIC	NP	NP
380	TCGA-69-7980-01	Tumour	LUNG	ENST00000572272	c.1391A>C	p.Q464P	COSMIC	NP	NP
381	TCGA-78-7149-01	Tumour	LUNG	ENST00000572272	c.3265G>A	p.E1089K	COSMIC	NP	NP
382	TCGA-95-7043-01	Tumour	LUNG	ENST00000572272	c.598G>T	p.E200*	COSMIC	NP	NP
383	TCGA-99-8032-01	Tumour	LUNG	ENST00000572272	c.3974T>C	p.V1325A	COSMIC	NP	NP
384	TCGA-A5-A0GP-01	Tumour	ENDOMETRIUM	ENST00000572272	c.1661A>G	p.Y554C	COSMIC	NP	NP
385	TCGA-A8-A097-01	Tumour	BREAST	ENST00000572272	c.3118A>G	p.I1040V	COSMIC	NP	NP
386	TCGA-AA-3510-01	Tumour	LARGE INTESTINE	ENST00000572272	c.3946G>T	p.E1316*	COSMIC	NP	NP
387	TCGA-AA-3525-01	Tumour	LARGE INTESTINE	ENST00000572272	c.1542G>T	p.W514C	COSMIC	NP	NP
388	TCGA-AA-3525-01	Tumour	LARGE INTESTINE	ENST00000572272	c.3673G>A	p.A1225T	COSMIC	NP	NP
389	TCGA-AA-3534-01	Tumour	LARGE INTESTINE	ENST00000572272	c.2959C>T	p.R987W	COSMIC	NP	NP
390	TCGA-AA-3715-01	Tumour	LARGE INTESTINE	ENST00000572272	c.4143T>C	p.F1381F	COSMIC	NP	NP
391	TCGA-AA-3821-01	Tumour	LARGE INTESTINE	ENST00000572272	c.3914A>G	p.K1305R	COSMIC	NP	NP
392	TCGA-AA-3833-01	Tumour	LARGE INTESTINE	ENST00000572272	c.3638C>T	p.S1213F	COSMIC	NP	NP
393	TCGA-AA-3864-01	Tumour	LARGE INTESTINE	ENST00000572272	c.3339G>A	p.T1113T	COSMIC	NP	NP
394	TCGA-AA-3977-01	Tumour	LARGE INTESTINE	ENST00000572272	c.2186C>T	p.T729M	COSMIC	NP	NP
395	TCGA-AA-3977-01	Tumour	LARGE INTESTINE	ENST00000572272	c.510C>T	p.S170S	COSMIC	NP	NP
396	TCGA-AA-3982-01	Tumour	LARGE INTESTINE	ENST00000572272	c.1371G>A	p.T457T	COSMIC	NP	NP
397	TCGA-AA-A00D-01	Tumour	LARGE INTESTINE	ENST00000572272	c.2809G>A	p.V937I	COSMIC	NP	NP
398	TCGA-AA-A00N-01	Tumour	LARGE INTESTINE	ENST00000572272	c.2266T>G	p.F756V	COSMIC	NP	NP
399	TCGA-AA-A010-01	Tumour	LARGE INTESTINE	ENST00000572272	c.373C>T	p.P125S	COSMIC	NP	NP
400	TCGA-AD-6889-01	Tumour	LARGE INTESTINE	ENST00000572272	c.2818C>T	p.R940*	COSMIC	NP	NP
401	TCGA-AG-3731-01	Tumour	LARGE INTESTINE	ENST00000572272	c.2668A>G	p.R890G	COSMIC	NP	NP
402	TCGA-AG-3892-01	Tumour	LARGE INTESTINE	ENST00000572272	c.1887C>A	p.F629L	COSMIC	NP	NP
403	TCGA-AG-3892-01	Tumour	LARGE INTESTINE	ENST00000572272	c.2214C>T	p.F738F	COSMIC	NP	NP
404	TCGA-AG-4007-01	Tumour	LARGE INTESTINE	ENST00000572272	c.3373G>A	p.V1125I	COSMIC	NP	NP
405	TCGA-AG-A011-01	Tumour	LARGE INTESTINE	ENST00000572272	c.4271G>T	p.S1424I	COSMIC	NP	NP
406	TCGA-AP-A056-01	Tumour	ENDOMETRIUM	ENST00000572272	c.2784C>T	p.D928D	COSMIC	NP	NP
407	TCGA-AP-A056-01	Tumour	ENDOMETRIUM	ENST00000572272	c.3387C>A	p.F1129L	COSMIC	NP	NP
408	TCGA-AP-A056-01	Tumour	ENDOMETRIUM	ENST00000572272	c.3865C>T	p.R1289C	COSMIC	NP	NP
