ApoCanD

Mutation Data (+)

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	CI1	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_003815	c.339A>C	p.R113S	CCLE	PASSENGER/OTHER	Possibly Damaging
2	HCC1954	Cell Line	BREAST	NP_003815	c.413C>T	p.T138I	CCLE	PASSENGER/OTHER	Benign
3	NCIH716	Cell Line	LARGE INTESTINE	NP_003815	c.331G>C	p.D111H	CCLE	PASSENGER/OTHER	Probably Damaging
4	18D	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000301838	c.427G>T	p.E143*	COSMIC	NP	NP
5	86507	Tumour	LUNG	ENST00000301838	c.581C>T	p.S194F	COSMIC	NP	NP
6	HCC37T	Tumour	LIVER	ENST00000301838	c.466G>A	p.A156T	COSMIC	NP	NP
7	LPJ128	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000301838	c.377T>A	p.I126N	COSMIC	NP	NP
8	Pa10X	Tumour	PANCREAS	ENST00000301838	c.375G>T	p.K125N	COSMIC	NP	NP
9	TCGA-04-1356-01	Tumour	OVARY	ENST00000301838	c.342G>C	p.R114S	COSMIC	NP	NP
10	TCGA-22-4591-01	Tumour	LUNG	ENST00000301838	c.81C>A	p.C27*	COSMIC	NP	NP
11	TCGA-44-5643-01	Tumour	LUNG	ENST00000301838	c.172G>T	p.G58W	COSMIC	NP	NP
12	TCGA-66-2785-01	Tumour	LUNG	ENST00000301838	c.186C>T	p.L62L	COSMIC	NP	NP
13	TCGA-BS-A0T9-01	Tumour	ENDOMETRIUM	ENST00000301838	c.410T>A	p.L137Q	COSMIC	NP	NP
14	TCGA-BT-A0YX-01	Tumour	URINARY TRACT	ENST00000301838	c.48G>A	p.S16S	COSMIC	NP	NP
15	TCGA-BT-A0YX-01	Tumour	URINARY TRACT	ENST00000301838	c.55G>A	p.E19K	COSMIC	NP	NP
16	TCGA-D5-6928-01	Tumour	LARGE INTESTINE	ENST00000301838	c.331G>C	p.D111H	COSMIC	NP	NP
17	pfg016T	Tumour	STOMACH	ENST00000301838	c.101G>A	p.R34H	COSMIC	NP	NP
18	HCC1599	Cell Line	BREAST	ENST00000301838	c.217C>A	p.H73N	COSMIC	CANCER	BENIGN
19	HCT15	Cell Line	LARGE_INTESTINE	ENST00000301838	c.474G>T	p.V158V	COSMIC	NP	NP
20	HDQP1	Cell Line	BREAST	ENST00000301838	c.138C>A	p.F46L	COSMIC	CANCER	PROBABLY DAMAGING
21	JEG3	Cell Line	PLACENTA	ENST00000301838	c.198G>C	p.L66L	COSMIC	NP	NP
22	JURKAT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000301838	c.393C>T	p.D131D	COSMIC	NP	NP
23	LNCAPCLONEFGC	Cell Line	PROSTATE	ENST00000301838	c.191G>A	p.R64H	COSMIC	CANCER	PROBABLY DAMAGING
24	MFE319	Cell Line	ENDOMETRIUM	ENST00000301838	c.543G>A	p.Q181Q	COSMIC	NP	NP
25	MHHES1	Cell Line	BONE	ENST00000301838	c.402C>A	p.P134P	COSMIC	NP	NP
26	MN60	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000301838	c.197T>C	p.L66P	COSMIC	CANCER	PROBABLY DAMAGING
27	NCIH2452	Cell Line	PLEURA	ENST00000301838	c.307G>A	p.V103I	COSMIC	PASSENGER/OTHER	BENIGN
28	NCIH630	Cell Line	LARGE_INTESTINE	ENST00000301838	c.603C>T	p.D201D	COSMIC	NP	NP
29	NCIH716	Cell Line	LARGE_INTESTINE	ENST00000301838	c.331G>C	p.D111H	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
30	SARC9371	Cell Line	BONE	ENST00000301838	c.615C>T	p.S205S	COSMIC	NP	NP
31	TGBC11TKB	Cell Line	STOMACH	ENST00000301838	c.480C>T	p.H160H	COSMIC	NP	NP
