ApoCanD

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	AGS	Cell Line	STOMACH	NP_001073594	c.1123T>C	p.S375P	CCLE	PASSENGER/OTHER	Benign
2	AGS	Cell Line	STOMACH	NP_001073594	c.1447T>A	p.S483T	CCLE	NP	NP
3	CAL27	Cell Line	UPPER AERODIGESTIVE TRACT	NP_001073594	c.699_702delAATC	p.I233fs	CCLE	NP	NP
4	CAL33	Cell Line	UPPER AERODIGESTIVE TRACT	NP_001073594	c.1414C>T	p.R472*	CCLE	NP	NP
5	CJM	Cell Line	SKIN	NP_001073594	c.1151G>C	p.G384A	CCLE	NP	NP
6	COLO775	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_001073594	c.601_606delATTTTC	p.IF201del	CCLE	NP	NP
7	COV362	Cell Line	OVARY	NP_001073594	c.1342C>T	p.Q448*	CCLE	NP	NP
8	CPCN	Cell Line	LUNG	NP_001073594	c.875G>C	p.R292P	CCLE	NP	NP
9	DV90	Cell Line	LUNG	NP_001073594	c.1366G>A	p.A456T	CCLE	NP	NP
10	EB2	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_001073594	c.1189T>C	p.S397P	CCLE	NP	NP
11	GCT	Cell Line	SOFT TISSUE	NP_001073594	c.837_splice	p.Q279_splice	CCLE	NP	NP
12	HCT15	Cell Line	LARGE INTESTINE	NP_001073594	c.872C>A	p.P291H	CCLE	NP	NP
13	HEC108	Cell Line	ENDOMETRIUM	NP_001073594	c.1514T>C	p.V505A	CCLE	NP	NP
14	HEC1A	Cell Line	ENDOMETRIUM	NP_001073594	c.379C>T	p.R127*	CCLE	NP	NP
15	HEC1A	Cell Line	ENDOMETRIUM	NP_001073594	c.538A>G	p.K180E	CCLE	NP	Benign
16	HEC1B	Cell Line	ENDOMETRIUM	NP_001073594	c.379C>T	p.R127*	CCLE	NP	NP
17	HEC1B	Cell Line	ENDOMETRIUM	NP_001073594	c.538A>G	p.K180E	CCLE	NP	Benign
18	HEC251	Cell Line	ENDOMETRIUM	NP_001073594	c.1616G>T	p.*539L	CCLE	NP	NP
19	HEC251	Cell Line	ENDOMETRIUM	NP_001073594	c.283G>T	p.E95*	CCLE	NP	NP
20	HEC251	Cell Line	ENDOMETRIUM	NP_001073594	c.527T>C	p.L176S	CCLE	NP	NP
21	HRT18	Cell Line	LARGE INTESTINE	NP_001073594	c.872C>A	p.P291H	CCLE	NP	NP
22	HS895T	Cell Line	SKIN	NP_001073594	c.34G>C	p.E12Q	CCLE	CANCER	Probably Damaging
23	HSC2	Cell Line	UPPER AERODIGESTIVE TRACT	NP_001073594	c.1492_1492delA	p.I498fs	CCLE	NP	NP
24	HSC3	Cell Line	UPPER AERODIGESTIVE TRACT	NP_001073594	c.1342C>T	p.Q448*	CCLE	NP	NP
25	IGROV1	Cell Line	OVARY	NP_001073594	c.1240_1240delT	p.F414fs	CCLE	NP	NP
26	JHUEM7	Cell Line	ENDOMETRIUM	NP_001073594	c.1415G>A	p.R472Q	CCLE	NP	NP
27	KYM1	Cell Line	SOFT TISSUE	NP_001073594	c.380G>C	p.R127P	CCLE	NP	NP
28	KYSE150	Cell Line	OESOPHAGUS	NP_001073594	c.550C>T	p.Q184*	CCLE	NP	NP
29	LOVO	Cell Line	LARGE INTESTINE	NP_001073594	c.874C>T	p.R292W	CCLE	NP	NP
30	LS411N	Cell Line	LARGE INTESTINE	NP_001073594	c.607_608delAT	p.I203fs	CCLE	NP	NP
31	MINO	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_001073594	c.185T>G	p.F62C	CCLE	NP	NP
32	PSN1	Cell Line	PANCREAS	NP_001073594	c.1568C>T	p.P523L	CCLE	NP	NP
33	RKO	Cell Line	LARGE INTESTINE	NP_001073594	c.534_536delTTT	p.F179del	CCLE	NP	NP
34	RL952	Cell Line	ENDOMETRIUM	NP_001073594	c.1240_1240delT	p.F414fs	CCLE	NP	NP
35	SKMEL2	Cell Line	SKIN	NP_001073594	c.822G>T	p.Q274H	CCLE	NP	NP
36	SNU520	Cell Line	STOMACH	NP_001073594	c.1471C>T	p.R491*	CCLE	NP	NP
37	SNUC4	Cell Line	LARGE INTESTINE	NP_001073594	c.1480C>T	p.R494*	CCLE	NP	NP
38	SUDHL10	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_001073594	c.1598T>G	p.L533R	CCLE	NP	NP
39	SW48	Cell Line	LARGE INTESTINE	NP_001073594	c.1112G>A	p.C371Y	CCLE	NP	NP
40	SW48	Cell Line	LARGE INTESTINE	NP_001073594	c.615G>A	p.M205I	CCLE	NP	NP
41	107048	Tumour	BREAST	ENST00000264275	c.1080G>C	p.L360F	COSMIC	NP	NP
42	112664	Tumour	OVARY	ENST00000264275	c.201C>T	p.F67F	COSMIC	NP	NP
43	1604875	Tumour	UPPER AERODIGESTIVE TRACT	ENST00000264275	c.872T>G	p.F291C	COSMIC	NP	NP
44	325	Tumour	UPPER AERODIGESTIVE TRACT	ENST00000264275	c.31G>A	p.G11R	COSMIC	NP	NP
45	587220	Tumour	LARGE INTESTINE	ENST00000264275	c.408G>A	p.M136I	COSMIC	NP	NP
46	587224	Tumour	LARGE INTESTINE	ENST00000264275	c.1036C>T	p.Q346*	COSMIC	NP	NP
47	587316	Tumour	LARGE INTESTINE	ENST00000264275	c.1376T>C	p.I459T	COSMIC	NP	NP
48	587342	Tumour	LARGE INTESTINE	ENST00000264275	c.746C>A	p.P249H	COSMIC	NP	NP
49	BB30-HNC	Cell Line	UPPER AERODIGESTIVE TRACT	ENST00000264275	c.1064C>T	p.S355F	COSMIC	NP	NP
50	ESO-0103	Tumour	OESOPHAGUS	ENST00000264275	c.686C>T	p.P229L	COSMIC	NP	NP
51	HCC2998	Cell Line	LARGE INTESTINE	ENST00000264275	c.735G>T	p.M245I	COSMIC	NP	NP
52	HCC98T	Tumour	LIVER	ENST00000264275	c.684T>A	p.S228S	COSMIC	NP	NP
53	HCT-15	Cell Line	LARGE INTESTINE	ENST00000264275	c.746C>A	p.P249H	COSMIC	NP	NP
54	HN	Tumour	62493 UPPER AERODIGESTIVE TRACT	ENST00000264275	c.410T>A	p.L137H	COSMIC	NP	NP
55	HN	Tumour	62652 UPPER AERODIGESTIVE TRACT	ENST00000264275	c.1208C>G	p.S403*	COSMIC	NP	NP
56	HN	Tumour	62854 UPPER AERODIGESTIVE TRACT	ENST00000264275	c.1175C>G	p.S392*	COSMIC	NP	NP
57	HN	Tumour	62861 UPPER AERODIGESTIVE TRACT	ENST00000264275	c.1356-1G>C	p.?	COSMIC	NP	NP
58	HN	Tumour	62921 UPPER AERODIGESTIVE TRACT	ENST00000264275	c.265G>T	p.E89*	COSMIC	NP	NP
59	HN	Tumour	63080 UPPER AERODIGESTIVE TRACT	ENST00000264275	c.1208C>G	p.S403*	COSMIC	NP	NP
60	HT-29	Cell Line	LARGE INTESTINE	ENST00000264275	c.1216C>T	p.Q406*	COSMIC	NP	NP
61	LAU63	Cell Line	SKIN	ENST00000264275	c.1234G>A	p.D412N	COSMIC	NP	NP
