ApoCanD

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	MEWO	Cell Line	SKIN	NP_116756	c.1490C>T	p.S497L	CCLE	PASSENGER/OTHER	Probably Damaging
2	HCT15	Cell Line	LARGE INTESTINE	NP_116759	c.42A>C	p.K14N	CCLE	PASSENGER/OTHER	Benign
3	HEC151	Cell Line	ENDOMETRIUM	NP_116759	c.554T>C	p.I185T	CCLE	CANCER	Probably Damaging
4	HEC251	Cell Line	ENDOMETRIUM	NP_116759	c.1136C>A	p.S379Y	CCLE	PASSENGER/OTHER	Probably Damaging
5	HS729	Cell Line	SOFT TISSUE	NP_116759	c.548G>T	p.R183I	CCLE	CANCER	Probably Damaging
6	IGROV1	Cell Line	OVARY	NP_116759	c.124C>A	p.L42I	CCLE	CANCER	Probably Damaging
7	L540	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_116759	c.1535T>G	p.V512G	CCLE	NP	NP
8	LS411N	Cell Line	LARGE INTESTINE	NP_116759	c.106G>A	p.V36M	CCLE	CANCER	Probably Damaging
9	NCIH1648	Cell Line	LUNG	NP_116759	c.813G>C	p.K271N	CCLE	PASSENGER/OTHER	Benign
10	NCIH1838	Cell Line	LUNG	NP_116759	c.683C>T	p.P228L	CCLE	PASSENGER/OTHER	Possibly Damaging
11	NCIH226	Cell Line	LUNG	NP_116759	c.683C>T	p.P228L	CCLE	PASSENGER/OTHER	Possibly Damaging
12	REH	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_116759	c.1415G>A	p.R472K	CCLE	PASSENGER/OTHER	Probably Damaging
13	RKO	Cell Line	LARGE INTESTINE	NP_116759	c.1134G>A	p.M378I	CCLE	PASSENGER/OTHER	Benign
14	SHSY5Y	Cell Line	AUTONOMIC GANGLIA	NP_116759	c.887C>T	p.S296F	CCLE	PASSENGER/OTHER	Probably Damaging
15	SKNSH	Cell Line	AUTONOMIC GANGLIA	NP_116759	c.887C>T	p.S296F	CCLE	PASSENGER/OTHER	Probably Damaging
16	SNU1040	Cell Line	LARGE INTESTINE	NP_116759	c.1049G>A	p.C350Y	CCLE	PASSENGER/OTHER	Probably Damaging
17	SNU175	Cell Line	LARGE INTESTINE	NP_116759	c.259C>T	p.R87W	CCLE	CANCER	Probably Damaging
18	SNUC5	Cell Line	LARGE INTESTINE	NP_116759	c.515A>G	p.D172G	CCLE	CANCER	Possibly Damaging
19	TUHR14TKB	Cell Line	KIDNEY	NP_116759	c.440T>C	p.M147T	CCLE	CANCER	Benign
20	587376	Tumour	LARGE INTESTINE	ENST00000286186	c.3G>T	p.M1I	COSMIC	NP	NP
21	91698	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000286186	c.95G>A	p.G32E	COSMIC	NP	NP
22	99179	Tumour	BREAST	ENST00000286186	c.174C>A	p.A58A	COSMIC	NP	NP
23	BN02T	Tumour	LIVER	ENST00000286186	c.231C>G	p.F77L	COSMIC	NP	NP
24	BT-549	Cell Line	BREAST	ENST00000286186	c.1202_1208delGCCAAGG	p.C401fs*15	COSMIC	NP	NP
25	COLO-829	Cell Line	SKIN	ENST00000286186	c.717T>C	p.S239S	COSMIC	NP	NP
26	ESO-717	Tumour	OESOPHAGUS	ENST00000286186	c.536C>T	p.P179L	COSMIC	NP	NP
27	HCC2998	Cell Line	LARGE INTESTINE	ENST00000286186	c.1237G>A	p.E413K	COSMIC	NP	NP
28	LUAD-F00365	Tumour	LUNG	ENST00000286186	c.293C>G	p.T98S	COSMIC	NP	NP
