ApoCanD

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	587376	Tumour	LARGE INTESTINE	ENST00000332896	c.38G>A	p.R13H	COSMIC	NP	NP
2	ESO-007	Tumour	OESOPHAGUS	ENST00000332896	c.502C>T	p.R168W	COSMIC	NP	NP
3	ESO-164	Tumour	OESOPHAGUS	ENST00000332896	c.502C>T	p.R168W	COSMIC	NP	NP
4	LUAD-RT-S01813	Tumour	LUNG	ENST00000332896	c.498T>C	p.R166R	COSMIC	NP	NP
5	LUAD-S01413	Tumour	LUNG	ENST00000332896	c.136G>T	p.A46S	COSMIC	NP	NP
6	TCGA-04-1347-01	Tumour	OVARY	ENST00000332896	c.66G>T	p.V22V	COSMIC	NP	NP
7	TCGA-29-1705-01	Tumour	OVARY	ENST00000332896	c.90C>G	p.L30L	COSMIC	NP	NP
8	TCGA-44-8119-01	Tumour	LUNG	ENST00000332896	c.243G>T	p.W81C	COSMIC	NP	NP
9	TCGA-66-2788-01	Tumour	LUNG	ENST00000332896	c.26T>A	p.L9H	COSMIC	NP	NP
10	TCGA-AA-3496-01	Tumour	LARGE INTESTINE	ENST00000332896	c.65T>C	p.V22A	COSMIC	NP	NP
11	TCGA-AA-3966-01	Tumour	LARGE INTESTINE	ENST00000332896	c.173T>C	p.L58P	COSMIC	NP	NP
12	TCGA-AA-3977-01	Tumour	LARGE INTESTINE	ENST00000332896	c.519G>A	p.K173K	COSMIC	NP	NP
13	TCGA-AA-A00D-01	Tumour	LARGE INTESTINE	ENST00000332896	c.406C>T	p.L136L	COSMIC	NP	NP
14	TCGA-AG-A002-01	Tumour	LARGE INTESTINE	ENST00000332896	c.252G>A	p.E84E	COSMIC	NP	NP
15	TCGA-AG-A036-01	Tumour	LARGE INTESTINE	ENST00000332896	c.473C>T	p.S158L	COSMIC	NP	NP
16	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000332896	c.38G>A	p.R13H	COSMIC	NP	NP
17	TCGA-BS-A0TA-01	Tumour	ENDOMETRIUM	ENST00000332896	c.439C>T	p.R147C	COSMIC	NP	NP
18	TCGA-CK-4947-01	Tumour	LARGE INTESTINE	ENST00000332896	c.66G>T	p.V22V	COSMIC	NP	NP
19	TCGA-CK-4952-01	Tumour	LARGE INTESTINE	ENST00000332896	c.66G>A	p.V22V	COSMIC	NP	NP
20	TCGA-CK-6746-01	Tumour	LARGE INTESTINE	ENST00000332896	c.553C>T	p.R185W	COSMIC	NP	NP
21	TCGA-D1-A174-01	Tumour	ENDOMETRIUM	ENST00000332896	c.470A>C	p.Q157P	COSMIC	NP	NP
22	ACN	Cell Line	AUTONOMIC_GANGLIA	ENST00000332896	c.308T>G	p.L103W	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
23	BECKER	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000332896	c.327C>T	p.H109H	COSMIC	NP	NP
24	DANG	Cell Line	PANCREAS	ENST00000332896	c.103A>C	p.I35L	COSMIC	PASSENGER/OTHER	BENIGN
25	DND41	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000332896	c.279C>G	p.A93A	COSMIC	NP	NP
26	DU145	Cell Line	PROSTATE	ENST00000332896	c.426G>T	p.Q142H	COSMIC	CANCER	BENIGN
27	FADU	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000332896	c.484G>T	p.E162*	COSMIC	NP	NP
28	HCC1428	Cell Line	BREAST	ENST00000332896	c.370G>T	p.A124S	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
29	HCT116	Cell Line	LARGE_INTESTINE	ENST00000332896	c.354G>A	p.R118R	COSMIC	NP	NP
30	IHH4	Cell Line	THYROID	ENST00000332896	c.324G>A	p.S108S	COSMIC	NP	NP
31	KNS42	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000332896	c.130A>C	p.I44L	COSMIC	PASSENGER/OTHER	BENIGN
32	MOLT13	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000332896	c.502C>T	p.R168W	COSMIC	CANCER	PROBABLY DAMAGING
33	NCIH1694	Cell Line	LUNG	ENST00000332896	c.428C>T	p.T143M	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
34	NCIH2066	Cell Line	LUNG	ENST00000332896	c.514G>T	p.G172W	COSMIC	CANCER	PROBABLY DAMAGING
35	NCIH522	Cell Line	LUNG	ENST00000332896	c.378G>A	p.R126R	COSMIC	NP	NP
36	OVKATE	Cell Line	OVARY	ENST00000332896	c.130A>C	p.I44L	COSMIC	PASSENGER/OTHER	BENIGN
37	SNGM	Cell Line	ENDOMETRIUM	ENST00000332896	c.227T>C	p.L76P	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
38	SNU175	Cell Line	LARGE_INTESTINE	ENST00000332896	c.575C>T	p.S192L	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
