ApoCanD

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	2313287	Cell Line	STOMACH	NP_001216	c.400C>T	p.R134C	CCLE	PASSENGER/OTHER	Probably Damaging
2	59M	Cell Line	OVARY	NP_001216	c.222A>T	p.Q74H	CCLE	PASSENGER/OTHER	Benign
3	BV173	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_001216	c.761T>C	p.I254T	CCLE	PASSENGER/OTHER	Probably Damaging
4	CMLT1	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_001216	c.925_splice	p.H309_splice	CCLE	NP	NP
5	COLO792	Cell Line	SKIN	NP_001216	c.939G>A	p.W313*	CCLE	NP	NP
6	HEC108	Cell Line	ENDOMETRIUM	NP_001216	c.215T>C	p.L72P	CCLE	PASSENGER/OTHER	Probably Damaging
7	HEC251	Cell Line	ENDOMETRIUM	NP_001216	c.1112_1113insT	p.F371fs	CCLE	NP	NP
8	HEC251	Cell Line	ENDOMETRIUM	NP_001216	c.337G>T	p.E113*	CCLE	NP	NP
9	HEC265	Cell Line	ENDOMETRIUM	NP_001216	c.716A>G	p.N239S	CCLE	PASSENGER/OTHER	Probably Damaging
10	JHH2	Cell Line	LIVER	NP_001216	c.156C>G	p.D52E	CCLE	PASSENGER/OTHER	Possibly Damaging
11	JHUEM7	Cell Line	ENDOMETRIUM	NP_001216	c.58G>A	p.D20N	CCLE	PASSENGER/OTHER	Benign
12	KCL22	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_001216	c.171G>T	p.M57I	CCLE	PASSENGER/OTHER	Benign
13	PF382	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_001216	c.653G>A	p.G218E	CCLE	PASSENGER/OTHER	Probably Damaging
14	SKNFI	Cell Line	AUTONOMIC GANGLIA	NP_001216	c.551T>C	p.M184T	CCLE	PASSENGER/OTHER	Probably Damaging
15	SNU1040	Cell Line	LARGE INTESTINE	NP_001216	c.956G>C	p.G319A	CCLE	PASSENGER/OTHER	Probably Damaging
16	SNU449	Cell Line	LIVER	NP_001216	c.377A>G	p.Y126C	CCLE	PASSENGER/OTHER	Probably Damaging
17	TEN	Cell Line	ENDOMETRIUM	NP_001216	c.782_splice	p.A261_splice	CCLE	NP	NP
18	VMRCLCP	Cell Line	LUNG	NP_001216	c.1068A>T	p.K356N	CCLE	PASSENGER/OTHER	Benign
19	09-182	Tumour	CENTRAL NERVOUS SYSTEM	ENST00000444739	c.722G>A	p.R241H	COSMIC	NP	NP
20	587234	Tumour	LARGE INTESTINE	ENST00000444739	c.869C>T	p.A290V	COSMIC	NP	NP
21	587256	Tumour	LARGE INTESTINE	ENST00000444739	c.632G>A	p.G211D	COSMIC	NP	NP
22	BN40T	Tumour	LIVER	ENST00000444739	c.804C>T	p.V268V	COSMIC	NP	NP
23	CLL041	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000444739	c.331C>T	p.H111Y	COSMIC	NP	NP
24	ESO-0133	Tumour	OESOPHAGUS	ENST00000444739	c.1022A>G	p.E341G	COSMIC	NP	NP
25	ESO-859	Tumour	OESOPHAGUS	ENST00000444739	c.617T>C	p.V206A	COSMIC	NP	NP
26	H2009	Cell Line	LUNG	ENST00000444739	c.1051G>C	p.E351Q	COSMIC	NP	NP
27	HCC37T	Tumour	LIVER	ENST00000444739	c.649T>A	p.C217S	COSMIC	NP	NP
28	HCC39T	Tumour	LIVER	ENST00000444739	c.947delG	p.S316fs*24	COSMIC	NP	NP
29	LB647-SCLC	Cell Line	LUNG	ENST00000444739	c.757A>G	p.I253V	COSMIC	NP	NP
30	LUAD-NYU669	Tumour	LUNG	ENST00000444739	c.572T>A	p.F191Y	COSMIC	NP	NP
31	MZ7-mel	Cell Line	SKIN	ENST00000444739	c.387G>A	p.K129K	COSMIC	NP	NP
32	NCI-H1770	Cell Line	LUNG	ENST00000444739	c.354T>C	p.C118C	COSMIC	NP	NP
33	RK056	Tumour	C01 LIVER	ENST00000444739	c.415C>G	p.L139V	COSMIC	NP	NP