29	LUAD-RT-S01699	Tumour	LUNG	ENST00000286186	c.1258G>A	p.E420K	COSMIC	NP	NP
30	MZ7-mel	Cell Line	SKIN	ENST00000286186	c.225C>T	p.D75D	COSMIC	NP	NP
31	PA285	Cell Line	PANCREAS	ENST00000286186	c.1419T>C	p.H473H	COSMIC	NP	NP
32	PD4105a	Tumour	BREAST	ENST00000286186	c.1452C>T	p.N484N	COSMIC	NP	NP
33	Pa10X	Tumour	PANCREAS	ENST00000286186	c.1366A>G	p.S456G	COSMIC	NP	NP
34	TCGA-05-4424-01	Tumour	LUNG	ENST00000286186	c.1360G>C	p.E454Q	COSMIC	NP	NP
35	TCGA-05-4424-01	Tumour	LUNG	ENST00000286186	c.251A>G	p.Y84C	COSMIC	NP	NP
36	TCGA-06-0156-01	Tumour	CENTRAL NERVOUS SYSTEM	ENST00000286186	c.1065T>C	p.I355I	COSMIC	NP	NP
37	TCGA-06-0156-01	Tumour	CENTRAL NERVOUS SYSTEM	ENST00000286186	c.1096T>A	p.S366T	COSMIC	NP	NP
38	TCGA-06-0210-01	Tumour	CENTRAL NERVOUS SYSTEM	ENST00000286186	c.1065T>A	p.I355I	COSMIC	NP	NP
39	TCGA-06-0210-01	Tumour	CENTRAL NERVOUS SYSTEM	ENST00000286186	c.1096T>A	p.S366T	COSMIC	NP	NP
40	TCGA-13-1482-01	Tumour	OVARY	ENST00000286186	c.756C>T	p.V252V	COSMIC	NP	NP
41	TCGA-33-4566-01	Tumour	LUNG	ENST00000286186	c.1262A>T	p.Q421L	COSMIC	NP	NP
42	TCGA-38-4625-01	Tumour	LUNG	ENST00000286186	c.1195C>T	p.Q399*	COSMIC	NP	NP
43	TCGA-55-8089-01	Tumour	LUNG	ENST00000286186	c.1393C>G	p.H465D	COSMIC	NP	NP
44	TCGA-60-2698-01	Tumour	LUNG	ENST00000286186	c.202G>A	p.E68K	COSMIC	NP	NP
45	TCGA-66-2778-01	Tumour	LUNG	ENST00000286186	c.620C>T	p.S207L	COSMIC	NP	NP
46	TCGA-A6-5657-01	Tumour	LARGE INTESTINE	ENST00000286186	c.755T>C	p.V252A	COSMIC	NP	NP
47	TCGA-AA-3516-01	Tumour	LARGE INTESTINE	ENST00000286186	c.1038C>T	p.A346A	COSMIC	NP	NP
48	TCGA-AA-3517-01	Tumour	LARGE INTESTINE	ENST00000286186	c.1117C>G	p.P373A	COSMIC	NP	NP
49	TCGA-AA-3712-01	Tumour	LARGE INTESTINE	ENST00000286186	c.755T>C	p.V252A	COSMIC	NP	NP
50	TCGA-AA-3877-01	Tumour	LARGE INTESTINE	ENST00000286186	c.648C>T	p.S216S	COSMIC	NP	NP
51	TCGA-AB-2849-03	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000286186	c.593C>A	p.T198K	COSMIC	NP	NP
52	TCGA-AG-A002-01	Tumour	LARGE INTESTINE	ENST00000286186	c.984G>A	p.T328T	COSMIC	NP	NP
53	TCGA-AP-A051-01	Tumour	ENDOMETRIUM	ENST00000286186	c.247C>A	p.L83I	COSMIC	NP	NP
54	TCGA-AP-A056-01	Tumour	ENDOMETRIUM	ENST00000286186	c.984G>A	p.T328T	COSMIC	NP	NP
55	TCGA-AP-A0LM-01	Tumour	ENDOMETRIUM	ENST00000286186	c.616G>A	p.E206K	COSMIC	NP	NP
56	TCGA-AZ-4315-01	Tumour	LARGE INTESTINE	ENST00000286186	c.984G>A	p.T328T	COSMIC	NP	NP
57	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000286186	c.66G>T	p.E22D	COSMIC	NP	NP
58	TCGA-BS-A0UV-01	Tumour	ENDOMETRIUM	ENST00000286186	c.195C>A	p.L65L	COSMIC	NP	NP
