ApoCanD

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	AN3CA	Cell Line	ENDOMETRIUM	NP_116764	c.756A>G	p.Q252Q	CCLE	NP	NP
2	BT474	Cell Line	BREAST	NP_116764	c.178C>G	p.L60V	CCLE	PASSENGER/OTHER	Possibly Damaging
3	CAL148	Cell Line	BREAST	NP_116764	c.1207G>A	p.V403M	CCLE	PASSENGER/OTHER	Probably Damaging
4	CJM	Cell Line	SKIN	NP_116764	c.1236A>G	p.A412A	CCLE	NP	NP
5	CL34	Cell Line	LARGE INTESTINE	NP_116764	c.392C>T	p.P131L	CCLE	PASSENGER/OTHER	Benign
6	HEC108	Cell Line	ENDOMETRIUM	NP_116764	c.404A>G	p.D135G	CCLE	PASSENGER/OTHER	Benign
7	HEC1A	Cell Line	ENDOMETRIUM	NP_116764	c.1212C>T	p.A404A	CCLE	NP	NP
8	HEC1B	Cell Line	ENDOMETRIUM	NP_116764	c.1212C>T	p.A404A	CCLE	NP	NP
9	HEC251	Cell Line	ENDOMETRIUM	NP_116764	c.1145G>A	p.R382Q	CCLE	PASSENGER/OTHER	Probably Damaging
10	KM12	Cell Line	LARGE INTESTINE	NP_116764	c.1336T>C	p.F446L	CCLE	PASSENGER/OTHER	Probably Damaging
11	MDAMB415	Cell Line	BREAST	NP_116764	c.690C>T	p.V230V	CCLE	NP	NP
12	NCIH1373	Cell Line	LUNG	NP_116764	c.1267G>T	p.G423C	CCLE	PASSENGER/OTHER	Probably Damaging
13	NCIH2347	Cell Line	LUNG	NP_116764	c.392C>T	p.P131L	CCLE	PASSENGER/OTHER	Benign
14	SNU1040	Cell Line	LARGE INTESTINE	NP_116764	c.1144C>T	p.R382*	CCLE	NP	NP
15	SNUC5	Cell Line	LARGE INTESTINE	NP_116764	c.828G>A	p.S276S	CCLE	NP	NP
16	SUDHL1	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_116764	c.1100G>T	p.G367V	CCLE	PASSENGER/OTHER	Probably Damaging
17	UMUC3	Cell Line	URINARY TRACT	NP_116764	c.476_splice	p.D159_splice	CCLE	NP	NP
18	YD38	Cell Line	UPPER AERODIGESTIVE TRACT	NP_116764	c.126G>A	p.K42K	CCLE	NP	NP
19	001	Tumour	KIDNEY	ENST00000310447	c.1148G>T	p.G383V	COSMIC	NP	NP
20	112146	Tumour	LUNG	ENST00000310447	c.225+2T>C	p.?	COSMIC	NP	NP
21	112533	Tumour	LUNG	ENST00000310447	c.133G>A	p.V45M	COSMIC	NP	NP
22	112676	Tumour	OVARY	ENST00000310447	c.664G>A	p.G222R	COSMIC	NP	NP
23	587220	Tumour	LARGE INTESTINE	ENST00000310447	c.1081C>T	p.R361C	COSMIC	NP	NP
24	HCC2998	Cell Line	LARGE INTESTINE	ENST00000310447	c.643G>T	p.E215*	COSMIC	NP	NP
25	HCC55T	Tumour	LIVER	ENST00000310447	c.1339C>T	p.P447S	COSMIC	NP	NP
26	HCT-116	Cell Line	LARGE INTESTINE	ENST00000310447	c.1193C>T	p.A398V	COSMIC	NP	NP
27	LUAD-B01811	Tumour	LUNG	ENST00000310447	c.92G>T	p.G31V	COSMIC	NP	NP
28	LUAD-NYU315	Tumour	LUNG	ENST00000310447	c.452A>T	p.Y151F	COSMIC	NP	NP
29	LUAD-NYU696	Tumour	LUNG	ENST00000310447	c.1133G>C	p.R378P	COSMIC	NP	NP
30	LUAD-S01315	Tumour	LUNG	ENST00000310447	c.346G>T	p.D116Y	COSMIC	NP	NP
31	LUAD-YINHD	Tumour	LUNG	ENST00000310447	c.499A>T	p.N167Y	COSMIC	NP	NP
