ApoCanD

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	COLO684	Cell Line	ENDOMETRIUM	NP_056062	c.122T>G	p.V41G	CCLE	NP	Possibly Damaging
2	COLO704	Cell Line	OVARY	NP_056062	c.122T>G	p.V41G	CCLE	NP	Possibly Damaging
3	DAOY	Cell Line	CENTRAL NERVOUS SYSTEM	NP_056062	c.1837T>G	p.F613V	CCLE	PASSENGER/OTHER	Probably Damaging
4	GP2D	Cell Line	LARGE INTESTINE	NP_056062	c.1615T>C	p.C539R	CCLE	PASSENGER/OTHER	Probably Damaging
5	GP2D	Cell Line	LARGE INTESTINE	NP_056062	c.2005G>A	p.V669M	CCLE	PASSENGER/OTHER	Probably Damaging
6	HCC366	Cell Line	LUNG	NP_056062	c.866C>T	p.A289V	CCLE	PASSENGER/OTHER	Probably Damaging
7	HCT15	Cell Line	LARGE INTESTINE	NP_056062	c.163G>A	p.V55M	CCLE	NP	Benign
8	HEC108	Cell Line	ENDOMETRIUM	NP_056062	c.926G>A	p.S309N	CCLE	NP	Benign
9	HEC59	Cell Line	ENDOMETRIUM	NP_056062	c.2432G>A	p.G811E	CCLE	NP	Probably Damaging
10	HLF	Cell Line	LIVER	NP_056062	c.964A>G	p.M322V	CCLE	PASSENGER/OTHER	Benign
11	HPBALL	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_056062	c.476_476delC	p.S159fs	CCLE	NP	NP
12	HRT18	Cell Line	LARGE INTESTINE	NP_056062	c.163G>A	p.V55M	CCLE	NP	Benign
13	HRT18	Cell Line	LARGE INTESTINE	NP_056062	c.2093C>A	p.P698H	CCLE	PASSENGER/OTHER	Probably Damaging
14	HRT18	Cell Line	LARGE INTESTINE	NP_056062	c.695T>C	p.I232T	CCLE	NP	Probably Damaging
15	IM95	Cell Line	STOMACH	NP_056062	c.2159_2159delA	p.E720fs	CCLE	NP	NP
16	KASUMI2	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_056062	c.583G>A	p.V195M	CCLE	PASSENGER/OTHER	Probably Damaging
17	KMM1	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_056062	c.1789C>A	p.H597N	CCLE	PASSENGER/OTHER	Probably Damaging
18	KYSE30	Cell Line	OESOPHAGUS	NP_056062	c.1327C>A	p.Q443K	CCLE	PASSENGER/OTHER	Possibly Damaging
19	LU65	Cell Line	LUNG	NP_056062	c.2673G>T	p.M891I	CCLE	PASSENGER/OTHER	Probably Damaging
20	MDAMB435S	Cell Line	SKIN	NP_056062	c.2311C>T	p.P771S	CCLE	PASSENGER/OTHER	Probably Damaging
21	MPP89	Cell Line	PLEURA	NP_056062	c.1579G>A	p.A527T	CCLE	PASSENGER/OTHER	Possibly Damaging
22	NCIH1339	Cell Line	LUNG	NP_056062	c.1018A>T	p.T340S	CCLE	NP	Benign
23	NCIH1836	Cell Line	LUNG	NP_056062	c.2759T>G	p.L920R	CCLE	NP	Benign
24	NCIH889	Cell Line	LUNG	NP_056062	c.1267C>T	p.L423F	CCLE	NP	Probably Damaging
25	SNGM	Cell Line	ENDOMETRIUM	NP_056062	c.46T>C	p.W16R	CCLE	NP	Benign
26	SNU1040	Cell Line	LARGE INTESTINE	NP_056062	c.2392G>A	p.E798K	CCLE	PASSENGER/OTHER	Probably Damaging
27	SNU81	Cell Line	LARGE INTESTINE	NP_056062	c.1052G>T	p.R351I	CCLE	NP	Possibly Damaging
28	SNUC4	Cell Line	LARGE INTESTINE	NP_056062	c.1754A>G	p.E585G	CCLE	NP	Possibly Damaging
29	SNUC5	Cell Line	LARGE INTESTINE	NP_056062	c.2794C>T	p.Q932*	CCLE	NP	NP
30	TGBC11TKB	Cell Line	STOMACH	NP_056062	c.2100_2100delA	p.L700fs	CCLE	NP	NP
31	10-497	Tumour	LARGE INTESTINE	ENST00000311559	c.2159delA	p.N722fs*13	COSMIC	NP	NP
32	10-78	Tumour	LARGE INTESTINE	ENST00000311559	c.2149A>T	p.I717F	COSMIC	NP	NP
33	1032115	Tumour	SKIN	ENST00000311559	c.?_?del?	p.?	COSMIC	NP	NP
34	1032116	Tumour	SKIN	ENST00000311559	c.1135G>T	p.E379*	COSMIC	NP	NP
35	1032117	Tumour	SKIN	ENST00000311559	c.2272C>T	p.R758*	COSMIC	NP	NP
36	1032118	Tumour	SKIN	ENST00000311559	c.?	p.?	COSMIC	NP	NP
37	1032119	Tumour	SKIN	ENST00000311559	c.2713C>T	p.Q905*	COSMIC	NP	NP
38	1032120	Tumour	SKIN	ENST00000311559	c.?	p.?	COSMIC	NP	NP
39	1032141	Tumour	SKIN	ENST00000311559	c.2541G>A	p.W847*	COSMIC	NP	NP
40	1308403	Tumour	SKIN	ENST00000311559	c.2272C>T	p.R758*	COSMIC	NP	NP
41	1308406	Tumour	SKIN	ENST00000311559	c.2032G>T	p.E678*	COSMIC	NP	NP
42	134413	Tumour	LUNG	ENST00000311559	c.1147G>T	p.D383Y	COSMIC	NP	NP
43	1352688	Tumour	SKIN	ENST00000311559	c.1739_1740insTGGA	p.E580fs*36	COSMIC	NP	NP
44	1352690	Tumour	SKIN	ENST00000311559	c.1794C>A	p.Y598*	COSMIC	NP	NP
45	1352693	Tumour	SKIN	ENST00000311559	c.1540_1541insA	p.T514fs*29	COSMIC	NP	NP
46	1352694	Tumour	SKIN	ENST00000311559	c.1112C>A	p.S371*	COSMIC	NP	NP
47	1352695	Tumour	SKIN	ENST00000311559	c.2467C>T	p.Q823*	COSMIC	NP	NP
48	1352696	Tumour	SKIN	ENST00000311559	c.2806C>T	p.R936*	COSMIC	NP	NP
49	1352699	Tumour	SKIN	ENST00000311559	c.2713C>T	p.Q905*	COSMIC	NP	NP
50	1352700	Tumour	SKIN	ENST00000311559	c.2046_2047insAGATCCG	p.E683fs*43	COSMIC	NP	NP
51	1352703	Tumour	SKIN	ENST00000311559	c.2107A>T	p.R703*	COSMIC	NP	NP
52	1432874	Tumour	SKIN	ENST00000311559	c.2322_2322delA	p.E774fs*2	COSMIC	NP	NP
53	1452109	Tumour	LARGE INTESTINE	ENST00000311559	c.2305_2305delA	p.I769fs*7	COSMIC	NP	NP
54	1507039	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000311559	c.2319G>A	p.L773L	COSMIC	NP	NP
55	1507216	Tumour	LARGE INTESTINE	ENST00000311559	c.2475C>T	p.H825H	COSMIC	NP	NP
56	1507217	Tumour	LARGE INTESTINE	ENST00000311559	c.1138+11A>C	p.?	COSMIC	NP	NP
57	1660225	Tumour	SKIN	ENST00000311559	c.1118_1119insA	p.N373fs*6	COSMIC	NP	NP
58	1660235	Tumour	SKIN	ENST00000311559	c.1327C>T	p.Q443*	COSMIC	NP	NP
59	1996374	Tumour	SKIN	ENST00000311559	c.2156_2157insT	p.M719fs*5	COSMIC	NP	NP
60	1996375	Tumour	SKIN	ENST00000311559	c.2032G>T	p.E678*	COSMIC	NP	NP
61	1996384	Tumour	SKIN	ENST00000311559	c.?	p.?	COSMIC	NP	NP
62	1996385	Tumour	SKIN	ENST00000311559	c.2359C>T	p.Q787*	COSMIC	NP	NP
63	1996389	Tumour	SKIN	ENST00000311559	c.2630_2630delA	p.K877fs*36	COSMIC	NP	NP
64	1996394	Tumour	SKIN	ENST00000311559	c.2242-2A>T	p.?	COSMIC	NP	NP