34	RK177	Tumour	C01 LIVER	ENST00000444739	c.157A>G	p.K53E	COSMIC	NP	NP
35	TCGA-13-2065-01	Tumour	OVARY	ENST00000444739	c.843G>A	p.Q281Q	COSMIC	NP	NP
36	TCGA-18-3409-01	Tumour	LUNG	ENST00000444739	c.705C>T	p.F235F	COSMIC	NP	NP
37	TCGA-22-4595-01	Tumour	LUNG	ENST00000444739	c.790G>T	p.G264W	COSMIC	NP	NP
38	TCGA-23-2079-01	Tumour	OVARY	ENST00000444739	c.581G>C	p.R194T	COSMIC	NP	NP
39	TCGA-34-5236-01	Tumour	LUNG	ENST00000444739	c.57A>T	p.K19N	COSMIC	NP	NP
40	TCGA-44-2668-01	Tumour	LUNG	ENST00000444739	c.198T>C	p.R66R	COSMIC	NP	NP
41	TCGA-44-2668-01	Tumour	LUNG	ENST00000444739	c.801G>T	p.W267C	COSMIC	NP	NP
42	TCGA-53-7624-01	Tumour	LUNG	ENST00000444739	c.928A>T	p.N310Y	COSMIC	NP	NP
43	TCGA-66-2770-01	Tumour	LUNG	ENST00000444739	c.91G>C	p.E31Q	COSMIC	NP	NP
44	TCGA-A5-A0GA-01	Tumour	ENDOMETRIUM	ENST00000444739	c.885C>T	p.H295H	COSMIC	NP	NP
45	TCGA-A6-5661-01	Tumour	LARGE INTESTINE	ENST00000444739	c.207A>G	p.G69G	COSMIC	NP	NP
46	TCGA-A6-5665-01	Tumour	LARGE INTESTINE	ENST00000444739	c.582A>G	p.R194R	COSMIC	NP	NP
47	TCGA-AA-3518-01	Tumour	LARGE INTESTINE	ENST00000444739	c.921G>A	p.T307T	COSMIC	NP	NP
48	TCGA-AA-3660-01	Tumour	LARGE INTESTINE	ENST00000444739	c.582A>G	p.R194R	COSMIC	NP	NP
49	TCGA-AA-3972-01	Tumour	LARGE INTESTINE	ENST00000444739	c.815C>A	p.P272Q	COSMIC	NP	NP
50	TCGA-AG-A002-01	Tumour	LARGE INTESTINE	ENST00000444739	c.129G>T	p.K43N	COSMIC	NP	NP
51	TCGA-AG-A002-01	Tumour	LARGE INTESTINE	ENST00000444739	c.262G>T	p.A88S	COSMIC	NP	NP
52	TCGA-AG-A002-01	Tumour	LARGE INTESTINE	ENST00000444739	c.561G>A	p.A187A	COSMIC	NP	NP
53	TCGA-AP-A056-01	Tumour	ENDOMETRIUM	ENST00000444739	c.921G>A	p.T307T	COSMIC	NP	NP
54	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000444739	c.754G>A	p.V252I	COSMIC	NP	NP
55	TCGA-AY-6197-01	Tumour	LARGE INTESTINE	ENST00000444739	c.111G>A	p.W37*	COSMIC	NP	NP
56	TCGA-AZ-6603-01	Tumour	LARGE INTESTINE	ENST00000444739	c.758T>C	p.I253T	COSMIC	NP	NP
57	TCGA-AZ-6607-01	Tumour	LARGE INTESTINE	ENST00000444739	c.582A>G	p.R194R	COSMIC	NP	NP
58	TCGA-B5-A11E-01	Tumour	ENDOMETRIUM	ENST00000444739	c.124A>C	p.K42Q	COSMIC	NP	NP
59	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000444739	c.163C>T	p.R55W	COSMIC	NP	NP
60	TCGA-BT-A20W-01	Tumour	URINARY TRACT	ENST00000444739	c.163C>T	p.R55W	COSMIC	NP	NP
61	TCGA-BT-A20W-01	Tumour	URINARY TRACT	ENST00000444739	c.163_164CG>TT	p.R55L	COSMIC	NP	NP
62	TCGA-CA-6717-01	Tumour	LARGE INTESTINE	ENST00000444739	c.1052A>C	p.E351A	COSMIC	NP	NP
63	TCGA-CK-4952-01	Tumour	LARGE INTESTINE	ENST00000444739	c.580A>T	p.R194*	COSMIC	NP	NP
64	TCGA-CM-6675-01	Tumour	LARGE INTESTINE	ENST00000444739	c.758T>C	p.I253T	COSMIC	NP	NP
65	TCGA-D1-A103-01	Tumour	ENDOMETRIUM	ENST00000444739	c.1077G>A	p.M359I	COSMIC	NP	NP
66	TCGA-D1-A16Y-01	Tumour	ENDOMETRIUM	ENST00000444739	c.163C>T	p.R55W	COSMIC	NP	NP
67	TCGA-D5-5537-01	Tumour	LARGE INTESTINE	ENST00000444739	c.759C>A	p.I253I	COSMIC	NP	NP
