ApoCanD

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	HCC24T	Tumour	LIVER	ENST00000422698	c.977T>C	p.I326T	COSMIC	NP	NP
2	HCC86T	Tumour	LIVER	ENST00000422698	c.808T>A	p.S270T	COSMIC	NP	NP
3	PD4937a	Tumour	BREAST	ENST00000422698	c.600C>G	p.F200L	COSMIC	NP	NP
4	ccRCC-11	Tumour	KIDNEY	ENST00000422698	c.467A>T	p.H156L	COSMIC	NP	NP
5	CAL12T	Cell Line	LUNG	ENST00000422698	c.585C>A	p.T195T	COSMIC	NP	NP
6	COLO792	Cell Line	SKIN	ENST00000422698	c.668-5C>T	p.?	COSMIC	NP	NP
7	COLO824	Cell Line	BREAST	ENST00000422698	c.28_29delGT	p.V10fs*18	COSMIC	NP	NP
8	FLO1	Cell Line	OESOPHAGUS	ENST00000422698	c.271G>A	p.D91N	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
9	GP5D	Cell Line	LARGE_INTESTINE	ENST00000422698	c.29T>C	p.V10A	COSMIC	PASSENGER/OTHER	BENIGN
10	HCC2998	Cell Line	LARGE_INTESTINE	ENST00000422698	c.910G>A	p.E304K	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
11	HT55	Cell Line	LARGE_INTESTINE	ENST00000422698	c.817+10T>A	p.?	COSMIC	NP	NP
12	ISTMEL1	Cell Line	SKIN	ENST00000422698	c.433G>A	p.E145K	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
13	JEKO1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000422698	c.709G>A	p.A237T	COSMIC	PASSENGER/OTHER	BENIGN
14	KM12	Cell Line	LARGE_INTESTINE	ENST00000422698	c.90G>C	p.L30F	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
15	KURAMOCHI	Cell Line	OVARY	ENST00000422698	c.709G>A	p.A237T	COSMIC	PASSENGER/OTHER	BENIGN
16	KYSE150	Cell Line	OESOPHAGUS	ENST00000422698	c.433-3C>G	p.?	COSMIC	NP	NP
17	MCF7	Cell Line	BREAST	ENST00000422698	c.817+7G>A	p.?	COSMIC	NP	NP
18	MOLT16	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000422698	c.608G>A	p.R203H	COSMIC	PASSENGER/OTHER	BENIGN
19	MS1	Cell Line	LUNG	ENST00000422698	c.709G>A	p.A237T	COSMIC	PASSENGER/OTHER	BENIGN
20	NCIH1105	Cell Line	LUNG	ENST00000422698	c.814C>A	p.P272T	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
21	NCIH1623	Cell Line	LUNG	ENST00000422698	c.76A>T	p.I26F	COSMIC	PASSENGER/OTHER	BENIGN
22	NCIH1693	Cell Line	LUNG	ENST00000422698	c.234G>T	p.W78C	COSMIC	PASSENGER/OTHER	BENIGN
23	NCIH1703	Cell Line	LUNG	ENST00000422698	c.286G>T	p.A96S	COSMIC	PASSENGER/OTHER	BENIGN
24	NCIH1792	Cell Line	LUNG	ENST00000422698	c.742G>A	p.G248S	COSMIC	PASSENGER/OTHER	BENIGN
25	NCIH187	Cell Line	LUNG	ENST00000422698	c.540G>T	p.G180G	COSMIC	NP	NP
26	NCIH2347	Cell Line	LUNG	ENST00000422698	c.297T>C	p.P99P	COSMIC	NP	NP
27	NCIH250	Cell Line	LUNG	ENST00000422698	c.49T>C	p.L17L	COSMIC	NP	NP
28	NCIH250	Cell Line	LUNG	ENST00000422698	c.639G>C	p.K213N	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
29	NCIH250	Cell Line	LUNG	ENST00000422698	c.990C>G	p.S330S	COSMIC	NP	NP
30	OSC19	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000422698	c.46A>T	p.K16*	COSMIC	NP	NP
31	ROS50	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000422698	c.310C>T	p.R104C	COSMIC	PASSENGER/OTHER	BENIGN
32	RPMI8866	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000422698	c.875A>G	p.Y292C	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
33	SCC9	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000422698	c.482C>A	p.S161Y	COSMIC	PASSENGER/OTHER	BENIGN
34	SKMES1	Cell Line	LUNG	ENST00000422698	c.612C>A	p.N204K	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
35	SKMM2	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000422698	c.871A>G	p.I291V	COSMIC	PASSENGER/OTHER	BENIGN
36	SKUT1	Cell Line	SOFT_TISSUE	ENST00000422698	c.294G>A	p.M98I	COSMIC	PASSENGER/OTHER	BENIGN
37	SN12C	Cell Line	KIDNEY	ENST00000422698	c.25G>C	p.G9R	COSMIC	PASSENGER/OTHER	BENIGN
38	SNGM	Cell Line	ENDOMETRIUM	ENST00000422698	c.246delA	p.K82fs*3	COSMIC	NP	NP
39	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000422698	c.660C>G	p.C220W	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
40	SNU81	Cell Line	LARGE_INTESTINE	ENST00000422698	c.833G>T	p.R278I	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
41	SW1573	Cell Line	LUNG	ENST00000422698	c.827C>A	p.S276Y	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
42	TT	Cell Line	OESOPHAGUS	ENST00000422698	c.445G>A	p.A149T	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
43	U2OS	Cell Line	BONE	ENST00000422698	c.214A>C	p.I72L	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