409	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000572272	c.4184C>T	p.S1395L	COSMIC	NP	NP
410	TCGA-AP-A0L8-01	Tumour	ENDOMETRIUM	ENST00000572272	c.1212G>A	p.R404R	COSMIC	NP	NP
411	TCGA-AP-A0LD-01	Tumour	ENDOMETRIUM	ENST00000572272	c.2698C>T	p.Q900*	COSMIC	NP	NP
412	TCGA-AP-A0LE-01	Tumour	ENDOMETRIUM	ENST00000572272	c.3669T>C	p.H1223H	COSMIC	NP	NP
413	TCGA-AP-A0LM-01	Tumour	ENDOMETRIUM	ENST00000572272	c.377C>T	p.A126V	COSMIC	NP	NP
414	TCGA-AX-A05Z-01	Tumour	ENDOMETRIUM	ENST00000572272	c.3720C>T	p.R1240R	COSMIC	NP	NP
415	TCGA-AX-A05Z-01	Tumour	ENDOMETRIUM	ENST00000572272	c.3962C>T	p.S1321L	COSMIC	NP	NP
416	TCGA-AX-A0J0-01	Tumour	ENDOMETRIUM	ENST00000572272	c.850C>A	p.L284I	COSMIC	NP	NP
417	TCGA-AZ-4315-01	Tumour	LARGE INTESTINE	ENST00000572272	c.2194A>G	p.T732A	COSMIC	NP	NP
418	TCGA-B0-4810-01	Tumour	KIDNEY	ENST00000572272	c.1542G>A	p.W514*	COSMIC	NP	NP
419	TCGA-B0-5094-01	Tumour	KIDNEY	ENST00000572272	c.3521-1G>T	p.?	COSMIC	NP	NP
420	TCGA-B5-A0JY-01	Tumour	ENDOMETRIUM	ENST00000572272	c.763T>C	p.W255R	COSMIC	NP	NP
421	TCGA-B5-A0JY-01	Tumour	ENDOMETRIUM	ENST00000572272	c.880C>T	p.P294S	COSMIC	NP	NP
422	TCGA-B5-A11E-01	Tumour	ENDOMETRIUM	ENST00000572272	c.3034C>T	p.R1012W	COSMIC	NP	NP
423	TCGA-BG-A0LX-01	Tumour	ENDOMETRIUM	ENST00000572272	c.3601G>T	p.E1201*	COSMIC	NP	NP
424	TCGA-BG-A0M4-01	Tumour	ENDOMETRIUM	ENST00000572272	c.784A>C	p.S262R	COSMIC	NP	NP
425	TCGA-BH-A0BV-01	Tumour	BREAST	ENST00000572272	c.1637C>T	p.T546I	COSMIC	NP	NP
426	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000572272	c.1887C>A	p.F629L	COSMIC	NP	NP
427	TCGA-CA-6717-01	Tumour	LARGE INTESTINE	ENST00000572272	c.3133+8C>T	p.?	COSMIC	NP	NP
428	TCGA-CA-6717-01	Tumour	LARGE INTESTINE	ENST00000572272	c.377C>T	p.A126V	COSMIC	NP	NP
429	TCGA-CA-6717-01	Tumour	LARGE INTESTINE	ENST00000572272	c.3865C>T	p.R1289C	COSMIC	NP	NP
430	TCGA-CA-6717-01	Tumour	LARGE INTESTINE	ENST00000572272	c.3870C>T	p.Y1290Y	COSMIC	NP	NP
431	TCGA-CA-6717-01	Tumour	LARGE INTESTINE	ENST00000572272	c.3878C>T	p.S1293F	COSMIC	NP	NP
432	TCGA-CA-6719-01	Tumour	LARGE INTESTINE	ENST00000572272	c.808A>G	p.K270E	COSMIC	NP	NP
433	TCGA-CH-5741-01	Tumour	PROSTATE	ENST00000572272	c.4169T>C	p.I1390T	COSMIC	NP	NP
434	TCGA-CK-5914-01	Tumour	LARGE INTESTINE	ENST00000572272	c.2390G>A	p.W797*	COSMIC	NP	NP
435	TCGA-CK-5916-01	Tumour	LARGE INTESTINE	ENST00000572272	c.1748delA	p.K583fs*14	COSMIC	NP	NP
436	TCGA-CK-6747-01	Tumour	LARGE INTESTINE	ENST00000572272	c.1142C>A	p.A381D	COSMIC	NP	NP
437	TCGA-CL-5917-01	Tumour	LARGE INTESTINE	ENST00000572272	c.1964A>G	p.K655R	COSMIC	NP	NP
