ApoCanD

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	639V	Cell Line	URINARY TRACT	NP_006776	c.1726C>T	p.R576W	CCLE	PASSENGER/OTHER	Probably Damaging
2	BT20	Cell Line	BREAST	NP_006776	c.1414G>T	p.D472Y	CCLE	PASSENGER/OTHER	Probably Damaging
3	EJM	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_006776	c.2156G>A	p.R719Q	CCLE	PASSENGER/OTHER	Possibly Damaging
4	EN	Cell Line	ENDOMETRIUM	NP_006776	c.1576A>G	p.T526A	CCLE	PASSENGER/OTHER	Probably Damaging
5	GP2D	Cell Line	LARGE INTESTINE	NP_006776	c.781T>C	p.F261L	CCLE	PASSENGER/OTHER	Possibly Damaging
6	HCC2935	Cell Line	LUNG	NP_006776	c.1238C>T	p.A413V	CCLE	PASSENGER/OTHER	Probably Damaging
7	HEC108	Cell Line	ENDOMETRIUM	NP_006776	c.1199T>C	p.L400P	CCLE	PASSENGER/OTHER	Probably Damaging
8	HS172T	Cell Line	URINARY TRACT	NP_006776	c.377_splice	p.G126_splice	CCLE	NP	NP
9	KM12	Cell Line	LARGE INTESTINE	NP_006776	c.1265A>G	p.N422S	CCLE	PASSENGER/OTHER	Probably Damaging
10	KMBC2	Cell Line	URINARY TRACT	NP_006776	c.982C>T	p.P328S	CCLE	PASSENGER/OTHER	Benign
11	KMS21BM	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_006776	c.409G>A	p.A137T	CCLE	PASSENGER/OTHER	Possibly Damaging
12	LCLC97TM1	Cell Line	LUNG	NP_006776	c.1894G>A	p.V632I	CCLE	PASSENGER/OTHER	Benign
13	LOVO	Cell Line	LARGE INTESTINE	NP_006776	c.1102G>A	p.E368K	CCLE	PASSENGER/OTHER	Probably Damaging
14	LOVO	Cell Line	LARGE INTESTINE	NP_006776	c.1651C>T	p.R551*	CCLE	NP	NP
15	MDAPCA2B	Cell Line	PROSTATE	NP_006776	c.1411G>A	p.D471N	CCLE	PASSENGER/OTHER	Probably Damaging
16	MKN7	Cell Line	STOMACH	NP_006776	c.1162G>A	p.E388K	CCLE	PASSENGER/OTHER	Probably Damaging
17	MORCPR	Cell Line	LUNG	NP_006776	c.1012C>T	p.P338S	CCLE	PASSENGER/OTHER	Benign
18	MSTO211H	Cell Line	PLEURA	NP_006776	c.488T>G	p.M163R	CCLE	PASSENGER/OTHER	Possibly Damaging
19	NCIH810	Cell Line	LUNG	NP_006776	c.2353G>T	p.A785S	CCLE	PASSENGER/OTHER	Benign
20	SKOV3	Cell Line	OVARY	NP_006776	c.814_814delA	p.K272fs	CCLE	NP	NP
21	SNU175	Cell Line	LARGE INTESTINE	NP_006776	c.1835T>C	p.M612T	CCLE	PASSENGER/OTHER	Probably Damaging
22	SNU81	Cell Line	LARGE INTESTINE	NP_006776	c.1675G>A	p.A559T	CCLE	PASSENGER/OTHER	Probably Damaging
23	SNU81	Cell Line	LARGE INTESTINE	NP_006776	c.496G>T	p.E166*	CCLE	NP	NP
24	SW780	Cell Line	URINARY TRACT	NP_006776	c.2411C>T	p.P804L	CCLE	PASSENGER/OTHER	Probably Damaging
25	TE9	Cell Line	OESOPHAGUS	NP_006776	c.425_426insG	p.Q142fs	CCLE	NP	NP
26	86788	Tumour	LUNG	ENST00000345724	c.1112C>T	p.S371L	COSMIC	NP	NP
27	Br27P	Tumour	CENTRAL NERVOUS SYSTEM	ENST00000345724	c.2383G>A	p.E795K	COSMIC	NP	NP
28	TCGA-24-0979-01	Tumour	OVARY	ENST00000345724	c.2238C>T	p.F746F	COSMIC	NP	NP
29	TCGA-25-1326-01	Tumour	OVARY	ENST00000345724	c.1044C>T	p.L348L	COSMIC	NP	NP
30	TCGA-AA-3516-01	Tumour	LARGE INTESTINE	ENST00000345724	c.1092G>T	p.Q364H	COSMIC	NP	NP
31	TCGA-AA-3864-01	Tumour	LARGE INTESTINE	ENST00000345724	c.1141C>T	p.R381C	COSMIC	NP	NP
32	TCGA-AA-3877-01	Tumour	LARGE INTESTINE	ENST00000345724	c.1442C>T	p.T481M	COSMIC	NP	NP
33	TCGA-AA-3877-01	Tumour	LARGE INTESTINE	ENST00000345724	c.2101A>G	p.I701V	COSMIC	NP	NP
34	TCGA-AA-3977-01	Tumour	LARGE INTESTINE	ENST00000345724	c.1391C>A	p.P464Q	COSMIC	NP	NP
35	TCGA-AA-3984-01	Tumour	LARGE INTESTINE	ENST00000345724	c.2110T>C	p.L704L	COSMIC	NP	NP
36	TCGA-AG-A002-01	Tumour	LARGE INTESTINE	ENST00000345724	c.485A>C	p.K162T	COSMIC	NP	NP
37	cSCCP2	Tumour	SKIN	ENST00000345724	c.839T>G	p.V280G	COSMIC	NP	NP
