ApoCanD

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	587226	Tumour	LARGE INTESTINE	ENST00000229239	c.985G>A	p.A329T	COSMIC	NP	NP
2	587338	Tumour	LARGE INTESTINE	ENST00000229239	c.203T>C	p.V68A	COSMIC	NP	NP
3	BN50T	Tumour	LIVER	ENST00000229239	c.770_775delACATCA	p.D257_K259>E	COSMIC	NP	NP
4	LUAD-S01356	Tumour	LUNG	ENST00000229239	c.304T>A	p.F102I	COSMIC	NP	NP
5	LUAD-YINHD	Tumour	LUNG	ENST00000229239	c.239G>C	p.R80P	COSMIC	NP	NP
6	MD-021	Tumour	CENTRAL NERVOUS SYSTEM	ENST00000229239	c.717C>A	p.N239K	COSMIC	NP	NP
7	TARGET-30-PARZIP	Tumour	AUTONOMIC GANGLIA	ENST00000229239	c.343G>A	p.G115R	COSMIC	NP	NP
8	TCGA-33-4566-01	Tumour	LUNG	ENST00000229239	c.187G>A	p.E63K	COSMIC	NP	NP
9	TCGA-50-5936-01	Tumour	LUNG	ENST00000229239	c.899G>A	p.G300D	COSMIC	NP	NP
10	TCGA-59-2372-01	Tumour	OVARY	ENST00000229239	c.511G>C	p.V171L	COSMIC	NP	NP
11	TCGA-60-2726-01	Tumour	LUNG	ENST00000229239	c.555G>T	p.Q185H	COSMIC	NP	NP
12	TCGA-A2-A25B-01	Tumour	BREAST	ENST00000229239	c.658G>C	p.V220L	COSMIC	NP	NP
13	TCGA-A5-A0VP-01	Tumour	ENDOMETRIUM	ENST00000229239	c.882C>A	p.T294T	COSMIC	NP	NP
14	TCGA-AP-A0LP-01	Tumour	ENDOMETRIUM	ENST00000229239	c.266A>G	p.D89G	COSMIC	NP	NP
15	TCGA-AZ-4315-01	Tumour	LARGE INTESTINE	ENST00000229239	c.103G>T	p.D35Y	COSMIC	NP	NP
16	TCGA-AZ-6601-01	Tumour	LARGE INTESTINE	ENST00000229239	c.339delG	p.G115fs*21	COSMIC	NP	NP
17	TCGA-B5-A11Y-01	Tumour	ENDOMETRIUM	ENST00000229239	c.283G>A	p.V95I	COSMIC	NP	NP
18	TCGA-DR-A0ZM-01	Tumour	CERVIX	ENST00000229239	c.599G>T	p.R200L	COSMIC	NP	NP
19	YUKLAB	Tumour	SKIN	ENST00000229239	c.272G>C	p.G91A	COSMIC	NP	NP
20	YULAN	Tumour	SKIN	ENST00000229239	c.16G>A	p.V6I	COSMIC	NP	NP
21	451LU	Cell Line	SKIN	ENST00000229239	c.706C>T	p.P236S	COSMIC	CANCER	POSSIBLY DAMAGING
22	AMO1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000229239	c.519A>T	p.G173G	COSMIC	NP	NP
23	CAL12T	Cell Line	LUNG	ENST00000229239	c.890C>G	p.A297G	COSMIC	PASSENGER/OTHER	BENIGN
24	CW2	Cell Line	LARGE_INTESTINE	ENST00000229239	c.401G>A	p.G134D	COSMIC	PASSENGER/OTHER	BENIGN
25	DAUDI	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000229239	c.636C>T	p.G212G	COSMIC	NP	NP
26	DAUDI	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000229239	c.666T>A	p.P222P	COSMIC	NP	NP
27	DND41	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000229239	c.690C>T	p.G230G	COSMIC	NP	NP
28	EBC1	Cell Line	LUNG	ENST00000229239	c.519A>T	p.G173G	COSMIC	NP	NP
29	H290	Cell Line	PLEURA	ENST00000229239	c.397A>G	p.M133V	COSMIC	PASSENGER/OTHER	BENIGN
30	HCT116	Cell Line	LARGE_INTESTINE	ENST00000229239	c.206T>C	p.I69T	COSMIC	PASSENGER/OTHER	BENIGN
31	IALM	Cell Line	LUNG	ENST00000229239	c.341G>T	p.G114V	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
32	JHH1	Cell Line	LIVER	ENST00000229239	c.519A>T	p.G173G	COSMIC	NP	NP
33	KARPAS45	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000229239	c.600C>T	p.R200R	COSMIC	NP	NP
34	KURAMOCHI	Cell Line	OVARY	ENST00000229239	c.519A>T	p.G173G	COSMIC	NP	NP