62	LUAD-E00897	Tumour	LUNG	ENST00000264275	c.1424A>T	p.N475I	COSMIC	NP	NP
63	LUAD-S01346	Tumour	LUNG	ENST00000264275	c.646+2T>G	p.?	COSMIC	NP	NP
64	MZ7-mel	Cell Line	SKIN	ENST00000264275	c.1213C>T	p.P405S	COSMIC	NP	NP
65	OV207	Tumour	OVARY	ENST00000264275	c.1114delT	p.F373fs*26	COSMIC	NP	NP
66	OV207	Tumour	OVARY	ENST00000264275	c.202C>T	p.R68*	COSMIC	NP	NP
67	PD4125a	Tumour	BREAST	ENST00000264275	c.1066C>T	p.Q356*	COSMIC	NP	NP
68	PD4127a	Tumour	BREAST	ENST00000264275	c.1444C>T	p.Q482*	COSMIC	NP	NP
69	PR-00-1165	Tumour	PROSTATE	ENST00000264275	c.1088C>A	p.P363H	COSMIC	NP	NP
70	RK061	Tumour	C01 LIVER	ENST00000264275	c.910T>G	p.C304G	COSMIC	NP	NP
71	SA051	Tumour	BREAST	ENST00000264275	c.1304G>C	p.G435A	COSMIC	NP	NP
72	SA214	Tumour	BREAST	ENST00000264275	c.161T>C	p.L54S	COSMIC	NP	NP
73	T155	Tumour	ENDOMETRIUM	ENST00000264275	c.1195G>T	p.E399*	COSMIC	NP	NP
74	TCGA-13-2061-01	Tumour	OVARY	ENST00000264275	c.283A>T	p.R95W	COSMIC	NP	NP
75	TCGA-22-5482-01	Tumour	LUNG	ENST00000264275	c.876A>G	p.E292E	COSMIC	NP	NP
76	TCGA-29-1699-01	Tumour	OVARY	ENST00000264275	c.1352C>T	p.P451L	COSMIC	NP	NP
77	TCGA-39-5022-01	Tumour	LUNG	ENST00000264275	c.1175C>G	p.S392*	COSMIC	NP	NP
78	TCGA-43-5668-01	Tumour	LUNG	ENST00000264275	c.422C>G	p.S141*	COSMIC	NP	NP
79	TCGA-44-2665-01	Tumour	LUNG	ENST00000264275	c.166G>T	p.E56*	COSMIC	NP	NP
80	TCGA-44-2665-01	Tumour	LUNG	ENST00000264275	c.537G>C	p.E179D	COSMIC	NP	NP
81	TCGA-49-4507-01	Tumour	LUNG	ENST00000264275	c.1064C>G	p.S355C	COSMIC	NP	NP
82	TCGA-95-7039-01	Tumour	LUNG	ENST00000264275	c.1034G>T	p.G345V	COSMIC	NP	NP
83	TCGA-A2-A0EV-01	Tumour	BREAST	ENST00000264275	c.595A>C	p.I199L	COSMIC	NP	NP
84	TCGA-AA-3489-01	Tumour	LARGE INTESTINE	ENST00000264275	c.24T>A	p.Y8*	COSMIC	NP	NP
85	TCGA-AA-3492-01	Tumour	LARGE INTESTINE	ENST00000264275	c.948C>A	p.Y316*	COSMIC	NP	NP
86	TCGA-AA-3518-01	Tumour	LARGE INTESTINE	ENST00000264275	c.1025G>A	p.G342D	COSMIC	NP	NP
87	TCGA-AA-3543-01	Tumour	LARGE INTESTINE	ENST00000264275	c.851C>T	p.A284V	COSMIC	NP	NP
88	TCGA-AA-3710-01	Tumour	LARGE INTESTINE	ENST00000264275	c.1464delA	p.K490fs*>7	COSMIC	NP	NP
89	TCGA-AA-3710-01	Tumour	LARGE INTESTINE	ENST00000264275	c.185T>C	p.L62P	COSMIC	NP	NP
90	TCGA-AA-3715-01	Tumour	LARGE INTESTINE	ENST00000264275	c.1280T>C	p.V427A	COSMIC	NP	NP
91	TCGA-AA-3864-01	Tumour	LARGE INTESTINE	ENST00000264275	c.1345C>T	p.R449*	COSMIC	NP	NP
92	TCGA-AA-3947-01	Tumour	LARGE INTESTINE	ENST00000264275	c.1427_1428insG	p.K478fs*19	COSMIC	NP	NP
93	TCGA-AA-A00A-01	Tumour	LARGE INTESTINE	ENST00000264275	c.7T>G	p.F3V	COSMIC	NP	NP
94	TCGA-AA-A00J-01	Tumour	LARGE INTESTINE	ENST00000264275	c.1345C>T	p.R449*	COSMIC	NP	NP
95	TCGA-AA-A00R-01	Tumour	LARGE INTESTINE	ENST00000264275	c.122C>A	p.A41D	COSMIC	NP	NP
96	TCGA-AA-A022-01	Tumour	LARGE INTESTINE	ENST00000264275	c.677C>T	p.S226L	COSMIC	NP	NP
97	TCGA-AD-6895-01	Tumour	LARGE INTESTINE	ENST00000264275	c.1330C>T	p.Q444*	COSMIC	NP	NP
98	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000264275	c.391C>T	p.L131L	COSMIC	NP	NP
99	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000264275	c.758G>A	p.C253Y	COSMIC	NP	NP
100	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000264275	c.987C>A	p.C329*	COSMIC	NP	NP
101	TCGA-AP-A05P-01	Tumour	ENDOMETRIUM	ENST00000264275	c.773A>G	p.N258S	COSMIC	NP	NP
102	TCGA-AP-A0LG-01	Tumour	ENDOMETRIUM	ENST00000264275	c.899C>T	p.P300L	COSMIC	NP	NP
103	TCGA-AR-A24Q-01	Tumour	BREAST	ENST00000264275	c.880C>T	p.L294F	COSMIC	NP	NP
104	TCGA-AX-A05S-01	Tumour	ENDOMETRIUM	ENST00000264275	c.1354C>T	p.R452*	COSMIC	NP	NP
105	TCGA-AX-A05Z-01	Tumour	ENDOMETRIUM	ENST00000264275	c.1109A>C	p.K370T	COSMIC	NP	NP
106	TCGA-AX-A05Z-01	Tumour	ENDOMETRIUM	ENST00000264275	c.203G>A	p.R68Q	COSMIC	NP	NP
107	TCGA-AX-A05Z-01	Tumour	ENDOMETRIUM	ENST00000264275	c.480C>T	p.I160I	COSMIC	NP	NP
108	TCGA-AX-A0J0-01	Tumour	ENDOMETRIUM	ENST00000264275	c.1195G>T	p.E399*	COSMIC	NP	NP
109	TCGA-AY-6197-01	Tumour	LARGE INTESTINE	ENST00000264275	c.1113_1114insT	p.I374fs*8	COSMIC	NP	NP
110	TCGA-AZ-6598-01	Tumour	LARGE INTESTINE	ENST00000264275	c.93G>A	p.P31P	COSMIC	NP	NP
111	TCGA-B0-5106-01	Tumour	KIDNEY	ENST00000264275	c.929A>G	p.Y310C	COSMIC	NP	NP
112	TCGA-B5-A0JY-01	Tumour	ENDOMETRIUM	ENST00000264275	c.480C>A	p.I160I	COSMIC	NP	NP
113	TCGA-B5-A11E-01	Tumour	ENDOMETRIUM	ENST00000264275	c.106G>T	p.E36*	COSMIC	NP	NP
114	TCGA-B5-A11N-01	Tumour	ENDOMETRIUM	ENST00000264275	c.14G>T	p.R5I	COSMIC	NP	NP
115	TCGA-B6-A0RP-01	Tumour	BREAST	ENST00000264275	c.796G>T	p.E266*	COSMIC	NP	NP
116	TCGA-BS-A0TA-01	Tumour	ENDOMETRIUM	ENST00000264275	c.646+1G>A	p.?	COSMIC	NP	NP
117	TCGA-BS-A0TJ-01	Tumour	ENDOMETRIUM	ENST00000264275	c.1311G>C	p.W437C	COSMIC	NP	NP
118	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000264275	c.508-1G>T	p.?	COSMIC	NP	NP
119	TCGA-BS-A0UJ-01	Tumour	ENDOMETRIUM	ENST00000264275	c.734T>C	p.M245T	COSMIC	NP	NP
120	TCGA-BS-A0UV-01	Tumour	ENDOMETRIUM	ENST00000264275	c.1381A>C	p.T461P	COSMIC	NP	NP
121	TCGA-BS-A0UV-01	Tumour	ENDOMETRIUM	ENST00000264275	c.155G>T	p.R52I	COSMIC	NP	NP
