ApoCanD

Mutation Data (+)

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	587284	Tumour	LARGE INTESTINE	ENST00000372642	c.388G>A	p.A130T	COSMIC	NP	NP
2	A498	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000372642	c.889_892delAAGT	p.K297fs?	COSMIC	NP	NP
3	LUAD-S00488	Tumour	LUNG	ENST00000372642	c.880G>A	p.A294T	COSMIC	NP	NP
4	TCGA-AZ-6598-01	Tumour	LARGE INTESTINE	ENST00000372642	c.873C>A	p.A291A	COSMIC	NP	NP
5	TCGA-B5-A11N-01	Tumour	ENDOMETRIUM	ENST00000372642	c.802G>A	p.E268K	COSMIC	NP	NP
6	TCGA-CM-5861-01	Tumour	LARGE INTESTINE	ENST00000372642	c.854G>T	p.R285L	COSMIC	NP	NP
7	TCGA-G4-6588-01	Tumour	LARGE INTESTINE	ENST00000372642	c.551G>A	p.R184H	COSMIC	NP	NP
8	TCGA-G4-6628-01	Tumour	LARGE INTESTINE	ENST00000372642	c.857C>T	p.A286V	COSMIC	NP	NP
9	CTV1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000372642	c.577G>A	p.V193I	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
10	DND41	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000372642	c.593G>T	p.G198V	COSMIC	CANCER	PROBABLY DAMAGING
11	SKMEL5	Cell Line	SKIN	ENST00000372642	c.550C>T	p.R184C	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
12	TALL1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000372642	c.508C>T	p.H170Y	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
13	587284	Tumour	LARGE INTESTINE	ENST00000372642	c.388G>A	p.A130T	COSMIC	NP	NP
14	A498	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000372642	c.889_892delAAGT	p.K297fs?	COSMIC	NP	NP
15	LUAD-S00488	Tumour	LUNG	ENST00000372642	c.880G>A	p.A294T	COSMIC	NP	NP
16	TCGA-AZ-6598-01	Tumour	LARGE INTESTINE	ENST00000372642	c.873C>A	p.A291A	COSMIC	NP	NP
17	TCGA-B5-A11N-01	Tumour	ENDOMETRIUM	ENST00000372642	c.802G>A	p.E268K	COSMIC	NP	NP
18	TCGA-CM-5861-01	Tumour	LARGE INTESTINE	ENST00000372642	c.854G>T	p.R285L	COSMIC	NP	NP
19	TCGA-G4-6588-01	Tumour	LARGE INTESTINE	ENST00000372642	c.551G>A	p.R184H	COSMIC	NP	NP
20	TCGA-G4-6628-01	Tumour	LARGE INTESTINE	ENST00000372642	c.857C>T	p.A286V	COSMIC	NP	NP
21	CTV1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000372642	c.577G>A	p.V193I	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
22	DND41	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000372642	c.593G>T	p.G198V	COSMIC	CANCER	PROBABLY DAMAGING
23	SKMEL5	Cell Line	SKIN	ENST00000372642	c.550C>T	p.R184C	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
24	TALL1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000372642	c.508C>T	p.H170Y	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING

*NP: Not Predicted

Copy number variation and expression profile (+)

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	9.1425	9.2536	0.0723	0.0437
BILIARY TRACT	7.9459	8.2736	-0.0132	-0.05184
BONE	8.1921	8.0348	0.0714	0.0056
BREAST	8.4668	8.5432	0.0521	0.0397
CENTRAL NERVOUS SYSTEM	7.9638	7.9112	0.0835	0.05145
ENDOMETRIUM	8.3750	8.3638	-0.0132	0.007304
HAEMATOPOIETIC AND LYMPHOID TISSUE	8.1497	8.242	-0.0693	-0.0145
KIDNEY	7.7189	7.8541	0.0197	0.0527
LARGE INTESTINE	8.5897	8.70005	0.0754	0.012368
LIVER	8.0991	8.2004	-0.0361	-0.0734
LUNG	8.3238	8.40495	-0.0337	0.01473
OESOPHAGUS	7.9237	7.9629	0.2669	0.3151
OVARY	8.2165	8.223	-0.1391	-0.1181
PANCREAS	8.0451	8.0905	0.0535	0.1241
PLEURA	8.5234	8.4912	0.1856	0.1619
PROSTATE	9.2555	8.94665	0.0054	0.0320765
SALIVARY GLAND	8.0296	8.0296	0.4607	0.4607
SKIN	7.9805	8.1063	-0.0890	-0.0473
SMALL INTESTINE	9.1489	9.1489	0.0044	0.004401
SOFT TISSUE	7.9373	8.1442	0.0325	0.012695
STOMACH	8.4414	8.49165	0.1223	0.13325
THYROID	7.9965	7.8324	0.0987	0.07065
UPPER AERODIGESTIVE TRACT	8.0684	7.9191	0.3734	0.38485
URINARY TRACT	8.1257	8.2333	0.1359	0.2093

Gene Essentiality Data (+)

Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.

test

Tertiary structure (+)

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Modelled Structure	Structures available in PDB
	Structure is not available in PDB

Structure Domains (+)

1. PFAM Domains:

Domain ID	Domain Name	Start Site	End Site	E-value
PF01223	Endonuclease_NS	78	282	2.9e-61
PF01223	Endonuclease_NS	78	282	2.9e-61

2. Superfamily Domains:

Domain ID	Start Site	End Site	E-value
0037998	63	282	7.06e-68
0037998	63	282	7.06e-68

Sequence Alignment (+)

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1. Sequence alignment with 1000 genome variations:

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2. Mutants are not present in CCLE!!

3. Sequence alignment with COSMIC mutants:

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4. Sequence alignment with homologus proteins:

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Sequence Profiles (+)

HMM
With Uniprot database	With Mutants	With 1000 Genome Variants

PSSM
With Uniprot database	With Mutants	With 1000 Genome Variant

Post Translational Modifications (+)

Post translational modifications are not found!!

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
ENDOG	ENDOG	ENDOG	ENSP00000361725	Q14249
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
Q14249	ENDOG	ENSP00000361725	ENDOG	Q14249
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
ENDOG	ENSP00000361725	600440	Q14249	PA27783

Protein: ENDOG

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)