32	RK147	Tumour	C01 LIVER	ENST00000310447	c.811A>G	p.I271V	COSMIC	NP	NP
33	TCGA-05-4420-01	Tumour	LUNG	ENST00000310447	c.96G>T	p.M32I	COSMIC	NP	NP
34	TCGA-05-4427-01	Tumour	LUNG	ENST00000310447	c.245G>T	p.S82I	COSMIC	NP	NP
35	TCGA-05-5423-01	Tumour	LUNG	ENST00000310447	c.1148G>T	p.G383V	COSMIC	NP	NP
36	TCGA-21-5786-01	Tumour	LUNG	ENST00000310447	c.327C>T	p.T109T	COSMIC	NP	NP
37	TCGA-44-3918-01	Tumour	LUNG	ENST00000310447	c.983G>T	p.G328V	COSMIC	NP	NP
38	TCGA-60-2698-01	Tumour	LUNG	ENST00000310447	c.1051G>T	p.E351*	COSMIC	NP	NP
39	TCGA-73-4666-01	Tumour	LUNG	ENST00000310447	c.16G>T	p.A6S	COSMIC	NP	NP
40	TCGA-78-7147-01	Tumour	LUNG	ENST00000310447	c.1039G>A	p.D347N	COSMIC	NP	NP
41	TCGA-78-7539-01	Tumour	LUNG	ENST00000310447	c.200C>T	p.T67I	COSMIC	NP	NP
42	TCGA-A2-A04Q-01	Tumour	BREAST	ENST00000310447	c.23C>T	p.S8F	COSMIC	NP	NP
43	TCGA-A3-3365-01	Tumour	KIDNEY	ENST00000310447	c.1322G>T	p.R441L	COSMIC	NP	NP
44	TCGA-AA-3554-01	Tumour	LARGE INTESTINE	ENST00000310447	c.595C>T	p.R199C	COSMIC	NP	NP
45	TCGA-AA-3715-01	Tumour	LARGE INTESTINE	ENST00000310447	c.540T>C	p.T180T	COSMIC	NP	NP
46	TCGA-AA-3864-01	Tumour	LARGE INTESTINE	ENST00000310447	c.907G>A	p.A303T	COSMIC	NP	NP
47	TCGA-AA-A00E-01	Tumour	LARGE INTESTINE	ENST00000310447	c.102T>C	p.P34P	COSMIC	NP	NP
48	TCGA-AA-A010-01	Tumour	LARGE INTESTINE	ENST00000310447	c.464G>A	p.R155H	COSMIC	NP	NP
49	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000310447	c.1249C>T	p.R417W	COSMIC	NP	NP
50	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000310447	c.373C>T	p.L125F	COSMIC	NP	NP
51	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000310447	c.695T>G	p.L232R	COSMIC	NP	NP
52	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000310447	c.843C>T	p.G281G	COSMIC	NP	NP
53	TCGA-AU-6004-01	Tumour	LARGE INTESTINE	ENST00000310447	c.718G>A	p.V240I	COSMIC	NP	NP
54	TCGA-AX-A0J1-01	Tumour	ENDOMETRIUM	ENST00000310447	c.1206C>T	p.H402H	COSMIC	NP	NP
55	TCGA-AZ-6603-01	Tumour	LARGE INTESTINE	ENST00000310447	c.1062G>A	p.P354P	COSMIC	NP	NP
56	TCGA-B5-A0JR-01	Tumour	ENDOMETRIUM	ENST00000310447	c.1101C>T	p.G367G	COSMIC	NP	NP
57	TCGA-B5-A11E-01	Tumour	ENDOMETRIUM	ENST00000310447	c.114A>G	p.E38E	COSMIC	NP	NP
58	TCGA-B5-A11E-01	Tumour	ENDOMETRIUM	ENST00000310447	c.1235C>T	p.A412V	COSMIC	NP	NP
59	TCGA-CA-6717-01	Tumour	LARGE INTESTINE	ENST00000310447	c.750A>C	p.E250D	COSMIC	NP	NP
60	TCGA-CJ-4913-01	Tumour	KIDNEY	ENST00000310447	c.990C>A	p.D330E	COSMIC	NP	NP
61	TCGA-D1-A15X-01	Tumour	ENDOMETRIUM	ENST00000310447	c.777A>G	p.A259A	COSMIC	NP	NP
