ApoCanD

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	CW2	Cell Line	LARGE INTESTINE	NP_004337	c.415_416insA	p.I139fs	CCLE	NP	NP
2	CW2	Cell Line	LARGE INTESTINE	NP_004337	c.491G>A	p.R164H	CCLE	PASSENGER/OTHER	Probably Damaging
3	DBTRG05MG	Cell Line	CENTRAL NERVOUS SYSTEM	NP_004337	c.478A>T	p.I160F	CCLE	PASSENGER/OTHER	Probably Damaging
4	DMS79	Cell Line	LUNG	NP_004337	c.167A>G	p.H56R	CCLE	PASSENGER/OTHER	Benign
5	HEC251	Cell Line	ENDOMETRIUM	NP_004337	c.824T>G	p.F275C	CCLE	PASSENGER/OTHER	Probably Damaging
6	HS578T	Cell Line	BREAST	NP_004337	c.60C>G	p.I20M	CCLE	PASSENGER/OTHER	Benign
7	JHUEM2	Cell Line	ENDOMETRIUM	NP_004337	c.662C>T	p.A221V	CCLE	PASSENGER/OTHER	Benign
8	RKO	Cell Line	LARGE INTESTINE	NP_004337	c.415_415delA	p.I139fs	CCLE	NP	NP
9	HCC2998	Cell Line	LARGE INTESTINE	ENST00000308394	c.814G>T	p.E272*	COSMIC	NP	NP
10	LUAD-B02594	Tumour	LUNG	ENST00000308394	c.295T>A	p.L99M	COSMIC	NP	NP
11	LUAD-QCHM7	Tumour	LUNG	ENST00000308394	c.429C>T	p.F143F	COSMIC	NP	NP
12	LUAD-S01315	Tumour	LUNG	ENST00000308394	c.197G>T	p.G66V	COSMIC	NP	NP
13	P04-2599	Tumour	PROSTATE	ENST00000308394	c.825T>A	p.F275L	COSMIC	NP	NP
14	PD2166a	Tumour	KIDNEY	ENST00000308394	c.483+1G>A	p.?	COSMIC	NP	NP
15	S00472	Tumour	LUNG	ENST00000308394	c.415A>G	p.I139V	COSMIC	NP	NP
16	TCGA-38-4631-01	Tumour	LUNG	ENST00000308394	c.482A>T	p.Q161L	COSMIC	NP	NP
17	TCGA-44-7671-01	Tumour	LUNG	ENST00000308394	c.343G>T	p.V115F	COSMIC	NP	NP
18	TCGA-44-7672-01	Tumour	LUNG	ENST00000308394	c.831C>G	p.H277Q	COSMIC	NP	NP
19	TCGA-91-6835-01	Tumour	LUNG	ENST00000308394	c.481C>T	p.Q161*	COSMIC	NP	NP
20	TCGA-A6-6141-01	Tumour	LARGE INTESTINE	ENST00000308394	c.159G>T	p.K53N	COSMIC	NP	NP
21	TCGA-AA-3977-01	Tumour	LARGE INTESTINE	ENST00000308394	c.207C>T	p.V69V	COSMIC	NP	NP
22	TCGA-AA-A010-01	Tumour	LARGE INTESTINE	ENST00000308394	c.268G>T	p.D90Y	COSMIC	NP	NP
23	TCGA-AB-2854-03	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000308394	c.730G>A	p.A244T	COSMIC	NP	NP
24	TCGA-AG-A002-01	Tumour	LARGE INTESTINE	ENST00000308394	c.428T>C	p.F143S	COSMIC	NP	NP
25	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000308394	c.619C>T	p.R207*	COSMIC	NP	NP
26	TCGA-AX-A0J0-01	Tumour	ENDOMETRIUM	ENST00000308394	c.340T>G	p.F114V	COSMIC	NP	NP
27	TCGA-B5-A0JY-01	Tumour	ENDOMETRIUM	ENST00000308394	c.321T>C	p.D107D	COSMIC	NP	NP
28	TCGA-B5-A0K9-01	Tumour	ENDOMETRIUM	ENST00000308394	c.72C>T	p.S24S	COSMIC	NP	NP
29	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000308394	c.352C>A	p.L118I	COSMIC	NP	NP
30	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000308394	c.574G>A	p.D192N	COSMIC	NP	NP
31	TCGA-D1-A16Y-01	Tumour	ENDOMETRIUM	ENST00000308394	c.207C>T	p.V69V	COSMIC	NP	NP
32	TCGA-DK-A2I1-01	Tumour	URINARY TRACT	ENST00000308394	c.538G>C	p.D180H	COSMIC	NP	NP
33	TCGA-G4-6586-01	Tumour	LARGE INTESTINE	ENST00000308394	c.721C>T	p.R241*	COSMIC	NP	NP
34	cSCCP8	Tumour	SKIN	ENST00000308394	c.385G>T	p.G129*	COSMIC	NP	NP
35	ccRCC-38	Tumour	KIDNEY	ENST00000308394	c.542A>C	p.D181A	COSMIC	NP	NP
36	CW2	Cell Line	LARGE_INTESTINE	ENST00000308394	c.415_416insA	p.I139fs*11	COSMIC	NP	NP
37	CW2	Cell Line	LARGE_INTESTINE	ENST00000308394	c.491G>A	p.R164H	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
