ApoCanD

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	EJM	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_063940	c.179C>T	p.A60V	CCLE	NA	Benign
2	IGROV1	Cell Line	OVARY	NP_063940	c.167C>T	p.A56V	CCLE	NA	Probably Damaging
3	KYSE140	Cell Line	OESOPHAGUS	NP_063940	c.96_97GC>TT	p.32_33KR>NW	CCLE	NA	NP
4	LNCAPCLONEFGC	Cell Line	PROSTATE	NP_063940	c.377C>T	p.S126L	CCLE	NA	Probably Damaging
5	MEWO	Cell Line	SKIN	NP_063940	c.335C>T	p.S112F	CCLE	NA	Probably Damaging
6	MFE319	Cell Line	ENDOMETRIUM	NP_063940	c.208A>G	p.S70G	CCLE	NA	Benign
7	NCIH1355	Cell Line	LUNG	NP_063940	c.19T>A	p.W7R	CCLE	NA	Benign
8	SKMEL2	Cell Line	SKIN	NP_063940	c.545C>A	p.T182N	CCLE	NA	Possibly Damaging
9	ESO-708	Tumour	OESOPHAGUS	ENST00000443649	c.666G>A	p.E222E	COSMIC	NP	NP
10	LC	Tumour	S12 LUNG	ENST00000443649	c.34G>T	p.V12L	COSMIC	NP	NP
11	LUAD-NYU1219	Tumour	LUNG	ENST00000443649	c.546C>T	p.T182T	COSMIC	NP	NP
12	PD4082a	Tumour	BREAST	ENST00000443649	c.116T>A	p.I39K	COSMIC	NP	NP
13	TCGA-23-1031-01	Tumour	OVARY	ENST00000443649	c.545C>A	p.T182N	COSMIC	NP	NP
14	TCGA-29-1764-01	Tumour	OVARY	ENST00000443649	c.459G>A	p.L153L	COSMIC	NP	NP
15	TCGA-67-4679-01	Tumour	LUNG	ENST00000443649	c.627A>T	p.A209A	COSMIC	NP	NP
16	TCGA-AA-3672-01	Tumour	LARGE INTESTINE	ENST00000443649	c.167C>T	p.A56V	COSMIC	NP	NP
17	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000443649	c.525C>T	p.G175G	COSMIC	NP	NP
18	TCGA-BG-A187-01	Tumour	ENDOMETRIUM	ENST00000443649	c.545C>A	p.T182N	COSMIC	NP	NP
19	TCGA-BS-A0TG-01	Tumour	ENDOMETRIUM	ENST00000443649	c.545C>A	p.T182N	COSMIC	NP	NP
20	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000443649	c.688T>C	p.S230P	COSMIC	NP	NP
21	TCGA-D1-A174-01	Tumour	ENDOMETRIUM	ENST00000443649	c.545C>A	p.T182N	COSMIC	NP	NP
22	TCGA-D1-A17Q-01	Tumour	ENDOMETRIUM	ENST00000443649	c.351T>G	p.Y117*	COSMIC	NP	NP
23	TCGA-D5-6540-01	Tumour	LARGE INTESTINE	ENST00000443649	c.284C>T	p.A95V	COSMIC	NP	NP
24	ccRCC-55	Tumour	KIDNEY	ENST00000443649	c.545C>A	p.T182N	COSMIC	NP	NP
25	BE13	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000443649	c.539C>G	p.S180C	COSMIC	no weights	PROBABLY DAMAGING
26	CP67MEL	Cell Line	SKIN	ENST00000443649	c.413_415delGAG	p.G138delG	COSMIC	NP	NP
27	DJM1	Cell Line	SKIN	ENST00000443649	c.524-8T>G	p.?	COSMIC	NP	NP
28	EJM	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000443649	c.179C>T	p.A60V	COSMIC	no weights	BENIGN
29	KYSE140	Cell Line	OESOPHAGUS	ENST00000443649	c.96G>T	p.K32N	COSMIC	no weights	POSSIBLY DAMAGING
30	KYSE140	Cell Line	OESOPHAGUS	ENST00000443649	c.97C>T	p.R33W	COSMIC	no weights	PROBABLY DAMAGING
31	LNCAPCLONEFGC	Cell Line	PROSTATE	ENST00000443649	c.377C>T	p.S126L	COSMIC	no weights	PROBABLY DAMAGING
32	MEWO	Cell Line	SKIN	ENST00000443649	c.335C>T	p.S112F	COSMIC	no weights	PROBABLY DAMAGING
33	MFE319	Cell Line	ENDOMETRIUM	ENST00000443649	c.208A>G	p.S70G	COSMIC	no weights	BENIGN
34	NCIH2023	Cell Line	LUNG	ENST00000443649	c.99G>T	p.R33R	COSMIC	NP	NP