62	TCGA-D1-A17Q-01	Tumour	ENDOMETRIUM	ENST00000310447	c.906C>T	p.N302N	COSMIC	NP	NP
63	TCGA-D1-A17U-01	Tumour	ENDOMETRIUM	ENST00000310447	c.1081C>T	p.R361C	COSMIC	NP	NP
64	TCGA-D5-6927-01	Tumour	LARGE INTESTINE	ENST00000310447	c.1129A>G	p.M377V	COSMIC	NP	NP
65	TCGA-D5-6930-01	Tumour	LARGE INTESTINE	ENST00000310447	c.759G>T	p.E253D	COSMIC	NP	NP
66	TCGA-E2-A15S-01	Tumour	BREAST	ENST00000310447	c.514G>T	p.V172F	COSMIC	NP	NP
67	TCGA-FI-A2EX-01	Tumour	ENDOMETRIUM	ENST00000310447	c.828delG	p.H277fs*80	COSMIC	NP	NP
68	TCGA-GC-A3I6-01	Tumour	URINARY TRACT	ENST00000310447	c.51G>T	p.L17L	COSMIC	NP	NP
69	YUGOE	Tumour	SKIN	ENST00000310447	c.917C>T	p.P306L	COSMIC	NP	NP
70	YUKLAB	Tumour	SKIN	ENST00000310447	c.19G>A	p.G7R	COSMIC	NP	NP
71	YUKLAB	Tumour	SKIN	ENST00000310447	c.446C>T	p.P149L	COSMIC	NP	NP
72	ccRCC-79	Tumour	KIDNEY	ENST00000310447	c.968A>G	p.D323G	COSMIC	NP	NP
73	pfg016T	Tumour	STOMACH	ENST00000310447	c.1118-4G>A	p.?	COSMIC	NP	NP
74	AN3CA	Cell Line	ENDOMETRIUM	ENST00000310447	c.756A>G	p.Q252Q	COSMIC	NP	NP
75	BT474	Cell Line	BREAST	ENST00000310447	c.178C>G	p.L60V	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
76	C33A	Cell Line	CERVIX	ENST00000310447	c.64A>G	p.R22G	COSMIC	PASSENGER/OTHER	BENIGN
77	CAL148	Cell Line	BREAST	ENST00000310447	c.1207G>A	p.V403M	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
78	CL34	Cell Line	LARGE_INTESTINE	ENST00000310447	c.392C>T	p.P131L	COSMIC	PASSENGER/OTHER	BENIGN
79	HCC2998	Cell Line	LARGE_INTESTINE	ENST00000310447	c.549T>G	p.F183L	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
80	HCC2998	Cell Line	LARGE_INTESTINE	ENST00000310447	c.643G>T	p.E215*	COSMIC	NP	NP
81	HCT116	Cell Line	LARGE_INTESTINE	ENST00000310447	c.1193C>T	p.A398V	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
82	HT115	Cell Line	LARGE_INTESTINE	ENST00000310447	c.366T>G	p.L122L	COSMIC	NP	NP
83	K2	Cell Line	SKIN	ENST00000310447	c.303C>T	p.A101A	COSMIC	NP	NP
84	KM12	Cell Line	LARGE_INTESTINE	ENST00000310447	c.1336T>C	p.F446L	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
85	MDAMB415	Cell Line	BREAST	ENST00000310447	c.690C>T	p.V230V	COSMIC	NP	NP
86	MOLT16	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000310447	c.393G>A	p.P131P	COSMIC	NP	NP
87	NCIH1838	Cell Line	LUNG	ENST00000310447	c.69A>G	p.G23G	COSMIC	NP	NP
88	NCIH2347	Cell Line	LUNG	ENST00000310447	c.392C>T	p.P131L	COSMIC	PASSENGER/OTHER	BENIGN
89	NCIH838	Cell Line	LUNG	ENST00000310447	c.441C>G	p.S147S	COSMIC	NP	NP
