ApoCanD

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	GC1	Tumour	T STOMACH	ENST00000309955	c.877C>G	p.L293V	COSMIC	NP	NP
2	LUAD-B02477	Tumour	LUNG	ENST00000309955	c.162C>G	p.D54E	COSMIC	NP	NP
3	LUAD-S01345	Tumour	LUNG	ENST00000309955	c.1031C>T	p.S344L	COSMIC	NP	NP
4	PD3904a	Tumour	BREAST	ENST00000309955	c.1093G>T	p.G365C	COSMIC	NP	NP
5	TCGA-37-4135-01	Tumour	LUNG	ENST00000309955	c.1171G>T	p.G391W	COSMIC	NP	NP
6	TCGA-43-3920-01	Tumour	LUNG	ENST00000309955	c.1249C>A	p.H417N	COSMIC	NP	NP
7	TCGA-67-3771-01	Tumour	LUNG	ENST00000309955	c.45A>C	p.T15T	COSMIC	NP	NP
8	TCGA-73-4668-01	Tumour	LUNG	ENST00000309955	c.1264C>T	p.L422L	COSMIC	NP	NP
9	TCGA-AA-3977-01	Tumour	LARGE INTESTINE	ENST00000309955	c.1143G>T	p.K381N	COSMIC	NP	NP
10	TCGA-AA-A01Z-01	Tumour	LARGE INTESTINE	ENST00000309955	c.877C>A	p.L293I	COSMIC	NP	NP
11	TCGA-AB-2812-03	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000309955	c.240G>A	p.E80E	COSMIC	NP	NP
12	TCGA-AG-A002-01	Tumour	LARGE INTESTINE	ENST00000309955	c.653G>A	p.G218D	COSMIC	NP	NP
13	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000309955	c.931G>A	p.V311I	COSMIC	NP	NP
14	TCGA-AX-A05Z-01	Tumour	ENDOMETRIUM	ENST00000309955	c.771C>T	p.I257I	COSMIC	NP	NP
15	TCGA-B0-4712-01	Tumour	KIDNEY	ENST00000309955	c.1028A>G	p.D343G	COSMIC	NP	NP
16	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000309955	c.1443A>G	p.481	COSMIC	NP	NP
17	TCGA-BS-A0UV-01	Tumour	ENDOMETRIUM	ENST00000309955	c.653G>A	p.G218D	COSMIC	NP	NP
18	TCGA-C8-A275-01	Tumour	BREAST	ENST00000309955	c.288G>T	p.L96L	COSMIC	NP	NP
19	TCGA-DS-A1OD-01	Tumour	CERVIX	ENST00000309955	c.934C>A	p.L312M	COSMIC	NP	NP
20	TCGA-G2-A3IE-01	Tumour	URINARY TRACT	ENST00000309955	c.957G>A	p.Q319Q	COSMIC	NP	NP
21	TCGA-H4-A2HQ-01	Tumour	URINARY TRACT	ENST00000309955	c.409G>A	p.E137K	COSMIC	NP	NP
22	YUGOE	Tumour	SKIN	ENST00000309955	c.31G>A	p.E11K	COSMIC	NP	NP
23	639V	Cell Line	URINARY_TRACT	ENST00000309955	c.133C>T	p.R45W	COSMIC	CANCER	PROBABLY DAMAGING
24	ACN	Cell Line	AUTONOMIC_GANGLIA	ENST00000309955	c.609C>T	p.L203L	COSMIC	NP	NP
25	AM38	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000309955	c.21T>C	p.H7H	COSMIC	NP	NP
26	ARH77	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000309955	c.1137G>C	p.A379A	COSMIC	NP	NP
27	CHL1	Cell Line	SKIN	ENST00000309955	c.707C>T	p.P236L	COSMIC	PASSENGER/OTHER	BENIGN
28	CORL95	Cell Line	LUNG	ENST00000309955	c.586G>T	p.D196Y	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
29	DU145	Cell Line	PROSTATE	ENST00000309955	c.606+7C>A	p.?	COSMIC	NP	NP
30	EOL1CELL	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000309955	c.280_282-3del2882	p.?	COSMIC	NP	NP
31	FTC133	Cell Line	THYROID	ENST00000309955	c.958A>G	p.S320G	COSMIC	PASSENGER/OTHER	BENIGN
32	GP5D	Cell Line	LARGE_INTESTINE	ENST00000309955	c.33A>G	p.E11E	COSMIC	NP	NP
33	HCC2998	Cell Line	LARGE_INTESTINE	ENST00000309955	c.363C>T	p.G121G	COSMIC	NP	NP