35	EJM	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_063940	c.179C>T	p.A60V	CCLE	NA	Benign
36	IGROV1	Cell Line	OVARY	NP_063940	c.167C>T	p.A56V	CCLE	NA	Probably Damaging
37	KYSE140	Cell Line	OESOPHAGUS	NP_063940	c.96_97GC>TT	p.32_33KR>NW	CCLE	NA	NP
38	LNCAPCLONEFGC	Cell Line	PROSTATE	NP_063940	c.377C>T	p.S126L	CCLE	NA	Probably Damaging
39	MEWO	Cell Line	SKIN	NP_063940	c.335C>T	p.S112F	CCLE	NA	Probably Damaging
40	MFE319	Cell Line	ENDOMETRIUM	NP_063940	c.208A>G	p.S70G	CCLE	NA	Benign
41	NCIH1355	Cell Line	LUNG	NP_063940	c.19T>A	p.W7R	CCLE	NA	Benign
42	SKMEL2	Cell Line	SKIN	NP_063940	c.545C>A	p.T182N	CCLE	NA	Possibly Damaging
43	ESO-708	Tumour	OESOPHAGUS	ENST00000443649	c.666G>A	p.E222E	COSMIC	NP	NP
44	LC	Tumour	S12 LUNG	ENST00000443649	c.34G>T	p.V12L	COSMIC	NP	NP
45	LUAD-NYU1219	Tumour	LUNG	ENST00000443649	c.546C>T	p.T182T	COSMIC	NP	NP
46	PD4082a	Tumour	BREAST	ENST00000443649	c.116T>A	p.I39K	COSMIC	NP	NP
47	TCGA-23-1031-01	Tumour	OVARY	ENST00000443649	c.545C>A	p.T182N	COSMIC	NP	NP
48	TCGA-29-1764-01	Tumour	OVARY	ENST00000443649	c.459G>A	p.L153L	COSMIC	NP	NP
49	TCGA-67-4679-01	Tumour	LUNG	ENST00000443649	c.627A>T	p.A209A	COSMIC	NP	NP
50	TCGA-AA-3672-01	Tumour	LARGE INTESTINE	ENST00000443649	c.167C>T	p.A56V	COSMIC	NP	NP
51	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000443649	c.525C>T	p.G175G	COSMIC	NP	NP
52	TCGA-BG-A187-01	Tumour	ENDOMETRIUM	ENST00000443649	c.545C>A	p.T182N	COSMIC	NP	NP
53	TCGA-BS-A0TG-01	Tumour	ENDOMETRIUM	ENST00000443649	c.545C>A	p.T182N	COSMIC	NP	NP
54	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000443649	c.688T>C	p.S230P	COSMIC	NP	NP
55	TCGA-D1-A174-01	Tumour	ENDOMETRIUM	ENST00000443649	c.545C>A	p.T182N	COSMIC	NP	NP
56	TCGA-D1-A17Q-01	Tumour	ENDOMETRIUM	ENST00000443649	c.351T>G	p.Y117*	COSMIC	NP	NP
57	TCGA-D5-6540-01	Tumour	LARGE INTESTINE	ENST00000443649	c.284C>T	p.A95V	COSMIC	NP	NP
58	ccRCC-55	Tumour	KIDNEY	ENST00000443649	c.545C>A	p.T182N	COSMIC	NP	NP
59	BE13	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000443649	c.539C>G	p.S180C	COSMIC	no weights	PROBABLY DAMAGING
60	CP67MEL	Cell Line	SKIN	ENST00000443649	c.413_415delGAG	p.G138delG	COSMIC	NP	NP
61	DJM1	Cell Line	SKIN	ENST00000443649	c.524-8T>G	p.?	COSMIC	NP	NP
62	EJM	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000443649	c.179C>T	p.A60V	COSMIC	no weights	BENIGN
63	KYSE140	Cell Line	OESOPHAGUS	ENST00000443649	c.96G>T	p.K32N	COSMIC	no weights	POSSIBLY DAMAGING
64	KYSE140	Cell Line	OESOPHAGUS	ENST00000443649	c.97C>T	p.R33W	COSMIC	no weights	PROBABLY DAMAGING
65	LNCAPCLONEFGC	Cell Line	PROSTATE	ENST00000443649	c.377C>T	p.S126L	COSMIC	no weights	PROBABLY DAMAGING
66	MEWO	Cell Line	SKIN	ENST00000443649	c.335C>T	p.S112F	COSMIC	no weights	PROBABLY DAMAGING
67	MFE319	Cell Line	ENDOMETRIUM	ENST00000443649	c.208A>G	p.S70G	COSMIC	no weights	BENIGN
68	NCIH2023	Cell Line	LUNG	ENST00000443649	c.99G>T	p.R33R	COSMIC	NP	NP