122	TCGA-BT-A20O-01	Tumour	URINARY TRACT	ENST00000264275	c.29T>C	p.I10T	COSMIC	NP	NP
123	TCGA-C4-A0F6-01	Tumour	URINARY TRACT	ENST00000264275	c.749G>A	p.R250Q	COSMIC	NP	NP
124	TCGA-CA-6717-01	Tumour	LARGE INTESTINE	ENST00000264275	c.1195G>T	p.E399*	COSMIC	NP	NP
125	TCGA-CA-6717-01	Tumour	LARGE INTESTINE	ENST00000264275	c.218A>C	p.D73A	COSMIC	NP	NP
126	TCGA-D1-A103-01	Tumour	ENDOMETRIUM	ENST00000264275	c.606C>T	p.S202S	COSMIC	NP	NP
127	TCGA-D1-A161-01	Tumour	ENDOMETRIUM	ENST00000264275	c.423_425delAGA	p.E143delE	COSMIC	NP	NP
128	TCGA-D1-A167-01	Tumour	ENDOMETRIUM	ENST00000264275	c.1106C>A	p.P369H	COSMIC	NP	NP
129	TCGA-D1-A16F-01	Tumour	ENDOMETRIUM	ENST00000264275	c.1221G>A	p.T407T	COSMIC	NP	NP
130	TCGA-D1-A16X-01	Tumour	ENDOMETRIUM	ENST00000264275	c.52G>T	p.D18Y	COSMIC	NP	NP
131	TCGA-D1-A17Q-01	Tumour	ENDOMETRIUM	ENST00000264275	c.1278T>C	p.C426C	COSMIC	NP	NP
132	TCGA-D1-A17Q-01	Tumour	ENDOMETRIUM	ENST00000264275	c.155G>T	p.R52I	COSMIC	NP	NP
133	TCGA-D1-A17Q-01	Tumour	ENDOMETRIUM	ENST00000264275	c.203G>A	p.R68Q	COSMIC	NP	NP
134	TCGA-D8-A1XW-01	Tumour	BREAST	ENST00000264275	c.728A>T	p.Y243F	COSMIC	NP	NP
135	TCGA-DM-A28F-01	Tumour	LARGE INTESTINE	ENST00000264275	c.1175C>T	p.S392L	COSMIC	NP	NP
136	TCGA-DS-A0VL-01	Tumour	CERVIX	ENST00000264275	c.1025G>A	p.G342D	COSMIC	NP	NP
137	TCGA-DS-A0VL-01	Tumour	CERVIX	ENST00000264275	c.422C>G	p.S141*	COSMIC	NP	NP
138	TCGA-E2-A1B6-01	Tumour	BREAST	ENST00000264275	c.998C>T	p.S333F	COSMIC	NP	NP
139	TCGA-E9-A22H-01	Tumour	BREAST	ENST00000264275	c.748C>T	p.R250W	COSMIC	NP	NP
140	TCGA-E9-A244-01	Tumour	BREAST	ENST00000264275	c.1220C>T	p.T407M	COSMIC	NP	NP
141	TCGA-EI-6507-01	Tumour	LARGE INTESTINE	ENST00000264275	c.660_661insG	p.V222fs*13	COSMIC	NP	NP
142	TCGA-EW-A1P3-01	Tumour	BREAST	ENST00000264275	c.202C>T	p.R68*	COSMIC	NP	NP
143	TCGA-FD-A3N6-01	Tumour	URINARY TRACT	ENST00000264275	c.1345C>T	p.R449*	COSMIC	NP	NP
144	TCGA-FI-A2EW-01	Tumour	ENDOMETRIUM	ENST00000264275	c.449G>A	p.R150K	COSMIC	NP	NP
145	TCGA-J2-8192-01	Tumour	LUNG	ENST00000264275	c.608T>G	p.L203R	COSMIC	NP	NP
146	5637	Cell Line	URINARY_TRACT	ENST00000264275	c.459G>A	p.K153K	COSMIC	NP	NP
147	A2780	Cell Line	OVARY	ENST00000264275	c.1355+5G>A	p.?	COSMIC	NP	NP
148	A388	Cell Line	SKIN	ENST00000264275	c.895A>T	p.K299*	COSMIC	NP	NP
149	A3KAW	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000264275	c.666A>G	p.V222V	COSMIC	NP	NP
150	A431	Cell Line	SKIN	ENST00000264275	c.184_186delCTG	p.L62delL	COSMIC	NP	NP
151	AGS	Cell Line	STOMACH	ENST00000264275	c.1321T>A	p.S441T	COSMIC	NP	NP
152	AGS	Cell Line	STOMACH	ENST00000264275	c.997T>C	p.S333P	COSMIC	NP	NP
153	BB30HNC	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000264275	c.1064C>T	p.S355F	COSMIC	NP	NP
154	BB49HNC	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000264275	c.1490G>C	p.*497S	COSMIC	NP	NP
155	C4I	Cell Line	CERVIX	ENST00000264275	c.296C>T	p.S99F	COSMIC	CANCER	PROBABLY DAMAGING
156	CAL27	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000264275	c.1476C>T	p.V492V	COSMIC	NP	NP
157	CAL27	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000264275	c.618_621delAATC	p.I207fs*15	COSMIC	NP	NP
158	CAL33	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000264275	c.1288C>T	p.R430*	COSMIC	NP	NP
159	CPCN	Cell Line	LUNG	ENST00000264275	c.749G>C	p.R250P	COSMIC	NP	NP
160	DMS79	Cell Line	LUNG	ENST00000264275	c.384C>G	p.V128V	COSMIC	NP	NP
161	EB2	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000264275	c.1063T>C	p.S355P	COSMIC	NP	NP
162	FARAGE	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000264275	c.1261G>A	p.A421T	COSMIC	NP	NP
163	GCT	Cell Line	SOFT_TISSUE	ENST00000264275	c.711+1G>A	p.?	COSMIC	NP	NP
164	GEO	Cell Line	LARGE_INTESTINE	ENST00000264275	c.970A>G	p.M324V	COSMIC	NP	NP
165	GRST	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000264275	c.885delT	p.F296fs*11	COSMIC	NP	NP
166	HCC2998	Cell Line	LARGE_INTESTINE	ENST00000264275	c.712-8T>C	p.?	COSMIC	NP	NP
167	HCC2998	Cell Line	LARGE_INTESTINE	ENST00000264275	c.735G>T	p.M245I	COSMIC	NP	NP
168	HCC44	Cell Line	LUNG	ENST00000264275	c.1356-3C>G	p.?	COSMIC	NP	NP
169	HCT15	Cell Line	LARGE_INTESTINE	ENST00000264275	c.746C>A	p.P249H	COSMIC	NP	NP
170	HEC1	Cell Line	ENDOMETRIUM	ENST00000264275	c.202C>T	p.R68*	COSMIC	NP	NP
171	HEC1	Cell Line	ENDOMETRIUM	ENST00000264275	c.457A>G	p.K153E	COSMIC	NP	NP
172	HN	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000264275	c.894C>A	p.I298I	COSMIC	NP	NP
173	HO1N1	Cell Line	SALIVARY_GLAND	ENST00000264275	c.422C>T	p.S141L	COSMIC	NP	NP
174	HSC2	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000264275	c.1366delA	p.I456fs*5	COSMIC	NP	NP
175	HSC3	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000264275	c.1216C>T	p.Q406*	COSMIC	NP	NP
176	HT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000264275	c.1272T>C	p.N424N	COSMIC	NP	NP
177	HT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000264275	c.853+7T>C	p.?	COSMIC	NP	NP