59	TCGA-BS-A0UV-01	Tumour	ENDOMETRIUM	ENST00000286186	c.993A>G	p.E331E	COSMIC	NP	NP
60	TCGA-CM-5861-01	Tumour	LARGE INTESTINE	ENST00000286186	c.903A>C	p.Q301H	COSMIC	NP	NP
61	TCGA-D1-A103-01	Tumour	ENDOMETRIUM	ENST00000286186	c.984G>A	p.T328T	COSMIC	NP	NP
62	TCGA-D1-A16Y-01	Tumour	ENDOMETRIUM	ENST00000286186	c.1123C>T	p.R375W	COSMIC	NP	NP
63	TCGA-D1-A17Q-01	Tumour	ENDOMETRIUM	ENST00000286186	c.64G>T	p.E22*	COSMIC	NP	NP
64	TCGA-G4-6293-01	Tumour	LARGE INTESTINE	ENST00000286186	c.755T>C	p.V252A	COSMIC	NP	NP
65	TWH	Tumour	STOMACH	ENST00000286186	c.159G>C	p.E53D	COSMIC	NP	NP
66	WA48	Tumour	PROSTATE	ENST00000286186	c.346A>T	p.R116*	COSMIC	NP	NP
67	YUDIALE	Tumour	SKIN	ENST00000286186	c.816G>A	p.R272R	COSMIC	NP	NP
68	AN3CA	Cell Line	ENDOMETRIUM	ENST00000286186	c.63T>C	p.R21R	COSMIC	NP	NP
69	COLO829	Cell Line	SKIN	ENST00000286186	c.717T>C	p.S239S	COSMIC	NP	NP
70	EFO27	Cell Line	OVARY	ENST00000286186	c.1227C>T	p.S409S	COSMIC	NP	NP
71	EN	Cell Line	ENDOMETRIUM	ENST00000286186	c.440T>C	p.M147T	COSMIC	CANCER	BENIGN
72	HCC1428	Cell Line	BREAST	ENST00000286186	c.1191C>T	p.F397F	COSMIC	NP	NP
73	HCC2998	Cell Line	LARGE_INTESTINE	ENST00000286186	c.1237G>A	p.E413K	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
74	HCT15	Cell Line	LARGE_INTESTINE	ENST00000286186	c.1038C>T	p.A346A	COSMIC	NP	NP
75	HCT15	Cell Line	LARGE_INTESTINE	ENST00000286186	c.42A>C	p.K14N	COSMIC	PASSENGER/OTHER	BENIGN
76	JURKAT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000286186	c.1088C>A	p.A363D	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
77	KCL22	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000286186	c.13G>A	p.G5S	COSMIC	PASSENGER/OTHER	BENIGN
78	L540	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000286186	c.1535T>G	p.V512G	COSMIC	NP	NP
79	LS411N	Cell Line	LARGE_INTESTINE	ENST00000286186	c.106G>A	p.V36M	COSMIC	CANCER	PROBABLY DAMAGING
80	MDAMB330	Cell Line	BREAST	ENST00000286186	c.195C>A	p.L65L	COSMIC	NP	NP
81	MZ1PC	Cell Line	PANCREAS	ENST00000286186	c.255C>A	p.I85I	COSMIC	NP	NP
82	MZ7MEL	Cell Line	SKIN	ENST00000286186	c.225C>T	p.D75D	COSMIC	NP	NP
83	NCIH1648	Cell Line	LUNG	ENST00000286186	c.813G>C	p.K271N	COSMIC	PASSENGER/OTHER	BENIGN
84	NCIH1838	Cell Line	LUNG	ENST00000286186	c.683C>T	p.P228L	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
85	NCIH226	Cell Line	LUNG	ENST00000286186	c.683C>T	p.P228L	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
86	NCIH28	Cell Line	PLEURA	ENST00000286186	c.722-4C>A	p.?	COSMIC	NP	NP
87	NCIH524	Cell Line	LUNG	ENST00000286186	c.348-10T>C	p.?	COSMIC	NP	NP