38	639V	Cell Line	URINARY TRACT	NP_006776	c.1726C>T	p.R576W	CCLE	PASSENGER/OTHER	Probably Damaging
39	BT20	Cell Line	BREAST	NP_006776	c.1414G>T	p.D472Y	CCLE	PASSENGER/OTHER	Probably Damaging
40	EJM	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_006776	c.2156G>A	p.R719Q	CCLE	PASSENGER/OTHER	Possibly Damaging
41	EN	Cell Line	ENDOMETRIUM	NP_006776	c.1576A>G	p.T526A	CCLE	PASSENGER/OTHER	Probably Damaging
42	GP2D	Cell Line	LARGE INTESTINE	NP_006776	c.781T>C	p.F261L	CCLE	PASSENGER/OTHER	Possibly Damaging
43	HCC2935	Cell Line	LUNG	NP_006776	c.1238C>T	p.A413V	CCLE	PASSENGER/OTHER	Probably Damaging
44	HEC108	Cell Line	ENDOMETRIUM	NP_006776	c.1199T>C	p.L400P	CCLE	PASSENGER/OTHER	Probably Damaging
45	HS172T	Cell Line	URINARY TRACT	NP_006776	c.377_splice	p.G126_splice	CCLE	NP	NP
46	KM12	Cell Line	LARGE INTESTINE	NP_006776	c.1265A>G	p.N422S	CCLE	PASSENGER/OTHER	Probably Damaging
47	KMBC2	Cell Line	URINARY TRACT	NP_006776	c.982C>T	p.P328S	CCLE	PASSENGER/OTHER	Benign
48	KMS21BM	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_006776	c.409G>A	p.A137T	CCLE	PASSENGER/OTHER	Possibly Damaging
49	LCLC97TM1	Cell Line	LUNG	NP_006776	c.1894G>A	p.V632I	CCLE	PASSENGER/OTHER	Benign
50	LOVO	Cell Line	LARGE INTESTINE	NP_006776	c.1102G>A	p.E368K	CCLE	PASSENGER/OTHER	Probably Damaging
51	LOVO	Cell Line	LARGE INTESTINE	NP_006776	c.1651C>T	p.R551*	CCLE	NP	NP
52	MDAPCA2B	Cell Line	PROSTATE	NP_006776	c.1411G>A	p.D471N	CCLE	PASSENGER/OTHER	Probably Damaging
53	MKN7	Cell Line	STOMACH	NP_006776	c.1162G>A	p.E388K	CCLE	PASSENGER/OTHER	Probably Damaging
54	MORCPR	Cell Line	LUNG	NP_006776	c.1012C>T	p.P338S	CCLE	PASSENGER/OTHER	Benign
55	MSTO211H	Cell Line	PLEURA	NP_006776	c.488T>G	p.M163R	CCLE	PASSENGER/OTHER	Possibly Damaging
56	NCIH810	Cell Line	LUNG	NP_006776	c.2353G>T	p.A785S	CCLE	PASSENGER/OTHER	Benign
57	SKOV3	Cell Line	OVARY	NP_006776	c.814_814delA	p.K272fs	CCLE	NP	NP
58	SNU175	Cell Line	LARGE INTESTINE	NP_006776	c.1835T>C	p.M612T	CCLE	PASSENGER/OTHER	Probably Damaging
59	SNU81	Cell Line	LARGE INTESTINE	NP_006776	c.1675G>A	p.A559T	CCLE	PASSENGER/OTHER	Probably Damaging
60	SNU81	Cell Line	LARGE INTESTINE	NP_006776	c.496G>T	p.E166*	CCLE	NP	NP
61	SW780	Cell Line	URINARY TRACT	NP_006776	c.2411C>T	p.P804L	CCLE	PASSENGER/OTHER	Probably Damaging
62	TE9	Cell Line	OESOPHAGUS	NP_006776	c.425_426insG	p.Q142fs	CCLE	NP	NP
63	86788	Tumour	LUNG	ENST00000345724	c.1112C>T	p.S371L	COSMIC	NP	NP
64	Br27P	Tumour	CENTRAL NERVOUS SYSTEM	ENST00000345724	c.2383G>A	p.E795K	COSMIC	NP	NP
65	TCGA-24-0979-01	Tumour	OVARY	ENST00000345724	c.2238C>T	p.F746F	COSMIC	NP	NP
66	TCGA-25-1326-01	Tumour	OVARY	ENST00000345724	c.1044C>T	p.L348L	COSMIC	NP	NP
67	TCGA-AA-3516-01	Tumour	LARGE INTESTINE	ENST00000345724	c.1092G>T	p.Q364H	COSMIC	NP	NP
68	TCGA-AA-3864-01	Tumour	LARGE INTESTINE	ENST00000345724	c.1141C>T	p.R381C	COSMIC	NP	NP
69	TCGA-AA-3877-01	Tumour	LARGE INTESTINE	ENST00000345724	c.1442C>T	p.T481M	COSMIC	NP	NP
70	TCGA-AA-3877-01	Tumour	LARGE INTESTINE	ENST00000345724	c.2101A>G	p.I701V	COSMIC	NP	NP
71	TCGA-AA-3977-01	Tumour	LARGE INTESTINE	ENST00000345724	c.1391C>A	p.P464Q	COSMIC	NP	NP
72	TCGA-AA-3984-01	Tumour	LARGE INTESTINE	ENST00000345724	c.2110T>C	p.L704L	COSMIC	NP	NP
73	TCGA-AG-A002-01	Tumour	LARGE INTESTINE	ENST00000345724	c.485A>C	p.K162T	COSMIC	NP	NP
74	cSCCP2	Tumour	SKIN	ENST00000345724	c.839T>G	p.V280G	COSMIC	NP	NP