178	HT115	Cell Line	LARGE_INTESTINE	ENST00000264275	c.203G>A	p.R68Q	COSMIC	CANCER	POSSIBLY DAMAGING
179	HT55	Cell Line	LARGE_INTESTINE	ENST00000264275	c.527T>C	p.I176T	COSMIC	NP	NP
180	IGROV1	Cell Line	OVARY	ENST00000264275	c.1114delT	p.F373fs*26	COSMIC	NP	NP
181	JSC1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000264275	c.814C>T	p.H272Y	COSMIC	NP	NP
182	JURKAT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000264275	c.143T>G	p.L48R	COSMIC	CANCER	PROBABLY DAMAGING
183	KMOE2	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000264275	c.159G>A	p.M53I	COSMIC	CANCER	BENIGN
184	KYM1	Cell Line	SOFT_TISSUE	ENST00000264275	c.203G>C	p.R68P	COSMIC	CANCER	PROBABLY DAMAGING
185	KYSE150	Cell Line	OESOPHAGUS	ENST00000264275	c.469C>T	p.Q157*	COSMIC	NP	NP
186	LB771HNC	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000264275	c.402-2A>T	p.?	COSMIC	NP	NP
187	LNCAPCLONEFGC	Cell Line	PROSTATE	ENST00000264275	c.711+7G>A	p.?	COSMIC	NP	NP
188	LOVO	Cell Line	LARGE_INTESTINE	ENST00000264275	c.748C>T	p.R250W	COSMIC	NP	NP
189	LS411N	Cell Line	LARGE_INTESTINE	ENST00000264275	c.526_527delAT	p.I176fs*35	COSMIC	NP	NP
190	MCC13	Cell Line	SKIN	ENST00000264275	c.1105C>T	p.P369S	COSMIC	NP	NP
191	MCC13	Cell Line	SKIN	ENST00000264275	c.1106C>T	p.P369L	COSMIC	NP	NP
192	MDAMB231	Cell Line	BREAST	ENST00000264275	c.396A>G	p.L132L	COSMIC	NP	NP
193	MFE319	Cell Line	ENDOMETRIUM	ENST00000264275	c.1134G>A	p.Q378Q	COSMIC	NP	NP
194	MOGGCCM	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000264275	c.859T>C	p.L287L	COSMIC	NP	NP
195	MZ7MEL	Cell Line	SKIN	ENST00000264275	c.1213C>T	p.P405S	COSMIC	NP	NP
196	OC314	Cell Line	OVARY	ENST00000264275	c.1114delT	p.F373fs*26	COSMIC	NP	NP
197	PEO1	Cell Line	OVARY	ENST00000264275	c.306-1086_402-10>ACATGA	p.?	COSMIC	NP	NP
198	PSN1	Cell Line	PANCREAS	ENST00000264275	c.1442C>T	p.P481L	COSMIC	NP	NP
199	RAMOS2G64C10	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000264275	c.401G>A	p.R134K	COSMIC	NP	NP
200	RKO	Cell Line	LARGE_INTESTINE	ENST00000264275	c.453_455delTTT	p.F152delF	COSMIC	NP	NP
201	RL952	Cell Line	ENDOMETRIUM	ENST00000264275	c.1114delT	p.F373fs*26	COSMIC	NP	NP
202	SAS	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000264275	c.1064C>T	p.S355F	COSMIC	NP	NP
203	SIHA	Cell Line	CERVIX	ENST00000264275	c.202C>T	p.R68*	COSMIC	NP	NP
204	SKGT2	Cell Line	STOMACH	ENST00000264275	c.459G>C	p.K153N	COSMIC	NP	NP
205	SNU407	Cell Line	LARGE_INTESTINE	ENST00000264275	c.431T>C	p.V144A	COSMIC	NP	NP
206	SNU81	Cell Line	LARGE_INTESTINE	ENST00000264275	c.1221G>T	p.T407T	COSMIC	NP	NP
207	SUDHL10	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000264275	c.1472T>G	p.L491R	COSMIC	NP	NP
208	SUPT1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000264275	c.749G>A	p.R250Q	COSMIC	NP	NP
209	SW48	Cell Line	LARGE_INTESTINE	ENST00000264275	c.534G>A	p.M178I	COSMIC	NP	NP
210	SW48	Cell Line	LARGE_INTESTINE	ENST00000264275	c.986G>A	p.C329Y	COSMIC	NP	NP
211	TE12	Cell Line	OESOPHAGUS	ENST00000264275	c.894C>A	p.I298I	COSMIC	NP	NP
212	WSUNHL	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000264275	c.1462A>G	p.R488G	COSMIC	NP	NP
213	AGS	Cell Line	STOMACH	NP_001073594	c.1123T>C	p.S375P	CCLE	PASSENGER/OTHER	Benign
214	AGS	Cell Line	STOMACH	NP_001073594	c.1447T>A	p.S483T	CCLE	NP	NP
215	CAL27	Cell Line	UPPER AERODIGESTIVE TRACT	NP_001073594	c.699_702delAATC	p.I233fs	CCLE	NP	NP
216	CAL33	Cell Line	UPPER AERODIGESTIVE TRACT	NP_001073594	c.1414C>T	p.R472*	CCLE	NP	NP
217	CJM	Cell Line	SKIN	NP_001073594	c.1151G>C	p.G384A	CCLE	NP	NP
218	COLO775	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_001073594	c.601_606delATTTTC	p.IF201del	CCLE	NP	NP
219	COV362	Cell Line	OVARY	NP_001073594	c.1342C>T	p.Q448*	CCLE	NP	NP
220	CPCN	Cell Line	LUNG	NP_001073594	c.875G>C	p.R292P	CCLE	NP	NP
221	DV90	Cell Line	LUNG	NP_001073594	c.1366G>A	p.A456T	CCLE	NP	NP
222	EB2	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_001073594	c.1189T>C	p.S397P	CCLE	NP	NP
223	GCT	Cell Line	SOFT TISSUE	NP_001073594	c.837_splice	p.Q279_splice	CCLE	NP	NP
224	HCT15	Cell Line	LARGE INTESTINE	NP_001073594	c.872C>A	p.P291H	CCLE	NP	NP
225	HEC108	Cell Line	ENDOMETRIUM	NP_001073594	c.1514T>C	p.V505A	CCLE	NP	NP
226	HEC1A	Cell Line	ENDOMETRIUM	NP_001073594	c.379C>T	p.R127*	CCLE	NP	NP
227	HEC1A	Cell Line	ENDOMETRIUM	NP_001073594	c.538A>G	p.K180E	CCLE	NP	Benign
228	HEC1B	Cell Line	ENDOMETRIUM	NP_001073594	c.379C>T	p.R127*	CCLE	NP	NP
229	HEC1B	Cell Line	ENDOMETRIUM	NP_001073594	c.538A>G	p.K180E	CCLE	NP	Benign
230	HEC251	Cell Line	ENDOMETRIUM	NP_001073594	c.1616G>T	p.*539L	CCLE	NP	NP
231	HEC251	Cell Line	ENDOMETRIUM	NP_001073594	c.283G>T	p.E95*	CCLE	NP	NP
232	HEC251	Cell Line	ENDOMETRIUM	NP_001073594	c.527T>C	p.L176S	CCLE	NP	NP
233	HRT18	Cell Line	LARGE INTESTINE	NP_001073594	c.872C>A	p.P291H	CCLE	NP	NP
234	HS895T	Cell Line	SKIN	NP_001073594	c.34G>C	p.E12Q	CCLE	CANCER	Probably Damaging
235	HSC2	Cell Line	UPPER AERODIGESTIVE TRACT	NP_001073594	c.1492_1492delA	p.I498fs	CCLE	NP	NP
236	HSC3	Cell Line	UPPER AERODIGESTIVE TRACT	NP_001073594	c.1342C>T	p.Q448*	CCLE	NP	NP
