ApoCanD

Mutation Data (+)

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	HCC1569	Cell Line	BREAST	NP_001217	c.41_splice	p.G14_splice	CCLE	NP	NP
2	JHOC5	Cell Line	OVARY	NP_001217	c.193C>T	p.R65W	CCLE	PASSENGER/OTHER	Probably Damaging
3	JHUEM2	Cell Line	ENDOMETRIUM	NP_001217	c.634G>A	p.V212I	CCLE	PASSENGER/OTHER	Benign
4	KG1	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_001217	c.85_86delGA	p.E29fs	CCLE	NP	NP
5	MDAMB231	Cell Line	BREAST	NP_001217	c.314C>T	p.T105I	CCLE	PASSENGER/OTHER	Benign
6	SNUC4	Cell Line	LARGE INTESTINE	NP_001217	c.41_splice	p.G14_splice	CCLE	NP	NP
7	SUPHD1	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_001217	c.28G>A	p.G10R	CCLE	PASSENGER/OTHER	Benign
8	107047	Tumour	BREAST	ENST00000265164	c.816G>A	p.K272K	COSMIC	NP	NP
9	HCC111T	Tumour	LIVER	ENST00000265164	c.237A>T	p.S79S	COSMIC	NP	NP
10	HCC85T	Tumour	LIVER	ENST00000265164	c.295A>G	p.K99E	COSMIC	NP	NP
11	HCC85T	Tumour	LIVER	ENST00000265164	c.302A>G	p.H101R	COSMIC	NP	NP
12	HN	Tumour	62421 UPPER AERODIGESTIVE TRACT	ENST00000265164	c.351C>T	p.V117V	COSMIC	NP	NP
13	LUAD-S01315	Tumour	LUNG	ENST00000265164	c.855G>T	p.K285N	COSMIC	NP	NP
14	TCGA-05-4427-01	Tumour	LUNG	ENST00000265164	c.739G>A	p.E247K	COSMIC	NP	NP
15	TCGA-24-1424-01	Tumour	OVARY	ENST00000265164	c.56T>G	p.M19R	COSMIC	NP	NP
16	TCGA-29-1702-01	Tumour	OVARY	ENST00000265164	c.447_448delCA	p.H149fs*31	COSMIC	NP	NP
17	TCGA-A5-A0GU-01	Tumour	ENDOMETRIUM	ENST00000265164	c.292C>T	p.L98F	COSMIC	NP	NP
18	TCGA-AA-A00E-01	Tumour	LARGE INTESTINE	ENST00000265164	c.623T>C	p.M208T	COSMIC	NP	NP
19	TCGA-AA-A03F-01	Tumour	LARGE INTESTINE	ENST00000265164	c.99G>A	p.P33P	COSMIC	NP	NP
20	TCGA-AD-6895-01	Tumour	LARGE INTESTINE	ENST00000265164	c.366C>T	p.G122G	COSMIC	NP	NP
21	TCGA-AG-A002-01	Tumour	LARGE INTESTINE	ENST00000265164	c.739G>T	p.E247*	COSMIC	NP	NP
22	TCGA-AP-A056-01	Tumour	ENDOMETRIUM	ENST00000265164	c.504C>T	p.H168H	COSMIC	NP	NP
23	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000265164	c.658C>T	p.R220W	COSMIC	NP	NP
24	TCGA-AZ-6601-01	Tumour	LARGE INTESTINE	ENST00000265164	c.507T>C	p.D169D	COSMIC	NP	NP
25	TCGA-B5-A11E-01	Tumour	ENDOMETRIUM	ENST00000265164	c.775C>T	p.R259C	COSMIC	NP	NP
26	TCGA-B6-A0WW-01	Tumour	BREAST	ENST00000265164	c.778C>T	p.R260*	COSMIC	NP	NP
27	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000265164	c.100G>A	p.A34T	COSMIC	NP	NP
28	TCGA-BS-A0UV-01	Tumour	ENDOMETRIUM	ENST00000265164	c.549G>T	p.E183D	COSMIC	NP	NP