65	1996396	Tumour	SKIN	ENST00000311559	c.1681_1682delTT	p.L561fs*8	COSMIC	NP	NP
66	1996396	Tumour	SKIN	ENST00000311559	c.2829T>A	p.Y943*	COSMIC	NP	NP
67	1996397	Tumour	SKIN	ENST00000311559	c.1681_1682delTT	p.L561fs*8	COSMIC	NP	NP
68	1996398	Tumour	SKIN	ENST00000311559	c.?	p.?	COSMIC	NP	NP
69	1996415	Tumour	SKIN	ENST00000311559	c.1932_1932delT	p.I644fs*5	COSMIC	NP	NP
70	1996416	Tumour	SKIN	ENST00000311559	c.2241+2T>C	p.?	COSMIC	NP	NP
71	1996419	Tumour	SKIN	ENST00000311559	c.?	p.?	COSMIC	NP	NP
72	1996420	Tumour	SKIN	ENST00000311559	c.2119C>T	p.Q707*	COSMIC	NP	NP
73	587222	Tumour	LARGE INTESTINE	ENST00000311559	c.1733A>C	p.K578T	COSMIC	NP	NP
74	8030245	Tumour	PANCREAS	ENST00000311559	c.1189C>T	p.R397C	COSMIC	NP	NP
75	90273	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000311559	c.340A>T	p.K114*	COSMIC	NP	NP
76	ESO-105	Tumour	OESOPHAGUS	ENST00000311559	c.1505C>T	p.A502V	COSMIC	NP	NP
77	HCC142T	Tumour	LIVER	ENST00000311559	c.956T>G	p.L319R	COSMIC	NP	NP
78	HCC2998	Cell Line	LARGE INTESTINE	ENST00000311559	c.733G>T	p.E245*	COSMIC	NP	NP
79	HN	Tumour	62755 UPPER AERODIGESTIVE TRACT	ENST00000311559	c.1554C>T	p.F518F	COSMIC	NP	NP
80	ICGC	Tumour	0056 PANCREAS	ENST00000311559	c.1189C>T	p.R397C	COSMIC	NP	NP
81	ID43	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000311559	c.1469G>T	p.W490L	COSMIC	NP	NP
82	KM-H2	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000311559	c.2109-3_2109-1TAG>AA	p.?	COSMIC	NP	NP
83	LUAD-F00162	Tumour	LUNG	ENST00000311559	c.1196C>T	p.S399L	COSMIC	NP	NP
84	LUAD-NYU284	Tumour	LUNG	ENST00000311559	c.2236G>A	p.A746T	COSMIC	NP	NP
85	LUAD-S01331	Tumour	LUNG	ENST00000311559	c.147T>C	p.Y49Y	COSMIC	NP	NP
86	MB	Tumour	Exm17 CENTRAL NERVOUS SYSTEM	ENST00000311559	c.2042A>T	p.D681V	COSMIC	NP	NP
87	MDA-N	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000311559	c.2311C>T	p.P771S	COSMIC	NP	NP
88	PA285	Cell Line	PANCREAS	ENST00000311559	c.106_107insAA	p.L38fs*10	COSMIC	NP	NP
89	PD3190a	Tumour	NS	ENST00000311559	c.2211delT	p.F738fs*6	COSMIC	NP	NP
90	SE4	Tumour	LARGE INTESTINE	ENST00000311559	c.2554G>A	p.G852S	COSMIC	NP	NP
91	T183	Tumour	KIDNEY	ENST00000311559	c.1715delA	p.E573fs*14	COSMIC	NP	NP
92	T183M	Tumour	KIDNEY	ENST00000311559	c.1715delA	p.E573fs*14	COSMIC	NP	NP
93	TCGA-02-0070-01	Tumour	CENTRAL NERVOUS SYSTEM	ENST00000311559	c.1681T>C	p.L561L	COSMIC	NP	NP
94	TCGA-02-0114-01	Tumour	CENTRAL NERVOUS SYSTEM	ENST00000311559	c.461C>T	p.A154V	COSMIC	NP	NP
95	TCGA-05-4398-01	Tumour	LUNG	ENST00000311559	c.1078_1079GG>TT	p.G360L	COSMIC	NP	NP
96	TCGA-05-4405-01	Tumour	LUNG	ENST00000311559	c.1778G>A	p.G593D	COSMIC	NP	NP
97	TCGA-05-4424-01	Tumour	LUNG	ENST00000311559	c.1206C>G	p.L402L	COSMIC	NP	NP
98	TCGA-06-0190-01	Tumour	CENTRAL NERVOUS SYSTEM	ENST00000311559	c.867G>A	p.A289A	COSMIC	NP	NP
99	TCGA-18-3409-01	Tumour	LUNG	ENST00000311559	c.949C>T	p.P317S	COSMIC	NP	NP
100	TCGA-22-5473-01	Tumour	LUNG	ENST00000311559	c.212G>T	p.G71V	COSMIC	NP	NP
101	TCGA-22-5480-01	Tumour	LUNG	ENST00000311559	c.2350+2T>A	p.?	COSMIC	NP	NP
102	TCGA-37-3783-01	Tumour	LUNG	ENST00000311559	c.2694G>C	p.Q898H	COSMIC	NP	NP
103	TCGA-37-4141-01	Tumour	LUNG	ENST00000311559	c.2590G>T	p.V864F	COSMIC	NP	NP
104	TCGA-39-5027-01	Tumour	LUNG	ENST00000311559	c.1726C>T	p.P576S	COSMIC	NP	NP
105	TCGA-55-7907-01	Tumour	LUNG	ENST00000311559	c.2699G>T	p.G900V	COSMIC	NP	NP
106	TCGA-60-2725-01	Tumour	LUNG	ENST00000311559	c.2241+1G>T	p.?	COSMIC	NP	NP
107	TCGA-64-1676-01	Tumour	LUNG	ENST00000311559	c.913G>T	p.A305S	COSMIC	NP	NP
108	TCGA-66-2785-01	Tumour	LUNG	ENST00000311559	c.2044C>A	p.P682T	COSMIC	NP	NP
109	TCGA-67-6215-01	Tumour	LUNG	ENST00000311559	c.341A>C	p.K114T	COSMIC	NP	NP
110	TCGA-69-7765-01	Tumour	LUNG	ENST00000311559	c.1944G>C	p.L648L	COSMIC	NP	NP
111	TCGA-69-7980-01	Tumour	LUNG	ENST00000311559	c.1168_1169GA>TT	p.E390L	COSMIC	NP	NP
112	TCGA-78-7146-01	Tumour	LUNG	ENST00000311559	c.1619G>T	p.R540M	COSMIC	NP	NP
113	TCGA-78-7158-01	Tumour	LUNG	ENST00000311559	c.1390C>T	p.P464S	COSMIC	NP	NP
114	TCGA-78-7161-01	Tumour	LUNG	ENST00000311559	c.2805A>G	p.A935A	COSMIC	NP	NP
115	TCGA-A3-3376-01	Tumour	KIDNEY	ENST00000311559	c.388C>A	p.P130T	COSMIC	NP	NP
116	TCGA-A5-A0G9-01	Tumour	ENDOMETRIUM	ENST00000311559	c.907A>G	p.I303V	COSMIC	NP	NP
117	TCGA-A5-A0GP-01	Tumour	ENDOMETRIUM	ENST00000311559	c.863T>G	p.F288C	COSMIC	NP	NP
118	TCGA-A5-A0VP-01	Tumour	ENDOMETRIUM	ENST00000311559	c.2179G>A	p.V727I	COSMIC	NP	NP
119	TCGA-A6-5657-01	Tumour	LARGE INTESTINE	ENST00000311559	c.1794C>A	p.Y598*	COSMIC	NP	NP
120	TCGA-AA-3496-01	Tumour	LARGE INTESTINE	ENST00000311559	c.865G>T	p.A289S	COSMIC	NP	NP
121	TCGA-AA-3510-01	Tumour	LARGE INTESTINE	ENST00000311559	c.865G>T	p.A289S	COSMIC	NP	NP
122	TCGA-AA-3660-01	Tumour	LARGE INTESTINE	ENST00000311559	c.2033A>G	p.E678G	COSMIC	NP	NP
123	TCGA-AA-3715-01	Tumour	LARGE INTESTINE	ENST00000311559	c.2159delA	p.N722fs*13	COSMIC	NP	NP
124	TCGA-AA-3815-01	Tumour	LARGE INTESTINE	ENST00000311559	c.1724C>A	p.T575N	COSMIC	NP	NP
125	TCGA-AA-3815-01	Tumour	LARGE INTESTINE	ENST00000311559	c.1724_1726delCTC	p.P577delP	COSMIC	NP	NP
126	TCGA-AA-3815-01	Tumour	LARGE INTESTINE	ENST00000311559	c.1726C>A	p.P576T	COSMIC	NP	NP
127	TCGA-AA-3815-01	Tumour	LARGE INTESTINE	ENST00000311559	c.2178C>T	p.G726G	COSMIC	NP	NP