438	TCGA-CM-4747-01	Tumour	LARGE INTESTINE	ENST00000572272	c.3174C>T	p.C1058C	COSMIC	NP	NP
439	TCGA-CM-5861-01	Tumour	LARGE INTESTINE	ENST00000572272	c.1330C>T	p.L444L	COSMIC	NP	NP
440	TCGA-CM-6162-01	Tumour	LARGE INTESTINE	ENST00000572272	c.226C>T	p.Q76*	COSMIC	NP	NP
441	TCGA-CM-6171-01	Tumour	LARGE INTESTINE	ENST00000572272	c.2529-1G>T	p.?	COSMIC	NP	NP
442	TCGA-D1-A167-01	Tumour	ENDOMETRIUM	ENST00000572272	c.436C>T	p.R146C	COSMIC	NP	NP
443	TCGA-D1-A16R-01	Tumour	ENDOMETRIUM	ENST00000572272	c.1399A>G	p.I467V	COSMIC	NP	NP
444	TCGA-D1-A17D-01	Tumour	ENDOMETRIUM	ENST00000572272	c.3778C>T	p.R1260W	COSMIC	NP	NP
445	TCGA-D1-A17Q-01	Tumour	ENDOMETRIUM	ENST00000572272	c.3275A>G	p.D1092G	COSMIC	NP	NP
446	TCGA-D1-A17Q-01	Tumour	ENDOMETRIUM	ENST00000572272	c.3934C>T	p.R1312*	COSMIC	NP	NP
447	TCGA-D5-5538-01	Tumour	LARGE INTESTINE	ENST00000572272	c.3200A>T	p.D1067V	COSMIC	NP	NP
448	TCGA-D8-A1XL-01	Tumour	BREAST	ENST00000572272	c.2142C>T	p.H714H	COSMIC	NP	NP
449	TCGA-DC-5337-01	Tumour	LARGE INTESTINE	ENST00000572272	c.1964A>G	p.K655R	COSMIC	NP	NP
450	TCGA-DK-A1A3-01	Tumour	URINARY TRACT	ENST00000572272	c.1194C>T	p.I398I	COSMIC	NP	NP
451	TCGA-DR-A0ZM-01	Tumour	CERVIX	ENST00000572272	c.3009G>C	p.M1003I	COSMIC	NP	NP
452	TCGA-DY-A0XA-01	Tumour	LARGE INTESTINE	ENST00000572272	c.809A>G	p.K270R	COSMIC	NP	NP
453	TCGA-G4-6293-01	Tumour	LARGE INTESTINE	ENST00000572272	c.2668A>G	p.R890G	COSMIC	NP	NP
454	TCGA-G9-6367-01	Tumour	PROSTATE	ENST00000572272	c.464T>A	p.L155H	COSMIC	NP	NP
455	YUAKER	Tumour	SKIN	ENST00000572272	c.3804G>A	p.M1268I	COSMIC	NP	NP
456	YUKLAB	Tumour	SKIN	ENST00000572272	c.1376_1377GG>AA	p.R459Q	COSMIC	NP	NP
457	YUKLAB	Tumour	SKIN	ENST00000572272	c.2251C>T	p.L751F	COSMIC	NP	NP
458	YUKLAB	Tumour	SKIN	ENST00000572272	c.3163G>A	p.E1055K	COSMIC	NP	NP
459	YULAN	Tumour	SKIN	ENST00000572272	c.4024G>A	p.E1342K	COSMIC	NP	NP
460	YUMUT	Tumour	SKIN	ENST00000572272	c.2302C>T	p.Q768*	COSMIC	NP	NP
461	YURIF	Cell Line	SKIN	ENST00000572272	c.1384G>A	p.A462T	COSMIC	NP	NP
462	YURTHE	Tumour	SKIN	ENST00000572272	c.1441T>C	p.F481L	COSMIC	NP	NP
463	YUVAIL	Tumour	SKIN	ENST00000572272	c.367G>A	p.E123K	COSMIC	NP	NP
464	ccRCC-77	Tumour	KIDNEY	ENST00000572272	c.491C>A	p.P164Q	COSMIC	NP	NP
465	pfg008T	Tumour	STOMACH	ENST00000572272	c.3396G>T	p.W1132C	COSMIC	NP	NP
466	451LU	Cell Line	SKIN	ENST00000572272	c.3706T>C	p.L1236L	COSMIC	NP	NP
467	639V	Cell Line	URINARY_TRACT	ENST00000572272	c.1370C>T	p.T457M	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
468	A498	Cell Line	KIDNEY	ENST00000572272	c.3811C>G	p.Q1271E	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