88	NCIH727	Cell Line	LUNG	ENST00000286186	c.1053C>T	p.F351F	COSMIC	NP	NP
89	NOMO1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000286186	c.1466G>A	p.R489Q	COSMIC	NP	NP
90	NY	Cell Line	BONE	ENST00000286186	c.681A>G	p.L227L	COSMIC	NP	NP
91	OCUBM	Cell Line	BREAST	ENST00000286186	c.332G>C	p.R111T	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
92	RH18	Cell Line	SOFT_TISSUE	ENST00000286186	c.853C>T	p.L285F	COSMIC	PASSENGER/OTHER	NP
93	RKO	Cell Line	LARGE_INTESTINE	ENST00000286186	c.1134G>A	p.M378I	COSMIC	PASSENGER/OTHER	BENIGN
94	SKNAS	Cell Line	AUTONOMIC_GANGLIA	ENST00000286186	c.643G>T	p.V215F	COSMIC	PASSENGER/OTHER	BENIGN
95	SN12C	Cell Line	KIDNEY	ENST00000286186	c.1386G>T	p.L462L	COSMIC	NP	NP
96	SNU175	Cell Line	LARGE_INTESTINE	ENST00000286186	c.259C>T	p.R87W	COSMIC	CANCER	PROBABLY DAMAGING
97	SNU407	Cell Line	LARGE_INTESTINE	ENST00000286186	c.226C>A	p.P76T	COSMIC	CANCER	BENIGN
98	SNUC5	Cell Line	LARGE_INTESTINE	ENST00000286186	c.515A>G	p.D172G	COSMIC	CANCER	POSSIBLY DAMAGING
99	MEWO	Cell Line	SKIN	NP_116756	c.1490C>T	p.S497L	CCLE	PASSENGER/OTHER	Probably Damaging
100	HCT15	Cell Line	LARGE INTESTINE	NP_116759	c.42A>C	p.K14N	CCLE	PASSENGER/OTHER	Benign
101	HEC151	Cell Line	ENDOMETRIUM	NP_116759	c.554T>C	p.I185T	CCLE	CANCER	Probably Damaging
102	HEC251	Cell Line	ENDOMETRIUM	NP_116759	c.1136C>A	p.S379Y	CCLE	PASSENGER/OTHER	Probably Damaging
103	HS729	Cell Line	SOFT TISSUE	NP_116759	c.548G>T	p.R183I	CCLE	CANCER	Probably Damaging
104	IGROV1	Cell Line	OVARY	NP_116759	c.124C>A	p.L42I	CCLE	CANCER	Probably Damaging
105	L540	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_116759	c.1535T>G	p.V512G	CCLE	NP	NP
106	LS411N	Cell Line	LARGE INTESTINE	NP_116759	c.106G>A	p.V36M	CCLE	CANCER	Probably Damaging
107	NCIH1648	Cell Line	LUNG	NP_116759	c.813G>C	p.K271N	CCLE	PASSENGER/OTHER	Benign
108	NCIH1838	Cell Line	LUNG	NP_116759	c.683C>T	p.P228L	CCLE	PASSENGER/OTHER	Possibly Damaging
109	NCIH226	Cell Line	LUNG	NP_116759	c.683C>T	p.P228L	CCLE	PASSENGER/OTHER	Possibly Damaging
110	REH	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_116759	c.1415G>A	p.R472K	CCLE	PASSENGER/OTHER	Probably Damaging
111	RKO	Cell Line	LARGE INTESTINE	NP_116759	c.1134G>A	p.M378I	CCLE	PASSENGER/OTHER	Benign
112	SHSY5Y	Cell Line	AUTONOMIC GANGLIA	NP_116759	c.887C>T	p.S296F	CCLE	PASSENGER/OTHER	Probably Damaging
113	SKNSH	Cell Line	AUTONOMIC GANGLIA	NP_116759	c.887C>T	p.S296F	CCLE	PASSENGER/OTHER	Probably Damaging
114	SNU1040	Cell Line	LARGE INTESTINE	NP_116759	c.1049G>A	p.C350Y	CCLE	PASSENGER/OTHER	Probably Damaging