68	TCGA-D5-5538-01	Tumour	LARGE INTESTINE	ENST00000444739	c.386A>G	p.K129R	COSMIC	NP	NP
69	TCGA-D5-6529-01	Tumour	LARGE INTESTINE	ENST00000444739	c.758T>C	p.I253T	COSMIC	NP	NP
70	TCGA-D8-A1JT-01	Tumour	BREAST	ENST00000444739	c.36G>C	p.K12N	COSMIC	NP	NP
71	TCGA-DI-A0WH-01	Tumour	ENDOMETRIUM	ENST00000444739	c.435G>C	p.E145D	COSMIC	NP	NP
72	TCGA-DY-A1H8-01	Tumour	LARGE INTESTINE	ENST00000444739	c.386A>G	p.K129R	COSMIC	NP	NP
73	TCGA-FD-A3NA-01	Tumour	URINARY TRACT	ENST00000444739	c.1051G>C	p.E351Q	COSMIC	NP	NP
74	YULAN	Tumour	SKIN	ENST00000444739	c.227T>A	p.F76Y	COSMIC	NP	NP
75	ccRCC-96	Tumour	KIDNEY	ENST00000444739	c.1035+5G>T	p.?	COSMIC	NP	NP
76	2313287	Cell Line	STOMACH	ENST00000444739	c.400C>T	p.R134C	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
77	639V	Cell Line	URINARY_TRACT	ENST00000444739	c.597C>A	p.S199S	COSMIC	NP	NP
78	A704	Cell Line	KIDNEY	ENST00000444739	c.407G>A	p.R136H	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
79	BV173	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000444739	c.761T>C	p.I254T	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
80	COLO792	Cell Line	SKIN	ENST00000444739	c.939G>A	p.W313*	COSMIC	NP	NP
81	DETROIT562	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000444739	c.407G>A	p.R136H	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
82	EW13	Cell Line	BONE	ENST00000444739	c.13A>T	p.N5Y	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
83	HCT116	Cell Line	LARGE_INTESTINE	ENST00000444739	c.925+6T>C	p.?	COSMIC	NP	NP
84	HT1376	Cell Line	URINARY_TRACT	ENST00000444739	c.1121T>C	p.F374S	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
85	JHH2	Cell Line	LIVER	ENST00000444739	c.156C>G	p.D52E	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
86	JHOS4	Cell Line	OVARY	ENST00000444739	c.849T>C	p.S283S	COSMIC	NP	NP
87	KCL22	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000444739	c.171G>T	p.M57I	COSMIC	PASSENGER/OTHER	BENIGN
88	LB647SCLC	Cell Line	LUNG	ENST00000444739	c.757A>G	p.I253V	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
89	LNCAPCLONEFGC	Cell Line	PROSTATE	ENST00000444739	c.709A>G	p.I237V	COSMIC	PASSENGER/OTHER	BENIGN
90	LS411N	Cell Line	LARGE_INTESTINE	ENST00000444739	c.261delA	p.A88fs*28	COSMIC	NP	NP
91	MZ7MEL	Cell Line	SKIN	ENST00000444739	c.387G>A	p.K129K	COSMIC	NP	NP
92	NCIH1650	Cell Line	LUNG	ENST00000444739	c.644G>A	p.G215E	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
93	NCIH1770	Cell Line	LUNG	ENST00000444739	c.354T>C	p.C118C	COSMIC	NP	NP
94	NCIH187	Cell Line	LUNG	ENST00000444739	c.1072C>G	p.Q358E	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
95	NCIH2009	Cell Line	LUNG	ENST00000444739	c.1051G>C	p.E351Q	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
96	NCIH2170	Cell Line	LUNG	ENST00000444739	c.501G>A	p.E167E	COSMIC	NP	NP
97	PF382	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000444739	c.653G>A	p.G218E	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