38	DBTRG05MG	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000308394	c.478A>T	p.I160F	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
39	DMS79	Cell Line	LUNG	ENST00000308394	c.167A>G	p.H56R	COSMIC	PASSENGER/OTHER	BENIGN
40	EMCBAC1	Cell Line	LUNG	ENST00000308394	c.433G>T	p.G145W	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
41	GP5D	Cell Line	LARGE_INTESTINE	ENST00000308394	c.78A>G	p.S26S	COSMIC	NP	NP
42	HCC2998	Cell Line	LARGE_INTESTINE	ENST00000308394	c.814G>T	p.E272*	COSMIC	NP	NP
43	HS578T	Cell Line	BREAST	ENST00000308394	c.60C>G	p.I20M	COSMIC	PASSENGER/OTHER	BENIGN
44	JURKAT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000308394	c.102C>T	p.D34D	COSMIC	NP	NP
45	JURKAT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000308394	c.570G>T	p.E190D	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
46	K5	Cell Line	THYROID	ENST00000308394	c.96C>T	p.S32S	COSMIC	NP	NP
47	LNCAPCLONEFGC	Cell Line	PROSTATE	ENST00000308394	c.604+8C>T	p.?	COSMIC	NP	NP
48	LS411N	Cell Line	LARGE_INTESTINE	ENST00000308394	c.525C>T	p.D175D	COSMIC	NP	NP
49	MCF7	Cell Line	BREAST	ENST00000308394	c.84_130del47	p.S29fs*7	COSMIC	NP	NP
50	MOLT4	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000308394	c.301C>T	p.R101C	COSMIC	PASSENGER/OTHER	BENIGN
51	PF382	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000308394	c.178+3A>G	p.?	COSMIC	NP	NP
52	SBC3	Cell Line	LUNG	ENST00000308394	c.604+8C>T	p.?	COSMIC	NP	NP
53	SCH	Cell Line	STOMACH	ENST00000308394	c.698T>A	p.M233K	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
54	TOV112D	Cell Line	OVARY	ENST00000308394	c.142A>G	p.I48V	COSMIC	PASSENGER/OTHER	BENIGN
55	CW2	Cell Line	LARGE INTESTINE	NP_004337	c.415_416insA	p.I139fs	CCLE	NP	NP
56	CW2	Cell Line	LARGE INTESTINE	NP_004337	c.491G>A	p.R164H	CCLE	PASSENGER/OTHER	Probably Damaging
57	DBTRG05MG	Cell Line	CENTRAL NERVOUS SYSTEM	NP_004337	c.478A>T	p.I160F	CCLE	PASSENGER/OTHER	Probably Damaging
58	DMS79	Cell Line	LUNG	NP_004337	c.167A>G	p.H56R	CCLE	PASSENGER/OTHER	Benign
59	HEC251	Cell Line	ENDOMETRIUM	NP_004337	c.824T>G	p.F275C	CCLE	PASSENGER/OTHER	Probably Damaging
60	HS578T	Cell Line	BREAST	NP_004337	c.60C>G	p.I20M	CCLE	PASSENGER/OTHER	Benign
61	JHUEM2	Cell Line	ENDOMETRIUM	NP_004337	c.662C>T	p.A221V	CCLE	PASSENGER/OTHER	Benign
62	RKO	Cell Line	LARGE INTESTINE	NP_004337	c.415_415delA	p.I139fs	CCLE	NP	NP
63	HCC2998	Cell Line	LARGE INTESTINE	ENST00000308394	c.814G>T	p.E272*	COSMIC	NP	NP
64	LUAD-B02594	Tumour	LUNG	ENST00000308394	c.295T>A	p.L99M	COSMIC	NP	NP
65	LUAD-QCHM7	Tumour	LUNG	ENST00000308394	c.429C>T	p.F143F	COSMIC	NP	NP
66	LUAD-S01315	Tumour	LUNG	ENST00000308394	c.197G>T	p.G66V	COSMIC	NP	NP
67	P04-2599	Tumour	PROSTATE	ENST00000308394	c.825T>A	p.F275L	COSMIC	NP	NP
68	PD2166a	Tumour	KIDNEY	ENST00000308394	c.483+1G>A	p.?	COSMIC	NP	NP
69	S00472	Tumour	LUNG	ENST00000308394	c.415A>G	p.I139V	COSMIC	NP	NP
70	TCGA-38-4631-01	Tumour	LUNG	ENST00000308394	c.482A>T	p.Q161L	COSMIC	NP	NP
71	TCGA-44-7671-01	Tumour	LUNG	ENST00000308394	c.343G>T	p.V115F	COSMIC	NP	NP
72	TCGA-44-7672-01	Tumour	LUNG	ENST00000308394	c.831C>G	p.H277Q	COSMIC	NP	NP
73	TCGA-91-6835-01	Tumour	LUNG	ENST00000308394	c.481C>T	p.Q161*	COSMIC	NP	NP
74	TCGA-A6-6141-01	Tumour	LARGE INTESTINE	ENST00000308394	c.159G>T	p.K53N	COSMIC	NP	NP