469	A4FUK	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000572272	c.2369T>C	p.V790A	COSMIC	PASSENGER/OTHER	BENIGN
470	BL70	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000572272	c.2320C>T	p.Q774*	COSMIC	NP	NP
471	BT20	Cell Line	BREAST	ENST00000572272	c.1746A>T	p.K582N	COSMIC	PASSENGER/OTHER	BENIGN
472	C32	Cell Line	SKIN	ENST00000572272	c.2170G>A	p.E724K	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
473	COLO741	Cell Line	LARGE_INTESTINE	ENST00000572272	c.883delC	p.L295fs*17	COSMIC	NP	NP
474	DG75	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000572272	c.524A>G	p.N175S	COSMIC	PASSENGER/OTHER	BENIGN
475	ECC10	Cell Line	STOMACH	ENST00000572272	c.525C>T	p.N175N	COSMIC	NP	NP
476	EN	Cell Line	ENDOMETRIUM	ENST00000572272	c.1399A>G	p.I467V	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
477	GRST	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000572272	c.3326G>A	p.R1109H	COSMIC	PASSENGER/OTHER	BENIGN
478	H2731	Cell Line	PLEURA	ENST00000572272	c.3355A>T	p.M1119L	COSMIC	PASSENGER/OTHER	BENIGN
479	H290	Cell Line	PLEURA	ENST00000572272	c.2077C>T	p.R693W	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
480	HCC1143	Cell Line	BREAST	ENST00000572272	c.2669G>A	p.R890K	COSMIC	PASSENGER/OTHER	BENIGN
481	HCC2998	Cell Line	LARGE_INTESTINE	ENST00000572272	c.1887C>T	p.F629F	COSMIC	NP	NP
482	HCC2998	Cell Line	LARGE_INTESTINE	ENST00000572272	c.3383A>C	p.E1128A	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
483	HCC2998	Cell Line	LARGE_INTESTINE	ENST00000572272	c.3521-9C>A	p.?	COSMIC	NP	NP
484	HCT15	Cell Line	LARGE_INTESTINE	ENST00000572272	c.3220G>A	p.G1074R	COSMIC	PASSENGER/OTHER	BENIGN
485	HS939T	Cell Line	SKIN	ENST00000572272	c.2394G>A	p.Q798Q	COSMIC	NP	NP
486	HT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000572272	c.2462G>T	p.S821I	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
487	HT115	Cell Line	LARGE_INTESTINE	ENST00000572272	c.4103-9C>T	p.?	COSMIC	NP	NP
488	HUTU80	Cell Line	SMALL_INTESTINE	ENST00000572272	c.3613A>G	p.I1205V	COSMIC	PASSENGER/OTHER	BENIGN
489	IGROV1	Cell Line	OVARY	ENST00000572272	c.1461G>T	p.K487N	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
490	IGROV1	Cell Line	OVARY	ENST00000572272	c.675G>A	p.E225E	COSMIC	NP	NP
491	IPC298	Cell Line	SKIN	ENST00000572272	c.2531T>C	p.L844S	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
492	JEG3	Cell Line	PLACENTA	ENST00000572272	c.2290G>A	p.V764M	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
493	JHH7	Cell Line	LIVER	ENST00000572272	c.525C>T	p.N175N	COSMIC	NP	NP
494	JHOS4	Cell Line	OVARY	ENST00000572272	c.1929A>G	p.R643R	COSMIC	NP	NP