29	TCGA-BS-A0UV-01	Tumour	ENDOMETRIUM	ENST00000265164	c.836C>T	p.A279V	COSMIC	NP	NP
30	TCGA-CA-6717-01	Tumour	LARGE INTESTINE	ENST00000265164	c.739G>T	p.E247*	COSMIC	NP	NP
31	TCGA-D1-A15X-01	Tumour	ENDOMETRIUM	ENST00000265164	c.90G>A	p.M30I	COSMIC	NP	NP
32	TCGA-E2-A1AZ-01	Tumour	BREAST	ENST00000265164	c.826C>T	p.P276S	COSMIC	NP	NP
33	A4FUK	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000265164	c.236C>T	p.S79L	COSMIC	PASSENGER/OTHER	BENIGN
34	HCC1569	Cell Line	BREAST	ENST00000265164	c.41-1G>C	p.?	COSMIC	NP	NP
35	KG1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000265164	c.85_86delGA	p.E29fs*3	COSMIC	NP	NP
36	KPNYS	Cell Line	AUTONOMIC_GANGLIA	ENST00000265164	c.236C>T	p.S79L	COSMIC	PASSENGER/OTHER	BENIGN
37	MDAMB231	Cell Line	BREAST	ENST00000265164	c.314C>T	p.T105I	COSMIC	PASSENGER/OTHER	BENIGN
38	MFE319	Cell Line	ENDOMETRIUM	ENST00000265164	c.291G>A	p.L97L	COSMIC	NP	NP
39	NY	Cell Line	BONE	ENST00000265164	c.236C>T	p.S79L	COSMIC	PASSENGER/OTHER	BENIGN
40	PEO1	Cell Line	OVARY	ENST00000265164	c.817A>C	p.K273Q	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
41	SKMEL5	Cell Line	SKIN	ENST00000265164	c.168T>C	p.F56F	COSMIC	NP	NP
42	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000265164	c.692A>T	p.D231V	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
43	HCC1569	Cell Line	BREAST	NP_001217	c.41_splice	p.G14_splice	CCLE	NP	NP
44	JHOC5	Cell Line	OVARY	NP_001217	c.193C>T	p.R65W	CCLE	PASSENGER/OTHER	Probably Damaging
45	JHUEM2	Cell Line	ENDOMETRIUM	NP_001217	c.634G>A	p.V212I	CCLE	PASSENGER/OTHER	Benign
46	KG1	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_001217	c.85_86delGA	p.E29fs	CCLE	NP	NP
47	MDAMB231	Cell Line	BREAST	NP_001217	c.314C>T	p.T105I	CCLE	PASSENGER/OTHER	Benign
48	SNUC4	Cell Line	LARGE INTESTINE	NP_001217	c.41_splice	p.G14_splice	CCLE	NP	NP
49	SUPHD1	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_001217	c.28G>A	p.G10R	CCLE	PASSENGER/OTHER	Benign
50	107047	Tumour	BREAST	ENST00000265164	c.816G>A	p.K272K	COSMIC	NP	NP
51	HCC111T	Tumour	LIVER	ENST00000265164	c.237A>T	p.S79S	COSMIC	NP	NP
52	HCC85T	Tumour	LIVER	ENST00000265164	c.295A>G	p.K99E	COSMIC	NP	NP
53	HCC85T	Tumour	LIVER	ENST00000265164	c.302A>G	p.H101R	COSMIC	NP	NP
54	HN	Tumour	62421 UPPER AERODIGESTIVE TRACT	ENST00000265164	c.351C>T	p.V117V	COSMIC	NP	NP
55	LUAD-S01315	Tumour	LUNG	ENST00000265164	c.855G>T	p.K285N	COSMIC	NP	NP
56	TCGA-05-4427-01	Tumour	LUNG	ENST00000265164	c.739G>A	p.E247K	COSMIC	NP	NP
57	TCGA-24-1424-01	Tumour	OVARY	ENST00000265164	c.56T>G	p.M19R	COSMIC	NP	NP
