ApoCanD

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	2313287	Cell Line	STOMACH	NP_203124	c.611G>C	p.C204S	CCLE	NA	NA
2	CW2	Cell Line	LARGE INTESTINE	NP_203124	c.189G>A	p.S63S	CCLE	NA	NA
3	G401	Cell Line	SOFT TISSUE	NP_203124	c.696G>A	p.S232S	CCLE	NA	NA
4	LC1F	Cell Line	LUNG	NP_203124	c.719C>G	p.A240G	CCLE	NA	NA
5	LC1SQSF	Cell Line	LUNG	NP_203124	c.719C>G	p.A240G	CCLE	NA	NA
6	MDAMB361	Cell Line	BREAST	NP_203124	c.949G>A	p.E317K	CCLE	NA	NA
7	MDAPCA2B	Cell Line	PROSTATE	NP_203124	c.695C>T	p.S232L	CCLE	NA	NA
8	MFE319	Cell Line	ENDOMETRIUM	NP_203124	c.714A>G	p.T238T	CCLE	NA	NA
9	NCIH1573	Cell Line	LUNG	NP_203124	c.625G>A	p.E209K	CCLE	NA	NA
10	NCIH650	Cell Line	LUNG	NP_203124	c.712A>T	p.T238S	CCLE	NA	NA
11	SNU1196	Cell Line	BILIARY TRACT	NP_203124	c.542A>T	p.N181I	CCLE	NA	NA
12	SNU81	Cell Line	LARGE INTESTINE	NP_203124	c.391T>G	p.F131V	CCLE	NA	NA
13	TGBC11TKB	Cell Line	STOMACH	NP_203124	c.100_splice	p.M34_splice	CCLE	NA	NA
14	TGBC11TKB	Cell Line	STOMACH	NP_203124	c.235C>T	p.R79*	CCLE	NA	NA
15	WM88	Cell Line	SKIN	NP_203124	c.490C>T	p.H164Y	CCLE	NA	NA
16	ESO-043	Tumour	OESOPHAGUS	ENST00000369321	c.119G>A	p.C40Y	COSMIC	NP	NP
17	LUAD-B01811	Tumour	LUNG	ENST00000369321	c.595delT	p.F199fs*10	COSMIC	NP	NP
18	NCI-H322M	Cell Line	LUNG	ENST00000369321	c.788A>C	p.Y263S	COSMIC	NP	NP
19	TCGA-13-0762-01	Tumour	OVARY	ENST00000369321	c.970G>T	p.V324L	COSMIC	NP	NP
20	TCGA-18-3409-01	Tumour	LUNG	ENST00000369321	c.155A>G	p.E52G	COSMIC	NP	NP
21	TCGA-66-2744-01	Tumour	LUNG	ENST00000369321	c.725C>A	p.P242H	COSMIC	NP	NP
22	TCGA-66-2758-01	Tumour	LUNG	ENST00000369321	c.663G>C	p.G221G	COSMIC	NP	NP
23	TCGA-73-4666-01	Tumour	LUNG	ENST00000369321	c.409C>T	p.L137L	COSMIC	NP	NP
24	TCGA-AA-A00J-01	Tumour	LARGE INTESTINE	ENST00000369321	c.604G>A	p.D202N	COSMIC	NP	NP
25	TCGA-AD-5900-01	Tumour	LARGE INTESTINE	ENST00000369321	c.469delA	p.A159fs*17	COSMIC	NP	NP
26	TCGA-AD-6964-01	Tumour	LARGE INTESTINE	ENST00000369321	c.800G>A	p.S267N	COSMIC	NP	NP
27	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000369321	c.882C>A	p.I294I	COSMIC	NP	NP
28	TCGA-AP-A0LM-01	Tumour	ENDOMETRIUM	ENST00000369321	c.97C>A	p.Q33K	COSMIC	NP	NP
29	TCGA-AY-6386-01	Tumour	LARGE INTESTINE	ENST00000369321	c.972G>T	p.V324V	COSMIC	NP	NP
30	TCGA-B5-A11E-01	Tumour	ENDOMETRIUM	ENST00000369321	c.52A>G	p.T18A	COSMIC	NP	NP
31	TCGA-BP-4162-01	Tumour	KIDNEY	ENST00000369321	c.796A>T	p.R266W	COSMIC	NP	NP
32	TCGA-BS-A0UV-01	Tumour	ENDOMETRIUM	ENST00000369321	c.327G>T	p.K109N	COSMIC	NP	NP
33	TCGA-D1-A103-01	Tumour	ENDOMETRIUM	ENST00000369321	c.129G>A	p.E43E	COSMIC	NP	NP
34	TCGA-EW-A1P8-01	Tumour	BREAST	ENST00000369321	c.770C>T	p.S257F	COSMIC	NP	NP
35	TCGA-G4-6586-01	Tumour	LARGE INTESTINE	ENST00000369321	c.936C>T	p.D312D	COSMIC	NP	NP
36	CW2	Cell Line	LARGE_INTESTINE	ENST00000369321	c.189G>A	p.S63S	COSMIC	NP	NP