128	TCGA-AA-3877-01	Tumour	LARGE INTESTINE	ENST00000311559	c.1542G>A	p.T514T	COSMIC	NP	NP
129	TCGA-AA-3973-01	Tumour	LARGE INTESTINE	ENST00000311559	c.125C>T	p.P42L	COSMIC	NP	NP
130	TCGA-AA-A010-01	Tumour	LARGE INTESTINE	ENST00000311559	c.478G>A	p.G160R	COSMIC	NP	NP
131	TCGA-AF-2693-01	Tumour	LARGE INTESTINE	ENST00000311559	c.1111T>C	p.S371P	COSMIC	NP	NP
132	TCGA-AG-A002-01	Tumour	LARGE INTESTINE	ENST00000311559	c.139G>T	p.G47*	COSMIC	NP	NP
133	TCGA-AG-A002-01	Tumour	LARGE INTESTINE	ENST00000311559	c.2677G>A	p.D893N	COSMIC	NP	NP
134	TCGA-AK-3427-01	Tumour	KIDNEY	ENST00000311559	c.2392G>T	p.E798*	COSMIC	NP	NP
135	TCGA-AP-A056-01	Tumour	ENDOMETRIUM	ENST00000311559	c.1239G>T	p.E413D	COSMIC	NP	NP
136	TCGA-AP-A056-01	Tumour	ENDOMETRIUM	ENST00000311559	c.2621C>A	p.A874D	COSMIC	NP	NP
137	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000311559	c.2409C>T	p.Y803Y	COSMIC	NP	NP
138	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000311559	c.277A>G	p.N93D	COSMIC	NP	NP
139	TCGA-AP-A0LM-01	Tumour	ENDOMETRIUM	ENST00000311559	c.1671C>T	p.R557R	COSMIC	NP	NP
140	TCGA-AR-A1AY-01	Tumour	BREAST	ENST00000311559	c.1787G>A	p.G596D	COSMIC	NP	NP
141	TCGA-AX-A05Z-01	Tumour	ENDOMETRIUM	ENST00000311559	c.2148A>C	p.Q716H	COSMIC	NP	NP
142	TCGA-AX-A0J0-01	Tumour	ENDOMETRIUM	ENST00000311559	c.5G>A	p.S2N	COSMIC	NP	NP
143	TCGA-AY-6196-01	Tumour	LARGE INTESTINE	ENST00000311559	c.2475C>T	p.H825H	COSMIC	NP	NP
144	TCGA-AZ-4315-01	Tumour	LARGE INTESTINE	ENST00000311559	c.1341A>C	p.E447D	COSMIC	NP	NP
145	TCGA-AZ-5407-01	Tumour	LARGE INTESTINE	ENST00000311559	c.1137A>G	p.E379E	COSMIC	NP	NP
146	TCGA-B5-A0JY-01	Tumour	ENDOMETRIUM	ENST00000311559	c.1914G>A	p.E638E	COSMIC	NP	NP
147	TCGA-B5-A0JY-01	Tumour	ENDOMETRIUM	ENST00000311559	c.906C>A	p.I302I	COSMIC	NP	NP
148	TCGA-B5-A11E-01	Tumour	ENDOMETRIUM	ENST00000311559	c.631G>A	p.A211T	COSMIC	NP	NP
149	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000311559	c.2055C>A	p.F685L	COSMIC	NP	NP
150	TCGA-BS-A0UV-01	Tumour	ENDOMETRIUM	ENST00000311559	c.1844C>A	p.S615Y	COSMIC	NP	NP
151	TCGA-BS-A0UV-01	Tumour	ENDOMETRIUM	ENST00000311559	c.557T>G	p.L186R	COSMIC	NP	NP
152	TCGA-CA-6717-01	Tumour	LARGE INTESTINE	ENST00000311559	c.1713A>G	p.V571V	COSMIC	NP	NP
153	TCGA-CA-6717-01	Tumour	LARGE INTESTINE	ENST00000311559	c.79G>T	p.E27*	COSMIC	NP	NP
154	TCGA-CK-4952-01	Tumour	LARGE INTESTINE	ENST00000311559	c.1683A>G	p.L561L	COSMIC	NP	NP
155	TCGA-CK-5912-01	Tumour	LARGE INTESTINE	ENST00000311559	c.1794C>T	p.Y598Y	COSMIC	NP	NP
156	TCGA-CM-5348-01	Tumour	LARGE INTESTINE	ENST00000311559	c.2033A>G	p.E678G	COSMIC	NP	NP
157	TCGA-CM-5860-01	Tumour	LARGE INTESTINE	ENST00000311559	c.2806C>T	p.R936*	COSMIC	NP	NP
158	TCGA-CM-6171-01	Tumour	LARGE INTESTINE	ENST00000311559	c.1137A>G	p.E379E	COSMIC	NP	NP
159	TCGA-CM-6171-01	Tumour	LARGE INTESTINE	ENST00000311559	c.2540G>A	p.W847*	COSMIC	NP	NP
160	TCGA-CM-6677-01	Tumour	LARGE INTESTINE	ENST00000311559	c.866C>A	p.A289E	COSMIC	NP	NP
161	TCGA-CM-6678-01	Tumour	LARGE INTESTINE	ENST00000311559	c.675C>T	p.V225V	COSMIC	NP	NP
162	TCGA-D1-A103-01	Tumour	ENDOMETRIUM	ENST00000311559	c.73C>A	p.L25I	COSMIC	NP	NP
163	TCGA-D1-A16X-01	Tumour	ENDOMETRIUM	ENST00000311559	c.2262T>C	p.I754I	COSMIC	NP	NP
164	TCGA-D1-A16Y-01	Tumour	ENDOMETRIUM	ENST00000311559	c.1670G>A	p.R557H	COSMIC	NP	NP
165	TCGA-D5-5539-01	Tumour	LARGE INTESTINE	ENST00000311559	c.2107A>G	p.R703G	COSMIC	NP	NP
166	TCGA-D5-6539-01	Tumour	LARGE INTESTINE	ENST00000311559	c.2032G>A	p.E678K	COSMIC	NP	NP
167	TCGA-DM-A28F-01	Tumour	LARGE INTESTINE	ENST00000311559	c.1113A>G	p.S371S	COSMIC	NP	NP
168	TCGA-DY-A1DC-01	Tumour	LARGE INTESTINE	ENST00000311559	c.1019C>T	p.T340I	COSMIC	NP	NP
169	TCGA-DY-A1DG-01	Tumour	LARGE INTESTINE	ENST00000311559	c.2034A>G	p.E678E	COSMIC	NP	NP
170	TCGA-EY-A1GS-01	Tumour	ENDOMETRIUM	ENST00000311559	c.2210C>G	p.S737C	COSMIC	NP	NP
171	TCGA-F4-6570-01	Tumour	LARGE INTESTINE	ENST00000311559	c.843T>C	p.D281D	COSMIC	NP	NP
172	TCGA-F4-6808-01	Tumour	LARGE INTESTINE	ENST00000311559	c.1683A>G	p.L561L	COSMIC	NP	NP
173	TCGA-F5-6571-01	Tumour	LARGE INTESTINE	ENST00000311559	c.2273G>T	p.R758L	COSMIC	NP	NP
174	TCGA-G4-6303-01	Tumour	LARGE INTESTINE	ENST00000311559	c.2033A>G	p.E678G	COSMIC	NP	NP
175	TCGA-G4-6586-01	Tumour	LARGE INTESTINE	ENST00000311559	c.2319G>A	p.L773L	COSMIC	NP	NP
176	TCGA-G4-6588-01	Tumour	LARGE INTESTINE	ENST00000311559	c.1794C>T	p.Y598Y	COSMIC	NP	NP
177	TCGA-G4-6626-01	Tumour	LARGE INTESTINE	ENST00000311559	c.1793A>T	p.Y598F	COSMIC	NP	NP
178	TCGA-G5-6235-01	Tumour	LARGE INTESTINE	ENST00000311559	c.2318T>A	p.L773Q	COSMIC	NP	NP
179	cSCCP7	Tumour	SKIN	ENST00000311559	c.76C>T	p.Q26*	COSMIC	NP	NP
180	pfg017T	Tumour	STOMACH	ENST00000311559	c.1139-8_1139-7insT	p.?	COSMIC	NP	NP
181	ASH3	Cell Line	THYROID	ENST00000311559	c.2319G>A	p.L773L	COSMIC	NP	NP
182	BALL1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000311559	c.2319G>A	p.L773L	COSMIC	NP	NP
183	BE2M17	Cell Line	AUTONOMIC_GANGLIA	ENST00000311559	c.1517T>A	p.L506Q	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
184	BT549	Cell Line	BREAST	ENST00000311559	c.59T>G	p.I20S	COSMIC	no weights	BENIGN
185	COLO320HSR	Cell Line	LARGE_INTESTINE	ENST00000311559	c.917+1G>T	p.?	COSMIC	NP	NP
186	COLO684	Cell Line	ENDOMETRIUM	ENST00000311559	c.122T>G	p.V41G	COSMIC	no weights	POSSIBLY DAMAGING