39	587376	Tumour	LARGE INTESTINE	ENST00000332896	c.38G>A	p.R13H	COSMIC	NP	NP
40	ESO-007	Tumour	OESOPHAGUS	ENST00000332896	c.502C>T	p.R168W	COSMIC	NP	NP
41	ESO-164	Tumour	OESOPHAGUS	ENST00000332896	c.502C>T	p.R168W	COSMIC	NP	NP
42	LUAD-RT-S01813	Tumour	LUNG	ENST00000332896	c.498T>C	p.R166R	COSMIC	NP	NP
43	LUAD-S01413	Tumour	LUNG	ENST00000332896	c.136G>T	p.A46S	COSMIC	NP	NP
44	TCGA-04-1347-01	Tumour	OVARY	ENST00000332896	c.66G>T	p.V22V	COSMIC	NP	NP
45	TCGA-29-1705-01	Tumour	OVARY	ENST00000332896	c.90C>G	p.L30L	COSMIC	NP	NP
46	TCGA-44-8119-01	Tumour	LUNG	ENST00000332896	c.243G>T	p.W81C	COSMIC	NP	NP
47	TCGA-66-2788-01	Tumour	LUNG	ENST00000332896	c.26T>A	p.L9H	COSMIC	NP	NP
48	TCGA-AA-3496-01	Tumour	LARGE INTESTINE	ENST00000332896	c.65T>C	p.V22A	COSMIC	NP	NP
49	TCGA-AA-3966-01	Tumour	LARGE INTESTINE	ENST00000332896	c.173T>C	p.L58P	COSMIC	NP	NP
50	TCGA-AA-3977-01	Tumour	LARGE INTESTINE	ENST00000332896	c.519G>A	p.K173K	COSMIC	NP	NP
51	TCGA-AA-A00D-01	Tumour	LARGE INTESTINE	ENST00000332896	c.406C>T	p.L136L	COSMIC	NP	NP
52	TCGA-AG-A002-01	Tumour	LARGE INTESTINE	ENST00000332896	c.252G>A	p.E84E	COSMIC	NP	NP
53	TCGA-AG-A036-01	Tumour	LARGE INTESTINE	ENST00000332896	c.473C>T	p.S158L	COSMIC	NP	NP
54	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000332896	c.38G>A	p.R13H	COSMIC	NP	NP
55	TCGA-BS-A0TA-01	Tumour	ENDOMETRIUM	ENST00000332896	c.439C>T	p.R147C	COSMIC	NP	NP
56	TCGA-CK-4947-01	Tumour	LARGE INTESTINE	ENST00000332896	c.66G>T	p.V22V	COSMIC	NP	NP
57	TCGA-CK-4952-01	Tumour	LARGE INTESTINE	ENST00000332896	c.66G>A	p.V22V	COSMIC	NP	NP
58	TCGA-CK-6746-01	Tumour	LARGE INTESTINE	ENST00000332896	c.553C>T	p.R185W	COSMIC	NP	NP
59	TCGA-D1-A174-01	Tumour	ENDOMETRIUM	ENST00000332896	c.470A>C	p.Q157P	COSMIC	NP	NP
60	ACN	Cell Line	AUTONOMIC_GANGLIA	ENST00000332896	c.308T>G	p.L103W	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
61	BECKER	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000332896	c.327C>T	p.H109H	COSMIC	NP	NP
62	DANG	Cell Line	PANCREAS	ENST00000332896	c.103A>C	p.I35L	COSMIC	PASSENGER/OTHER	BENIGN
63	DND41	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000332896	c.279C>G	p.A93A	COSMIC	NP	NP
64	DU145	Cell Line	PROSTATE	ENST00000332896	c.426G>T	p.Q142H	COSMIC	CANCER	BENIGN
65	FADU	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000332896	c.484G>T	p.E162*	COSMIC	NP	NP
66	HCC1428	Cell Line	BREAST	ENST00000332896	c.370G>T	p.A124S	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
67	HCT116	Cell Line	LARGE_INTESTINE	ENST00000332896	c.354G>A	p.R118R	COSMIC	NP	NP
68	IHH4	Cell Line	THYROID	ENST00000332896	c.324G>A	p.S108S	COSMIC	NP	NP
69	KNS42	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000332896	c.130A>C	p.I44L	COSMIC	PASSENGER/OTHER	BENIGN
70	MOLT13	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000332896	c.502C>T	p.R168W	COSMIC	CANCER	PROBABLY DAMAGING
71	NCIH1694	Cell Line	LUNG	ENST00000332896	c.428C>T	p.T143M	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
72	NCIH2066	Cell Line	LUNG	ENST00000332896	c.514G>T	p.G172W	COSMIC	CANCER	PROBABLY DAMAGING
73	NCIH522	Cell Line	LUNG	ENST00000332896	c.378G>A	p.R126R	COSMIC	NP	NP
74	OVKATE	Cell Line	OVARY	ENST00000332896	c.130A>C	p.I44L	COSMIC	PASSENGER/OTHER	BENIGN
75	SNGM	Cell Line	ENDOMETRIUM	ENST00000332896	c.227T>C	p.L76P	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
76	SNU175	Cell Line	LARGE_INTESTINE	ENST00000332896	c.575C>T	p.S192L	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING

*NP: Not Predicted

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	7.8910	7.7437	0.0404	-0.004935
BILIARY TRACT	7.2846	7.5191	-0.0045	-0.0575
BONE	7.6342	7.7998	0.0242	-0.005644
BREAST	7.4711	7.4939	-0.0238	-0.01295
CENTRAL NERVOUS SYSTEM	7.6782	7.5651	-0.0622	-0.0345
ENDOMETRIUM	7.1279	7.0792	-0.0136	-0.005293
HAEMATOPOIETIC AND LYMPHOID TISSUE	8.0229	8.0223	-0.0259	-0.01125
KIDNEY	7.6047	7.6705	0.1400	0.0916
LARGE INTESTINE	7.5078	7.5487	0.0334	0.01005
LIVER	7.5081	7.5489	0.1285	0.1456
LUNG	7.4346	7.36285	0.0927	0.097385
OESOPHAGUS	7.1701	7.1523	-0.0092	0.0238
OVARY	7.2317	7.2429	-0.0754	0.01789
PANCREAS	7.1109	6.9754	-0.0189	0.1018
PLEURA	7.6527	7.526	0.0385	0.02444
PROSTATE	7.9256	8.049	0.1365	0.07815
SALIVARY GLAND	6.5114	6.5114	-0.3863	-0.3863
SKIN	7.8745	7.8282	-0.0250	2e-04
SMALL INTESTINE	6.8264	6.8264	0.0043	0.0043
SOFT TISSUE	7.1886	7.01405	-0.0768	-0.02043
STOMACH	7.3926	7.39225	-0.0846	-0.00979
THYROID	7.3025	7.2235	-0.0106	0.03475
UPPER AERODIGESTIVE TRACT	7.1962	7.11205	0.0467	0.069525
URINARY TRACT	7.4712	7.4607	0.1199	0.0797

Domain ID	Domain Name	Start Site	End Site	E-value
PF00619	CARD	7	79	8.8e-16
PF00531	Death	119	188	2.3e-13
PF00619	CARD	7	79	8.8e-16
PF00531	Death	119	188	2.3e-13

Domain ID	Start Site	End Site	E-value
0045502	1	90	1.67e-23
0036368	105	188	3.92e-19
0045502	1	90	1.67e-23
0036368	105	188	3.92e-19

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
CRADD	CRADD	CRADD	ENSP00000327647	P78560
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
P78560	CRADD	ENSP00000327647	CRADD	P78560
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
CRADD	ENSP00000327647	603454	P78560	PA26860

Protein: CRADD

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)

Modelled Structure	Structures available in PDB
	2O71, 2OF5, 3CRD