37	EVSAT	Cell Line	BREAST	ENST00000369321	c.99+5G>A	p.?	COSMIC	NP	NP
38	GP5D	Cell Line	LARGE_INTESTINE	ENST00000369321	c.15T>C	p.G5G	COSMIC	NP	NP
39	LC1SQ	Cell Line	LUNG	ENST00000369321	c.719C>G	p.A240G	COSMIC	NP	NP
40	LNCAPCLONEFGC	Cell Line	PROSTATE	ENST00000369321	c.600G>A	p.R200R	COSMIC	NP	NP
41	MDAMB361	Cell Line	BREAST	ENST00000369321	c.949G>A	p.E317K	COSMIC	NP	NP
42	MFE319	Cell Line	ENDOMETRIUM	ENST00000369321	c.714A>G	p.T238T	COSMIC	NP	NP
43	NCIH1573	Cell Line	LUNG	ENST00000369321	c.625G>A	p.E209K	COSMIC	NP	NP
44	NCIH322M	Cell Line	LUNG	ENST00000369321	c.788A>C	p.Y263S	COSMIC	NP	NP
45	NCIH630	Cell Line	LARGE_INTESTINE	ENST00000369321	c.83C>T	p.A28V	COSMIC	NP	NP
46	NCIH650	Cell Line	LUNG	ENST00000369321	c.712A>T	p.T238S	COSMIC	NP	NP
47	OCUBM	Cell Line	BREAST	ENST00000369321	c.258delC	p.R87fs*9	COSMIC	NP	NP
48	SKN	Cell Line	SOFT_TISSUE	ENST00000369321	c.200C>A	p.S67Y	COSMIC	NP	NP
49	SNU81	Cell Line	LARGE_INTESTINE	ENST00000369321	c.391T>G	p.F131V	COSMIC	NP	NP
50	SUPT1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000369321	c.856G>A	p.G286R	COSMIC	NP	NP
51	SW684	Cell Line	SOFT_TISSUE	ENST00000369321	c.684C>T	p.I228I	COSMIC	NP	NP
52	TGBC11TKB	Cell Line	STOMACH	ENST00000369321	c.100-2A>G	p.?	COSMIC	NP	NP
53	TGBC11TKB	Cell Line	STOMACH	ENST00000369321	c.235C>T	p.R79*	COSMIC	NP	NP
54	U2OS	Cell Line	BONE	ENST00000369321	c.210-10A>G	p.?	COSMIC	NP	NP
55	2313287	Cell Line	STOMACH	NP_203124	c.611G>C	p.C204S	CCLE	NA	NA
56	CW2	Cell Line	LARGE INTESTINE	NP_203124	c.189G>A	p.S63S	CCLE	NA	NA
57	G401	Cell Line	SOFT TISSUE	NP_203124	c.696G>A	p.S232S	CCLE	NA	NA
58	LC1F	Cell Line	LUNG	NP_203124	c.719C>G	p.A240G	CCLE	NA	NA
59	LC1SQSF	Cell Line	LUNG	NP_203124	c.719C>G	p.A240G	CCLE	NA	NA
60	MDAMB361	Cell Line	BREAST	NP_203124	c.949G>A	p.E317K	CCLE	NA	NA
61	MDAPCA2B	Cell Line	PROSTATE	NP_203124	c.695C>T	p.S232L	CCLE	NA	NA
62	MFE319	Cell Line	ENDOMETRIUM	NP_203124	c.714A>G	p.T238T	CCLE	NA	NA
63	NCIH1573	Cell Line	LUNG	NP_203124	c.625G>A	p.E209K	CCLE	NA	NA
64	NCIH650	Cell Line	LUNG	NP_203124	c.712A>T	p.T238S	CCLE	NA	NA
65	SNU1196	Cell Line	BILIARY TRACT	NP_203124	c.542A>T	p.N181I	CCLE	NA	NA
66	SNU81	Cell Line	LARGE INTESTINE	NP_203124	c.391T>G	p.F131V	CCLE	NA	NA
67	TGBC11TKB	Cell Line	STOMACH	NP_203124	c.100_splice	p.M34_splice	CCLE	NA	NA
68	TGBC11TKB	Cell Line	STOMACH	NP_203124	c.235C>T	p.R79*	CCLE	NA	NA
69	WM88	Cell Line	SKIN	NP_203124	c.490C>T	p.H164Y	CCLE	NA	NA
70	ESO-043	Tumour	OESOPHAGUS	ENST00000369321	c.119G>A	p.C40Y	COSMIC	NP	NP
71	LUAD-B01811	Tumour	LUNG	ENST00000369321	c.595delT	p.F199fs*10	COSMIC	NP	NP
72	NCI-H322M	Cell Line	LUNG	ENST00000369321	c.788A>C	p.Y263S	COSMIC	NP	NP
73	TCGA-13-0762-01	Tumour	OVARY	ENST00000369321	c.970G>T	p.V324L	COSMIC	NP	NP
74	TCGA-18-3409-01	Tumour	LUNG	ENST00000369321	c.155A>G	p.E52G	COSMIC	NP	NP