115	SNU175	Cell Line	LARGE INTESTINE	NP_116759	c.259C>T	p.R87W	CCLE	CANCER	Probably Damaging
116	SNUC5	Cell Line	LARGE INTESTINE	NP_116759	c.515A>G	p.D172G	CCLE	CANCER	Possibly Damaging
117	TUHR14TKB	Cell Line	KIDNEY	NP_116759	c.440T>C	p.M147T	CCLE	CANCER	Benign
118	587376	Tumour	LARGE INTESTINE	ENST00000286186	c.3G>T	p.M1I	COSMIC	NP	NP
119	91698	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000286186	c.95G>A	p.G32E	COSMIC	NP	NP
120	99179	Tumour	BREAST	ENST00000286186	c.174C>A	p.A58A	COSMIC	NP	NP
121	BN02T	Tumour	LIVER	ENST00000286186	c.231C>G	p.F77L	COSMIC	NP	NP
122	BT-549	Cell Line	BREAST	ENST00000286186	c.1202_1208delGCCAAGG	p.C401fs*15	COSMIC	NP	NP
123	COLO-829	Cell Line	SKIN	ENST00000286186	c.717T>C	p.S239S	COSMIC	NP	NP
124	ESO-717	Tumour	OESOPHAGUS	ENST00000286186	c.536C>T	p.P179L	COSMIC	NP	NP
125	HCC2998	Cell Line	LARGE INTESTINE	ENST00000286186	c.1237G>A	p.E413K	COSMIC	NP	NP
126	LUAD-F00365	Tumour	LUNG	ENST00000286186	c.293C>G	p.T98S	COSMIC	NP	NP
127	LUAD-RT-S01699	Tumour	LUNG	ENST00000286186	c.1258G>A	p.E420K	COSMIC	NP	NP
128	MZ7-mel	Cell Line	SKIN	ENST00000286186	c.225C>T	p.D75D	COSMIC	NP	NP
129	PA285	Cell Line	PANCREAS	ENST00000286186	c.1419T>C	p.H473H	COSMIC	NP	NP
130	PD4105a	Tumour	BREAST	ENST00000286186	c.1452C>T	p.N484N	COSMIC	NP	NP
131	Pa10X	Tumour	PANCREAS	ENST00000286186	c.1366A>G	p.S456G	COSMIC	NP	NP
132	TCGA-05-4424-01	Tumour	LUNG	ENST00000286186	c.1360G>C	p.E454Q	COSMIC	NP	NP
133	TCGA-05-4424-01	Tumour	LUNG	ENST00000286186	c.251A>G	p.Y84C	COSMIC	NP	NP
134	TCGA-06-0156-01	Tumour	CENTRAL NERVOUS SYSTEM	ENST00000286186	c.1065T>C	p.I355I	COSMIC	NP	NP
135	TCGA-06-0156-01	Tumour	CENTRAL NERVOUS SYSTEM	ENST00000286186	c.1096T>A	p.S366T	COSMIC	NP	NP
136	TCGA-06-0210-01	Tumour	CENTRAL NERVOUS SYSTEM	ENST00000286186	c.1065T>A	p.I355I	COSMIC	NP	NP
137	TCGA-06-0210-01	Tumour	CENTRAL NERVOUS SYSTEM	ENST00000286186	c.1096T>A	p.S366T	COSMIC	NP	NP
138	TCGA-13-1482-01	Tumour	OVARY	ENST00000286186	c.756C>T	p.V252V	COSMIC	NP	NP
139	TCGA-33-4566-01	Tumour	LUNG	ENST00000286186	c.1262A>T	p.Q421L	COSMIC	NP	NP
140	TCGA-38-4625-01	Tumour	LUNG	ENST00000286186	c.1195C>T	p.Q399*	COSMIC	NP	NP
141	TCGA-55-8089-01	Tumour	LUNG	ENST00000286186	c.1393C>G	p.H465D	COSMIC	NP	NP
142	TCGA-60-2698-01	Tumour	LUNG	ENST00000286186	c.202G>A	p.E68K	COSMIC	NP	NP
143	TCGA-66-2778-01	Tumour	LUNG	ENST00000286186	c.620C>T	p.S207L	COSMIC	NP	NP
144	TCGA-A6-5657-01	Tumour	LARGE INTESTINE	ENST00000286186	c.755T>C	p.V252A	COSMIC	NP	NP
145	TCGA-AA-3516-01	Tumour	LARGE INTESTINE	ENST00000286186	c.1038C>T	p.A346A	COSMIC	NP	NP