90	NCIH838	Cell Line	LUNG	ENST00000310447	c.876+5G>A	p.?	COSMIC	NP	NP
91	NCISNU16	Cell Line	STOMACH	ENST00000310447	c.927G>A	p.Q309Q	COSMIC	NP	NP
92	RO82W1	Cell Line	THYROID	ENST00000310447	c.1144C>T	p.R382*	COSMIC	NP	NP
93	RPMI8866	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000310447	c.1120A>T	p.T374S	COSMIC	PASSENGER/OTHER	BENIGN
94	RXF393	Cell Line	KIDNEY	ENST00000310447	c.596G>A	p.R199H	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
95	SARC9371	Cell Line	BONE	ENST00000310447	c.288C>T	p.P96P	COSMIC	NP	NP
96	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000310447	c.1144C>T	p.R382*	COSMIC	NP	NP
97	SNUC5	Cell Line	LARGE_INTESTINE	ENST00000310447	c.828G>A	p.S276S	COSMIC	NP	NP
98	SUPT1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000310447	c.1190G>A	p.R397Q	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
99	TCYIK	Cell Line	CERVIX	ENST00000310447	c.74+10G>A	p.?	COSMIC	NP	NP
100	TK	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000310447	c.1081C>T	p.R361C	COSMIC	PASSENGER/OTHER	BENIGN
101	YMB1E	Cell Line	BREAST	ENST00000310447	c.876+5G>A	p.?	COSMIC	NP	NP
102	AN3CA	Cell Line	ENDOMETRIUM	NP_116764	c.756A>G	p.Q252Q	CCLE	NP	NP
103	BT474	Cell Line	BREAST	NP_116764	c.178C>G	p.L60V	CCLE	PASSENGER/OTHER	Possibly Damaging
104	CAL148	Cell Line	BREAST	NP_116764	c.1207G>A	p.V403M	CCLE	PASSENGER/OTHER	Probably Damaging
105	CJM	Cell Line	SKIN	NP_116764	c.1236A>G	p.A412A	CCLE	NP	NP
106	CL34	Cell Line	LARGE INTESTINE	NP_116764	c.392C>T	p.P131L	CCLE	PASSENGER/OTHER	Benign
107	HEC108	Cell Line	ENDOMETRIUM	NP_116764	c.404A>G	p.D135G	CCLE	PASSENGER/OTHER	Benign
108	HEC1A	Cell Line	ENDOMETRIUM	NP_116764	c.1212C>T	p.A404A	CCLE	NP	NP
109	HEC1B	Cell Line	ENDOMETRIUM	NP_116764	c.1212C>T	p.A404A	CCLE	NP	NP
110	HEC251	Cell Line	ENDOMETRIUM	NP_116764	c.1145G>A	p.R382Q	CCLE	PASSENGER/OTHER	Probably Damaging
111	KM12	Cell Line	LARGE INTESTINE	NP_116764	c.1336T>C	p.F446L	CCLE	PASSENGER/OTHER	Probably Damaging
112	MDAMB415	Cell Line	BREAST	NP_116764	c.690C>T	p.V230V	CCLE	NP	NP
113	NCIH1373	Cell Line	LUNG	NP_116764	c.1267G>T	p.G423C	CCLE	PASSENGER/OTHER	Probably Damaging
114	NCIH2347	Cell Line	LUNG	NP_116764	c.392C>T	p.P131L	CCLE	PASSENGER/OTHER	Benign
115	SNU1040	Cell Line	LARGE INTESTINE	NP_116764	c.1144C>T	p.R382*	CCLE	NP	NP
116	SNUC5	Cell Line	LARGE INTESTINE	NP_116764	c.828G>A	p.S276S	CCLE	NP	NP
117	SUDHL1	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_116764	c.1100G>T	p.G367V	CCLE	PASSENGER/OTHER	Probably Damaging