75	TCGA-66-2744-01	Tumour	LUNG	ENST00000369321	c.725C>A	p.P242H	COSMIC	NP	NP
76	TCGA-66-2758-01	Tumour	LUNG	ENST00000369321	c.663G>C	p.G221G	COSMIC	NP	NP
77	TCGA-73-4666-01	Tumour	LUNG	ENST00000369321	c.409C>T	p.L137L	COSMIC	NP	NP
78	TCGA-AA-A00J-01	Tumour	LARGE INTESTINE	ENST00000369321	c.604G>A	p.D202N	COSMIC	NP	NP
79	TCGA-AD-5900-01	Tumour	LARGE INTESTINE	ENST00000369321	c.469delA	p.A159fs*17	COSMIC	NP	NP
80	TCGA-AD-6964-01	Tumour	LARGE INTESTINE	ENST00000369321	c.800G>A	p.S267N	COSMIC	NP	NP
81	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000369321	c.882C>A	p.I294I	COSMIC	NP	NP
82	TCGA-AP-A0LM-01	Tumour	ENDOMETRIUM	ENST00000369321	c.97C>A	p.Q33K	COSMIC	NP	NP
83	TCGA-AY-6386-01	Tumour	LARGE INTESTINE	ENST00000369321	c.972G>T	p.V324V	COSMIC	NP	NP
84	TCGA-B5-A11E-01	Tumour	ENDOMETRIUM	ENST00000369321	c.52A>G	p.T18A	COSMIC	NP	NP
85	TCGA-BP-4162-01	Tumour	KIDNEY	ENST00000369321	c.796A>T	p.R266W	COSMIC	NP	NP
86	TCGA-BS-A0UV-01	Tumour	ENDOMETRIUM	ENST00000369321	c.327G>T	p.K109N	COSMIC	NP	NP
87	TCGA-D1-A103-01	Tumour	ENDOMETRIUM	ENST00000369321	c.129G>A	p.E43E	COSMIC	NP	NP
88	TCGA-EW-A1P8-01	Tumour	BREAST	ENST00000369321	c.770C>T	p.S257F	COSMIC	NP	NP
89	TCGA-G4-6586-01	Tumour	LARGE INTESTINE	ENST00000369321	c.936C>T	p.D312D	COSMIC	NP	NP
90	CW2	Cell Line	LARGE_INTESTINE	ENST00000369321	c.189G>A	p.S63S	COSMIC	NP	NP
91	EVSAT	Cell Line	BREAST	ENST00000369321	c.99+5G>A	p.?	COSMIC	NP	NP
92	GP5D	Cell Line	LARGE_INTESTINE	ENST00000369321	c.15T>C	p.G5G	COSMIC	NP	NP
93	LC1SQ	Cell Line	LUNG	ENST00000369321	c.719C>G	p.A240G	COSMIC	NP	NP
94	LNCAPCLONEFGC	Cell Line	PROSTATE	ENST00000369321	c.600G>A	p.R200R	COSMIC	NP	NP
95	MDAMB361	Cell Line	BREAST	ENST00000369321	c.949G>A	p.E317K	COSMIC	NP	NP
96	MFE319	Cell Line	ENDOMETRIUM	ENST00000369321	c.714A>G	p.T238T	COSMIC	NP	NP
97	NCIH1573	Cell Line	LUNG	ENST00000369321	c.625G>A	p.E209K	COSMIC	NP	NP
98	NCIH322M	Cell Line	LUNG	ENST00000369321	c.788A>C	p.Y263S	COSMIC	NP	NP
99	NCIH630	Cell Line	LARGE_INTESTINE	ENST00000369321	c.83C>T	p.A28V	COSMIC	NP	NP
100	NCIH650	Cell Line	LUNG	ENST00000369321	c.712A>T	p.T238S	COSMIC	NP	NP
101	OCUBM	Cell Line	BREAST	ENST00000369321	c.258delC	p.R87fs*9	COSMIC	NP	NP
102	SKN	Cell Line	SOFT_TISSUE	ENST00000369321	c.200C>A	p.S67Y	COSMIC	NP	NP
103	SNU81	Cell Line	LARGE_INTESTINE	ENST00000369321	c.391T>G	p.F131V	COSMIC	NP	NP
104	SUPT1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000369321	c.856G>A	p.G286R	COSMIC	NP	NP
105	SW684	Cell Line	SOFT_TISSUE	ENST00000369321	c.684C>T	p.I228I	COSMIC	NP	NP
106	TGBC11TKB	Cell Line	STOMACH	ENST00000369321	c.100-2A>G	p.?	COSMIC	NP	NP
107	TGBC11TKB	Cell Line	STOMACH	ENST00000369321	c.235C>T	p.R79*	COSMIC	NP	NP
108	U2OS	Cell Line	BONE	ENST00000369321	c.210-10A>G	p.?	COSMIC	NP	NP