187	DAOY	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000311559	c.1837T>G	p.F613V	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
188	EFM192A	Cell Line	BREAST	ENST00000311559	c.2025T>C	p.F675F	COSMIC	NP	NP
189	GP5D	Cell Line	LARGE_INTESTINE	ENST00000311559	c.1615T>C	p.C539R	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
190	HCC2998	Cell Line	LARGE_INTESTINE	ENST00000311559	c.101A>C	p.Q34P	COSMIC	no weights	BENIGN
191	HCC2998	Cell Line	LARGE_INTESTINE	ENST00000311559	c.733G>T	p.E245*	COSMIC	NP	NP
192	HCC366	Cell Line	LUNG	ENST00000311559	c.866C>T	p.A289V	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
193	HCT15	Cell Line	LARGE_INTESTINE	ENST00000311559	c.163G>A	p.V55M	COSMIC	no weights	BENIGN
194	HLE	Cell Line	LIVER	ENST00000311559	c.964A>G	p.M322V	COSMIC	PASSENGER/OTHER	BENIGN
195	HUH7	Cell Line	LIVER	ENST00000311559	c.2465C>A	p.T822N	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
196	IHH4	Cell Line	THYROID	ENST00000311559	c.1567T>C	p.Y523H	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
197	IM95	Cell Line	STOMACH	ENST00000311559	c.2159delA	p.N722fs*13	COSMIC	NP	NP
198	JURKAT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000311559	c.535G>A	p.G179R	COSMIC	CANCER	PROBABLY DAMAGING
199	K2	Cell Line	SKIN	ENST00000311559	c.1939C>T	p.P647S	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
200	KARPAS45	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000311559	c.2241+10A>G	p.?	COSMIC	NP	NP
201	KASUMI1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000311559	c.2319G>A	p.L773L	COSMIC	NP	NP
202	KYSE30	Cell Line	OESOPHAGUS	ENST00000311559	c.1327C>A	p.Q443K	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
203	KYSE50	Cell Line	OESOPHAGUS	ENST00000311559	c.2104A>G	p.I702V	COSMIC	PASSENGER/OTHER	BENIGN
204	LU65	Cell Line	LUNG	ENST00000311559	c.2673G>T	p.M891I	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
205	M14	Cell Line	SKIN	ENST00000311559	c.2311C>T	p.P771S	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
206	MCAS	Cell Line	OVARY	ENST00000311559	c.1659T>C	p.N553N	COSMIC	NP	NP
207	MCC13	Cell Line	SKIN	ENST00000311559	c.1685-8C>T	p.?	COSMIC	NP	NP
208	MESSA	Cell Line	SOFT_TISSUE	ENST00000311559	c.1021+9T>G	p.?	COSMIC	NP	NP
209	MOLT4	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000311559	c.944G>T	p.R315M	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
210	NCIH1792	Cell Line	LUNG	ENST00000311559	c.1190G>A	p.R397H	COSMIC	no weights	BENIGN
211	NCIH1836	Cell Line	LUNG	ENST00000311559	c.2759T>G	p.L920R	COSMIC	no weights	BENIGN
212	NCIH64	Cell Line	LUNG	ENST00000311559	c.2532A>G	p.L844L	COSMIC	NP	NP
213	OPM2	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000311559	c.675C>T	p.V225V	COSMIC	NP	NP
214	PF382	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000311559	c.2681G>A	p.R894Q	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
215	REH	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000311559	c.2567G>A	p.C856Y	COSMIC	PASSENGER/OTHER	BENIGN
216	RERFLCFM	Cell Line	LUNG	ENST00000311559	c.951C>T	p.P317P	COSMIC	NP	NP
217	SCC15	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000311559	c.1455T>C	p.Y485Y	COSMIC	NP	NP
218	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000311559	c.2392G>A	p.E798K	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
219	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000311559	c.2421C>T	p.D807D	COSMIC	NP	NP
220	SNU475	Cell Line	LIVER	ENST00000311559	c.933G>A	p.T311T	COSMIC	NP	NP
221	SNUC5	Cell Line	LARGE_INTESTINE	ENST00000311559	c.2794C>T	p.Q932*	COSMIC	NP	NP
222	TGBC11TKB	Cell Line	STOMACH	ENST00000311559	c.2100delA	p.I702fs*1	COSMIC	NP	NP
223	TYKNU	Cell Line	OVARY	ENST00000311559	c.2814G>A	p.L938L	COSMIC	NP	NP
224	COLO684	Cell Line	ENDOMETRIUM	NP_056062	c.122T>G	p.V41G	CCLE	NP	Possibly Damaging
225	COLO704	Cell Line	OVARY	NP_056062	c.122T>G	p.V41G	CCLE	NP	Possibly Damaging
226	DAOY	Cell Line	CENTRAL NERVOUS SYSTEM	NP_056062	c.1837T>G	p.F613V	CCLE	PASSENGER/OTHER	Probably Damaging
227	GP2D	Cell Line	LARGE INTESTINE	NP_056062	c.1615T>C	p.C539R	CCLE	PASSENGER/OTHER	Probably Damaging
228	GP2D	Cell Line	LARGE INTESTINE	NP_056062	c.2005G>A	p.V669M	CCLE	PASSENGER/OTHER	Probably Damaging
229	HCC366	Cell Line	LUNG	NP_056062	c.866C>T	p.A289V	CCLE	PASSENGER/OTHER	Probably Damaging
230	HCT15	Cell Line	LARGE INTESTINE	NP_056062	c.163G>A	p.V55M	CCLE	NP	Benign
231	HEC108	Cell Line	ENDOMETRIUM	NP_056062	c.926G>A	p.S309N	CCLE	NP	Benign
232	HEC59	Cell Line	ENDOMETRIUM	NP_056062	c.2432G>A	p.G811E	CCLE	NP	Probably Damaging
233	HLF	Cell Line	LIVER	NP_056062	c.964A>G	p.M322V	CCLE	PASSENGER/OTHER	Benign
234	HPBALL	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_056062	c.476_476delC	p.S159fs	CCLE	NP	NP
235	HRT18	Cell Line	LARGE INTESTINE	NP_056062	c.163G>A	p.V55M	CCLE	NP	Benign
236	HRT18	Cell Line	LARGE INTESTINE	NP_056062	c.2093C>A	p.P698H	CCLE	PASSENGER/OTHER	Probably Damaging
237	HRT18	Cell Line	LARGE INTESTINE	NP_056062	c.695T>C	p.I232T	CCLE	NP	Probably Damaging
238	IM95	Cell Line	STOMACH	NP_056062	c.2159_2159delA	p.E720fs	CCLE	NP	NP
239	KASUMI2	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_056062	c.583G>A	p.V195M	CCLE	PASSENGER/OTHER	Probably Damaging
240	KMM1	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_056062	c.1789C>A	p.H597N	CCLE	PASSENGER/OTHER	Probably Damaging