75	TCGA-AA-3977-01	Tumour	LARGE INTESTINE	ENST00000308394	c.207C>T	p.V69V	COSMIC	NP	NP
76	TCGA-AA-A010-01	Tumour	LARGE INTESTINE	ENST00000308394	c.268G>T	p.D90Y	COSMIC	NP	NP
77	TCGA-AB-2854-03	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000308394	c.730G>A	p.A244T	COSMIC	NP	NP
78	TCGA-AG-A002-01	Tumour	LARGE INTESTINE	ENST00000308394	c.428T>C	p.F143S	COSMIC	NP	NP
79	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000308394	c.619C>T	p.R207*	COSMIC	NP	NP
80	TCGA-AX-A0J0-01	Tumour	ENDOMETRIUM	ENST00000308394	c.340T>G	p.F114V	COSMIC	NP	NP
81	TCGA-B5-A0JY-01	Tumour	ENDOMETRIUM	ENST00000308394	c.321T>C	p.D107D	COSMIC	NP	NP
82	TCGA-B5-A0K9-01	Tumour	ENDOMETRIUM	ENST00000308394	c.72C>T	p.S24S	COSMIC	NP	NP
83	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000308394	c.352C>A	p.L118I	COSMIC	NP	NP
84	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000308394	c.574G>A	p.D192N	COSMIC	NP	NP
85	TCGA-D1-A16Y-01	Tumour	ENDOMETRIUM	ENST00000308394	c.207C>T	p.V69V	COSMIC	NP	NP
86	TCGA-DK-A2I1-01	Tumour	URINARY TRACT	ENST00000308394	c.538G>C	p.D180H	COSMIC	NP	NP
87	TCGA-G4-6586-01	Tumour	LARGE INTESTINE	ENST00000308394	c.721C>T	p.R241*	COSMIC	NP	NP
88	cSCCP8	Tumour	SKIN	ENST00000308394	c.385G>T	p.G129*	COSMIC	NP	NP
89	ccRCC-38	Tumour	KIDNEY	ENST00000308394	c.542A>C	p.D181A	COSMIC	NP	NP
90	CW2	Cell Line	LARGE_INTESTINE	ENST00000308394	c.415_416insA	p.I139fs*11	COSMIC	NP	NP
91	CW2	Cell Line	LARGE_INTESTINE	ENST00000308394	c.491G>A	p.R164H	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
92	DBTRG05MG	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000308394	c.478A>T	p.I160F	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
93	DMS79	Cell Line	LUNG	ENST00000308394	c.167A>G	p.H56R	COSMIC	PASSENGER/OTHER	BENIGN
94	EMCBAC1	Cell Line	LUNG	ENST00000308394	c.433G>T	p.G145W	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
95	GP5D	Cell Line	LARGE_INTESTINE	ENST00000308394	c.78A>G	p.S26S	COSMIC	NP	NP
96	HCC2998	Cell Line	LARGE_INTESTINE	ENST00000308394	c.814G>T	p.E272*	COSMIC	NP	NP
97	HS578T	Cell Line	BREAST	ENST00000308394	c.60C>G	p.I20M	COSMIC	PASSENGER/OTHER	BENIGN
98	JURKAT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000308394	c.102C>T	p.D34D	COSMIC	NP	NP
99	JURKAT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000308394	c.570G>T	p.E190D	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
100	K5	Cell Line	THYROID	ENST00000308394	c.96C>T	p.S32S	COSMIC	NP	NP
101	LNCAPCLONEFGC	Cell Line	PROSTATE	ENST00000308394	c.604+8C>T	p.?	COSMIC	NP	NP
102	LS411N	Cell Line	LARGE_INTESTINE	ENST00000308394	c.525C>T	p.D175D	COSMIC	NP	NP
103	MCF7	Cell Line	BREAST	ENST00000308394	c.84_130del47	p.S29fs*7	COSMIC	NP	NP
104	MOLT4	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000308394	c.301C>T	p.R101C	COSMIC	PASSENGER/OTHER	BENIGN
105	PF382	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000308394	c.178+3A>G	p.?	COSMIC	NP	NP
106	SBC3	Cell Line	LUNG	ENST00000308394	c.604+8C>T	p.?	COSMIC	NP	NP
107	SCH	Cell Line	STOMACH	ENST00000308394	c.698T>A	p.M233K	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
108	TOV112D	Cell Line	OVARY	ENST00000308394	c.142A>G	p.I48V	COSMIC	PASSENGER/OTHER	BENIGN