*NP: Not Predicted

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	6.9156	7.3092	-0.0737	-0.0283
BILIARY TRACT	8.4141	8.4988	0.0540	0.0241
BONE	8.6630	8.6284	-0.0464	-0.0025
BREAST	8.5551	8.5684	-0.2016	-0.20365
CENTRAL NERVOUS SYSTEM	8.5352	8.6517	-0.2270	-0.1372
ENDOMETRIUM	8.4818	8.6058	-0.0201	0.003583
HAEMATOPOIETIC AND LYMPHOID TISSUE	8.5468	8.6915	-0.0864	-0.01856
KIDNEY	8.7658	8.6809	0.1258	0.0876
LARGE INTESTINE	8.9536	8.9923	0.0294	0.017665
LIVER	8.7757	8.7601	0.0410	0.06869
LUNG	8.1226	8.33825	-0.1711	-0.13175
OESOPHAGUS	8.5307	8.60555	-0.0982	-0.1022
OVARY	8.5330	8.6327	-0.0519	-0.005719
PANCREAS	8.7156	8.8614	0.0846	0.1324
PLEURA	8.4124	8.3539	-0.0586	0.0395
PROSTATE	8.5264	8.79825	-0.2288	-0.20366
SALIVARY GLAND	9.7663	9.7663	0.0933	0.09331
SKIN	8.1934	8.1989	-0.2461	-0.2178
SMALL INTESTINE	8.9209	8.9209	0.0299	0.0299
SOFT TISSUE	8.9072	8.57385	0.0114	0.00661
STOMACH	8.8253	8.72565	0.0120	-0.03024
THYROID	8.1607	8.04985	-0.0631	0.00545
UPPER AERODIGESTIVE TRACT	8.8762	9.0565	-0.0002	0.02945
URINARY TRACT	8.5297	8.74175	-0.1675	-0.12005

Domain ID	Domain Name	Start Site	End Site	E-value
PF00656	Peptidase_C14	68	301	5.3e-50
PF00656	Peptidase_C14	68	301	5.3e-50

Domain ID	Start Site	End Site	E-value
0037330	58	301	4.64e-95
0037330	58	301	4.64e-95

S. No.	Position	Amino acid	Type	Description
1	16	S	Phosphorylation	Phosphoserine
2	16	S	Phosphorylation	Phosphoserine.
3	173	T	Phosphorylation	Phosphothreonine
4	198	D	Proteolytic Cleavage	none
5	2	A	Acetylation	N-acetylalanine.
6	23	D	Proteolytic Cleavage	none
7	239	S	Phosphorylation	Phosphoserine
8	30	S	Phosphorylation	Phosphoserine
9	16	S	Phosphorylation	Phosphoserine
10	16	S	Phosphorylation	Phosphoserine.
11	173	T	Phosphorylation	Phosphothreonine
12	198	D	Proteolytic Cleavage	none
13	2	A	Acetylation	N-acetylalanine.
14	23	D	Proteolytic Cleavage	none
15	239	S	Phosphorylation	Phosphoserine
16	30	S	Phosphorylation	Phosphoserine

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
CASP7	CASP7	CASP7	ENSP00000298701	P55210
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
P55210	CASP7	ENSP00000298701	CASP7	P55210
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
CASP7	ENSP00000298701	601761	P55210	PA26091

Protein: CASP7

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)

Modelled Structure	Structures available in PDB
	1F1J, 1GQF, 1I4O, 1I51, 1K86, 1K88, 1KMC, 1MIA, 1SHJ, 1SHL, 2QL5, 2QL7, 2QL9, 2QLB, 2QLF, 2QLJ, 3EDR, 3H1P, 3IBC, 3IBF, 3R5K, 4FDL, 4FEA, 4HQ0, 4HQR, 4JB8, 4JJ8, 4JR1, 4JR2