35	LCLC97TM1	Cell Line	LUNG	ENST00000229239	c.1003G>T	p.E335*	COSMIC	NP	NP
36	MDAMB361	Cell Line	BREAST	ENST00000229239	c.374C>G	p.S125C	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
37	MM1S	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000229239	c.55A>G	p.T19A	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
38	NCIH716	Cell Line	LARGE_INTESTINE	ENST00000229239	c.123C>G	p.N41K	COSMIC	PASSENGER/OTHER	BENIGN
39	OCIAML5	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000229239	c.636C>T	p.G212G	COSMIC	NP	NP
40	OCIAML5	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000229239	c.666T>A	p.P222P	COSMIC	NP	NP
41	OCIM1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000229239	c.63T>A	p.A21A	COSMIC	NP	NP
42	PF382	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000229239	c.313A>G	p.M105V	COSMIC	PASSENGER/OTHER	BENIGN
43	RCHACV	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000229239	c.177C>T	p.T59T	COSMIC	NP	NP
44	RL	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000229239	c.18C>T	p.V6V	COSMIC	NP	NP
45	SNGM	Cell Line	ENDOMETRIUM	ENST00000229239	c.301G>A	p.V101I	COSMIC	PASSENGER/OTHER	BENIGN
46	SW756	Cell Line	CERVIX	ENST00000229239	c.526-10C>G	p.?	COSMIC	NP	NP
47	TCCSUP	Cell Line	URINARY_TRACT	ENST00000229239	c.432C>G	p.L144L	COSMIC	NP	NP
48	WM115	Cell Line	SKIN	ENST00000229239	c.316G>A	p.E106K	COSMIC	PASSENGER/OTHER	BENIGN
49	YKG1	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000229239	c.519A>T	p.G173G	COSMIC	NP	NP
50	587226	Tumour	LARGE INTESTINE	ENST00000229239	c.985G>A	p.A329T	COSMIC	NP	NP
51	587338	Tumour	LARGE INTESTINE	ENST00000229239	c.203T>C	p.V68A	COSMIC	NP	NP
52	BN50T	Tumour	LIVER	ENST00000229239	c.770_775delACATCA	p.D257_K259>E	COSMIC	NP	NP
53	LUAD-S01356	Tumour	LUNG	ENST00000229239	c.304T>A	p.F102I	COSMIC	NP	NP
54	LUAD-YINHD	Tumour	LUNG	ENST00000229239	c.239G>C	p.R80P	COSMIC	NP	NP
55	MD-021	Tumour	CENTRAL NERVOUS SYSTEM	ENST00000229239	c.717C>A	p.N239K	COSMIC	NP	NP
56	TARGET-30-PARZIP	Tumour	AUTONOMIC GANGLIA	ENST00000229239	c.343G>A	p.G115R	COSMIC	NP	NP
57	TCGA-33-4566-01	Tumour	LUNG	ENST00000229239	c.187G>A	p.E63K	COSMIC	NP	NP
58	TCGA-50-5936-01	Tumour	LUNG	ENST00000229239	c.899G>A	p.G300D	COSMIC	NP	NP
59	TCGA-59-2372-01	Tumour	OVARY	ENST00000229239	c.511G>C	p.V171L	COSMIC	NP	NP
60	TCGA-60-2726-01	Tumour	LUNG	ENST00000229239	c.555G>T	p.Q185H	COSMIC	NP	NP
61	TCGA-A2-A25B-01	Tumour	BREAST	ENST00000229239	c.658G>C	p.V220L	COSMIC	NP	NP
62	TCGA-A5-A0VP-01	Tumour	ENDOMETRIUM	ENST00000229239	c.882C>A	p.T294T	COSMIC	NP	NP
63	TCGA-AP-A0LP-01	Tumour	ENDOMETRIUM	ENST00000229239	c.266A>G	p.D89G	COSMIC	NP	NP
64	TCGA-AZ-4315-01	Tumour	LARGE INTESTINE	ENST00000229239	c.103G>T	p.D35Y	COSMIC	NP	NP
65	TCGA-AZ-6601-01	Tumour	LARGE INTESTINE	ENST00000229239	c.339delG	p.G115fs*21	COSMIC	NP	NP
66	TCGA-B5-A11Y-01	Tumour	ENDOMETRIUM	ENST00000229239	c.283G>A	p.V95I	COSMIC	NP	NP
67	TCGA-DR-A0ZM-01	Tumour	CERVIX	ENST00000229239	c.599G>T	p.R200L	COSMIC	NP	NP