98	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000444739	c.956G>C	p.G319A	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
99	SNU449	Cell Line	LIVER	ENST00000444739	c.377A>G	p.Y126C	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
100	SUPT1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000444739	c.231_232insT	p.N78fs*1	COSMIC	NP	NP
101	2313287	Cell Line	STOMACH	NP_001216	c.400C>T	p.R134C	CCLE	PASSENGER/OTHER	Probably Damaging
102	59M	Cell Line	OVARY	NP_001216	c.222A>T	p.Q74H	CCLE	PASSENGER/OTHER	Benign
103	BV173	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_001216	c.761T>C	p.I254T	CCLE	PASSENGER/OTHER	Probably Damaging
104	CMLT1	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_001216	c.925_splice	p.H309_splice	CCLE	NP	NP
105	COLO792	Cell Line	SKIN	NP_001216	c.939G>A	p.W313*	CCLE	NP	NP
106	HEC108	Cell Line	ENDOMETRIUM	NP_001216	c.215T>C	p.L72P	CCLE	PASSENGER/OTHER	Probably Damaging
107	HEC251	Cell Line	ENDOMETRIUM	NP_001216	c.1112_1113insT	p.F371fs	CCLE	NP	NP
108	HEC251	Cell Line	ENDOMETRIUM	NP_001216	c.337G>T	p.E113*	CCLE	NP	NP
109	HEC265	Cell Line	ENDOMETRIUM	NP_001216	c.716A>G	p.N239S	CCLE	PASSENGER/OTHER	Probably Damaging
110	JHH2	Cell Line	LIVER	NP_001216	c.156C>G	p.D52E	CCLE	PASSENGER/OTHER	Possibly Damaging
111	JHUEM7	Cell Line	ENDOMETRIUM	NP_001216	c.58G>A	p.D20N	CCLE	PASSENGER/OTHER	Benign
112	KCL22	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_001216	c.171G>T	p.M57I	CCLE	PASSENGER/OTHER	Benign
113	PF382	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_001216	c.653G>A	p.G218E	CCLE	PASSENGER/OTHER	Probably Damaging
114	SKNFI	Cell Line	AUTONOMIC GANGLIA	NP_001216	c.551T>C	p.M184T	CCLE	PASSENGER/OTHER	Probably Damaging
115	SNU1040	Cell Line	LARGE INTESTINE	NP_001216	c.956G>C	p.G319A	CCLE	PASSENGER/OTHER	Probably Damaging
116	SNU449	Cell Line	LIVER	NP_001216	c.377A>G	p.Y126C	CCLE	PASSENGER/OTHER	Probably Damaging
117	TEN	Cell Line	ENDOMETRIUM	NP_001216	c.782_splice	p.A261_splice	CCLE	NP	NP
118	VMRCLCP	Cell Line	LUNG	NP_001216	c.1068A>T	p.K356N	CCLE	PASSENGER/OTHER	Benign
119	09-182	Tumour	CENTRAL NERVOUS SYSTEM	ENST00000444739	c.722G>A	p.R241H	COSMIC	NP	NP
120	587234	Tumour	LARGE INTESTINE	ENST00000444739	c.869C>T	p.A290V	COSMIC	NP	NP
121	587256	Tumour	LARGE INTESTINE	ENST00000444739	c.632G>A	p.G211D	COSMIC	NP	NP
122	BN40T	Tumour	LIVER	ENST00000444739	c.804C>T	p.V268V	COSMIC	NP	NP
123	CLL041	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000444739	c.331C>T	p.H111Y	COSMIC	NP	NP
124	ESO-0133	Tumour	OESOPHAGUS	ENST00000444739	c.1022A>G	p.E341G	COSMIC	NP	NP
125	ESO-859	Tumour	OESOPHAGUS	ENST00000444739	c.617T>C	p.V206A	COSMIC	NP	NP
126	H2009	Cell Line	LUNG	ENST00000444739	c.1051G>C	p.E351Q	COSMIC	NP	NP
127	HCC37T	Tumour	LIVER	ENST00000444739	c.649T>A	p.C217S	COSMIC	NP	NP
128	HCC39T	Tumour	LIVER	ENST00000444739	c.947delG	p.S316fs*24	COSMIC	NP	NP