*NP: Not Predicted

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	7.2206	7.0306	-0.2538	-0.06286
BILIARY TRACT	8.1510	7.7846	-0.4255	-0.5693
BONE	8.3440	8.4545	-0.0657	-0.02169
BREAST	7.8611	7.8482	-0.4505	-0.35965
CENTRAL NERVOUS SYSTEM	8.8904	8.9249	-0.1844	-0.0492
ENDOMETRIUM	9.2584	8.818	-0.2093	-0.1007
HAEMATOPOIETIC AND LYMPHOID TISSUE	8.4337	8.482	0.0471	3e-04
KIDNEY	9.2066	9.326	-0.3031	-0.2195
LARGE INTESTINE	8.1423	8.20085	-0.5028	-0.32945
LIVER	8.2221	8.1609	-0.3485	-0.3804
LUNG	8.0250	7.9447	-0.2041	-0.1717
OESOPHAGUS	7.3430	7.311	-0.8969	-0.78505
OVARY	8.2392	8.1249	-0.4215	-0.4627
PANCREAS	7.6743	7.6062	-0.7084	-0.706
PLEURA	8.9117	9.0187	-0.2252	-0.0912
PROSTATE	8.9726	9.2232	0.0102	0.02544
SALIVARY GLAND	7.3398	7.3398	-1.0200	-1.02
SKIN	8.2920	8.3702	-0.1643	-0.0772
SMALL INTESTINE	8.5495	8.5495	-0.0043	-0.0043
SOFT TISSUE	8.0105	8.06165	-0.2033	-0.055995
STOMACH	8.0076	8.16545	-0.3288	-0.18955
THYROID	8.4379	8.6262	-0.2321	-0.2403
UPPER AERODIGESTIVE TRACT	7.8313	7.89695	-0.7292	-0.7337
URINARY TRACT	8.0122	7.74595	-0.2755	-0.14945

Domain ID	Domain Name	Start Site	End Site	E-value
PF13895	Ig_2	132	194	9.2e-11
PF13895	Ig_2	231	308	6.8e-12
PF00656	Peptidase_C14	343	470	3e-17
PF13895	Ig_2	132	194	9.2e-11
PF13895	Ig_2	231	308	6.8e-12
PF00656	Peptidase_C14	343	470	3e-17

Domain ID	Start Site	End Site	E-value
0049359	334	563	4.93e-39
0050544	28	138	5.24e-24
0035573	127	213	1.34e-15
0048595	225	308	1.09e-14
0049359	334	563	4.93e-39
0050544	28	138	5.24e-24
0035573	127	213	1.34e-15
0048595	225	308	1.09e-14

S. No.	Position	Amino acid	Type	Description
1	135	S	Phosphorylation	Phosphoserine
2	135	S	Phosphorylation	Phosphoserine.
3	648	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
4	135	S	Phosphorylation	Phosphoserine
5	135	S	Phosphorylation	Phosphoserine.
6	648	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
MALT1	MALT1	MALT1	ENSP00000304161	Q9UDY8
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
Q9UDY8	MALT1	ENSP00000304161	MALT1	Q9UDY8
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
MALT1	ENSP00000304161	604860	Q9UDY8	PA30568

Protein: MALT1

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)

Modelled Structure	Structures available in PDB
	2G7R, 3BFO, 3K0W, 3UO8, 3UOA, 3V4O, 3V55, 4I1R