237	IGROV1	Cell Line	OVARY	NP_001073594	c.1240_1240delT	p.F414fs	CCLE	NP	NP
238	JHUEM7	Cell Line	ENDOMETRIUM	NP_001073594	c.1415G>A	p.R472Q	CCLE	NP	NP
239	KYM1	Cell Line	SOFT TISSUE	NP_001073594	c.380G>C	p.R127P	CCLE	NP	NP
240	KYSE150	Cell Line	OESOPHAGUS	NP_001073594	c.550C>T	p.Q184*	CCLE	NP	NP
241	LOVO	Cell Line	LARGE INTESTINE	NP_001073594	c.874C>T	p.R292W	CCLE	NP	NP
242	LS411N	Cell Line	LARGE INTESTINE	NP_001073594	c.607_608delAT	p.I203fs	CCLE	NP	NP
243	MINO	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_001073594	c.185T>G	p.F62C	CCLE	NP	NP
244	PSN1	Cell Line	PANCREAS	NP_001073594	c.1568C>T	p.P523L	CCLE	NP	NP
245	RKO	Cell Line	LARGE INTESTINE	NP_001073594	c.534_536delTTT	p.F179del	CCLE	NP	NP
246	RL952	Cell Line	ENDOMETRIUM	NP_001073594	c.1240_1240delT	p.F414fs	CCLE	NP	NP
247	SKMEL2	Cell Line	SKIN	NP_001073594	c.822G>T	p.Q274H	CCLE	NP	NP
248	SNU520	Cell Line	STOMACH	NP_001073594	c.1471C>T	p.R491*	CCLE	NP	NP
249	SNUC4	Cell Line	LARGE INTESTINE	NP_001073594	c.1480C>T	p.R494*	CCLE	NP	NP
250	SUDHL10	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_001073594	c.1598T>G	p.L533R	CCLE	NP	NP
251	SW48	Cell Line	LARGE INTESTINE	NP_001073594	c.1112G>A	p.C371Y	CCLE	NP	NP
252	SW48	Cell Line	LARGE INTESTINE	NP_001073594	c.615G>A	p.M205I	CCLE	NP	NP
253	107048	Tumour	BREAST	ENST00000264275	c.1080G>C	p.L360F	COSMIC	NP	NP
254	112664	Tumour	OVARY	ENST00000264275	c.201C>T	p.F67F	COSMIC	NP	NP
255	1604875	Tumour	UPPER AERODIGESTIVE TRACT	ENST00000264275	c.872T>G	p.F291C	COSMIC	NP	NP
256	325	Tumour	UPPER AERODIGESTIVE TRACT	ENST00000264275	c.31G>A	p.G11R	COSMIC	NP	NP
257	587220	Tumour	LARGE INTESTINE	ENST00000264275	c.408G>A	p.M136I	COSMIC	NP	NP
258	587224	Tumour	LARGE INTESTINE	ENST00000264275	c.1036C>T	p.Q346*	COSMIC	NP	NP
259	587316	Tumour	LARGE INTESTINE	ENST00000264275	c.1376T>C	p.I459T	COSMIC	NP	NP
260	587342	Tumour	LARGE INTESTINE	ENST00000264275	c.746C>A	p.P249H	COSMIC	NP	NP
261	BB30-HNC	Cell Line	UPPER AERODIGESTIVE TRACT	ENST00000264275	c.1064C>T	p.S355F	COSMIC	NP	NP
262	ESO-0103	Tumour	OESOPHAGUS	ENST00000264275	c.686C>T	p.P229L	COSMIC	NP	NP
263	HCC2998	Cell Line	LARGE INTESTINE	ENST00000264275	c.735G>T	p.M245I	COSMIC	NP	NP
264	HCC98T	Tumour	LIVER	ENST00000264275	c.684T>A	p.S228S	COSMIC	NP	NP
265	HCT-15	Cell Line	LARGE INTESTINE	ENST00000264275	c.746C>A	p.P249H	COSMIC	NP	NP
266	HN	Tumour	62493 UPPER AERODIGESTIVE TRACT	ENST00000264275	c.410T>A	p.L137H	COSMIC	NP	NP
267	HN	Tumour	62652 UPPER AERODIGESTIVE TRACT	ENST00000264275	c.1208C>G	p.S403*	COSMIC	NP	NP
268	HN	Tumour	62854 UPPER AERODIGESTIVE TRACT	ENST00000264275	c.1175C>G	p.S392*	COSMIC	NP	NP
269	HN	Tumour	62861 UPPER AERODIGESTIVE TRACT	ENST00000264275	c.1356-1G>C	p.?	COSMIC	NP	NP
270	HN	Tumour	62921 UPPER AERODIGESTIVE TRACT	ENST00000264275	c.265G>T	p.E89*	COSMIC	NP	NP
271	HN	Tumour	63080 UPPER AERODIGESTIVE TRACT	ENST00000264275	c.1208C>G	p.S403*	COSMIC	NP	NP
272	HT-29	Cell Line	LARGE INTESTINE	ENST00000264275	c.1216C>T	p.Q406*	COSMIC	NP	NP
273	LAU63	Cell Line	SKIN	ENST00000264275	c.1234G>A	p.D412N	COSMIC	NP	NP
274	LUAD-E00897	Tumour	LUNG	ENST00000264275	c.1424A>T	p.N475I	COSMIC	NP	NP
275	LUAD-S01346	Tumour	LUNG	ENST00000264275	c.646+2T>G	p.?	COSMIC	NP	NP
276	MZ7-mel	Cell Line	SKIN	ENST00000264275	c.1213C>T	p.P405S	COSMIC	NP	NP
277	OV207	Tumour	OVARY	ENST00000264275	c.1114delT	p.F373fs*26	COSMIC	NP	NP
278	OV207	Tumour	OVARY	ENST00000264275	c.202C>T	p.R68*	COSMIC	NP	NP
279	PD4125a	Tumour	BREAST	ENST00000264275	c.1066C>T	p.Q356*	COSMIC	NP	NP
280	PD4127a	Tumour	BREAST	ENST00000264275	c.1444C>T	p.Q482*	COSMIC	NP	NP
281	PR-00-1165	Tumour	PROSTATE	ENST00000264275	c.1088C>A	p.P363H	COSMIC	NP	NP
282	RK061	Tumour	C01 LIVER	ENST00000264275	c.910T>G	p.C304G	COSMIC	NP	NP
283	SA051	Tumour	BREAST	ENST00000264275	c.1304G>C	p.G435A	COSMIC	NP	NP
284	SA214	Tumour	BREAST	ENST00000264275	c.161T>C	p.L54S	COSMIC	NP	NP
285	T155	Tumour	ENDOMETRIUM	ENST00000264275	c.1195G>T	p.E399*	COSMIC	NP	NP
286	TCGA-13-2061-01	Tumour	OVARY	ENST00000264275	c.283A>T	p.R95W	COSMIC	NP	NP
287	TCGA-22-5482-01	Tumour	LUNG	ENST00000264275	c.876A>G	p.E292E	COSMIC	NP	NP
288	TCGA-29-1699-01	Tumour	OVARY	ENST00000264275	c.1352C>T	p.P451L	COSMIC	NP	NP
289	TCGA-39-5022-01	Tumour	LUNG	ENST00000264275	c.1175C>G	p.S392*	COSMIC	NP	NP
290	TCGA-43-5668-01	Tumour	LUNG	ENST00000264275	c.422C>G	p.S141*	COSMIC	NP	NP
291	TCGA-44-2665-01	Tumour	LUNG	ENST00000264275	c.166G>T	p.E56*	COSMIC	NP	NP
292	TCGA-44-2665-01	Tumour	LUNG	ENST00000264275	c.537G>C	p.E179D	COSMIC	NP	NP
293	TCGA-49-4507-01	Tumour	LUNG	ENST00000264275	c.1064C>G	p.S355C	COSMIC	NP	NP
294	TCGA-95-7039-01	Tumour	LUNG	ENST00000264275	c.1034G>T	p.G345V	COSMIC	NP	NP
295	TCGA-A2-A0EV-01	Tumour	BREAST	ENST00000264275	c.595A>C	p.I199L	COSMIC	NP	NP
296	TCGA-AA-3489-01	Tumour	LARGE INTESTINE	ENST00000264275	c.24T>A	p.Y8*	COSMIC	NP	NP
297	TCGA-AA-3492-01	Tumour	LARGE INTESTINE	ENST00000264275	c.948C>A	p.Y316*	COSMIC	NP	NP
298	TCGA-AA-3518-01	Tumour	LARGE INTESTINE	ENST00000264275	c.1025G>A	p.G342D	COSMIC	NP	NP