68	YUKLAB	Tumour	SKIN	ENST00000229239	c.272G>C	p.G91A	COSMIC	NP	NP
69	YULAN	Tumour	SKIN	ENST00000229239	c.16G>A	p.V6I	COSMIC	NP	NP
70	451LU	Cell Line	SKIN	ENST00000229239	c.706C>T	p.P236S	COSMIC	CANCER	POSSIBLY DAMAGING
71	AMO1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000229239	c.519A>T	p.G173G	COSMIC	NP	NP
72	CAL12T	Cell Line	LUNG	ENST00000229239	c.890C>G	p.A297G	COSMIC	PASSENGER/OTHER	BENIGN
73	CW2	Cell Line	LARGE_INTESTINE	ENST00000229239	c.401G>A	p.G134D	COSMIC	PASSENGER/OTHER	BENIGN
74	DAUDI	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000229239	c.636C>T	p.G212G	COSMIC	NP	NP
75	DAUDI	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000229239	c.666T>A	p.P222P	COSMIC	NP	NP
76	DND41	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000229239	c.690C>T	p.G230G	COSMIC	NP	NP
77	EBC1	Cell Line	LUNG	ENST00000229239	c.519A>T	p.G173G	COSMIC	NP	NP
78	H290	Cell Line	PLEURA	ENST00000229239	c.397A>G	p.M133V	COSMIC	PASSENGER/OTHER	BENIGN
79	HCT116	Cell Line	LARGE_INTESTINE	ENST00000229239	c.206T>C	p.I69T	COSMIC	PASSENGER/OTHER	BENIGN
80	IALM	Cell Line	LUNG	ENST00000229239	c.341G>T	p.G114V	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
81	JHH1	Cell Line	LIVER	ENST00000229239	c.519A>T	p.G173G	COSMIC	NP	NP
82	KARPAS45	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000229239	c.600C>T	p.R200R	COSMIC	NP	NP
83	KURAMOCHI	Cell Line	OVARY	ENST00000229239	c.519A>T	p.G173G	COSMIC	NP	NP
84	LCLC97TM1	Cell Line	LUNG	ENST00000229239	c.1003G>T	p.E335*	COSMIC	NP	NP
85	MDAMB361	Cell Line	BREAST	ENST00000229239	c.374C>G	p.S125C	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
86	MM1S	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000229239	c.55A>G	p.T19A	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
87	NCIH716	Cell Line	LARGE_INTESTINE	ENST00000229239	c.123C>G	p.N41K	COSMIC	PASSENGER/OTHER	BENIGN
88	OCIAML5	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000229239	c.636C>T	p.G212G	COSMIC	NP	NP
89	OCIAML5	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000229239	c.666T>A	p.P222P	COSMIC	NP	NP
90	OCIM1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000229239	c.63T>A	p.A21A	COSMIC	NP	NP
91	PF382	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000229239	c.313A>G	p.M105V	COSMIC	PASSENGER/OTHER	BENIGN
92	RCHACV	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000229239	c.177C>T	p.T59T	COSMIC	NP	NP
93	RL	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000229239	c.18C>T	p.V6V	COSMIC	NP	NP
94	SNGM	Cell Line	ENDOMETRIUM	ENST00000229239	c.301G>A	p.V101I	COSMIC	PASSENGER/OTHER	BENIGN
95	SW756	Cell Line	CERVIX	ENST00000229239	c.526-10C>G	p.?	COSMIC	NP	NP
96	TCCSUP	Cell Line	URINARY_TRACT	ENST00000229239	c.432C>G	p.L144L	COSMIC	NP	NP
97	WM115	Cell Line	SKIN	ENST00000229239	c.316G>A	p.E106K	COSMIC	PASSENGER/OTHER	BENIGN
98	YKG1	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000229239	c.519A>T	p.G173G	COSMIC	NP	NP