118	UMUC3	Cell Line	URINARY TRACT	NP_116764	c.476_splice	p.D159_splice	CCLE	NP	NP
119	YD38	Cell Line	UPPER AERODIGESTIVE TRACT	NP_116764	c.126G>A	p.K42K	CCLE	NP	NP
120	001	Tumour	KIDNEY	ENST00000310447	c.1148G>T	p.G383V	COSMIC	NP	NP
121	112146	Tumour	LUNG	ENST00000310447	c.225+2T>C	p.?	COSMIC	NP	NP
122	112533	Tumour	LUNG	ENST00000310447	c.133G>A	p.V45M	COSMIC	NP	NP
123	112676	Tumour	OVARY	ENST00000310447	c.664G>A	p.G222R	COSMIC	NP	NP
124	587220	Tumour	LARGE INTESTINE	ENST00000310447	c.1081C>T	p.R361C	COSMIC	NP	NP
125	HCC2998	Cell Line	LARGE INTESTINE	ENST00000310447	c.643G>T	p.E215*	COSMIC	NP	NP
126	HCC55T	Tumour	LIVER	ENST00000310447	c.1339C>T	p.P447S	COSMIC	NP	NP
127	HCT-116	Cell Line	LARGE INTESTINE	ENST00000310447	c.1193C>T	p.A398V	COSMIC	NP	NP
128	LUAD-B01811	Tumour	LUNG	ENST00000310447	c.92G>T	p.G31V	COSMIC	NP	NP
129	LUAD-NYU315	Tumour	LUNG	ENST00000310447	c.452A>T	p.Y151F	COSMIC	NP	NP
130	LUAD-NYU696	Tumour	LUNG	ENST00000310447	c.1133G>C	p.R378P	COSMIC	NP	NP
131	LUAD-S01315	Tumour	LUNG	ENST00000310447	c.346G>T	p.D116Y	COSMIC	NP	NP
132	LUAD-YINHD	Tumour	LUNG	ENST00000310447	c.499A>T	p.N167Y	COSMIC	NP	NP
133	RK147	Tumour	C01 LIVER	ENST00000310447	c.811A>G	p.I271V	COSMIC	NP	NP
134	TCGA-05-4420-01	Tumour	LUNG	ENST00000310447	c.96G>T	p.M32I	COSMIC	NP	NP
135	TCGA-05-4427-01	Tumour	LUNG	ENST00000310447	c.245G>T	p.S82I	COSMIC	NP	NP
136	TCGA-05-5423-01	Tumour	LUNG	ENST00000310447	c.1148G>T	p.G383V	COSMIC	NP	NP
137	TCGA-21-5786-01	Tumour	LUNG	ENST00000310447	c.327C>T	p.T109T	COSMIC	NP	NP
138	TCGA-44-3918-01	Tumour	LUNG	ENST00000310447	c.983G>T	p.G328V	COSMIC	NP	NP
139	TCGA-60-2698-01	Tumour	LUNG	ENST00000310447	c.1051G>T	p.E351*	COSMIC	NP	NP
140	TCGA-73-4666-01	Tumour	LUNG	ENST00000310447	c.16G>T	p.A6S	COSMIC	NP	NP
141	TCGA-78-7147-01	Tumour	LUNG	ENST00000310447	c.1039G>A	p.D347N	COSMIC	NP	NP
142	TCGA-78-7539-01	Tumour	LUNG	ENST00000310447	c.200C>T	p.T67I	COSMIC	NP	NP
143	TCGA-A2-A04Q-01	Tumour	BREAST	ENST00000310447	c.23C>T	p.S8F	COSMIC	NP	NP
144	TCGA-A3-3365-01	Tumour	KIDNEY	ENST00000310447	c.1322G>T	p.R441L	COSMIC	NP	NP
145	TCGA-AA-3554-01	Tumour	LARGE INTESTINE	ENST00000310447	c.595C>T	p.R199C	COSMIC	NP	NP
146	TCGA-AA-3715-01	Tumour	LARGE INTESTINE	ENST00000310447	c.540T>C	p.T180T	COSMIC	NP	NP
147	TCGA-AA-3864-01	Tumour	LARGE INTESTINE	ENST00000310447	c.907G>A	p.A303T	COSMIC	NP	NP
148	TCGA-AA-A00E-01	Tumour	LARGE INTESTINE	ENST00000310447	c.102T>C	p.P34P	COSMIC	NP	NP
149	TCGA-AA-A010-01	Tumour	LARGE INTESTINE	ENST00000310447	c.464G>A	p.R155H	COSMIC	NP	NP