241	KYSE30	Cell Line	OESOPHAGUS	NP_056062	c.1327C>A	p.Q443K	CCLE	PASSENGER/OTHER	Possibly Damaging
242	LU65	Cell Line	LUNG	NP_056062	c.2673G>T	p.M891I	CCLE	PASSENGER/OTHER	Probably Damaging
243	MDAMB435S	Cell Line	SKIN	NP_056062	c.2311C>T	p.P771S	CCLE	PASSENGER/OTHER	Probably Damaging
244	MPP89	Cell Line	PLEURA	NP_056062	c.1579G>A	p.A527T	CCLE	PASSENGER/OTHER	Possibly Damaging
245	NCIH1339	Cell Line	LUNG	NP_056062	c.1018A>T	p.T340S	CCLE	NP	Benign
246	NCIH1836	Cell Line	LUNG	NP_056062	c.2759T>G	p.L920R	CCLE	NP	Benign
247	NCIH889	Cell Line	LUNG	NP_056062	c.1267C>T	p.L423F	CCLE	NP	Probably Damaging
248	SNGM	Cell Line	ENDOMETRIUM	NP_056062	c.46T>C	p.W16R	CCLE	NP	Benign
249	SNU1040	Cell Line	LARGE INTESTINE	NP_056062	c.2392G>A	p.E798K	CCLE	PASSENGER/OTHER	Probably Damaging
250	SNU81	Cell Line	LARGE INTESTINE	NP_056062	c.1052G>T	p.R351I	CCLE	NP	Possibly Damaging
251	SNUC4	Cell Line	LARGE INTESTINE	NP_056062	c.1754A>G	p.E585G	CCLE	NP	Possibly Damaging
252	SNUC5	Cell Line	LARGE INTESTINE	NP_056062	c.2794C>T	p.Q932*	CCLE	NP	NP
253	TGBC11TKB	Cell Line	STOMACH	NP_056062	c.2100_2100delA	p.L700fs	CCLE	NP	NP
254	10-497	Tumour	LARGE INTESTINE	ENST00000311559	c.2159delA	p.N722fs*13	COSMIC	NP	NP
255	10-78	Tumour	LARGE INTESTINE	ENST00000311559	c.2149A>T	p.I717F	COSMIC	NP	NP
256	1032115	Tumour	SKIN	ENST00000311559	c.?_?del?	p.?	COSMIC	NP	NP
257	1032116	Tumour	SKIN	ENST00000311559	c.1135G>T	p.E379*	COSMIC	NP	NP
258	1032117	Tumour	SKIN	ENST00000311559	c.2272C>T	p.R758*	COSMIC	NP	NP
259	1032118	Tumour	SKIN	ENST00000311559	c.?	p.?	COSMIC	NP	NP
260	1032119	Tumour	SKIN	ENST00000311559	c.2713C>T	p.Q905*	COSMIC	NP	NP
261	1032120	Tumour	SKIN	ENST00000311559	c.?	p.?	COSMIC	NP	NP
262	1032141	Tumour	SKIN	ENST00000311559	c.2541G>A	p.W847*	COSMIC	NP	NP
263	1308403	Tumour	SKIN	ENST00000311559	c.2272C>T	p.R758*	COSMIC	NP	NP
264	1308406	Tumour	SKIN	ENST00000311559	c.2032G>T	p.E678*	COSMIC	NP	NP
265	134413	Tumour	LUNG	ENST00000311559	c.1147G>T	p.D383Y	COSMIC	NP	NP
266	1352688	Tumour	SKIN	ENST00000311559	c.1739_1740insTGGA	p.E580fs*36	COSMIC	NP	NP
267	1352690	Tumour	SKIN	ENST00000311559	c.1794C>A	p.Y598*	COSMIC	NP	NP
268	1352693	Tumour	SKIN	ENST00000311559	c.1540_1541insA	p.T514fs*29	COSMIC	NP	NP
269	1352694	Tumour	SKIN	ENST00000311559	c.1112C>A	p.S371*	COSMIC	NP	NP
270	1352695	Tumour	SKIN	ENST00000311559	c.2467C>T	p.Q823*	COSMIC	NP	NP
271	1352696	Tumour	SKIN	ENST00000311559	c.2806C>T	p.R936*	COSMIC	NP	NP
272	1352699	Tumour	SKIN	ENST00000311559	c.2713C>T	p.Q905*	COSMIC	NP	NP
273	1352700	Tumour	SKIN	ENST00000311559	c.2046_2047insAGATCCG	p.E683fs*43	COSMIC	NP	NP
274	1352703	Tumour	SKIN	ENST00000311559	c.2107A>T	p.R703*	COSMIC	NP	NP
275	1432874	Tumour	SKIN	ENST00000311559	c.2322_2322delA	p.E774fs*2	COSMIC	NP	NP
276	1452109	Tumour	LARGE INTESTINE	ENST00000311559	c.2305_2305delA	p.I769fs*7	COSMIC	NP	NP
277	1507039	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000311559	c.2319G>A	p.L773L	COSMIC	NP	NP
278	1507216	Tumour	LARGE INTESTINE	ENST00000311559	c.2475C>T	p.H825H	COSMIC	NP	NP
279	1507217	Tumour	LARGE INTESTINE	ENST00000311559	c.1138+11A>C	p.?	COSMIC	NP	NP
280	1660225	Tumour	SKIN	ENST00000311559	c.1118_1119insA	p.N373fs*6	COSMIC	NP	NP
281	1660235	Tumour	SKIN	ENST00000311559	c.1327C>T	p.Q443*	COSMIC	NP	NP
282	1996374	Tumour	SKIN	ENST00000311559	c.2156_2157insT	p.M719fs*5	COSMIC	NP	NP
283	1996375	Tumour	SKIN	ENST00000311559	c.2032G>T	p.E678*	COSMIC	NP	NP
284	1996384	Tumour	SKIN	ENST00000311559	c.?	p.?	COSMIC	NP	NP
285	1996385	Tumour	SKIN	ENST00000311559	c.2359C>T	p.Q787*	COSMIC	NP	NP
286	1996389	Tumour	SKIN	ENST00000311559	c.2630_2630delA	p.K877fs*36	COSMIC	NP	NP
287	1996394	Tumour	SKIN	ENST00000311559	c.2242-2A>T	p.?	COSMIC	NP	NP
288	1996396	Tumour	SKIN	ENST00000311559	c.1681_1682delTT	p.L561fs*8	COSMIC	NP	NP
289	1996396	Tumour	SKIN	ENST00000311559	c.2829T>A	p.Y943*	COSMIC	NP	NP
290	1996397	Tumour	SKIN	ENST00000311559	c.1681_1682delTT	p.L561fs*8	COSMIC	NP	NP
291	1996398	Tumour	SKIN	ENST00000311559	c.?	p.?	COSMIC	NP	NP
292	1996415	Tumour	SKIN	ENST00000311559	c.1932_1932delT	p.I644fs*5	COSMIC	NP	NP
293	1996416	Tumour	SKIN	ENST00000311559	c.2241+2T>C	p.?	COSMIC	NP	NP
294	1996419	Tumour	SKIN	ENST00000311559	c.?	p.?	COSMIC	NP	NP
295	1996420	Tumour	SKIN	ENST00000311559	c.2119C>T	p.Q707*	COSMIC	NP	NP
296	587222	Tumour	LARGE INTESTINE	ENST00000311559	c.1733A>C	p.K578T	COSMIC	NP	NP
297	8030245	Tumour	PANCREAS	ENST00000311559	c.1189C>T	p.R397C	COSMIC	NP	NP
298	90273	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000311559	c.340A>T	p.K114*	COSMIC	NP	NP
299	ESO-105	Tumour	OESOPHAGUS	ENST00000311559	c.1505C>T	p.A502V	COSMIC	NP	NP
300	HCC142T	Tumour	LIVER	ENST00000311559	c.956T>G	p.L319R	COSMIC	NP	NP
301	HCC2998	Cell Line	LARGE INTESTINE	ENST00000311559	c.733G>T	p.E245*	COSMIC	NP	NP
302	HN	Tumour	62755 UPPER AERODIGESTIVE TRACT	ENST00000311559	c.1554C>T	p.F518F	COSMIC	NP	NP
303	ICGC	Tumour	0056 PANCREAS	ENST00000311559	c.1189C>T	p.R397C	COSMIC	NP	NP
304	ID43	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000311559	c.1469G>T	p.W490L	COSMIC	NP	NP
305	KM-H2	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000311559	c.2109-3_2109-1TAG>AA	p.?	COSMIC	NP	NP
306	LUAD-F00162	Tumour	LUNG	ENST00000311559	c.1196C>T	p.S399L	COSMIC	NP	NP