146	TCGA-AA-3517-01	Tumour	LARGE INTESTINE	ENST00000286186	c.1117C>G	p.P373A	COSMIC	NP	NP
147	TCGA-AA-3712-01	Tumour	LARGE INTESTINE	ENST00000286186	c.755T>C	p.V252A	COSMIC	NP	NP
148	TCGA-AA-3877-01	Tumour	LARGE INTESTINE	ENST00000286186	c.648C>T	p.S216S	COSMIC	NP	NP
149	TCGA-AB-2849-03	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000286186	c.593C>A	p.T198K	COSMIC	NP	NP
150	TCGA-AG-A002-01	Tumour	LARGE INTESTINE	ENST00000286186	c.984G>A	p.T328T	COSMIC	NP	NP
151	TCGA-AP-A051-01	Tumour	ENDOMETRIUM	ENST00000286186	c.247C>A	p.L83I	COSMIC	NP	NP
152	TCGA-AP-A056-01	Tumour	ENDOMETRIUM	ENST00000286186	c.984G>A	p.T328T	COSMIC	NP	NP
153	TCGA-AP-A0LM-01	Tumour	ENDOMETRIUM	ENST00000286186	c.616G>A	p.E206K	COSMIC	NP	NP
154	TCGA-AZ-4315-01	Tumour	LARGE INTESTINE	ENST00000286186	c.984G>A	p.T328T	COSMIC	NP	NP
155	TCGA-BS-A0UF-01	Tumour	ENDOMETRIUM	ENST00000286186	c.66G>T	p.E22D	COSMIC	NP	NP
156	TCGA-BS-A0UV-01	Tumour	ENDOMETRIUM	ENST00000286186	c.195C>A	p.L65L	COSMIC	NP	NP
157	TCGA-BS-A0UV-01	Tumour	ENDOMETRIUM	ENST00000286186	c.993A>G	p.E331E	COSMIC	NP	NP
158	TCGA-CM-5861-01	Tumour	LARGE INTESTINE	ENST00000286186	c.903A>C	p.Q301H	COSMIC	NP	NP
159	TCGA-D1-A103-01	Tumour	ENDOMETRIUM	ENST00000286186	c.984G>A	p.T328T	COSMIC	NP	NP
160	TCGA-D1-A16Y-01	Tumour	ENDOMETRIUM	ENST00000286186	c.1123C>T	p.R375W	COSMIC	NP	NP
161	TCGA-D1-A17Q-01	Tumour	ENDOMETRIUM	ENST00000286186	c.64G>T	p.E22*	COSMIC	NP	NP
162	TCGA-G4-6293-01	Tumour	LARGE INTESTINE	ENST00000286186	c.755T>C	p.V252A	COSMIC	NP	NP
163	TWH	Tumour	STOMACH	ENST00000286186	c.159G>C	p.E53D	COSMIC	NP	NP
164	WA48	Tumour	PROSTATE	ENST00000286186	c.346A>T	p.R116*	COSMIC	NP	NP
165	YUDIALE	Tumour	SKIN	ENST00000286186	c.816G>A	p.R272R	COSMIC	NP	NP
166	AN3CA	Cell Line	ENDOMETRIUM	ENST00000286186	c.63T>C	p.R21R	COSMIC	NP	NP
167	COLO829	Cell Line	SKIN	ENST00000286186	c.717T>C	p.S239S	COSMIC	NP	NP
168	EFO27	Cell Line	OVARY	ENST00000286186	c.1227C>T	p.S409S	COSMIC	NP	NP
169	EN	Cell Line	ENDOMETRIUM	ENST00000286186	c.440T>C	p.M147T	COSMIC	CANCER	BENIGN
170	HCC1428	Cell Line	BREAST	ENST00000286186	c.1191C>T	p.F397F	COSMIC	NP	NP
171	HCC2998	Cell Line	LARGE_INTESTINE	ENST00000286186	c.1237G>A	p.E413K	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
172	HCT15	Cell Line	LARGE_INTESTINE	ENST00000286186	c.1038C>T	p.A346A	COSMIC	NP	NP
173	HCT15	Cell Line	LARGE_INTESTINE	ENST00000286186	c.42A>C	p.K14N	COSMIC	PASSENGER/OTHER	BENIGN
174	JURKAT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000286186	c.1088C>A	p.A363D	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
