ApoCanD

Mutation Data (+)

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	587338	Tumour	LARGE INTESTINE	ENST00000258080	c.254C>T	p.A85V	COSMIC	NP	NP
2	587376	Tumour	LARGE INTESTINE	ENST00000258080	c.782G>A	p.G261E	COSMIC	NP	NP
3	ESO-913	Tumour	OESOPHAGUS	ENST00000258080	c.1078C>T	p.R360C	COSMIC	NP	NP
4	LC	Tumour	C24 LUNG	ENST00000258080	c.149T>G	p.V50G	COSMIC	NP	NP
5	LUAD-B00416	Tumour	LUNG	ENST00000258080	c.1349T>G	p.L450*	COSMIC	NP	NP
6	RK069	Tumour	C01 LIVER	ENST00000258080	c.1344G>C	p.L448L	COSMIC	NP	NP
7	TCGA-22-5474-01	Tumour	LUNG	ENST00000258080	c.70C>T	p.R24C	COSMIC	NP	NP
8	TCGA-25-1319-01	Tumour	OVARY	ENST00000258080	c.718C>T	p.L240F	COSMIC	NP	NP
9	TCGA-64-1678-01	Tumour	LUNG	ENST00000258080	c.1241T>A	p.L414*	COSMIC	NP	NP
10	TCGA-66-2785-01	Tumour	LUNG	ENST00000258080	c.835C>G	p.Q279E	COSMIC	NP	NP
11	TCGA-70-6722-01	Tumour	LUNG	ENST00000258080	c.12G>A	p.P4P	COSMIC	NP	NP
12	TCGA-91-6848-01	Tumour	LUNG	ENST00000258080	c.379G>T	p.G127C	COSMIC	NP	NP
13	TCGA-AA-3864-01	Tumour	LARGE INTESTINE	ENST00000258080	c.1031G>A	p.R344H	COSMIC	NP	NP
14	TCGA-AA-3949-01	Tumour	LARGE INTESTINE	ENST00000258080	c.191G>A	p.G64E	COSMIC	NP	NP
15	TCGA-AA-3977-01	Tumour	LARGE INTESTINE	ENST00000258080	c.1285G>T	p.E429*	COSMIC	NP	NP
16	TCGA-AX-A0J0-01	Tumour	ENDOMETRIUM	ENST00000258080	c.1295G>A	p.R432Q	COSMIC	NP	NP
17	TCGA-B5-A0JY-01	Tumour	ENDOMETRIUM	ENST00000258080	c.1138C>T	p.R380*	COSMIC	NP	NP
18	TCGA-B5-A11E-01	Tumour	ENDOMETRIUM	ENST00000258080	c.1078C>T	p.R360C	COSMIC	NP	NP
19	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000258080	c.1016G>A	p.R339Q	COSMIC	NP	NP
20	TCGA-CF-A1HR-01	Tumour	URINARY TRACT	ENST00000258080	c.12G>A	p.P4P	COSMIC	NP	NP
21	TCGA-D1-A167-01	Tumour	ENDOMETRIUM	ENST00000258080	c.1009C>A	p.R337S	COSMIC	NP	NP
22	cSCCP4	Tumour	SKIN	ENST00000258080	c.539C>G	p.S180W	COSMIC	NP	NP
23	ALLPO	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000258080	c.618C>G	p.V206V	COSMIC	NP	NP
24	CHP134	Cell Line	AUTONOMIC_GANGLIA	ENST00000258080	c.1258A>G	p.M420V	COSMIC	PASSENGER/OTHER	BENIGN
25	COLO792	Cell Line	SKIN	ENST00000258080	c.1212-1G>A	p.?	COSMIC	NP	NP
26	GP5D	Cell Line	LARGE_INTESTINE	ENST00000258080	c.1324C>T	p.R442W	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
27	GP5D	Cell Line	LARGE_INTESTINE	ENST00000258080	c.573G>A	p.G191G	COSMIC	NP	NP
28	JURKAT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000258080	c.71G>A	p.R24H	COSMIC	PASSENGER/OTHER	BENIGN
29	KARPAS45	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000258080	c.114G>A	p.L38L	COSMIC	NP	NP
30	MCC13	Cell Line	SKIN	ENST00000258080	c.507-8C>T	p.?	COSMIC	NP	NP
31	MFE280	Cell Line	ENDOMETRIUM	ENST00000258080	c.1233T>G	p.D411E	COSMIC	CANCER	POSSIBLY DAMAGING
32	MFM223	Cell Line	BREAST	ENST00000258080	c.506+5_506+7delTGG	p.?	COSMIC	NP	NP
33	MOLT4	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000258080	c.688G>A	p.A230T	COSMIC	CANCER	PROBABLY DAMAGING
34	NALM6	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000258080	c.518T>G	p.L173W	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
35	NCCIT	Cell Line	TESTIS	ENST00000258080	c.123A>T	p.S41S	COSMIC	NP	NP
36	NCIH1734	Cell Line	LUNG	ENST00000258080	c.935A>T	p.N312I	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
37	RCCJF	Cell Line	KIDNEY	ENST00000258080	c.879A>G	p.E293E	COSMIC	NP	NP
38	SNU175	Cell Line	LARGE_INTESTINE	ENST00000258080	c.1079G>A	p.R360H	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
39	SUPB15	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000258080	c.1057G>C	p.G353R	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