307	LUAD-NYU284	Tumour	LUNG	ENST00000311559	c.2236G>A	p.A746T	COSMIC	NP	NP
308	LUAD-S01331	Tumour	LUNG	ENST00000311559	c.147T>C	p.Y49Y	COSMIC	NP	NP
309	MB	Tumour	Exm17 CENTRAL NERVOUS SYSTEM	ENST00000311559	c.2042A>T	p.D681V	COSMIC	NP	NP
310	MDA-N	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000311559	c.2311C>T	p.P771S	COSMIC	NP	NP
311	PA285	Cell Line	PANCREAS	ENST00000311559	c.106_107insAA	p.L38fs*10	COSMIC	NP	NP
312	PD3190a	Tumour	NS	ENST00000311559	c.2211delT	p.F738fs*6	COSMIC	NP	NP
313	SE4	Tumour	LARGE INTESTINE	ENST00000311559	c.2554G>A	p.G852S	COSMIC	NP	NP
314	T183	Tumour	KIDNEY	ENST00000311559	c.1715delA	p.E573fs*14	COSMIC	NP	NP
315	T183M	Tumour	KIDNEY	ENST00000311559	c.1715delA	p.E573fs*14	COSMIC	NP	NP
316	TCGA-02-0070-01	Tumour	CENTRAL NERVOUS SYSTEM	ENST00000311559	c.1681T>C	p.L561L	COSMIC	NP	NP
317	TCGA-02-0114-01	Tumour	CENTRAL NERVOUS SYSTEM	ENST00000311559	c.461C>T	p.A154V	COSMIC	NP	NP
318	TCGA-05-4398-01	Tumour	LUNG	ENST00000311559	c.1078_1079GG>TT	p.G360L	COSMIC	NP	NP
319	TCGA-05-4405-01	Tumour	LUNG	ENST00000311559	c.1778G>A	p.G593D	COSMIC	NP	NP
320	TCGA-05-4424-01	Tumour	LUNG	ENST00000311559	c.1206C>G	p.L402L	COSMIC	NP	NP
321	TCGA-06-0190-01	Tumour	CENTRAL NERVOUS SYSTEM	ENST00000311559	c.867G>A	p.A289A	COSMIC	NP	NP
322	TCGA-18-3409-01	Tumour	LUNG	ENST00000311559	c.949C>T	p.P317S	COSMIC	NP	NP
323	TCGA-22-5473-01	Tumour	LUNG	ENST00000311559	c.212G>T	p.G71V	COSMIC	NP	NP
324	TCGA-22-5480-01	Tumour	LUNG	ENST00000311559	c.2350+2T>A	p.?	COSMIC	NP	NP
325	TCGA-37-3783-01	Tumour	LUNG	ENST00000311559	c.2694G>C	p.Q898H	COSMIC	NP	NP
326	TCGA-37-4141-01	Tumour	LUNG	ENST00000311559	c.2590G>T	p.V864F	COSMIC	NP	NP
327	TCGA-39-5027-01	Tumour	LUNG	ENST00000311559	c.1726C>T	p.P576S	COSMIC	NP	NP
328	TCGA-55-7907-01	Tumour	LUNG	ENST00000311559	c.2699G>T	p.G900V	COSMIC	NP	NP
329	TCGA-60-2725-01	Tumour	LUNG	ENST00000311559	c.2241+1G>T	p.?	COSMIC	NP	NP
330	TCGA-64-1676-01	Tumour	LUNG	ENST00000311559	c.913G>T	p.A305S	COSMIC	NP	NP
331	TCGA-66-2785-01	Tumour	LUNG	ENST00000311559	c.2044C>A	p.P682T	COSMIC	NP	NP
332	TCGA-67-6215-01	Tumour	LUNG	ENST00000311559	c.341A>C	p.K114T	COSMIC	NP	NP
333	TCGA-69-7765-01	Tumour	LUNG	ENST00000311559	c.1944G>C	p.L648L	COSMIC	NP	NP
334	TCGA-69-7980-01	Tumour	LUNG	ENST00000311559	c.1168_1169GA>TT	p.E390L	COSMIC	NP	NP
335	TCGA-78-7146-01	Tumour	LUNG	ENST00000311559	c.1619G>T	p.R540M	COSMIC	NP	NP
336	TCGA-78-7158-01	Tumour	LUNG	ENST00000311559	c.1390C>T	p.P464S	COSMIC	NP	NP
337	TCGA-78-7161-01	Tumour	LUNG	ENST00000311559	c.2805A>G	p.A935A	COSMIC	NP	NP
338	TCGA-A3-3376-01	Tumour	KIDNEY	ENST00000311559	c.388C>A	p.P130T	COSMIC	NP	NP
339	TCGA-A5-A0G9-01	Tumour	ENDOMETRIUM	ENST00000311559	c.907A>G	p.I303V	COSMIC	NP	NP
340	TCGA-A5-A0GP-01	Tumour	ENDOMETRIUM	ENST00000311559	c.863T>G	p.F288C	COSMIC	NP	NP
341	TCGA-A5-A0VP-01	Tumour	ENDOMETRIUM	ENST00000311559	c.2179G>A	p.V727I	COSMIC	NP	NP
342	TCGA-A6-5657-01	Tumour	LARGE INTESTINE	ENST00000311559	c.1794C>A	p.Y598*	COSMIC	NP	NP
343	TCGA-AA-3496-01	Tumour	LARGE INTESTINE	ENST00000311559	c.865G>T	p.A289S	COSMIC	NP	NP
344	TCGA-AA-3510-01	Tumour	LARGE INTESTINE	ENST00000311559	c.865G>T	p.A289S	COSMIC	NP	NP
345	TCGA-AA-3660-01	Tumour	LARGE INTESTINE	ENST00000311559	c.2033A>G	p.E678G	COSMIC	NP	NP
346	TCGA-AA-3715-01	Tumour	LARGE INTESTINE	ENST00000311559	c.2159delA	p.N722fs*13	COSMIC	NP	NP
347	TCGA-AA-3815-01	Tumour	LARGE INTESTINE	ENST00000311559	c.1724C>A	p.T575N	COSMIC	NP	NP
348	TCGA-AA-3815-01	Tumour	LARGE INTESTINE	ENST00000311559	c.1724_1726delCTC	p.P577delP	COSMIC	NP	NP
349	TCGA-AA-3815-01	Tumour	LARGE INTESTINE	ENST00000311559	c.1726C>A	p.P576T	COSMIC	NP	NP
350	TCGA-AA-3815-01	Tumour	LARGE INTESTINE	ENST00000311559	c.2178C>T	p.G726G	COSMIC	NP	NP
351	TCGA-AA-3877-01	Tumour	LARGE INTESTINE	ENST00000311559	c.1542G>A	p.T514T	COSMIC	NP	NP
352	TCGA-AA-3973-01	Tumour	LARGE INTESTINE	ENST00000311559	c.125C>T	p.P42L	COSMIC	NP	NP
353	TCGA-AA-A010-01	Tumour	LARGE INTESTINE	ENST00000311559	c.478G>A	p.G160R	COSMIC	NP	NP
354	TCGA-AF-2693-01	Tumour	LARGE INTESTINE	ENST00000311559	c.1111T>C	p.S371P	COSMIC	NP	NP
355	TCGA-AG-A002-01	Tumour	LARGE INTESTINE	ENST00000311559	c.139G>T	p.G47*	COSMIC	NP	NP
356	TCGA-AG-A002-01	Tumour	LARGE INTESTINE	ENST00000311559	c.2677G>A	p.D893N	COSMIC	NP	NP
357	TCGA-AK-3427-01	Tumour	KIDNEY	ENST00000311559	c.2392G>T	p.E798*	COSMIC	NP	NP
358	TCGA-AP-A056-01	Tumour	ENDOMETRIUM	ENST00000311559	c.1239G>T	p.E413D	COSMIC	NP	NP
359	TCGA-AP-A056-01	Tumour	ENDOMETRIUM	ENST00000311559	c.2621C>A	p.A874D	COSMIC	NP	NP
360	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000311559	c.2409C>T	p.Y803Y	COSMIC	NP	NP
361	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000311559	c.277A>G	p.N93D	COSMIC	NP	NP
362	TCGA-AP-A0LM-01	Tumour	ENDOMETRIUM	ENST00000311559	c.1671C>T	p.R557R	COSMIC	NP	NP
363	TCGA-AR-A1AY-01	Tumour	BREAST	ENST00000311559	c.1787G>A	p.G596D	COSMIC	NP	NP
364	TCGA-AX-A05Z-01	Tumour	ENDOMETRIUM	ENST00000311559	c.2148A>C	p.Q716H	COSMIC	NP	NP
365	TCGA-AX-A0J0-01	Tumour	ENDOMETRIUM	ENST00000311559	c.5G>A	p.S2N	COSMIC	NP	NP
366	TCGA-AY-6196-01	Tumour	LARGE INTESTINE	ENST00000311559	c.2475C>T	p.H825H	COSMIC	NP	NP
367	TCGA-AZ-4315-01	Tumour	LARGE INTESTINE	ENST00000311559	c.1341A>C	p.E447D	COSMIC	NP	NP