44	HCC24T	Tumour	LIVER	ENST00000422698	c.977T>C	p.I326T	COSMIC	NP	NP
45	HCC86T	Tumour	LIVER	ENST00000422698	c.808T>A	p.S270T	COSMIC	NP	NP
46	PD4937a	Tumour	BREAST	ENST00000422698	c.600C>G	p.F200L	COSMIC	NP	NP
47	ccRCC-11	Tumour	KIDNEY	ENST00000422698	c.467A>T	p.H156L	COSMIC	NP	NP
48	CAL12T	Cell Line	LUNG	ENST00000422698	c.585C>A	p.T195T	COSMIC	NP	NP
49	COLO792	Cell Line	SKIN	ENST00000422698	c.668-5C>T	p.?	COSMIC	NP	NP
50	COLO824	Cell Line	BREAST	ENST00000422698	c.28_29delGT	p.V10fs*18	COSMIC	NP	NP
51	FLO1	Cell Line	OESOPHAGUS	ENST00000422698	c.271G>A	p.D91N	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
52	GP5D	Cell Line	LARGE_INTESTINE	ENST00000422698	c.29T>C	p.V10A	COSMIC	PASSENGER/OTHER	BENIGN
53	HCC2998	Cell Line	LARGE_INTESTINE	ENST00000422698	c.910G>A	p.E304K	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
54	HT55	Cell Line	LARGE_INTESTINE	ENST00000422698	c.817+10T>A	p.?	COSMIC	NP	NP
55	ISTMEL1	Cell Line	SKIN	ENST00000422698	c.433G>A	p.E145K	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
56	JEKO1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000422698	c.709G>A	p.A237T	COSMIC	PASSENGER/OTHER	BENIGN
57	KM12	Cell Line	LARGE_INTESTINE	ENST00000422698	c.90G>C	p.L30F	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
58	KURAMOCHI	Cell Line	OVARY	ENST00000422698	c.709G>A	p.A237T	COSMIC	PASSENGER/OTHER	BENIGN
59	KYSE150	Cell Line	OESOPHAGUS	ENST00000422698	c.433-3C>G	p.?	COSMIC	NP	NP
60	MCF7	Cell Line	BREAST	ENST00000422698	c.817+7G>A	p.?	COSMIC	NP	NP
61	MOLT16	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000422698	c.608G>A	p.R203H	COSMIC	PASSENGER/OTHER	BENIGN
62	MS1	Cell Line	LUNG	ENST00000422698	c.709G>A	p.A237T	COSMIC	PASSENGER/OTHER	BENIGN
63	NCIH1105	Cell Line	LUNG	ENST00000422698	c.814C>A	p.P272T	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
64	NCIH1623	Cell Line	LUNG	ENST00000422698	c.76A>T	p.I26F	COSMIC	PASSENGER/OTHER	BENIGN
65	NCIH1693	Cell Line	LUNG	ENST00000422698	c.234G>T	p.W78C	COSMIC	PASSENGER/OTHER	BENIGN
66	NCIH1703	Cell Line	LUNG	ENST00000422698	c.286G>T	p.A96S	COSMIC	PASSENGER/OTHER	BENIGN
67	NCIH1792	Cell Line	LUNG	ENST00000422698	c.742G>A	p.G248S	COSMIC	PASSENGER/OTHER	BENIGN
68	NCIH187	Cell Line	LUNG	ENST00000422698	c.540G>T	p.G180G	COSMIC	NP	NP
69	NCIH2347	Cell Line	LUNG	ENST00000422698	c.297T>C	p.P99P	COSMIC	NP	NP
70	NCIH250	Cell Line	LUNG	ENST00000422698	c.49T>C	p.L17L	COSMIC	NP	NP
71	NCIH250	Cell Line	LUNG	ENST00000422698	c.639G>C	p.K213N	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
72	NCIH250	Cell Line	LUNG	ENST00000422698	c.990C>G	p.S330S	COSMIC	NP	NP
73	OSC19	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000422698	c.46A>T	p.K16*	COSMIC	NP	NP
74	ROS50	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000422698	c.310C>T	p.R104C	COSMIC	PASSENGER/OTHER	BENIGN
75	RPMI8866	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000422698	c.875A>G	p.Y292C	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
76	SCC9	Cell Line	UPPER_AERODIGESTIVE_TRACT	ENST00000422698	c.482C>A	p.S161Y	COSMIC	PASSENGER/OTHER	BENIGN
77	SKMES1	Cell Line	LUNG	ENST00000422698	c.612C>A	p.N204K	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
78	SKMM2	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000422698	c.871A>G	p.I291V	COSMIC	PASSENGER/OTHER	BENIGN
79	SKUT1	Cell Line	SOFT_TISSUE	ENST00000422698	c.294G>A	p.M98I	COSMIC	PASSENGER/OTHER	BENIGN
80	SN12C	Cell Line	KIDNEY	ENST00000422698	c.25G>C	p.G9R	COSMIC	PASSENGER/OTHER	BENIGN
81	SNGM	Cell Line	ENDOMETRIUM	ENST00000422698	c.246delA	p.K82fs*3	COSMIC	NP	NP
82	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000422698	c.660C>G	p.C220W	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
83	SNU81	Cell Line	LARGE_INTESTINE	ENST00000422698	c.833G>T	p.R278I	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
84	SW1573	Cell Line	LUNG	ENST00000422698	c.827C>A	p.S276Y	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
85	TT	Cell Line	OESOPHAGUS	ENST00000422698	c.445G>A	p.A149T	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
86	U2OS	Cell Line	BONE	ENST00000422698	c.214A>C	p.I72L	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING

*NP: Not Predicted

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	3.8103	3.8039	-0.2392	-0.1185
BILIARY TRACT	3.9622	3.9417	-0.1917	-0.1996
BONE	3.8871	3.8682	-0.0032	-0.0033
BREAST	3.8529	3.8428	-0.1577	-0.04385
CENTRAL NERVOUS SYSTEM	3.8992	3.895	-0.1444	-0.0773
ENDOMETRIUM	3.9066	3.8696	-0.0138	-0.0087
HAEMATOPOIETIC AND LYMPHOID TISSUE	4.0137	4.0091	0.0230	-0.00438
KIDNEY	3.8615	3.805	-0.2082	-0.1612
LARGE INTESTINE	3.8787	3.8334	0.0745	-0.00275
LIVER	3.8658	3.8634	-0.0431	0.05235
LUNG	3.8402	3.8249	0.1136	0.12525
OESOPHAGUS	3.8654	3.88295	0.0050	0.14885
OVARY	3.8794	3.8392	0.0965	0.1005
PANCREAS	3.9432	3.9069	0.2020	0.2523
PLEURA	3.8749	3.8633	-0.1663	-0.1774
PROSTATE	3.7746	3.7187	0.0955	0.04605
SALIVARY GLAND	4.0962	4.0962	-0.4050	-0.405
SKIN	3.8979	3.8935	-0.3170	-0.1878
SMALL INTESTINE	3.7719	3.7719	-0.0067	-0.0067
SOFT TISSUE	3.9005	3.84365	-0.0533	-0.022675
STOMACH	3.9600	3.91305	0.0887	0.10805
THYROID	3.7450	3.7002	0.0004	-0.01511
UPPER AERODIGESTIVE TRACT	3.9332	3.90185	-0.0140	0.020045
URINARY TRACT	3.8956	3.82435	-0.0758	-0.00175

Domain ID	Domain Name	Start Site	End Site	E-value
PF00619	CARD	13	89	2e-14
PF00656	Peptidase_C14	103	336	2.5e-37
PF01504	PIP5K	204	317	0.13
PF00619	CARD	13	89	2e-14
PF00656	Peptidase_C14	103	336	2.5e-37
PF01504	PIP5K	204	317	0.13

Domain ID	Start Site	End Site	E-value
0039807	101	340	9.42e-73
0036420	9	87	1.71e-12
0039807	101	340	9.42e-73
0036420	9	87	1.71e-12

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
CASP12	CASP12	CASP12	ENSP00000424038	Q6UXS9
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
Q6UXS9	CASP12	ENSP00000424038	CASP12	Q6UXS9
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
CASP12	ENSP00000424038	608633	Q6UXS9	PA38776

Protein: CASP12

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)

Modelled Structure	Structures available in PDB
	Structure is not available in PDB