299	TCGA-AA-3543-01	Tumour	LARGE INTESTINE	ENST00000264275	c.851C>T	p.A284V	COSMIC	NP	NP
300	TCGA-AA-3710-01	Tumour	LARGE INTESTINE	ENST00000264275	c.1464delA	p.K490fs*>7	COSMIC	NP	NP
301	TCGA-AA-3710-01	Tumour	LARGE INTESTINE	ENST00000264275	c.185T>C	p.L62P	COSMIC	NP	NP
302	TCGA-AA-3715-01	Tumour	LARGE INTESTINE	ENST00000264275	c.1280T>C	p.V427A	COSMIC	NP	NP
303	TCGA-AA-3864-01	Tumour	LARGE INTESTINE	ENST00000264275	c.1345C>T	p.R449*	COSMIC	NP	NP
304	TCGA-AA-3947-01	Tumour	LARGE INTESTINE	ENST00000264275	c.1427_1428insG	p.K478fs*19	COSMIC	NP	NP
305	TCGA-AA-A00A-01	Tumour	LARGE INTESTINE	ENST00000264275	c.7T>G	p.F3V	COSMIC	NP	NP
306	TCGA-AA-A00J-01	Tumour	LARGE INTESTINE	ENST00000264275	c.1345C>T	p.R449*	COSMIC	NP	NP
307	TCGA-AA-A00R-01	Tumour	LARGE INTESTINE	ENST00000264275	c.122C>A	p.A41D	COSMIC	NP	NP
308	TCGA-AA-A022-01	Tumour	LARGE INTESTINE	ENST00000264275	c.677C>T	p.S226L	COSMIC	NP	NP
309	TCGA-AD-6895-01	Tumour	LARGE INTESTINE	ENST00000264275	c.1330C>T	p.Q444*	COSMIC	NP	NP
310	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000264275	c.391C>T	p.L131L	COSMIC	NP	NP
311	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000264275	c.758G>A	p.C253Y	COSMIC	NP	NP
312	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000264275	c.987C>A	p.C329*	COSMIC	NP	NP
313	TCGA-AP-A05P-01	Tumour	ENDOMETRIUM	ENST00000264275	c.773A>G	p.N258S	COSMIC	NP	NP
314	TCGA-AP-A0LG-01	Tumour	ENDOMETRIUM	ENST00000264275	c.899C>T	p.P300L	COSMIC	NP	NP
315	TCGA-AR-A24Q-01	Tumour	BREAST	ENST00000264275	c.880C>T	p.L294F	COSMIC	NP	NP
316	TCGA-AX-A05S-01	Tumour	ENDOMETRIUM	ENST00000264275	c.1354C>T	p.R452*	COSMIC	NP	NP
317	TCGA-AX-A05Z-01	Tumour	ENDOMETRIUM	ENST00000264275	c.1109A>C	p.K370T	COSMIC	NP	NP
318	TCGA-AX-A05Z-01	Tumour	ENDOMETRIUM	ENST00000264275	c.203G>A	p.R68Q	COSMIC	NP	NP
319	TCGA-AX-A05Z-01	Tumour	ENDOMETRIUM	ENST00000264275	c.480C>T	p.I160I	COSMIC	NP	NP
320	TCGA-AX-A0J0-01	Tumour	ENDOMETRIUM	ENST00000264275	c.1195G>T	p.E399*	COSMIC	NP	NP
321	TCGA-AY-6197-01	Tumour	LARGE INTESTINE	ENST00000264275	c.1113_1114insT	p.I374fs*8	COSMIC	NP	NP
322	TCGA-AZ-6598-01	Tumour	LARGE INTESTINE	ENST00000264275	c.93G>A	p.P31P	COSMIC	NP	NP
323	TCGA-B0-5106-01	Tumour	KIDNEY	ENST00000264275	c.929A>G	p.Y310C	COSMIC	NP	NP
324	TCGA-B5-A0JY-01	Tumour	ENDOMETRIUM	ENST00000264275	c.480C>A	p.I160I	COSMIC	NP	NP
325	TCGA-B5-A11E-01	Tumour	ENDOMETRIUM	ENST00000264275	c.106G>T	p.E36*	COSMIC	NP	NP
326	TCGA-B5-A11N-01	Tumour	ENDOMETRIUM	ENST00000264275	c.14G>T	p.R5I	COSMIC	NP	NP
327	TCGA-B6-A0RP-01	Tumour	BREAST	ENST00000264275	c.796G>T	p.E266*	COSMIC	NP	NP
328	TCGA-BS-A0TA-01	Tumour	ENDOMETRIUM	ENST00000264275	c.646+1G>A	p.?	COSMIC	NP	NP
329	TCGA-BS-A0TJ-01	Tumour	ENDOMETRIUM	ENST00000264275	c.1311G>C	p.W437C	COSMIC	NP	NP
330	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000264275	c.508-1G>T	p.?	COSMIC	NP	NP
331	TCGA-BS-A0UJ-01	Tumour	ENDOMETRIUM	ENST00000264275	c.734T>C	p.M245T	COSMIC	NP	NP
332	TCGA-BS-A0UV-01	Tumour	ENDOMETRIUM	ENST00000264275	c.1381A>C	p.T461P	COSMIC	NP	NP
333	TCGA-BS-A0UV-01	Tumour	ENDOMETRIUM	ENST00000264275	c.155G>T	p.R52I	COSMIC	NP	NP
334	TCGA-BT-A20O-01	Tumour	URINARY TRACT	ENST00000264275	c.29T>C	p.I10T	COSMIC	NP	NP
335	TCGA-C4-A0F6-01	Tumour	URINARY TRACT	ENST00000264275	c.749G>A	p.R250Q	COSMIC	NP	NP
336	TCGA-CA-6717-01	Tumour	LARGE INTESTINE	ENST00000264275	c.1195G>T	p.E399*	COSMIC	NP	NP
337	TCGA-CA-6717-01	Tumour	LARGE INTESTINE	ENST00000264275	c.218A>C	p.D73A	COSMIC	NP	NP
338	TCGA-D1-A103-01	Tumour	ENDOMETRIUM	ENST00000264275	c.606C>T	p.S202S	COSMIC	NP	NP
339	TCGA-D1-A161-01	Tumour	ENDOMETRIUM	ENST00000264275	c.423_425delAGA	p.E143delE	COSMIC	NP	NP
340	TCGA-D1-A167-01	Tumour	ENDOMETRIUM	ENST00000264275	c.1106C>A	p.P369H	COSMIC	NP	NP
341	TCGA-D1-A16F-01	Tumour	ENDOMETRIUM	ENST00000264275	c.1221G>A	p.T407T	COSMIC	NP	NP
342	TCGA-D1-A16X-01	Tumour	ENDOMETRIUM	ENST00000264275	c.52G>T	p.D18Y	COSMIC	NP	NP
343	TCGA-D1-A17Q-01	Tumour	ENDOMETRIUM	ENST00000264275	c.1278T>C	p.C426C	COSMIC	NP	NP
344	TCGA-D1-A17Q-01	Tumour	ENDOMETRIUM	ENST00000264275	c.155G>T	p.R52I	COSMIC	NP	NP
345	TCGA-D1-A17Q-01	Tumour	ENDOMETRIUM	ENST00000264275	c.203G>A	p.R68Q	COSMIC	NP	NP
346	TCGA-D8-A1XW-01	Tumour	BREAST	ENST00000264275	c.728A>T	p.Y243F	COSMIC	NP	NP
347	TCGA-DM-A28F-01	Tumour	LARGE INTESTINE	ENST00000264275	c.1175C>T	p.S392L	COSMIC	NP	NP
348	TCGA-DS-A0VL-01	Tumour	CERVIX	ENST00000264275	c.1025G>A	p.G342D	COSMIC	NP	NP
349	TCGA-DS-A0VL-01	Tumour	CERVIX	ENST00000264275	c.422C>G	p.S141*	COSMIC	NP	NP
350	TCGA-E2-A1B6-01	Tumour	BREAST	ENST00000264275	c.998C>T	p.S333F	COSMIC	NP	NP
351	TCGA-E9-A22H-01	Tumour	BREAST	ENST00000264275	c.748C>T	p.R250W	COSMIC	NP	NP
352	TCGA-E9-A244-01	Tumour	BREAST	ENST00000264275	c.1220C>T	p.T407M	COSMIC	NP	NP
353	TCGA-EI-6507-01	Tumour	LARGE INTESTINE	ENST00000264275	c.660_661insG	p.V222fs*13	COSMIC	NP	NP
354	TCGA-EW-A1P3-01	Tumour	BREAST	ENST00000264275	c.202C>T	p.R68*	COSMIC	NP	NP