368	TCGA-AZ-5407-01	Tumour	LARGE INTESTINE	ENST00000311559	c.1137A>G	p.E379E	COSMIC	NP	NP
369	TCGA-B5-A0JY-01	Tumour	ENDOMETRIUM	ENST00000311559	c.1914G>A	p.E638E	COSMIC	NP	NP
370	TCGA-B5-A0JY-01	Tumour	ENDOMETRIUM	ENST00000311559	c.906C>A	p.I302I	COSMIC	NP	NP
371	TCGA-B5-A11E-01	Tumour	ENDOMETRIUM	ENST00000311559	c.631G>A	p.A211T	COSMIC	NP	NP
372	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000311559	c.2055C>A	p.F685L	COSMIC	NP	NP
373	TCGA-BS-A0UV-01	Tumour	ENDOMETRIUM	ENST00000311559	c.1844C>A	p.S615Y	COSMIC	NP	NP
374	TCGA-BS-A0UV-01	Tumour	ENDOMETRIUM	ENST00000311559	c.557T>G	p.L186R	COSMIC	NP	NP
375	TCGA-CA-6717-01	Tumour	LARGE INTESTINE	ENST00000311559	c.1713A>G	p.V571V	COSMIC	NP	NP
376	TCGA-CA-6717-01	Tumour	LARGE INTESTINE	ENST00000311559	c.79G>T	p.E27*	COSMIC	NP	NP
377	TCGA-CK-4952-01	Tumour	LARGE INTESTINE	ENST00000311559	c.1683A>G	p.L561L	COSMIC	NP	NP
378	TCGA-CK-5912-01	Tumour	LARGE INTESTINE	ENST00000311559	c.1794C>T	p.Y598Y	COSMIC	NP	NP
379	TCGA-CM-5348-01	Tumour	LARGE INTESTINE	ENST00000311559	c.2033A>G	p.E678G	COSMIC	NP	NP
380	TCGA-CM-5860-01	Tumour	LARGE INTESTINE	ENST00000311559	c.2806C>T	p.R936*	COSMIC	NP	NP
381	TCGA-CM-6171-01	Tumour	LARGE INTESTINE	ENST00000311559	c.1137A>G	p.E379E	COSMIC	NP	NP
382	TCGA-CM-6171-01	Tumour	LARGE INTESTINE	ENST00000311559	c.2540G>A	p.W847*	COSMIC	NP	NP
383	TCGA-CM-6677-01	Tumour	LARGE INTESTINE	ENST00000311559	c.866C>A	p.A289E	COSMIC	NP	NP
384	TCGA-CM-6678-01	Tumour	LARGE INTESTINE	ENST00000311559	c.675C>T	p.V225V	COSMIC	NP	NP
385	TCGA-D1-A103-01	Tumour	ENDOMETRIUM	ENST00000311559	c.73C>A	p.L25I	COSMIC	NP	NP
386	TCGA-D1-A16X-01	Tumour	ENDOMETRIUM	ENST00000311559	c.2262T>C	p.I754I	COSMIC	NP	NP
387	TCGA-D1-A16Y-01	Tumour	ENDOMETRIUM	ENST00000311559	c.1670G>A	p.R557H	COSMIC	NP	NP
388	TCGA-D5-5539-01	Tumour	LARGE INTESTINE	ENST00000311559	c.2107A>G	p.R703G	COSMIC	NP	NP
389	TCGA-D5-6539-01	Tumour	LARGE INTESTINE	ENST00000311559	c.2032G>A	p.E678K	COSMIC	NP	NP
390	TCGA-DM-A28F-01	Tumour	LARGE INTESTINE	ENST00000311559	c.1113A>G	p.S371S	COSMIC	NP	NP
391	TCGA-DY-A1DC-01	Tumour	LARGE INTESTINE	ENST00000311559	c.1019C>T	p.T340I	COSMIC	NP	NP
392	TCGA-DY-A1DG-01	Tumour	LARGE INTESTINE	ENST00000311559	c.2034A>G	p.E678E	COSMIC	NP	NP
393	TCGA-EY-A1GS-01	Tumour	ENDOMETRIUM	ENST00000311559	c.2210C>G	p.S737C	COSMIC	NP	NP
394	TCGA-F4-6570-01	Tumour	LARGE INTESTINE	ENST00000311559	c.843T>C	p.D281D	COSMIC	NP	NP
395	TCGA-F4-6808-01	Tumour	LARGE INTESTINE	ENST00000311559	c.1683A>G	p.L561L	COSMIC	NP	NP
396	TCGA-F5-6571-01	Tumour	LARGE INTESTINE	ENST00000311559	c.2273G>T	p.R758L	COSMIC	NP	NP
397	TCGA-G4-6303-01	Tumour	LARGE INTESTINE	ENST00000311559	c.2033A>G	p.E678G	COSMIC	NP	NP
398	TCGA-G4-6586-01	Tumour	LARGE INTESTINE	ENST00000311559	c.2319G>A	p.L773L	COSMIC	NP	NP
399	TCGA-G4-6588-01	Tumour	LARGE INTESTINE	ENST00000311559	c.1794C>T	p.Y598Y	COSMIC	NP	NP
400	TCGA-G4-6626-01	Tumour	LARGE INTESTINE	ENST00000311559	c.1793A>T	p.Y598F	COSMIC	NP	NP
401	TCGA-G5-6235-01	Tumour	LARGE INTESTINE	ENST00000311559	c.2318T>A	p.L773Q	COSMIC	NP	NP
402	cSCCP7	Tumour	SKIN	ENST00000311559	c.76C>T	p.Q26*	COSMIC	NP	NP
403	pfg017T	Tumour	STOMACH	ENST00000311559	c.1139-8_1139-7insT	p.?	COSMIC	NP	NP
404	ASH3	Cell Line	THYROID	ENST00000311559	c.2319G>A	p.L773L	COSMIC	NP	NP
405	BALL1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000311559	c.2319G>A	p.L773L	COSMIC	NP	NP
406	BE2M17	Cell Line	AUTONOMIC_GANGLIA	ENST00000311559	c.1517T>A	p.L506Q	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
407	BT549	Cell Line	BREAST	ENST00000311559	c.59T>G	p.I20S	COSMIC	no weights	BENIGN
408	COLO320HSR	Cell Line	LARGE_INTESTINE	ENST00000311559	c.917+1G>T	p.?	COSMIC	NP	NP
409	COLO684	Cell Line	ENDOMETRIUM	ENST00000311559	c.122T>G	p.V41G	COSMIC	no weights	POSSIBLY DAMAGING
410	DAOY	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000311559	c.1837T>G	p.F613V	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
411	EFM192A	Cell Line	BREAST	ENST00000311559	c.2025T>C	p.F675F	COSMIC	NP	NP
412	GP5D	Cell Line	LARGE_INTESTINE	ENST00000311559	c.1615T>C	p.C539R	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
413	HCC2998	Cell Line	LARGE_INTESTINE	ENST00000311559	c.101A>C	p.Q34P	COSMIC	no weights	BENIGN
414	HCC2998	Cell Line	LARGE_INTESTINE	ENST00000311559	c.733G>T	p.E245*	COSMIC	NP	NP
415	HCC366	Cell Line	LUNG	ENST00000311559	c.866C>T	p.A289V	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
416	HCT15	Cell Line	LARGE_INTESTINE	ENST00000311559	c.163G>A	p.V55M	COSMIC	no weights	BENIGN
417	HLE	Cell Line	LIVER	ENST00000311559	c.964A>G	p.M322V	COSMIC	PASSENGER/OTHER	BENIGN
418	HUH7	Cell Line	LIVER	ENST00000311559	c.2465C>A	p.T822N	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
419	IHH4	Cell Line	THYROID	ENST00000311559	c.1567T>C	p.Y523H	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
420	IM95	Cell Line	STOMACH	ENST00000311559	c.2159delA	p.N722fs*13	COSMIC	NP	NP
421	JURKAT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000311559	c.535G>A	p.G179R	COSMIC	CANCER	PROBABLY DAMAGING
422	K2	Cell Line	SKIN	ENST00000311559	c.1939C>T	p.P647S	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
423	KARPAS45	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000311559	c.2241+10A>G	p.?	COSMIC	NP	NP
424	KASUMI1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000311559	c.2319G>A	p.L773L	COSMIC	NP	NP