495	JURKAT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000572272	c.2808C>T	p.D936D	COSMIC	NP	NP
496	KARPAS45	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000572272	c.1990G>T	p.G664C	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
497	KINGS1	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000572272	c.2002G>T	p.A668S	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
498	KYSE270	Cell Line	OESOPHAGUS	ENST00000572272	c.1199C>G	p.S400C	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
499	KYSE450	Cell Line	OESOPHAGUS	ENST00000572272	c.3001G>A	p.G1001R	COSMIC	PASSENGER/OTHER	BENIGN
500	L428	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000572272	c.3678G>A	p.L1226L	COSMIC	NP	NP
501	L540	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000572272	c.361A>T	p.I121F	COSMIC	PASSENGER/OTHER	BENIGN
502	LS411N	Cell Line	LARGE_INTESTINE	ENST00000572272	c.4279C>T	p.R1427W	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
503	MCC26	Cell Line	SKIN	ENST00000572272	c.2911C>A	p.L971M	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
504	MCF7	Cell Line	BREAST	ENST00000572272	c.725C>A	p.P242Q	COSMIC	PASSENGER/OTHER	BENIGN
505	MDAMB157	Cell Line	BREAST	ENST00000572272	c.343G>A	p.A115T	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
506	MEWO	Cell Line	SKIN	ENST00000572272	c.3732G>A	p.E1244E	COSMIC	NP	NP
507	MFE319	Cell Line	ENDOMETRIUM	ENST00000572272	c.3046G>T	p.G1016*	COSMIC	NP	NP
508	MFE319	Cell Line	ENDOMETRIUM	ENST00000572272	c.68A>G	p.E23G	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
509	MKN1	Cell Line	STOMACH	ENST00000572272	c.1555G>T	p.V519L	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
510	MOLM13	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000572272	c.2809G>A	p.V937I	COSMIC	PASSENGER/OTHER	BENIGN
511	MOLT4	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000572272	c.922C>T	p.R308*	COSMIC	NP	NP
512	MZ7MEL	Cell Line	SKIN	ENST00000572272	c.489C>T	p.S163S	COSMIC	NP	NP
513	NCIH128	Cell Line	LUNG	ENST00000572272	c.3453G>T	p.L1151L	COSMIC	NP	NP
514	NCIH1437	Cell Line	LUNG	ENST00000572272	c.2389T>A	p.W797R	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
515	NCIH1792	Cell Line	LUNG	ENST00000572272	c.2056A>G	p.M686V	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
516	NCIH1792	Cell Line	LUNG	ENST00000572272	c.3721G>A	p.V1241I	COSMIC	PASSENGER/OTHER	BENIGN
517	NCIH1876	Cell Line	LUNG	ENST00000572272	c.1424G>A	p.W475*	COSMIC	NP	NP
518	NCIH2170	Cell Line	LUNG	ENST00000572272	c.2864G>T	p.R955L	COSMIC	PASSENGER/OTHER	BENIGN
519	NCIH630	Cell Line	LARGE_INTESTINE	ENST00000572272	c.4058-3C>T	p.?	COSMIC	NP	NP