*NP: Not Predicted

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	9.5229	9.3736	-0.0597	-0.0553
BILIARY TRACT	8.8029	8.8956	-0.3981	-0.4156
BONE	9.4782	9.4767	-0.0924	-0.0169
BREAST	9.3626	9.4061	-0.1977	-0.013777
CENTRAL NERVOUS SYSTEM	9.0996	9.2343	-0.2773	-0.1479
ENDOMETRIUM	9.3132	9.48	-0.3213	-0.1019
HAEMATOPOIETIC AND LYMPHOID TISSUE	10.1933	10.143	-0.0556	-0.0045
KIDNEY	9.4858	9.3915	-0.1069	-0.0234
LARGE INTESTINE	9.3310	9.37475	-0.2603	-0.1321
LIVER	9.1227	9.1238	-0.3912	-0.3985
LUNG	9.1183	9.14495	-0.2673	-0.2191
OESOPHAGUS	8.9382	8.86525	-0.3140	-0.34985
OVARY	9.0373	8.9272	-0.3693	-0.3515
PANCREAS	8.9950	8.9192	-0.2773	-0.2634
PLEURA	9.6921	9.6941	-0.2567	-0.1615
PROSTATE	8.8520	8.9592	-0.3915	-0.28025
SALIVARY GLAND	8.9863	8.9863	-0.3853	-0.3853
SKIN	9.3130	9.2602	-0.1689	-0.1239
SMALL INTESTINE	9.4597	9.4597	0.0575	0.05753
SOFT TISSUE	9.3759	9.3733	-0.2264	-0.042835
STOMACH	9.3937	9.48225	-0.2319	-0.20135
THYROID	9.1105	9.0024	-0.2235	-0.2126
UPPER AERODIGESTIVE TRACT	8.7216	8.60775	-0.4291	-0.4086
URINARY TRACT	9.2986	9.166	-0.3042	-0.32625

Domain ID	Domain Name	Start Site	End Site	E-value
PF00656	Peptidase_C14	45	275	4.6e-49
PF12878	SICA_beta	181	250	0.2
PF00656	Peptidase_C14	45	275	4.6e-49
PF12878	SICA_beta	181	250	0.2

Domain ID	Start Site	End Site	E-value
0036096	36	276	2.54e-95
0036096	36	276	2.54e-95

S. No.	Position	Amino acid	Type	Description
1	1	M	Acetylation	N-acetylmethionine.
2	150	S	Phosphorylation	Phosphoserine
3	150	S	Phosphorylation	Phosphoserine (MAPK14)
4	163	C	S-Nitrosylation	S-nitrosocysteine
5	163	C	S-nitrosylation	S-nitrosocysteine
6	163	C	S-nitrosylation	S-nitrosocysteine; in inhibited form.
7	175	D	Proteolytic Cleavage	none
8	229	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
9	26	S	Phosphorylation	Phosphoserine
10	270	T	Phosphorylation	Phosphothreonine
11	82	K	Acetylation	N6-acetyllysine
12	82	K	Acetylation	N6-acetyllysine.
13	82	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
14	9	D	Proteolytic Cleavage	none
15	1	M	Acetylation	N-acetylmethionine.
16	150	S	Phosphorylation	Phosphoserine
17	150	S	Phosphorylation	Phosphoserine (MAPK14)
18	163	C	S-Nitrosylation	S-nitrosocysteine
19	163	C	S-nitrosylation	S-nitrosocysteine
20	163	C	S-nitrosylation	S-nitrosocysteine; in inhibited form.
21	175	D	Proteolytic Cleavage	none
22	229	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
23	26	S	Phosphorylation	Phosphoserine
24	270	T	Phosphorylation	Phosphothreonine
25	82	K	Acetylation	N6-acetyllysine
26	82	K	Acetylation	N6-acetyllysine.
27	82	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
28	9	D	Proteolytic Cleavage	none

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
CASP3	CASP3	CASP3	ENSP00000311032	P42574
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
P42574	CASP3	ENSP00000311032	CASP3	P42574
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
CASP3	ENSP00000311032	600636	P42574	PA26087

Protein: CASP3

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)