425	KYSE30	Cell Line	OESOPHAGUS	ENST00000311559	c.1327C>A	p.Q443K	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
426	KYSE50	Cell Line	OESOPHAGUS	ENST00000311559	c.2104A>G	p.I702V	COSMIC	PASSENGER/OTHER	BENIGN
427	LU65	Cell Line	LUNG	ENST00000311559	c.2673G>T	p.M891I	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
428	M14	Cell Line	SKIN	ENST00000311559	c.2311C>T	p.P771S	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
429	MCAS	Cell Line	OVARY	ENST00000311559	c.1659T>C	p.N553N	COSMIC	NP	NP
430	MCC13	Cell Line	SKIN	ENST00000311559	c.1685-8C>T	p.?	COSMIC	NP	NP
431	MESSA	Cell Line	SOFT_TISSUE	ENST00000311559	c.1021+9T>G	p.?	COSMIC	NP	NP
432	MOLT4	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000311559	c.944G>T	p.R315M	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
433	NCIH1792	Cell Line	LUNG	ENST00000311559	c.1190G>A	p.R397H	COSMIC	no weights	BENIGN
434	NCIH1836	Cell Line	LUNG	ENST00000311559	c.2759T>G	p.L920R	COSMIC	no weights	BENIGN
435	NCIH64	Cell Line	LUNG	ENST00000311559	c.2532A>G	p.L844L	COSMIC	NP	NP
436	OPM2	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000311559	c.675C>T	p.V225V	COSMIC	NP	NP
437	PF382	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000311559	c.2681G>A	p.R894Q	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
438	REH	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000311559	c.2567G>A	p.C856Y	COSMIC	PASSENGER/OTHER	BENIGN
439	RERFLCFM	Cell Line	LUNG	ENST00000311559	c.951C>T	p.P317P	COSMIC	NP	NP
440	SCC15	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000311559	c.1455T>C	p.Y485Y	COSMIC	NP	NP
441	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000311559	c.2392G>A	p.E798K	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
442	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000311559	c.2421C>T	p.D807D	COSMIC	NP	NP
443	SNU475	Cell Line	LIVER	ENST00000311559	c.933G>A	p.T311T	COSMIC	NP	NP
444	SNUC5	Cell Line	LARGE_INTESTINE	ENST00000311559	c.2794C>T	p.Q932*	COSMIC	NP	NP
445	TGBC11TKB	Cell Line	STOMACH	ENST00000311559	c.2100delA	p.I702fs*1	COSMIC	NP	NP
446	TYKNU	Cell Line	OVARY	ENST00000311559	c.2814G>A	p.L938L	COSMIC	NP	NP

*NP: Not Predicted

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	6.5927	6.5975	0.0235	0.006695
BILIARY TRACT	5.9496	5.6997	-0.1528	-0.1928
BONE	6.3878	6.5457	-0.1294	-0.01469
BREAST	6.2352	6.2158	-0.1820	-0.072755
CENTRAL NERVOUS SYSTEM	6.8170	6.7712	0.0068	-0.0172
ENDOMETRIUM	6.1595	6.1461	-0.0414	-0.0235
HAEMATOPOIETIC AND LYMPHOID TISSUE	7.0799	7.0106	-0.0963	-0.01944
KIDNEY	6.7000	6.6417	0.0401	0.0452
LARGE INTESTINE	5.9282	5.8245	0.0165	-0.01966
LIVER	6.0414	5.8511	-0.1039	-0.0875
LUNG	6.2315	6.19575	-0.0264	-0.02
OESOPHAGUS	5.9101	5.86615	0.1080	0.07605
OVARY	5.9988	6.0477	-0.0638	0.0077
PANCREAS	6.1436	6.1149	-0.0110	0.133
PLEURA	7.2193	7.3175	0.0696	0.06537
PROSTATE	5.9688	6.14375	-0.1545	-0.01845
SALIVARY GLAND	5.5629	5.5629	-0.1045	-0.1045
SKIN	6.1216	6.0405	-0.1274	-0.0454
SMALL INTESTINE	5.4498	5.4498	0.0160	0.01602
SOFT TISSUE	6.2108	6.02175	-0.0244	-0.035
STOMACH	6.0258	6.1345	-0.0530	-0.05725
THYROID	6.9785	6.90255	-0.0536	-0.013865
UPPER AERODIGESTIVE TRACT	6.6386	6.4905	0.0059	0.028595
URINARY TRACT	6.2753	6.05435	-0.0248	-0.00138785

Domain ID	Domain Name	Start Site	End Site	E-value
PF01302	CAP_GLY	127	202	1.9e-13
PF01302	CAP_GLY	232	290	1.7e-07
PF01302	CAP_GLY	472	539	2.4e-15
PF00443	UCH	593	889	3.7e-09
PF06481	COX_ARM	621	646	0.037
PF01302	CAP_GLY	127	202	1.9e-13
PF01302	CAP_GLY	232	290	1.7e-07
PF01302	CAP_GLY	472	539	2.4e-15
PF00443	UCH	593	889	3.7e-09
PF06481	COX_ARM	621	646	0.037

Domain ID	Start Site	End Site	E-value
0044814	590	889	1.16e-31
0052214	443	611	1.28e-32
0052214	95	226	4.84e-25
0050559	223	299	2.49e-17
0044814	590	889	1.16e-31
0052214	443	611	1.28e-32
0052214	95	226	4.84e-25
0050559	223	299	2.49e-17

S. No.	Position	Amino acid	Type	Description
1	356	Y	Phosphorylation	Phosphotyrosine
2	393	T	Phosphorylation	Phosphothreonine
3	399	S	Phosphorylation	Phosphoserine
4	399	S	Phosphorylation	Phosphoserine.
5	418	S	Phosphorylation	Phosphoserine
6	418	S	Phosphorylation	Phosphoserine.
7	422	S	Phosphorylation	Phosphoserine
8	432	S	Phosphorylation	Phosphoserine
9	436	S	Phosphorylation	Phosphoserine
10	439	S	Phosphorylation	Phosphoserine
11	441	S	Phosphorylation	Phosphoserine
12	444	S	Phosphorylation	Phosphoserine
13	356	Y	Phosphorylation	Phosphotyrosine
14	393	T	Phosphorylation	Phosphothreonine
15	399	S	Phosphorylation	Phosphoserine
16	399	S	Phosphorylation	Phosphoserine.
17	418	S	Phosphorylation	Phosphoserine
18	418	S	Phosphorylation	Phosphoserine.
19	422	S	Phosphorylation	Phosphoserine
20	432	S	Phosphorylation	Phosphoserine
21	436	S	Phosphorylation	Phosphoserine
22	439	S	Phosphorylation	Phosphoserine
23	441	S	Phosphorylation	Phosphoserine
24	444	S	Phosphorylation	Phosphoserine

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
CYLD	CYLD	CYLD	NA	Q9NQC7
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
Q9NQC7	CYLD	NA	CYLD	Q9NQC7
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
CYLD	NA	605018	Q9NQC7	PA27084

Protein: CYLD

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)

Modelled Structure	Structures available in PDB
	1IXD, 1WHL, 1WHM, 2VHF