34	HCC827	Cell Line	LUNG	ENST00000309955	c.1035C>T	p.C345C	COSMIC	NP	NP
35	HEC1	Cell Line	ENDOMETRIUM	ENST00000309955	c.381G>T	p.K127N	COSMIC	CANCER	PROBABLY DAMAGING
36	HMVII	Cell Line	SKIN	ENST00000309955	c.829G>A	p.E277K	COSMIC	PASSENGER/OTHER	BENIGN
37	HOS	Cell Line	BONE	ENST00000309955	c.798T>G	p.L266L	COSMIC	NP	NP
38	HT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000309955	c.1292T>C	p.L431P	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
39	JURKAT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000309955	c.1395C>T	p.V465V	COSMIC	NP	NP
40	LP1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000309955	c.613A>G	p.N205D	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
41	MDAMB231	Cell Line	BREAST	ENST00000309955	c.1223C>T	p.A408V	COSMIC	PASSENGER/OTHER	BENIGN
42	MZ1PC	Cell Line	PANCREAS	ENST00000309955	c.241A>C	p.T81P	COSMIC	PASSENGER/OTHER	BENIGN
43	NB10	Cell Line	AUTONOMIC_GANGLIA	ENST00000309955	c.240G>T	p.E80D	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
44	NUGC4	Cell Line	STOMACH	ENST00000309955	c.388-3_388-2insA	p.?	COSMIC	NP	NP
45	RCCAB	Cell Line	KIDNEY	ENST00000309955	c.1398G>C	p.W466C	COSMIC	PASSENGER/OTHER	BENIGN
46	RCCJF	Cell Line	KIDNEY	ENST00000309955	c.1115T>A	p.L372H	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
47	RERFLCFM	Cell Line	LUNG	ENST00000309955	c.1294A>C	p.R432R	COSMIC	NP	NP
48	SNUC2B	Cell Line	LARGE_INTESTINE	ENST00000309955	c.198C>T	p.D66D	COSMIC	NP	NP
49	GC1	Tumour	T STOMACH	ENST00000309955	c.877C>G	p.L293V	COSMIC	NP	NP
50	LUAD-B02477	Tumour	LUNG	ENST00000309955	c.162C>G	p.D54E	COSMIC	NP	NP
51	LUAD-S01345	Tumour	LUNG	ENST00000309955	c.1031C>T	p.S344L	COSMIC	NP	NP
52	PD3904a	Tumour	BREAST	ENST00000309955	c.1093G>T	p.G365C	COSMIC	NP	NP
53	TCGA-37-4135-01	Tumour	LUNG	ENST00000309955	c.1171G>T	p.G391W	COSMIC	NP	NP
54	TCGA-43-3920-01	Tumour	LUNG	ENST00000309955	c.1249C>A	p.H417N	COSMIC	NP	NP
55	TCGA-67-3771-01	Tumour	LUNG	ENST00000309955	c.45A>C	p.T15T	COSMIC	NP	NP
56	TCGA-73-4668-01	Tumour	LUNG	ENST00000309955	c.1264C>T	p.L422L	COSMIC	NP	NP
57	TCGA-AA-3977-01	Tumour	LARGE INTESTINE	ENST00000309955	c.1143G>T	p.K381N	COSMIC	NP	NP
58	TCGA-AA-A01Z-01	Tumour	LARGE INTESTINE	ENST00000309955	c.877C>A	p.L293I	COSMIC	NP	NP
59	TCGA-AB-2812-03	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000309955	c.240G>A	p.E80E	COSMIC	NP	NP
60	TCGA-AG-A002-01	Tumour	LARGE INTESTINE	ENST00000309955	c.653G>A	p.G218D	COSMIC	NP	NP
61	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000309955	c.931G>A	p.V311I	COSMIC	NP	NP
62	TCGA-AX-A05Z-01	Tumour	ENDOMETRIUM	ENST00000309955	c.771C>T	p.I257I	COSMIC	NP	NP
63	TCGA-B0-4712-01	Tumour	KIDNEY	ENST00000309955	c.1028A>G	p.D343G	COSMIC	NP	NP
64	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000309955	c.1443A>G	p.481	COSMIC	NP	NP
65	TCGA-BS-A0UV-01	Tumour	ENDOMETRIUM	ENST00000309955	c.653G>A	p.G218D	COSMIC	NP	NP