129	LB647-SCLC	Cell Line	LUNG	ENST00000444739	c.757A>G	p.I253V	COSMIC	NP	NP
130	LUAD-NYU669	Tumour	LUNG	ENST00000444739	c.572T>A	p.F191Y	COSMIC	NP	NP
131	MZ7-mel	Cell Line	SKIN	ENST00000444739	c.387G>A	p.K129K	COSMIC	NP	NP
132	NCI-H1770	Cell Line	LUNG	ENST00000444739	c.354T>C	p.C118C	COSMIC	NP	NP
133	RK056	Tumour	C01 LIVER	ENST00000444739	c.415C>G	p.L139V	COSMIC	NP	NP
134	RK177	Tumour	C01 LIVER	ENST00000444739	c.157A>G	p.K53E	COSMIC	NP	NP
135	TCGA-13-2065-01	Tumour	OVARY	ENST00000444739	c.843G>A	p.Q281Q	COSMIC	NP	NP
136	TCGA-18-3409-01	Tumour	LUNG	ENST00000444739	c.705C>T	p.F235F	COSMIC	NP	NP
137	TCGA-22-4595-01	Tumour	LUNG	ENST00000444739	c.790G>T	p.G264W	COSMIC	NP	NP
138	TCGA-23-2079-01	Tumour	OVARY	ENST00000444739	c.581G>C	p.R194T	COSMIC	NP	NP
139	TCGA-34-5236-01	Tumour	LUNG	ENST00000444739	c.57A>T	p.K19N	COSMIC	NP	NP
140	TCGA-44-2668-01	Tumour	LUNG	ENST00000444739	c.198T>C	p.R66R	COSMIC	NP	NP
141	TCGA-44-2668-01	Tumour	LUNG	ENST00000444739	c.801G>T	p.W267C	COSMIC	NP	NP
142	TCGA-53-7624-01	Tumour	LUNG	ENST00000444739	c.928A>T	p.N310Y	COSMIC	NP	NP
143	TCGA-66-2770-01	Tumour	LUNG	ENST00000444739	c.91G>C	p.E31Q	COSMIC	NP	NP
144	TCGA-A5-A0GA-01	Tumour	ENDOMETRIUM	ENST00000444739	c.885C>T	p.H295H	COSMIC	NP	NP
145	TCGA-A6-5661-01	Tumour	LARGE INTESTINE	ENST00000444739	c.207A>G	p.G69G	COSMIC	NP	NP
146	TCGA-A6-5665-01	Tumour	LARGE INTESTINE	ENST00000444739	c.582A>G	p.R194R	COSMIC	NP	NP
147	TCGA-AA-3518-01	Tumour	LARGE INTESTINE	ENST00000444739	c.921G>A	p.T307T	COSMIC	NP	NP
148	TCGA-AA-3660-01	Tumour	LARGE INTESTINE	ENST00000444739	c.582A>G	p.R194R	COSMIC	NP	NP
149	TCGA-AA-3972-01	Tumour	LARGE INTESTINE	ENST00000444739	c.815C>A	p.P272Q	COSMIC	NP	NP
150	TCGA-AG-A002-01	Tumour	LARGE INTESTINE	ENST00000444739	c.129G>T	p.K43N	COSMIC	NP	NP
151	TCGA-AG-A002-01	Tumour	LARGE INTESTINE	ENST00000444739	c.262G>T	p.A88S	COSMIC	NP	NP
152	TCGA-AG-A002-01	Tumour	LARGE INTESTINE	ENST00000444739	c.561G>A	p.A187A	COSMIC	NP	NP
153	TCGA-AP-A056-01	Tumour	ENDOMETRIUM	ENST00000444739	c.921G>A	p.T307T	COSMIC	NP	NP
154	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000444739	c.754G>A	p.V252I	COSMIC	NP	NP
155	TCGA-AY-6197-01	Tumour	LARGE INTESTINE	ENST00000444739	c.111G>A	p.W37*	COSMIC	NP	NP
156	TCGA-AZ-6603-01	Tumour	LARGE INTESTINE	ENST00000444739	c.758T>C	p.I253T	COSMIC	NP	NP
157	TCGA-AZ-6607-01	Tumour	LARGE INTESTINE	ENST00000444739	c.582A>G	p.R194R	COSMIC	NP	NP
158	TCGA-B5-A11E-01	Tumour	ENDOMETRIUM	ENST00000444739	c.124A>C	p.K42Q	COSMIC	NP	NP
159	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000444739	c.163C>T	p.R55W	COSMIC	NP	NP
160	TCGA-BT-A20W-01	Tumour	URINARY TRACT	ENST00000444739	c.163C>T	p.R55W	COSMIC	NP	NP
161	TCGA-BT-A20W-01	Tumour	URINARY TRACT	ENST00000444739	c.163_164CG>TT	p.R55L	COSMIC	NP	NP
162	TCGA-CA-6717-01	Tumour	LARGE INTESTINE	ENST00000444739	c.1052A>C	p.E351A	COSMIC	NP	NP
163	TCGA-CK-4952-01	Tumour	LARGE INTESTINE	ENST00000444739	c.580A>T	p.R194*	COSMIC	NP	NP