355	TCGA-FD-A3N6-01	Tumour	URINARY TRACT	ENST00000264275	c.1345C>T	p.R449*	COSMIC	NP	NP
356	TCGA-FI-A2EW-01	Tumour	ENDOMETRIUM	ENST00000264275	c.449G>A	p.R150K	COSMIC	NP	NP
357	TCGA-J2-8192-01	Tumour	LUNG	ENST00000264275	c.608T>G	p.L203R	COSMIC	NP	NP
358	5637	Cell Line	URINARY_TRACT	ENST00000264275	c.459G>A	p.K153K	COSMIC	NP	NP
359	A2780	Cell Line	OVARY	ENST00000264275	c.1355+5G>A	p.?	COSMIC	NP	NP
360	A388	Cell Line	SKIN	ENST00000264275	c.895A>T	p.K299*	COSMIC	NP	NP
361	A3KAW	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000264275	c.666A>G	p.V222V	COSMIC	NP	NP
362	A431	Cell Line	SKIN	ENST00000264275	c.184_186delCTG	p.L62delL	COSMIC	NP	NP
363	AGS	Cell Line	STOMACH	ENST00000264275	c.1321T>A	p.S441T	COSMIC	NP	NP
364	AGS	Cell Line	STOMACH	ENST00000264275	c.997T>C	p.S333P	COSMIC	NP	NP
365	BB30HNC	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000264275	c.1064C>T	p.S355F	COSMIC	NP	NP
366	BB49HNC	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000264275	c.1490G>C	p.*497S	COSMIC	NP	NP
367	C4I	Cell Line	CERVIX	ENST00000264275	c.296C>T	p.S99F	COSMIC	CANCER	PROBABLY DAMAGING
368	CAL27	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000264275	c.1476C>T	p.V492V	COSMIC	NP	NP
369	CAL27	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000264275	c.618_621delAATC	p.I207fs*15	COSMIC	NP	NP
370	CAL33	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000264275	c.1288C>T	p.R430*	COSMIC	NP	NP
371	CPCN	Cell Line	LUNG	ENST00000264275	c.749G>C	p.R250P	COSMIC	NP	NP
372	DMS79	Cell Line	LUNG	ENST00000264275	c.384C>G	p.V128V	COSMIC	NP	NP
373	EB2	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000264275	c.1063T>C	p.S355P	COSMIC	NP	NP
374	FARAGE	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000264275	c.1261G>A	p.A421T	COSMIC	NP	NP
375	GCT	Cell Line	SOFT_TISSUE	ENST00000264275	c.711+1G>A	p.?	COSMIC	NP	NP
376	GEO	Cell Line	LARGE_INTESTINE	ENST00000264275	c.970A>G	p.M324V	COSMIC	NP	NP
377	GRST	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000264275	c.885delT	p.F296fs*11	COSMIC	NP	NP
378	HCC2998	Cell Line	LARGE_INTESTINE	ENST00000264275	c.712-8T>C	p.?	COSMIC	NP	NP
379	HCC2998	Cell Line	LARGE_INTESTINE	ENST00000264275	c.735G>T	p.M245I	COSMIC	NP	NP
380	HCC44	Cell Line	LUNG	ENST00000264275	c.1356-3C>G	p.?	COSMIC	NP	NP
381	HCT15	Cell Line	LARGE_INTESTINE	ENST00000264275	c.746C>A	p.P249H	COSMIC	NP	NP
382	HEC1	Cell Line	ENDOMETRIUM	ENST00000264275	c.202C>T	p.R68*	COSMIC	NP	NP
383	HEC1	Cell Line	ENDOMETRIUM	ENST00000264275	c.457A>G	p.K153E	COSMIC	NP	NP
384	HN	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000264275	c.894C>A	p.I298I	COSMIC	NP	NP
385	HO1N1	Cell Line	SALIVARY_GLAND	ENST00000264275	c.422C>T	p.S141L	COSMIC	NP	NP
386	HSC2	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000264275	c.1366delA	p.I456fs*5	COSMIC	NP	NP
387	HSC3	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000264275	c.1216C>T	p.Q406*	COSMIC	NP	NP
388	HT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000264275	c.1272T>C	p.N424N	COSMIC	NP	NP
389	HT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000264275	c.853+7T>C	p.?	COSMIC	NP	NP
390	HT115	Cell Line	LARGE_INTESTINE	ENST00000264275	c.203G>A	p.R68Q	COSMIC	CANCER	POSSIBLY DAMAGING
391	HT55	Cell Line	LARGE_INTESTINE	ENST00000264275	c.527T>C	p.I176T	COSMIC	NP	NP
392	IGROV1	Cell Line	OVARY	ENST00000264275	c.1114delT	p.F373fs*26	COSMIC	NP	NP
393	JSC1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000264275	c.814C>T	p.H272Y	COSMIC	NP	NP
394	JURKAT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000264275	c.143T>G	p.L48R	COSMIC	CANCER	PROBABLY DAMAGING
395	KMOE2	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000264275	c.159G>A	p.M53I	COSMIC	CANCER	BENIGN
396	KYM1	Cell Line	SOFT_TISSUE	ENST00000264275	c.203G>C	p.R68P	COSMIC	CANCER	PROBABLY DAMAGING
397	KYSE150	Cell Line	OESOPHAGUS	ENST00000264275	c.469C>T	p.Q157*	COSMIC	NP	NP
398	LB771HNC	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000264275	c.402-2A>T	p.?	COSMIC	NP	NP
399	LNCAPCLONEFGC	Cell Line	PROSTATE	ENST00000264275	c.711+7G>A	p.?	COSMIC	NP	NP
400	LOVO	Cell Line	LARGE_INTESTINE	ENST00000264275	c.748C>T	p.R250W	COSMIC	NP	NP
401	LS411N	Cell Line	LARGE_INTESTINE	ENST00000264275	c.526_527delAT	p.I176fs*35	COSMIC	NP	NP
402	MCC13	Cell Line	SKIN	ENST00000264275	c.1105C>T	p.P369S	COSMIC	NP	NP
403	MCC13	Cell Line	SKIN	ENST00000264275	c.1106C>T	p.P369L	COSMIC	NP	NP
404	MDAMB231	Cell Line	BREAST	ENST00000264275	c.396A>G	p.L132L	COSMIC	NP	NP
405	MFE319	Cell Line	ENDOMETRIUM	ENST00000264275	c.1134G>A	p.Q378Q	COSMIC	NP	NP
406	MOGGCCM	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000264275	c.859T>C	p.L287L	COSMIC	NP	NP
407	MZ7MEL	Cell Line	SKIN	ENST00000264275	c.1213C>T	p.P405S	COSMIC	NP	NP
408	OC314	Cell Line	OVARY	ENST00000264275	c.1114delT	p.F373fs*26	COSMIC	NP	NP
409	PEO1	Cell Line	OVARY	ENST00000264275	c.306-1086_402-10>ACATGA	p.?	COSMIC	NP	NP
410	PSN1	Cell Line	PANCREAS	ENST00000264275	c.1442C>T	p.P481L	COSMIC	NP	NP