66	TCGA-C8-A275-01	Tumour	BREAST	ENST00000309955	c.288G>T	p.L96L	COSMIC	NP	NP
67	TCGA-DS-A1OD-01	Tumour	CERVIX	ENST00000309955	c.934C>A	p.L312M	COSMIC	NP	NP
68	TCGA-G2-A3IE-01	Tumour	URINARY TRACT	ENST00000309955	c.957G>A	p.Q319Q	COSMIC	NP	NP
69	TCGA-H4-A2HQ-01	Tumour	URINARY TRACT	ENST00000309955	c.409G>A	p.E137K	COSMIC	NP	NP
70	YUGOE	Tumour	SKIN	ENST00000309955	c.31G>A	p.E11K	COSMIC	NP	NP
71	639V	Cell Line	URINARY_TRACT	ENST00000309955	c.133C>T	p.R45W	COSMIC	CANCER	PROBABLY DAMAGING
72	ACN	Cell Line	AUTONOMIC_GANGLIA	ENST00000309955	c.609C>T	p.L203L	COSMIC	NP	NP
73	AM38	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000309955	c.21T>C	p.H7H	COSMIC	NP	NP
74	ARH77	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000309955	c.1137G>C	p.A379A	COSMIC	NP	NP
75	CHL1	Cell Line	SKIN	ENST00000309955	c.707C>T	p.P236L	COSMIC	PASSENGER/OTHER	BENIGN
76	CORL95	Cell Line	LUNG	ENST00000309955	c.586G>T	p.D196Y	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
77	DU145	Cell Line	PROSTATE	ENST00000309955	c.606+7C>A	p.?	COSMIC	NP	NP
78	EOL1CELL	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000309955	c.280_282-3del2882	p.?	COSMIC	NP	NP
79	FTC133	Cell Line	THYROID	ENST00000309955	c.958A>G	p.S320G	COSMIC	PASSENGER/OTHER	BENIGN
80	GP5D	Cell Line	LARGE_INTESTINE	ENST00000309955	c.33A>G	p.E11E	COSMIC	NP	NP
81	HCC2998	Cell Line	LARGE_INTESTINE	ENST00000309955	c.363C>T	p.G121G	COSMIC	NP	NP
82	HCC827	Cell Line	LUNG	ENST00000309955	c.1035C>T	p.C345C	COSMIC	NP	NP
83	HEC1	Cell Line	ENDOMETRIUM	ENST00000309955	c.381G>T	p.K127N	COSMIC	CANCER	PROBABLY DAMAGING
84	HMVII	Cell Line	SKIN	ENST00000309955	c.829G>A	p.E277K	COSMIC	PASSENGER/OTHER	BENIGN
85	HOS	Cell Line	BONE	ENST00000309955	c.798T>G	p.L266L	COSMIC	NP	NP
86	HT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000309955	c.1292T>C	p.L431P	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
87	JURKAT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000309955	c.1395C>T	p.V465V	COSMIC	NP	NP
88	LP1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000309955	c.613A>G	p.N205D	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
89	MDAMB231	Cell Line	BREAST	ENST00000309955	c.1223C>T	p.A408V	COSMIC	PASSENGER/OTHER	BENIGN
90	MZ1PC	Cell Line	PANCREAS	ENST00000309955	c.241A>C	p.T81P	COSMIC	PASSENGER/OTHER	BENIGN
91	NB10	Cell Line	AUTONOMIC_GANGLIA	ENST00000309955	c.240G>T	p.E80D	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
92	NUGC4	Cell Line	STOMACH	ENST00000309955	c.388-3_388-2insA	p.?	COSMIC	NP	NP
93	RCCAB	Cell Line	KIDNEY	ENST00000309955	c.1398G>C	p.W466C	COSMIC	PASSENGER/OTHER	BENIGN
94	RCCJF	Cell Line	KIDNEY	ENST00000309955	c.1115T>A	p.L372H	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
95	RERFLCFM	Cell Line	LUNG	ENST00000309955	c.1294A>C	p.R432R	COSMIC	NP	NP
96	SNUC2B	Cell Line	LARGE_INTESTINE	ENST00000309955	c.198C>T	p.D66D	COSMIC	NP	NP