32	CI1	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_003815	c.339A>C	p.R113S	CCLE	PASSENGER/OTHER	Possibly Damaging
33	HCC1954	Cell Line	BREAST	NP_003815	c.413C>T	p.T138I	CCLE	PASSENGER/OTHER	Benign
34	NCIH716	Cell Line	LARGE INTESTINE	NP_003815	c.331G>C	p.D111H	CCLE	PASSENGER/OTHER	Probably Damaging
35	18D	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000301838	c.427G>T	p.E143*	COSMIC	NP	NP
36	86507	Tumour	LUNG	ENST00000301838	c.581C>T	p.S194F	COSMIC	NP	NP
37	HCC37T	Tumour	LIVER	ENST00000301838	c.466G>A	p.A156T	COSMIC	NP	NP
38	LPJ128	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000301838	c.377T>A	p.I126N	COSMIC	NP	NP
39	Pa10X	Tumour	PANCREAS	ENST00000301838	c.375G>T	p.K125N	COSMIC	NP	NP
40	TCGA-04-1356-01	Tumour	OVARY	ENST00000301838	c.342G>C	p.R114S	COSMIC	NP	NP
41	TCGA-22-4591-01	Tumour	LUNG	ENST00000301838	c.81C>A	p.C27*	COSMIC	NP	NP
42	TCGA-44-5643-01	Tumour	LUNG	ENST00000301838	c.172G>T	p.G58W	COSMIC	NP	NP
43	TCGA-66-2785-01	Tumour	LUNG	ENST00000301838	c.186C>T	p.L62L	COSMIC	NP	NP
44	TCGA-BS-A0T9-01	Tumour	ENDOMETRIUM	ENST00000301838	c.410T>A	p.L137Q	COSMIC	NP	NP
45	TCGA-BT-A0YX-01	Tumour	URINARY TRACT	ENST00000301838	c.48G>A	p.S16S	COSMIC	NP	NP
46	TCGA-BT-A0YX-01	Tumour	URINARY TRACT	ENST00000301838	c.55G>A	p.E19K	COSMIC	NP	NP
47	TCGA-D5-6928-01	Tumour	LARGE INTESTINE	ENST00000301838	c.331G>C	p.D111H	COSMIC	NP	NP
48	pfg016T	Tumour	STOMACH	ENST00000301838	c.101G>A	p.R34H	COSMIC	NP	NP
49	HCC1599	Cell Line	BREAST	ENST00000301838	c.217C>A	p.H73N	COSMIC	CANCER	BENIGN
50	HCT15	Cell Line	LARGE_INTESTINE	ENST00000301838	c.474G>T	p.V158V	COSMIC	NP	NP
51	HDQP1	Cell Line	BREAST	ENST00000301838	c.138C>A	p.F46L	COSMIC	CANCER	PROBABLY DAMAGING
52	JEG3	Cell Line	PLACENTA	ENST00000301838	c.198G>C	p.L66L	COSMIC	NP	NP
53	JURKAT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000301838	c.393C>T	p.D131D	COSMIC	NP	NP
54	LNCAPCLONEFGC	Cell Line	PROSTATE	ENST00000301838	c.191G>A	p.R64H	COSMIC	CANCER	PROBABLY DAMAGING
55	MFE319	Cell Line	ENDOMETRIUM	ENST00000301838	c.543G>A	p.Q181Q	COSMIC	NP	NP
56	MHHES1	Cell Line	BONE	ENST00000301838	c.402C>A	p.P134P	COSMIC	NP	NP
57	MN60	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000301838	c.197T>C	p.L66P	COSMIC	CANCER	PROBABLY DAMAGING
58	NCIH2452	Cell Line	PLEURA	ENST00000301838	c.307G>A	p.V103I	COSMIC	PASSENGER/OTHER	BENIGN
59	NCIH630	Cell Line	LARGE_INTESTINE	ENST00000301838	c.603C>T	p.D201D	COSMIC	NP	NP
60	NCIH716	Cell Line	LARGE_INTESTINE	ENST00000301838	c.331G>C	p.D111H	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
61	SARC9371	Cell Line	BONE	ENST00000301838	c.615C>T	p.S205S	COSMIC	NP	NP
62	TGBC11TKB	Cell Line	STOMACH	ENST00000301838	c.480C>T	p.H160H	COSMIC	NP	NP