58	TCGA-29-1702-01	Tumour	OVARY	ENST00000265164	c.447_448delCA	p.H149fs*31	COSMIC	NP	NP
59	TCGA-A5-A0GU-01	Tumour	ENDOMETRIUM	ENST00000265164	c.292C>T	p.L98F	COSMIC	NP	NP
60	TCGA-AA-A00E-01	Tumour	LARGE INTESTINE	ENST00000265164	c.623T>C	p.M208T	COSMIC	NP	NP
61	TCGA-AA-A03F-01	Tumour	LARGE INTESTINE	ENST00000265164	c.99G>A	p.P33P	COSMIC	NP	NP
62	TCGA-AD-6895-01	Tumour	LARGE INTESTINE	ENST00000265164	c.366C>T	p.G122G	COSMIC	NP	NP
63	TCGA-AG-A002-01	Tumour	LARGE INTESTINE	ENST00000265164	c.739G>T	p.E247*	COSMIC	NP	NP
64	TCGA-AP-A056-01	Tumour	ENDOMETRIUM	ENST00000265164	c.504C>T	p.H168H	COSMIC	NP	NP
65	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000265164	c.658C>T	p.R220W	COSMIC	NP	NP
66	TCGA-AZ-6601-01	Tumour	LARGE INTESTINE	ENST00000265164	c.507T>C	p.D169D	COSMIC	NP	NP
67	TCGA-B5-A11E-01	Tumour	ENDOMETRIUM	ENST00000265164	c.775C>T	p.R259C	COSMIC	NP	NP
68	TCGA-B6-A0WW-01	Tumour	BREAST	ENST00000265164	c.778C>T	p.R260*	COSMIC	NP	NP
69	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000265164	c.100G>A	p.A34T	COSMIC	NP	NP
70	TCGA-BS-A0UV-01	Tumour	ENDOMETRIUM	ENST00000265164	c.549G>T	p.E183D	COSMIC	NP	NP
71	TCGA-BS-A0UV-01	Tumour	ENDOMETRIUM	ENST00000265164	c.836C>T	p.A279V	COSMIC	NP	NP
72	TCGA-CA-6717-01	Tumour	LARGE INTESTINE	ENST00000265164	c.739G>T	p.E247*	COSMIC	NP	NP
73	TCGA-D1-A15X-01	Tumour	ENDOMETRIUM	ENST00000265164	c.90G>A	p.M30I	COSMIC	NP	NP
74	TCGA-E2-A1AZ-01	Tumour	BREAST	ENST00000265164	c.826C>T	p.P276S	COSMIC	NP	NP
75	A4FUK	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000265164	c.236C>T	p.S79L	COSMIC	PASSENGER/OTHER	BENIGN
76	HCC1569	Cell Line	BREAST	ENST00000265164	c.41-1G>C	p.?	COSMIC	NP	NP
77	KG1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000265164	c.85_86delGA	p.E29fs*3	COSMIC	NP	NP
78	KPNYS	Cell Line	AUTONOMIC_GANGLIA	ENST00000265164	c.236C>T	p.S79L	COSMIC	PASSENGER/OTHER	BENIGN
79	MDAMB231	Cell Line	BREAST	ENST00000265164	c.314C>T	p.T105I	COSMIC	PASSENGER/OTHER	BENIGN
80	MFE319	Cell Line	ENDOMETRIUM	ENST00000265164	c.291G>A	p.L97L	COSMIC	NP	NP
81	NY	Cell Line	BONE	ENST00000265164	c.236C>T	p.S79L	COSMIC	PASSENGER/OTHER	BENIGN
82	PEO1	Cell Line	OVARY	ENST00000265164	c.817A>C	p.K273Q	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
83	SKMEL5	Cell Line	SKIN	ENST00000265164	c.168T>C	p.F56F	COSMIC	NP	NP
84	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000265164	c.692A>T	p.D231V	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING

*NP: Not Predicted

Copy number variation and expression profile (+)

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	7.6369	7.4969	-0.0814	-0.0681
BILIARY TRACT	9.0068	9.2455	-0.2451	-0.3442
BONE	8.6599	8.6583	-0.0501	0.0039
BREAST	9.2511	9.2833	-0.0815	-0.030005
CENTRAL NERVOUS SYSTEM	8.8722	8.883	-0.2779	-0.1947
ENDOMETRIUM	9.0514	9.3541	-0.1468	-0.0837
HAEMATOPOIETIC AND LYMPHOID TISSUE	9.0728	9.1146	0.0137	0.00308
KIDNEY	9.3982	9.4958	-0.1117	-0.0352
LARGE INTESTINE	9.7804	9.7776	-0.2219	-0.0834
LIVER	9.3250	9.3888	-0.4411	-0.4025
LUNG	9.1031	9.11505	-0.2025	-0.19945
OESOPHAGUS	8.5549	8.5906	-0.3370	-0.33385
OVARY	9.1770	9.1197	-0.2484	-0.2741
PANCREAS	9.0724	9.1836	-0.2495	-0.2618
PLEURA	8.9318	9.0327	-0.2192	-0.1024
PROSTATE	8.7679	8.8105	-0.2288	-0.14893
SALIVARY GLAND	9.3392	9.3392	-0.3711	-0.3711
SKIN	8.3268	8.4321	-0.1474	-0.1114
SMALL INTESTINE	8.7916	8.7916	0.0179	0.01786
SOFT TISSUE	8.8402	8.86635	-0.1216	-0.047655
STOMACH	9.3758	9.24705	-0.2093	-0.2289
THYROID	8.4311	8.2984	-0.2131	-0.18272
UPPER AERODIGESTIVE TRACT	8.1440	8.1214	-0.3665	-0.41825
URINARY TRACT	9.1374	8.98245	-0.3144	-0.3217

Gene Essentiality Data (+)

Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.

test

Tertiary structure (+)

Users must enabled the Java in their browser to see structure.

Modelled Structure	Structures available in PDB
	1MI9, 2WDP, 3K7E, 3NKF, 3NR2, 3OD5, 3P45, 3P4U, 3QNW, 3S70, 3S8E, 3V6L, 3V6M, 4EJF, 4FXO, 4HVA, 4IYR, 4N5D, 4N6G, 4N7J, 4N7M, 4NBK, 4NBL, 4NBN

Structure Domains (+)

1. PFAM Domains:

Domain ID	Domain Name	Start Site	End Site	E-value
PF00656	Peptidase_C14	45	288	1.9e-43
PF00656	Peptidase_C14	45	288	1.9e-43

2. Superfamily Domains:

Domain ID	Start Site	End Site	E-value
0039807	33	291	3.44e-87
0039807	33	291	3.44e-87

Sequence Alignment (+)

Users must enabled the Java in their browser to see sequence alignments.

1. Sequence alignment with 1000 genome variations:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

2. Sequence alignment with CCLE mutants:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

3. Sequence alignment with COSMIC mutants:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

4. Sequence alignment with homologus proteins:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

Sequence Profiles (+)

HMM
With Uniprot database	With Mutants	With 1000 Genome Variants

PSSM
With Uniprot database	With Mutants	With 1000 Genome Variant

Post Translational Modifications (+)

S. No.	Position	Amino acid	Type	Description
1	144	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
2	179	D	Proteolytic Cleavage	none
3	193	D	Proteolytic Cleavage	none
4	2	S	Acetylation	N-acetylserine
5	23	D	Proteolytic Cleavage	none
6	257	S	Phosphorylation	Phosphoserine
7	257	S	Phosphorylation	Phosphoserine (AMPK_group;NuaK1)
8	257	S	Phosphorylation	Phosphoserine; by NUAK1.
9	257	S	Phosphorylation (NUAK1)	Phosphoserine
10	90	D	Proteolytic Cleavage	none
11	144	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
12	179	D	Proteolytic Cleavage	none
13	193	D	Proteolytic Cleavage	none
14	2	S	Acetylation	N-acetylserine
15	23	D	Proteolytic Cleavage	none
16	257	S	Phosphorylation	Phosphoserine
17	257	S	Phosphorylation	Phosphoserine (AMPK_group;NuaK1)
18	257	S	Phosphorylation	Phosphoserine; by NUAK1.
19	257	S	Phosphorylation (NUAK1)	Phosphoserine
20	90	D	Proteolytic Cleavage	none

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
CASP6	CASP6	CASP6	ENSP00000265164	P55212
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
P55212	CASP6	ENSP00000265164	CASP6	P55212
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
CASP6	ENSP00000265164	601532	P55212	PA26090

Protein: CASP6

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)