*NP: Not Predicted

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	14.6437	14.627	0.1062	0.0089
BILIARY TRACT	14.6039	14.587	0.0947	0.0904
BONE	14.6648	14.655	0.0766	-0.0124
BREAST	14.6289	14.6345	-0.0071	-0.0043
CENTRAL NERVOUS SYSTEM	14.6592	14.708	-0.0776	-0.0487
ENDOMETRIUM	14.6166	14.611	-0.0554	-0.0226
HAEMATOPOIETIC AND LYMPHOID TISSUE	14.5819	14.612	-0.0023	0.015
KIDNEY	14.7310	14.752	0.1686	0.1023
LARGE INTESTINE	14.6363	14.6515	0.1454	0.0489
LIVER	14.5927	14.598	0.0257	0.1226
LUNG	14.6472	14.664	0.0880	0.08347
OESOPHAGUS	14.6701	14.692	0.2445	0.2498
OVARY	14.6109	14.699	0.0415	0.0391
PANCREAS	14.6320	14.648	0.1123	0.1942
PLEURA	14.6968	14.749	0.0363	0.0089
PROSTATE	14.5727	14.6175	-0.1582	-0.18255
SALIVARY GLAND	14.5820	14.582	-0.4107	-0.4107
SKIN	14.7365	14.747	0.0048	-0.008317
SMALL INTESTINE	14.4440	14.444	0.0223	0.0223
SOFT TISSUE	14.6391	14.686	-0.0934	-0.0346
STOMACH	14.6148	14.6275	0.0340	-0.01192
THYROID	14.6731	14.676	-0.0455	-0.055
UPPER AERODIGESTIVE TRACT	14.5872	14.608	0.1723	0.11905
URINARY TRACT	14.6845	14.7155	0.1404	0.20925

Domain ID	Domain Name	Start Site	End Site	E-value
PF00044	Gp_dh_N	4	152	3.9e-60
PF02800	Gp_dh_C	157	314	1.3e-72
PF00044	Gp_dh_N	4	152	3.9e-60
PF02800	Gp_dh_C	157	314	1.3e-72

Domain ID	Start Site	End Site	E-value
0041770	4	173	1.01e-88
0039896	151	314	1.50e-88
0041770	4	173	1.01e-88
0039896	151	314	1.50e-88

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
GAPDH	GAPDH	GAPDH	ENSP00000229239	P04406
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
P04406	GAPDH	ENSP00000229239	GAPDH	P04406
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
GAPDH	ENSP00000229239	138400	P04406	PA28554

Protein: GAPDH

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)

Modelled Structure	Structures available in PDB
	1U8F, 1ZNQ, 2FEH, 3GPD