150	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000310447	c.1249C>T	p.R417W	COSMIC	NP	NP
151	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000310447	c.373C>T	p.L125F	COSMIC	NP	NP
152	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000310447	c.695T>G	p.L232R	COSMIC	NP	NP
153	TCGA-AP-A059-01	Tumour	ENDOMETRIUM	ENST00000310447	c.843C>T	p.G281G	COSMIC	NP	NP
154	TCGA-AU-6004-01	Tumour	LARGE INTESTINE	ENST00000310447	c.718G>A	p.V240I	COSMIC	NP	NP
155	TCGA-AX-A0J1-01	Tumour	ENDOMETRIUM	ENST00000310447	c.1206C>T	p.H402H	COSMIC	NP	NP
156	TCGA-AZ-6603-01	Tumour	LARGE INTESTINE	ENST00000310447	c.1062G>A	p.P354P	COSMIC	NP	NP
157	TCGA-B5-A0JR-01	Tumour	ENDOMETRIUM	ENST00000310447	c.1101C>T	p.G367G	COSMIC	NP	NP
158	TCGA-B5-A11E-01	Tumour	ENDOMETRIUM	ENST00000310447	c.114A>G	p.E38E	COSMIC	NP	NP
159	TCGA-B5-A11E-01	Tumour	ENDOMETRIUM	ENST00000310447	c.1235C>T	p.A412V	COSMIC	NP	NP
160	TCGA-CA-6717-01	Tumour	LARGE INTESTINE	ENST00000310447	c.750A>C	p.E250D	COSMIC	NP	NP
161	TCGA-CJ-4913-01	Tumour	KIDNEY	ENST00000310447	c.990C>A	p.D330E	COSMIC	NP	NP
162	TCGA-D1-A15X-01	Tumour	ENDOMETRIUM	ENST00000310447	c.777A>G	p.A259A	COSMIC	NP	NP
163	TCGA-D1-A17Q-01	Tumour	ENDOMETRIUM	ENST00000310447	c.906C>T	p.N302N	COSMIC	NP	NP
164	TCGA-D1-A17U-01	Tumour	ENDOMETRIUM	ENST00000310447	c.1081C>T	p.R361C	COSMIC	NP	NP
165	TCGA-D5-6927-01	Tumour	LARGE INTESTINE	ENST00000310447	c.1129A>G	p.M377V	COSMIC	NP	NP
166	TCGA-D5-6930-01	Tumour	LARGE INTESTINE	ENST00000310447	c.759G>T	p.E253D	COSMIC	NP	NP
167	TCGA-E2-A15S-01	Tumour	BREAST	ENST00000310447	c.514G>T	p.V172F	COSMIC	NP	NP
168	TCGA-FI-A2EX-01	Tumour	ENDOMETRIUM	ENST00000310447	c.828delG	p.H277fs*80	COSMIC	NP	NP
169	TCGA-GC-A3I6-01	Tumour	URINARY TRACT	ENST00000310447	c.51G>T	p.L17L	COSMIC	NP	NP
170	YUGOE	Tumour	SKIN	ENST00000310447	c.917C>T	p.P306L	COSMIC	NP	NP
171	YUKLAB	Tumour	SKIN	ENST00000310447	c.19G>A	p.G7R	COSMIC	NP	NP
172	YUKLAB	Tumour	SKIN	ENST00000310447	c.446C>T	p.P149L	COSMIC	NP	NP
173	ccRCC-79	Tumour	KIDNEY	ENST00000310447	c.968A>G	p.D323G	COSMIC	NP	NP
174	pfg016T	Tumour	STOMACH	ENST00000310447	c.1118-4G>A	p.?	COSMIC	NP	NP
175	AN3CA	Cell Line	ENDOMETRIUM	ENST00000310447	c.756A>G	p.Q252Q	COSMIC	NP	NP
176	BT474	Cell Line	BREAST	ENST00000310447	c.178C>G	p.L60V	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
177	C33A	Cell Line	CERVIX	ENST00000310447	c.64A>G	p.R22G	COSMIC	PASSENGER/OTHER	BENIGN
178	CAL148	Cell Line	BREAST	ENST00000310447	c.1207G>A	p.V403M	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