164	TCGA-CM-6675-01	Tumour	LARGE INTESTINE	ENST00000444739	c.758T>C	p.I253T	COSMIC	NP	NP
165	TCGA-D1-A103-01	Tumour	ENDOMETRIUM	ENST00000444739	c.1077G>A	p.M359I	COSMIC	NP	NP
166	TCGA-D1-A16Y-01	Tumour	ENDOMETRIUM	ENST00000444739	c.163C>T	p.R55W	COSMIC	NP	NP
167	TCGA-D5-5537-01	Tumour	LARGE INTESTINE	ENST00000444739	c.759C>A	p.I253I	COSMIC	NP	NP
168	TCGA-D5-5538-01	Tumour	LARGE INTESTINE	ENST00000444739	c.386A>G	p.K129R	COSMIC	NP	NP
169	TCGA-D5-6529-01	Tumour	LARGE INTESTINE	ENST00000444739	c.758T>C	p.I253T	COSMIC	NP	NP
170	TCGA-D8-A1JT-01	Tumour	BREAST	ENST00000444739	c.36G>C	p.K12N	COSMIC	NP	NP
171	TCGA-DI-A0WH-01	Tumour	ENDOMETRIUM	ENST00000444739	c.435G>C	p.E145D	COSMIC	NP	NP
172	TCGA-DY-A1H8-01	Tumour	LARGE INTESTINE	ENST00000444739	c.386A>G	p.K129R	COSMIC	NP	NP
173	TCGA-FD-A3NA-01	Tumour	URINARY TRACT	ENST00000444739	c.1051G>C	p.E351Q	COSMIC	NP	NP
174	YULAN	Tumour	SKIN	ENST00000444739	c.227T>A	p.F76Y	COSMIC	NP	NP
175	ccRCC-96	Tumour	KIDNEY	ENST00000444739	c.1035+5G>T	p.?	COSMIC	NP	NP
176	2313287	Cell Line	STOMACH	ENST00000444739	c.400C>T	p.R134C	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
177	639V	Cell Line	URINARY_TRACT	ENST00000444739	c.597C>A	p.S199S	COSMIC	NP	NP
178	A704	Cell Line	KIDNEY	ENST00000444739	c.407G>A	p.R136H	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
179	BV173	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000444739	c.761T>C	p.I254T	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
180	COLO792	Cell Line	SKIN	ENST00000444739	c.939G>A	p.W313*	COSMIC	NP	NP
181	DETROIT562	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000444739	c.407G>A	p.R136H	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
182	EW13	Cell Line	BONE	ENST00000444739	c.13A>T	p.N5Y	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
183	HCT116	Cell Line	LARGE_INTESTINE	ENST00000444739	c.925+6T>C	p.?	COSMIC	NP	NP
184	HT1376	Cell Line	URINARY_TRACT	ENST00000444739	c.1121T>C	p.F374S	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
185	JHH2	Cell Line	LIVER	ENST00000444739	c.156C>G	p.D52E	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
186	JHOS4	Cell Line	OVARY	ENST00000444739	c.849T>C	p.S283S	COSMIC	NP	NP
187	KCL22	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000444739	c.171G>T	p.M57I	COSMIC	PASSENGER/OTHER	BENIGN
188	LB647SCLC	Cell Line	LUNG	ENST00000444739	c.757A>G	p.I253V	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
189	LNCAPCLONEFGC	Cell Line	PROSTATE	ENST00000444739	c.709A>G	p.I237V	COSMIC	PASSENGER/OTHER	BENIGN
190	LS411N	Cell Line	LARGE_INTESTINE	ENST00000444739	c.261delA	p.A88fs*28	COSMIC	NP	NP
191	MZ7MEL	Cell Line	SKIN	ENST00000444739	c.387G>A	p.K129K	COSMIC	NP	NP
192	NCIH1650	Cell Line	LUNG	ENST00000444739	c.644G>A	p.G215E	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
193	NCIH1770	Cell Line	LUNG	ENST00000444739	c.354T>C	p.C118C	COSMIC	NP	NP