411	RAMOS2G64C10	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000264275	c.401G>A	p.R134K	COSMIC	NP	NP
412	RKO	Cell Line	LARGE_INTESTINE	ENST00000264275	c.453_455delTTT	p.F152delF	COSMIC	NP	NP
413	RL952	Cell Line	ENDOMETRIUM	ENST00000264275	c.1114delT	p.F373fs*26	COSMIC	NP	NP
414	SAS	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000264275	c.1064C>T	p.S355F	COSMIC	NP	NP
415	SIHA	Cell Line	CERVIX	ENST00000264275	c.202C>T	p.R68*	COSMIC	NP	NP
416	SKGT2	Cell Line	STOMACH	ENST00000264275	c.459G>C	p.K153N	COSMIC	NP	NP
417	SNU407	Cell Line	LARGE_INTESTINE	ENST00000264275	c.431T>C	p.V144A	COSMIC	NP	NP
418	SNU81	Cell Line	LARGE_INTESTINE	ENST00000264275	c.1221G>T	p.T407T	COSMIC	NP	NP
419	SUDHL10	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000264275	c.1472T>G	p.L491R	COSMIC	NP	NP
420	SUPT1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000264275	c.749G>A	p.R250Q	COSMIC	NP	NP
421	SW48	Cell Line	LARGE_INTESTINE	ENST00000264275	c.534G>A	p.M178I	COSMIC	NP	NP
422	SW48	Cell Line	LARGE_INTESTINE	ENST00000264275	c.986G>A	p.C329Y	COSMIC	NP	NP
423	TE12	Cell Line	OESOPHAGUS	ENST00000264275	c.894C>A	p.I298I	COSMIC	NP	NP
424	WSUNHL	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000264275	c.1462A>G	p.R488G	COSMIC	NP	NP

*NP: Not Predicted

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	5.4551	5.0318	0.0664	0.01474
BILIARY TRACT	7.7548	7.9045	0.0997	0.1237
BONE	6.7050	7.0198	0.0308	0.01738
BREAST	7.1003	7.21345	-0.0843	-0.042735
CENTRAL NERVOUS SYSTEM	7.1083	7.2396	-0.0107	-0.0404
ENDOMETRIUM	7.4088	7.4678	-0.0005	-0.0004109
HAEMATOPOIETIC AND LYMPHOID TISSUE	7.9396	7.9043	-0.0326	-3.3e-05
KIDNEY	8.0676	8.0801	0.1781	0.1613
LARGE INTESTINE	7.5889	7.80585	0.0288	0.0245
LIVER	7.6045	7.7277	0.1685	0.1936
LUNG	7.0560	7.2786	0.0329	0.0332
OESOPHAGUS	7.0438	6.924	-0.3760	-0.27755
OVARY	7.5271	7.5574	0.0154	0.0253
PANCREAS	7.9061	7.9023	0.0950	0.1188
PLEURA	7.9568	8.0381	0.1439	0.1769
PROSTATE	6.6928	6.9543	-0.0755	-0.030465
SALIVARY GLAND	7.3830	7.383	0.0894	0.0894
SKIN	7.2325	7.2923	0.1123	0.1091
SMALL INTESTINE	4.5712	4.5712	0.0182	0.01817
SOFT TISSUE	7.1139	7.2788	0.0797	-0.00402
STOMACH	7.3965	7.675	0.0310	0.017325
THYROID	7.5502	7.5484	-0.0385	-0.07963
UPPER AERODIGESTIVE TRACT	7.4368	7.4876	-0.0785	-0.0107936
URINARY TRACT	7.4918	7.4569	-0.0087	-0.0207

Domain ID	Domain Name	Start Site	End Site	E-value
PF01335	DED	3	86	3.4e-25
PF01335	DED	101	181	1.2e-20
PF00656	Peptidase_C14	234	475	2.4e-43
PF01335	DED	3	86	3.4e-25
PF01335	DED	101	181	1.2e-20
PF00656	Peptidase_C14	234	475	2.4e-43

Domain ID	Start Site	End Site	E-value
0042978	224	478	1.29e-89
0048274	1	113	2.12e-33
0045697	98	179	2.51e-19
0042978	224	478	1.29e-89
0048274	1	113	2.12e-33
0045697	98	179	2.51e-19

S. No.	Position	Amino acid	Type	Description
1	148	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
2	156	K	Acetylation	N6-acetyllysine
3	210	D	Proteolytic Cleavage	none
4	216	D	Proteolytic Cleavage	none
5	217	S	Phosphorylation	Phosphoserine
6	219	S	Phosphorylation	Phosphoserine
7	219	S	Phosphorylation	Phosphoserine.
8	230	S	Phosphorylation	Phosphoserine
9	263	T	Phosphorylation	Phosphothreonine
10	334	Y	Phosphorylation	Phosphotyrosine
11	334	Y	Phosphorylation	Phosphotyrosine.
12	347	S	Phosphorylation	Phosphoserine
13	347	S	Phosphorylation	Phosphoserine (MAPK14)
14	374	D	Proteolytic Cleavage	none
15	380	Y	Phosphorylation	Phosphotyrosine
16	384	D	Proteolytic Cleavage	none
17	387	S	Phosphorylation	Phosphoserine
18	387	S	Phosphorylation	Phosphoserine; by CDK1.
19	448	Y	Phosphorylation	Phosphotyrosine
20	461	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
21	63	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
22	148	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
23	156	K	Acetylation	N6-acetyllysine
24	210	D	Proteolytic Cleavage	none
25	216	D	Proteolytic Cleavage	none
26	217	S	Phosphorylation	Phosphoserine
27	219	S	Phosphorylation	Phosphoserine
28	219	S	Phosphorylation	Phosphoserine.
29	230	S	Phosphorylation	Phosphoserine
30	263	T	Phosphorylation	Phosphothreonine
31	334	Y	Phosphorylation	Phosphotyrosine
32	334	Y	Phosphorylation	Phosphotyrosine.
33	347	S	Phosphorylation	Phosphoserine
34	347	S	Phosphorylation	Phosphoserine (MAPK14)
35	374	D	Proteolytic Cleavage	none
36	380	Y	Phosphorylation	Phosphotyrosine
37	384	D	Proteolytic Cleavage	none
38	387	S	Phosphorylation	Phosphoserine
39	387	S	Phosphorylation	Phosphoserine; by CDK1.
40	448	Y	Phosphorylation	Phosphotyrosine
41	461	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
42	63	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
CASP8	CASP8	CASP8	ENSP00000264274	Q14790
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
Q14790	CASP8	ENSP00000264274	CASP8	Q14790
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
CASP8	ENSP00000264274	601763	Q14790	PA26092

Protein: CASP8

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)

Modelled Structure	Structures available in PDB
	1F9E, 1I4E, 1QDU, 1QTN, 2C2Z, 2FUN, 2K7Z, 2Y1L, 3H11, 3KJN, 3KJQ, 4JJ7