520	NCIH660	Cell Line	PROSTATE	ENST00000572272	c.302G>T	p.S101I	COSMIC	PASSENGER/OTHER	BENIGN
521	NCIH661	Cell Line	LUNG	ENST00000572272	c.4095C>A	p.A1365A	COSMIC	NP	NP
522	NCIH748	Cell Line	LUNG	ENST00000572272	c.2720C>T	p.T907M	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
523	OVK18	Cell Line	OVARY	ENST00000572272	c.2639C>T	p.A880V	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
524	OVMIU	Cell Line	OVARY	ENST00000572272	c.994C>G	p.L332V	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
525	SARC9371	Cell Line	BONE	ENST00000572272	c.3804G>A	p.M1268I	COSMIC	PASSENGER/OTHER	BENIGN
526	SH4	Cell Line	SKIN	ENST00000572272	c.3296+8A>C	p.?	COSMIC	NP	NP
527	SKMEL1	Cell Line	SKIN	ENST00000572272	c.1607G>A	p.R536Q	COSMIC	PASSENGER/OTHER	BENIGN
528	SKMEL1	Cell Line	SKIN	ENST00000572272	c.766G>A	p.E256K	COSMIC	PASSENGER/OTHER	BENIGN
529	SKMEL1	Cell Line	SKIN	ENST00000572272	c.768G>A	p.E256E	COSMIC	NP	NP
530	SKMEL31	Cell Line	SKIN	ENST00000572272	c.1346T>C	p.L449P	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
531	SKMEL31	Cell Line	SKIN	ENST00000572272	c.1349C>T	p.P450L	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
532	SKMEL31	Cell Line	SKIN	ENST00000572272	c.1350C>A	p.P450P	COSMIC	NP	NP
533	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000572272	c.2154C>T	p.S718S	COSMIC	NP	NP
534	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000572272	c.2356C>A	p.L786M	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
535	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000572272	c.3365C>T	p.A1122V	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
536	SNU175	Cell Line	LARGE_INTESTINE	ENST00000572272	c.3720C>T	p.R1240R	COSMIC	NP	NP
537	SNU81	Cell Line	LARGE_INTESTINE	ENST00000572272	c.4356T>C	p.H1452H	COSMIC	NP	NP
538	SNUC2B	Cell Line	LARGE_INTESTINE	ENST00000572272	c.983G>A	p.R328H	COSMIC	PASSENGER/OTHER	BENIGN
539	SUPB15	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000572272	c.4193T>A	p.V1398D	COSMIC	PASSENGER/OTHER	BENIGN
540	SW13	Cell Line	ADRENAL_GLAND	ENST00000572272	c.331C>T	p.P111S	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
541	SW684	Cell Line	SOFT_TISSUE	ENST00000572272	c.665G>A	p.R222K	COSMIC	PASSENGER/OTHER	BENIGN
542	SW756	Cell Line	CERVIX	ENST00000572272	c.1828C>G	p.L610V	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
543	TCYIK	Cell Line	CERVIX	ENST00000572272	c.1310A>G	p.D437G	COSMIC	PASSENGER/OTHER	BENIGN
544	TE4	Cell Line	OESOPHAGUS	ENST00000572272	c.1740G>T	p.W580C	COSMIC	PASSENGER/OTHER	BENIGN
545	TOV21G	Cell Line	OVARY	ENST00000572272	c.1748delA	p.K583fs*14	COSMIC	NP	NP