40	587338	Tumour	LARGE INTESTINE	ENST00000258080	c.254C>T	p.A85V	COSMIC	NP	NP
41	587376	Tumour	LARGE INTESTINE	ENST00000258080	c.782G>A	p.G261E	COSMIC	NP	NP
42	ESO-913	Tumour	OESOPHAGUS	ENST00000258080	c.1078C>T	p.R360C	COSMIC	NP	NP
43	LC	Tumour	C24 LUNG	ENST00000258080	c.149T>G	p.V50G	COSMIC	NP	NP
44	LUAD-B00416	Tumour	LUNG	ENST00000258080	c.1349T>G	p.L450*	COSMIC	NP	NP
45	RK069	Tumour	C01 LIVER	ENST00000258080	c.1344G>C	p.L448L	COSMIC	NP	NP
46	TCGA-22-5474-01	Tumour	LUNG	ENST00000258080	c.70C>T	p.R24C	COSMIC	NP	NP
47	TCGA-25-1319-01	Tumour	OVARY	ENST00000258080	c.718C>T	p.L240F	COSMIC	NP	NP
48	TCGA-64-1678-01	Tumour	LUNG	ENST00000258080	c.1241T>A	p.L414*	COSMIC	NP	NP
49	TCGA-66-2785-01	Tumour	LUNG	ENST00000258080	c.835C>G	p.Q279E	COSMIC	NP	NP
50	TCGA-70-6722-01	Tumour	LUNG	ENST00000258080	c.12G>A	p.P4P	COSMIC	NP	NP
51	TCGA-91-6848-01	Tumour	LUNG	ENST00000258080	c.379G>T	p.G127C	COSMIC	NP	NP
52	TCGA-AA-3864-01	Tumour	LARGE INTESTINE	ENST00000258080	c.1031G>A	p.R344H	COSMIC	NP	NP
53	TCGA-AA-3949-01	Tumour	LARGE INTESTINE	ENST00000258080	c.191G>A	p.G64E	COSMIC	NP	NP
54	TCGA-AA-3977-01	Tumour	LARGE INTESTINE	ENST00000258080	c.1285G>T	p.E429*	COSMIC	NP	NP
55	TCGA-AX-A0J0-01	Tumour	ENDOMETRIUM	ENST00000258080	c.1295G>A	p.R432Q	COSMIC	NP	NP
56	TCGA-B5-A0JY-01	Tumour	ENDOMETRIUM	ENST00000258080	c.1138C>T	p.R380*	COSMIC	NP	NP
57	TCGA-B5-A11E-01	Tumour	ENDOMETRIUM	ENST00000258080	c.1078C>T	p.R360C	COSMIC	NP	NP
58	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000258080	c.1016G>A	p.R339Q	COSMIC	NP	NP
59	TCGA-CF-A1HR-01	Tumour	URINARY TRACT	ENST00000258080	c.12G>A	p.P4P	COSMIC	NP	NP
60	TCGA-D1-A167-01	Tumour	ENDOMETRIUM	ENST00000258080	c.1009C>A	p.R337S	COSMIC	NP	NP
61	cSCCP4	Tumour	SKIN	ENST00000258080	c.539C>G	p.S180W	COSMIC	NP	NP
62	ALLPO	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000258080	c.618C>G	p.V206V	COSMIC	NP	NP
63	CHP134	Cell Line	AUTONOMIC_GANGLIA	ENST00000258080	c.1258A>G	p.M420V	COSMIC	PASSENGER/OTHER	BENIGN
64	COLO792	Cell Line	SKIN	ENST00000258080	c.1212-1G>A	p.?	COSMIC	NP	NP
65	GP5D	Cell Line	LARGE_INTESTINE	ENST00000258080	c.1324C>T	p.R442W	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
66	GP5D	Cell Line	LARGE_INTESTINE	ENST00000258080	c.573G>A	p.G191G	COSMIC	NP	NP
67	JURKAT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000258080	c.71G>A	p.R24H	COSMIC	PASSENGER/OTHER	BENIGN
68	KARPAS45	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000258080	c.114G>A	p.L38L	COSMIC	NP	NP
69	MCC13	Cell Line	SKIN	ENST00000258080	c.507-8C>T	p.?	COSMIC	NP	NP
70	MFE280	Cell Line	ENDOMETRIUM	ENST00000258080	c.1233T>G	p.D411E	COSMIC	CANCER	POSSIBLY DAMAGING
71	MFM223	Cell Line	BREAST	ENST00000258080	c.506+5_506+7delTGG	p.?	COSMIC	NP	NP
72	MOLT4	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000258080	c.688G>A	p.A230T	COSMIC	CANCER	PROBABLY DAMAGING
73	NALM6	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000258080	c.518T>G	p.L173W	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
74	NCCIT	Cell Line	TESTIS	ENST00000258080	c.123A>T	p.S41S	COSMIC	NP	NP
75	NCIH1734	Cell Line	LUNG	ENST00000258080	c.935A>T	p.N312I	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
76	RCCJF	Cell Line	KIDNEY	ENST00000258080	c.879A>G	p.E293E	COSMIC	NP	NP
77	SNU175	Cell Line	LARGE_INTESTINE	ENST00000258080	c.1079G>A	p.R360H	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
78	SUPB15	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000258080	c.1057G>C	p.G353R	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING

*NP: Not Predicted

Copy number variation and expression profile (+)

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	8.7449	8.7826	0.1201	0.04874
BILIARY TRACT	7.9395	8.1195	0.0682	0.0549
BONE	8.2720	8.2275	0.0225	0.0051
BREAST	8.2797	8.30565	0.0517	0.0234
CENTRAL NERVOUS SYSTEM	8.4654	8.3665	0.0435	0.06
ENDOMETRIUM	8.2689	8.3184	0.0602	0.0191
HAEMATOPOIETIC AND LYMPHOID TISSUE	8.9901	9.0087	0.0176	0.003
KIDNEY	7.9984	7.998	0.1310	0.1258
LARGE INTESTINE	8.2809	8.38505	0.0688	0.014388
LIVER	8.1188	8.2205	0.1623	0.1771
LUNG	8.3261	8.3762	0.1068	0.10435
OESOPHAGUS	8.1120	8.2199	0.0942	0.13935
OVARY	8.2706	8.3514	0.1069	0.1139
PANCREAS	8.0399	8.033	0.0854	0.122
PLEURA	8.7262	8.6665	0.1610	0.0799
PROSTATE	8.4223	8.41555	-0.1115	0.00615
SALIVARY GLAND	7.6803	7.6803	0.0879	0.0879
SKIN	8.6128	8.5616	0.1105	0.1128
SMALL INTESTINE	8.4662	8.4662	0.0234	0.0234
SOFT TISSUE	8.6221	8.77665	0.1519	0.1217
STOMACH	8.3262	8.388	0.0776	0.0926
THYROID	8.5517	8.50225	-0.0504	0.000345000000000002
UPPER AERODIGESTIVE TRACT	7.9296	7.88135	0.0484	0.0705
URINARY TRACT	8.1356	8.09175	-0.0318	-0.00645

Gene Essentiality Data (+)

Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.

test

Tertiary structure (+)

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Modelled Structure	Structures available in PDB
	1LCY, 2PZD

Structure Domains (+)

1. PFAM Domains:

Domain ID	Domain Name	Start Site	End Site	E-value
PF13365	Trypsin_2	182	320	1.6e-21
PF13180	PDZ_2	361	453	2e-10
PF13365	Trypsin_2	182	320	1.6e-21
PF13180	PDZ_2	361	453	2e-10

2. Superfamily Domains:

Domain ID	Start Site	End Site	E-value
0043683	147	344	8.80e-57
0040455	359	455	5.26e-24
0043683	147	344	8.80e-57
0040455	359	455	5.26e-24

Sequence Alignment (+)

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1. Sequence alignment with 1000 genome variations:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

2. Mutants are not present in CCLE!!

3. Sequence alignment with COSMIC mutants:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

4. Sequence alignment with homologus proteins:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

Sequence Profiles (+)

HMM
With Uniprot database	With Mutants	With 1000 Genome Variants

PSSM
With Uniprot database	With Mutants	With 1000 Genome Variant

Post Translational Modifications (+)

S. No.	Position	Amino acid	Type	Description
1	142	S	Phosphorylation	Phosphoserine
2	212	S	Phosphorylation	Phosphoserine
3	237	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
4	361	Y	Phosphorylation	Phosphotyrosine
5	395	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
6	400	S	Phosphorylation	Phosphoserine
7	51	T	Phosphorylation	Phosphothreonine
8	54	T	Phosphorylation	Phosphothreonine
9	142	S	Phosphorylation	Phosphoserine
10	212	S	Phosphorylation	Phosphoserine
11	237	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
12	361	Y	Phosphorylation	Phosphotyrosine
13	395	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
14	400	S	Phosphorylation	Phosphoserine
15	51	T	Phosphorylation	Phosphothreonine
16	54	T	Phosphorylation	Phosphothreonine

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
HTRA2	HTRA2	HTRA2	ENSP00000258080	O43464
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
O43464	HTRA2	ENSP00000258080	HTRA2	O43464
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
HTRA2	ENSP00000258080	606441	O43464	PA33836

Protein: HTRA2

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)