*NP: Not Predicted

Copy number variation and expression profile (+)

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	8.8343	8.7299	-0.0397	-0.02101
BILIARY TRACT	9.7124	9.5616	0.1361	0.0395
BONE	10.0005	9.9815	0.1884	0.01183
BREAST	9.9981	9.67375	0.4874	0.23485
CENTRAL NERVOUS SYSTEM	9.7291	9.7481	-0.0230	-0.024
ENDOMETRIUM	9.6661	9.6862	0.0644	0.002562
HAEMATOPOIETIC AND LYMPHOID TISSUE	9.4107	9.4373	0.0726	0.004622
KIDNEY	9.7072	9.7663	-0.0613	0.0309
LARGE INTESTINE	9.6733	9.60595	0.1000	0.01255
LIVER	10.0634	9.8414	0.5514	0.2625
LUNG	9.6498	9.62365	0.2067	0.16425
OESOPHAGUS	10.6925	10.5085	1.0758	1.06615
OVARY	9.8494	9.865	0.2760	0.1278
PANCREAS	10.0102	10.021	0.2676	0.2464
PLEURA	10.1237	9.9814	-0.0096	-0.09416
PROSTATE	9.6324	9.3846	0.0940	0.0470778
SALIVARY GLAND	10.9560	10.956	1.7670	1.767
SKIN	9.8883	9.7869	0.0477	-0.007633
SMALL INTESTINE	9.6904	9.6904	-0.0067	-0.0067
SOFT TISSUE	9.5044	9.433	-0.0590	0
STOMACH	9.8740	9.774	0.3091	0.23305
THYROID	9.7281	9.85935	0.1599	0.3537
UPPER AERODIGESTIVE TRACT	10.7747	10.6345	1.1994	1.2475
URINARY TRACT	10.1133	9.8082	0.4953	0.2793

Gene Essentiality Data (+)

Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.

test

Tertiary structure (+)

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Modelled Structure	Structures available in PDB
	1A1W, 1A1Z, 1E3Y, 1E41, 2GF5, 3EZQ, 3OQ9

Structure Domains (+)

1. PFAM Domains:

Domain ID	Domain Name	Start Site	End Site	E-value
PF01335	DED	4	84	5.9e-24
PF12307	DUF3631	77	170	0.078
PF00531	Death	101	179	3.2e-23
PF01335	DED	4	84	5.9e-24
PF12307	DUF3631	77	170	0.078
PF00531	Death	101	179	3.2e-23

2. Superfamily Domains:

Domain ID	Start Site	End Site	E-value
0048274	1	133	3.53e-35
0048274	1	133	3.53e-35

Sequence Alignment (+)

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1. Variants are not present in 1000 Genomes!!

2. Sequence alignment with CCLE mutants:

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3. Sequence alignment with COSMIC mutants:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

4. Sequence alignment with homologus proteins:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

Sequence Profiles (+)

HMM
With Uniprot database	With Mutants	With 1000 Genome Variants

PSSM
With Uniprot database	With Mutants	With 1000 Genome Variant

Post Translational Modifications (+)

S. No.	Position	Amino acid	Type	Description
1	1	M	Acetylation	N-acetylmethionine.
2	18	S	Phosphorylation	Phosphoserine
3	190	S	Phosphorylation	Phosphoserine
4	194	S	Phosphorylation	Phosphoserine
5	194	S	Phosphorylation	Phosphoserine (HIPK3;HIPK3)
6	194	S	Phosphorylation	Phosphoserine.
7	194	S	Phosphorylation (CSNK1A1)	Phosphoserine
8	194	S	Phosphorylation (HIPK3)	Phosphoserine
9	197	S	Phosphorylation	Phosphoserine
10	197	S	Phosphorylation	Phosphoserine.
11	203	S	Phosphorylation	Phosphoserine
12	21	T	Phosphorylation	Phosphothreonine
13	41	S	Phosphorylation	Phosphoserine
14	41	S	Phosphorylation	Phosphoserine.
15	1	M	Acetylation	N-acetylmethionine.
16	18	S	Phosphorylation	Phosphoserine
17	190	S	Phosphorylation	Phosphoserine
18	194	S	Phosphorylation	Phosphoserine
19	194	S	Phosphorylation	Phosphoserine (HIPK3;HIPK3)
20	194	S	Phosphorylation	Phosphoserine.
21	194	S	Phosphorylation (CSNK1A1)	Phosphoserine
22	194	S	Phosphorylation (HIPK3)	Phosphoserine
23	197	S	Phosphorylation	Phosphoserine
24	197	S	Phosphorylation	Phosphoserine.
25	203	S	Phosphorylation	Phosphoserine
26	21	T	Phosphorylation	Phosphothreonine
27	41	S	Phosphorylation	Phosphoserine
28	41	S	Phosphorylation	Phosphoserine.

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
FADD	FADD	FADD	ENSP00000301838	Q13158
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
Q13158	FADD	ENSP00000301838	FADD	Q13158
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
FADD	ENSP00000301838	602457	Q13158	PA27972

Protein: FADD

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)