194	NCIH187	Cell Line	LUNG	ENST00000444739	c.1072C>G	p.Q358E	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
195	NCIH2009	Cell Line	LUNG	ENST00000444739	c.1051G>C	p.E351Q	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
196	NCIH2170	Cell Line	LUNG	ENST00000444739	c.501G>A	p.E167E	COSMIC	NP	NP
197	PF382	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000444739	c.653G>A	p.G218E	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
198	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000444739	c.956G>C	p.G319A	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
199	SNU449	Cell Line	LIVER	ENST00000444739	c.377A>G	p.Y126C	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
200	SUPT1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000444739	c.231_232insT	p.N78fs*1	COSMIC	NP	NP

*NP: Not Predicted

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	4.3055	3.6597	-0.2433	-0.1185
BILIARY TRACT	7.6409	7.6035	-0.4362	-0.3536
BONE	8.0972	8.3949	-0.0032	-0.0033
BREAST	7.3698	7.779	-0.1577	-0.04385
CENTRAL NERVOUS SYSTEM	8.2015	8.5401	-0.1443	-0.0773
ENDOMETRIUM	7.0503	8.1471	-0.0138	-0.0087
HAEMATOPOIETIC AND LYMPHOID TISSUE	7.8908	8.4196	0.0230	-0.00438
KIDNEY	8.2603	8.3704	-0.2754	-0.1976
LARGE INTESTINE	8.3260	8.49505	0.0591	-0.005012
LIVER	7.8674	8.3046	-0.0431	0.05235
LUNG	7.6075	8.4152	0.1139	0.12525
OESOPHAGUS	8.6572	8.79535	0.0050	0.14885
OVARY	8.2695	8.6772	0.0965	0.1005
PANCREAS	9.1704	9.176	0.2031	0.2523
PLEURA	8.6874	8.9831	-0.1663	-0.1774
PROSTATE	7.1940	7.9159	0.0955	0.04605
SALIVARY GLAND	8.0391	8.0391	-0.4050	-0.405
SKIN	8.2241	8.1326	-0.3170	-0.1878
SMALL INTESTINE	3.8239	3.8239	-0.0067	-0.0067
SOFT TISSUE	6.8158	7.735	-0.0533	-0.022675
STOMACH	7.9815	8.56275	0.0887	0.10805
THYROID	8.7309	8.8554	0.0004	-0.01511
UPPER AERODIGESTIVE TRACT	9.4947	9.3856	-0.0140	0.020045
URINARY TRACT	8.8748	8.7558	-0.0758	-0.00175

Domain ID	Domain Name	Start Site	End Site	E-value
PF00619	CARD	5	83	2.6e-17
PF02020	W2	27	59	0.23
PF00656	Peptidase_C14	136	372	2.1e-46
PF00619	CARD	5	83	2.6e-17
PF02020	W2	27	59	0.23
PF00656	Peptidase_C14	136	372	2.1e-46

Domain ID	Start Site	End Site	E-value
0049359	102	376	4.78e-80
0036420	4	85	4.12e-15
0049359	102	376	4.78e-80
0036420	4	85	4.12e-15

S. No.	Position	Amino acid	Type	Description
1	83	S	Phosphorylation	Phosphoserine
2	83	S	Phosphorylation	Phosphoserine.
3	83	S	Phosphorylation	Phosphoserine
4	83	S	Phosphorylation	Phosphoserine.

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
CASP4	CASP4	CASP4	ENSP00000376857	P49662
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
P49662	CASP4	ENSP00000376857	CASP4	P49662
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
CASP4	ENSP00000376857	602664	P49662	PA26088

Protein: CASP4

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)

Modelled Structure	Structures available in PDB
	Structure is not available in PDB