*NP: Not Predicted

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	4.1876	4.1714	0.0664	0.01474
BILIARY TRACT	4.6683	4.6756	0.0997	0.1237
BONE	4.3565	4.3668	0.0308	0.01738
BREAST	4.2675	4.27025	-0.0843	-0.042735
CENTRAL NERVOUS SYSTEM	4.4428	4.3718	0.0014	0.0066
ENDOMETRIUM	4.5288	4.3725	-0.0005	-0.0004109
HAEMATOPOIETIC AND LYMPHOID TISSUE	4.4673	4.4595	-0.0101	9e-04
KIDNEY	5.1124	5.0094	0.1781	0.1613
LARGE INTESTINE	4.5297	4.45055	0.0288	0.0245
LIVER	4.7134	4.4612	0.1685	0.1936
LUNG	4.4999	4.3727	0.0469	0.0436
OESOPHAGUS	4.2768	4.28715	-0.3351	-0.258
OVARY	4.4165	4.3079	0.0273	0.04754
PANCREAS	4.6139	4.5379	0.1047	0.1231
PLEURA	4.8350	4.7886	0.1439	0.1769
PROSTATE	4.2340	4.11335	-0.0755	-0.030465
SALIVARY GLAND	4.1231	4.1231	0.0894	0.0894
SKIN	4.2367	4.1782	0.1123	0.1091
SMALL INTESTINE	4.3647	4.3647	0.0182	0.01817
SOFT TISSUE	4.4110	4.316	0.0797	-0.00402
STOMACH	4.4909	4.37605	0.0310	0.017325
THYROID	4.4371	4.29825	-0.0385	-0.07963
UPPER AERODIGESTIVE TRACT	4.5121	4.4457	-0.0785	-0.0107936
URINARY TRACT	4.4868	4.4317	-0.0087	-0.0207

Domain ID	Domain Name	Start Site	End Site	E-value
PF01335	DED	4	79	1.3e-16
PF01335	DED	93	175	3.2e-27
PF00656	Peptidase_C14	262	461	3.4e-13
PF01335	DED	4	79	1.3e-16
PF01335	DED	93	175	3.2e-27
PF00656	Peptidase_C14	262	461	3.4e-13

Domain ID	Start Site	End Site	E-value
0039807	233	477	1.50e-58
0048274	90	187	2.83e-22
0045697	5	74	4.41e-09
0039807	233	477	1.50e-58
0048274	90	187	2.83e-22
0045697	5	74	4.41e-09

S. No.	Position	Amino acid	Type	Description
1	192	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
2	193	S	Phosphorylation	Phosphoserine
3	254	C	S-nitrosylation	S-nitrosocysteine
4	259	C	S-nitrosylation	S-nitrosocysteine
5	273	S	Phosphorylation	Phosphoserine
6	376	D	Proteolytic Cleavage	none
7	192	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
8	193	S	Phosphorylation	Phosphoserine
9	254	C	S-nitrosylation	S-nitrosocysteine
10	259	C	S-nitrosylation	S-nitrosocysteine
11	273	S	Phosphorylation	Phosphoserine
12	376	D	Proteolytic Cleavage	none

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
CFLAR	CFLAR	CFLAR	ENSP00000312455	O15519
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
O15519	CFLAR	ENSP00000312455	CFLAR	O15519
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
CFLAR	ENSP00000312455	603599	O15519	PA24733

Protein: CFLAR

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)

Modelled Structure	Structures available in PDB
	3H11, 3H13