546	WM115	Cell Line	SKIN	ENST00000572272	c.1708G>A	p.D570N	COSMIC	PASSENGER/OTHER	BENIGN
547	YT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000572272	c.525C>T	p.N175N	COSMIC	NP	NP
548	ZR7530	Cell Line	BREAST	ENST00000572272	c.4167G>A	p.L1389L	COSMIC	NP	NP

*NP: Not Predicted

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	4.2368	4.1513	-0.2381	-0.09234
BILIARY TRACT	4.4041	4.3519	-0.2135	-0.3225
BONE	4.8832	5.1806	-0.0608	-0.0352
BREAST	4.5626	4.2863	-0.2460	-0.10255
CENTRAL NERVOUS SYSTEM	4.5593	4.413	-0.0912	-0.01298
ENDOMETRIUM	4.7551	4.3856	0.0232	-0.0079
HAEMATOPOIETIC AND LYMPHOID TISSUE	5.4490	5.2656	-0.2776	-0.0526
KIDNEY	5.0273	4.8333	-0.0008	0.0859
LARGE INTESTINE	4.4250	4.2254	-0.2331	-0.1032
LIVER	4.5722	4.2671	-0.1731	-0.2333
LUNG	4.5262	4.27695	-0.1590	-0.10135
OESOPHAGUS	4.9582	4.3571	0.0779	0.1163
OVARY	4.4662	4.2672	-0.3399	-0.2623
PANCREAS	4.6438	4.4236	-0.3720	-0.4088
PLEURA	4.7391	4.5132	-0.0685	-0.0688
PROSTATE	4.5697	4.48965	0.0708	0.04535
SALIVARY GLAND	4.8823	4.8823	0.3234	0.3234
SKIN	4.7438	4.3717	-0.1169	-0.0168
SMALL INTESTINE	4.1746	4.1746	0.0092	0.009153
SOFT TISSUE	4.7352	4.57035	-0.1011	-0.01035
STOMACH	4.6761	4.32355	-0.2732	-0.15475
THYROID	5.6902	5.10185	-0.1083	-0.09015
UPPER AERODIGESTIVE TRACT	5.3395	5.1238	0.0267	0.016885
URINARY TRACT	4.7205	4.49905	-0.3454	-0.3506

Domain ID	Domain Name	Start Site	End Site	E-value
PF02758	PYRIN	9	88	4.4e-12
PF05729	NACHT	328	497	2.8e-45
PF03042	Birna_VP5	514	534	0.027
PF13516	LRR_6	808	830	0.13
PF13516	LRR_6	864	887	0.00021
PF12799	LRR_4	895	937	0.022
PF13553	FIIND	1099	1355	1.8e-133
PF00619	CARD	1380	1460	1.6e-18
PF02758	PYRIN	9	88	4.4e-12
PF05729	NACHT	328	497	2.8e-45
PF03042	Birna_VP5	514	534	0.027
PF13516	LRR_6	808	830	0.13
PF13516	LRR_6	864	887	0.00021
PF12799	LRR_4	895	937	0.022
PF13553	FIIND	1099	1355	1.8e-133
PF00619	CARD	1380	1460	1.6e-18

Domain ID	Start Site	End Site	E-value
0045711	714	969	1.57e-50
0042393	1	91	2.71e-21
0036193	1376	1462	1.37e-16
0053686	313	415	4.07e-12
0045711	714	969	1.57e-50
0042393	1	91	2.71e-21
0036193	1376	1462	1.37e-16
0053686	313	415	4.07e-12

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
NLRP1	NLRP1	NLRP1	ENSP00000262467	Q9C000
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
Q9C000	NLRP1	ENSP00000262467	NLRP1	Q9C000
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
NLRP1	ENSP00000262467	606636	Q9C000	PA162397797

Protein: NLRP1

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)

Modelled Structure	Structures available in PDB
	1PN5, 3KAT, 4IFP, 4IM6