179	CL34	Cell Line	LARGE_INTESTINE	ENST00000310447	c.392C>T	p.P131L	COSMIC	PASSENGER/OTHER	BENIGN
180	HCC2998	Cell Line	LARGE_INTESTINE	ENST00000310447	c.549T>G	p.F183L	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
181	HCC2998	Cell Line	LARGE_INTESTINE	ENST00000310447	c.643G>T	p.E215*	COSMIC	NP	NP
182	HCT116	Cell Line	LARGE_INTESTINE	ENST00000310447	c.1193C>T	p.A398V	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
183	HT115	Cell Line	LARGE_INTESTINE	ENST00000310447	c.366T>G	p.L122L	COSMIC	NP	NP
184	K2	Cell Line	SKIN	ENST00000310447	c.303C>T	p.A101A	COSMIC	NP	NP
185	KM12	Cell Line	LARGE_INTESTINE	ENST00000310447	c.1336T>C	p.F446L	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
186	MDAMB415	Cell Line	BREAST	ENST00000310447	c.690C>T	p.V230V	COSMIC	NP	NP
187	MOLT16	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000310447	c.393G>A	p.P131P	COSMIC	NP	NP
188	NCIH1838	Cell Line	LUNG	ENST00000310447	c.69A>G	p.G23G	COSMIC	NP	NP
189	NCIH2347	Cell Line	LUNG	ENST00000310447	c.392C>T	p.P131L	COSMIC	PASSENGER/OTHER	BENIGN
190	NCIH838	Cell Line	LUNG	ENST00000310447	c.441C>G	p.S147S	COSMIC	NP	NP
191	NCIH838	Cell Line	LUNG	ENST00000310447	c.876+5G>A	p.?	COSMIC	NP	NP
192	NCISNU16	Cell Line	STOMACH	ENST00000310447	c.927G>A	p.Q309Q	COSMIC	NP	NP
193	RO82W1	Cell Line	THYROID	ENST00000310447	c.1144C>T	p.R382*	COSMIC	NP	NP
194	RPMI8866	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000310447	c.1120A>T	p.T374S	COSMIC	PASSENGER/OTHER	BENIGN
195	RXF393	Cell Line	KIDNEY	ENST00000310447	c.596G>A	p.R199H	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
196	SARC9371	Cell Line	BONE	ENST00000310447	c.288C>T	p.P96P	COSMIC	NP	NP
197	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000310447	c.1144C>T	p.R382*	COSMIC	NP	NP
198	SNUC5	Cell Line	LARGE_INTESTINE	ENST00000310447	c.828G>A	p.S276S	COSMIC	NP	NP
199	SUPT1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000310447	c.1190G>A	p.R397Q	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
200	TCYIK	Cell Line	CERVIX	ENST00000310447	c.74+10G>A	p.?	COSMIC	NP	NP
201	TK	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000310447	c.1081C>T	p.R361C	COSMIC	PASSENGER/OTHER	BENIGN
202	YMB1E	Cell Line	BREAST	ENST00000310447	c.876+5G>A	p.?	COSMIC	NP	NP

*NP: Not Predicted

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	6.7982	6.8528	0.2727	0.246
BILIARY TRACT	6.6868	6.8401	0.1851	0.1527
BONE	6.2704	6.2634	-0.0330	0.0216
BREAST	6.7807	6.74095	0.1781	0.21445
CENTRAL NERVOUS SYSTEM	6.6822	6.6473	0.3388	0.4267