*NP: Not Predicted

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	11.3597	11.239	0.0801	0.0416
BILIARY TRACT	10.8280	10.763	-0.0019	-0.0573
BONE	10.5506	10.497	-0.0069	-0.0063
BREAST	10.6902	10.5815	-0.0469	0.0007435
CENTRAL NERVOUS SYSTEM	10.7117	10.654	-0.0461	-0.0285
ENDOMETRIUM	10.8851	10.846	0.0385	0.0004179
HAEMATOPOIETIC AND LYMPHOID TISSUE	10.7272	10.735	0.0016	-0.0005936
KIDNEY	10.7777	10.74	0.1612	0.0916
LARGE INTESTINE	10.8245	10.8385	0.0521	0.00804
LIVER	10.7832	10.838	-0.0383	-0.0135
LUNG	10.8510	10.812	0.0627	0.07934
OESOPHAGUS	10.7188	10.718	-0.0661	-0.031785
OVARY	10.8387	10.814	-0.0258	0.009674
PANCREAS	10.6149	10.59	-0.0178	-0.006831
PLEURA	10.9923	11.015	0.0545	0.02444
PROSTATE	10.8603	10.8925	0.1748	0.10606
SALIVARY GLAND	10.1890	10.189	-0.2980	-0.298
SKIN	10.6185	10.609	-0.0110	2e-04
SMALL INTESTINE	10.4670	10.467	0.0043	0.0043
SOFT TISSUE	10.7796	10.833	-0.0047	-0.01077
STOMACH	10.8279	10.806	0.0290	0.03638
THYROID	10.6500	10.514	-0.0302	0.0141605
UPPER AERODIGESTIVE TRACT	10.6723	10.6665	0.0345	0.059195
URINARY TRACT	10.9000	10.926	0.1316	0.14095

Domain ID	Domain Name	Start Site	End Site	E-value
PF09057	Smac_DIABLO	6	239	3.5e-116
PF07928	Vps54	85	145	0.15
PF13355	DUF4101	163	233	0.041
PF09057	Smac_DIABLO	6	239	3.5e-116
PF07928	Vps54	85	145	0.15
PF13355	DUF4101	163	233	0.041

Domain ID	Start Site	End Site	E-value
0046764	67	239	4.19e-81
0037967	23	60	6.28e-04
0046764	67	239	4.19e-81
0037967	23	60	6.28e-04

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
DIABLO	DIABLO	DIABLO	ENSP00000267169	Q9NR28
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
Q9NR28	DIABLO	ENSP00000267169	DIABLO	Q9NR28
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
DIABLO	ENSP00000267169	605219	Q9NR28	PA134945044

Protein: DIABLO

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)

Modelled Structure	Structures available in PDB
	1FEW, 1G3F, 1G73, 1OXQ, 1TW6, 1XB0, 1XB1, 3D9U, 3UIH, 3UIJ