ENDOMETRIUM	6.7478	6.9066	0.0525	0.0125
HAEMATOPOIETIC AND LYMPHOID TISSUE	7.4822	7.5148	0.1059	0.0508
KIDNEY	6.4194	6.3293	0.3769	0.3357
LARGE INTESTINE	6.9613	6.89055	0.2306	0.15945
LIVER	6.2922	6.1819	0.1083	0.1044
LUNG	6.5706	6.5738	0.1286	0.17285
OESOPHAGUS	5.9687	5.9272	-0.1883	-0.1697
OVARY	6.5096	6.466	0.1492	0.141
PANCREAS	6.4861	6.395	0.0987	0.1328
PLEURA	6.1559	6.1897	0.0921	0.1496
PROSTATE	6.5347	6.5218	0.0837	0.0987
SALIVARY GLAND	5.6940	5.694	-0.3989	-0.3989
SKIN	6.4761	6.4746	0.4776	0.5014
SMALL INTESTINE	6.1286	6.1286	0.0081	0.0081
SOFT TISSUE	6.4510	6.51405	0.0756	0.0644
STOMACH	6.6464	6.65905	0.1169	0.06515
THYROID	6.7873	6.73575	0.1525	0.1896
UPPER AERODIGESTIVE TRACT	6.1911	5.97155	-0.0614	-0.01175
URINARY TRACT	6.8346	6.94615	0.0776	0.06197

Domain ID	Domain Name	Start Site	End Site	E-value
PF00619	CARD	37	118	8.3e-19
PF00656	Peptidase_C14	201	442	2.2e-36
PF00619	CARD	37	118	8.3e-19
PF00656	Peptidase_C14	201	442	2.2e-36

Domain ID	Start Site	End Site	E-value
0042519	176	450	2.54e-84
0053685	32	121	6.12e-23
0042519	176	450	2.54e-84
0053685	32	121	6.12e-23

S. No.	Position	Amino acid	Type	Description
1	139	S	Phosphorylation	Phosphoserine
2	157	S	Phosphorylation	Phosphoserine
3	158	T	Phosphorylation	Phosphothreonine
4	169	D	Proteolytic Cleavage	none
5	2	A	Acetylation	N-acetylalanine.
6	340	S	Phosphorylation	Phosphoserine
7	415	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
8	77	K	Sumoylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
9	77	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
10	93	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
11	139	S	Phosphorylation	Phosphoserine
12	157	S	Phosphorylation	Phosphoserine
13	158	T	Phosphorylation	Phosphothreonine
14	169	D	Proteolytic Cleavage	none
15	2	A	Acetylation	N-acetylalanine.
16	340	S	Phosphorylation	Phosphoserine
17	415	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
18	77	K	Sumoylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
19	77	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
20	93	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
CASP2	CASP2	CASP2	ENSP00000312664	P42575
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
P42575	CASP2	ENSP00000312664	CASP2	P42575
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
CASP2	ENSP00000312664	600639	P42575	PA26086

Protein: CASP2

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)

Modelled Structure	Structures available in PDB
	1PYO, 2P2C, 3R5J, 3R6G, 3R6L, 3R7B, 3R7N, 3R7S, 3RJM