175	KCL22	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000286186	c.13G>A	p.G5S	COSMIC	PASSENGER/OTHER	BENIGN
176	L540	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000286186	c.1535T>G	p.V512G	COSMIC	NP	NP
177	LS411N	Cell Line	LARGE_INTESTINE	ENST00000286186	c.106G>A	p.V36M	COSMIC	CANCER	PROBABLY DAMAGING
178	MDAMB330	Cell Line	BREAST	ENST00000286186	c.195C>A	p.L65L	COSMIC	NP	NP
179	MZ1PC	Cell Line	PANCREAS	ENST00000286186	c.255C>A	p.I85I	COSMIC	NP	NP
180	MZ7MEL	Cell Line	SKIN	ENST00000286186	c.225C>T	p.D75D	COSMIC	NP	NP
181	NCIH1648	Cell Line	LUNG	ENST00000286186	c.813G>C	p.K271N	COSMIC	PASSENGER/OTHER	BENIGN
182	NCIH1838	Cell Line	LUNG	ENST00000286186	c.683C>T	p.P228L	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
183	NCIH226	Cell Line	LUNG	ENST00000286186	c.683C>T	p.P228L	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
184	NCIH28	Cell Line	PLEURA	ENST00000286186	c.722-4C>A	p.?	COSMIC	NP	NP
185	NCIH524	Cell Line	LUNG	ENST00000286186	c.348-10T>C	p.?	COSMIC	NP	NP
186	NCIH727	Cell Line	LUNG	ENST00000286186	c.1053C>T	p.F351F	COSMIC	NP	NP
187	NOMO1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000286186	c.1466G>A	p.R489Q	COSMIC	NP	NP
188	NY	Cell Line	BONE	ENST00000286186	c.681A>G	p.L227L	COSMIC	NP	NP
189	OCUBM	Cell Line	BREAST	ENST00000286186	c.332G>C	p.R111T	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
190	RH18	Cell Line	SOFT_TISSUE	ENST00000286186	c.853C>T	p.L285F	COSMIC	PASSENGER/OTHER	NP
191	RKO	Cell Line	LARGE_INTESTINE	ENST00000286186	c.1134G>A	p.M378I	COSMIC	PASSENGER/OTHER	BENIGN
192	SKNAS	Cell Line	AUTONOMIC_GANGLIA	ENST00000286186	c.643G>T	p.V215F	COSMIC	PASSENGER/OTHER	BENIGN
193	SN12C	Cell Line	KIDNEY	ENST00000286186	c.1386G>T	p.L462L	COSMIC	NP	NP
194	SNU175	Cell Line	LARGE_INTESTINE	ENST00000286186	c.259C>T	p.R87W	COSMIC	CANCER	PROBABLY DAMAGING
195	SNU407	Cell Line	LARGE_INTESTINE	ENST00000286186	c.226C>A	p.P76T	COSMIC	CANCER	BENIGN
196	SNUC5	Cell Line	LARGE_INTESTINE	ENST00000286186	c.515A>G	p.D172G	COSMIC	CANCER	POSSIBLY DAMAGING

*NP: Not Predicted

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	4.4295	4.4528	0.0664	0.01474
BILIARY TRACT	4.9352	4.9158	0.0997	0.1237
BONE	4.4318	4.4351	0.0308	0.01738
BREAST	4.6432	4.5793	-0.0843	-0.042735
CENTRAL NERVOUS SYSTEM	4.5670	4.5784	0.0014	0.0066
ENDOMETRIUM	4.6957	4.6962	-0.0005	-0.0004109
HAEMATOPOIETIC AND LYMPHOID TISSUE	5.0142	4.9135	-0.0463	4.008e-05
KIDNEY	4.8447	4.8895	0.1781	0.1613
LARGE INTESTINE	4.8037	4.7874	0.0288	0.0245
LIVER	4.6681	4.6483	0.1685	0.1936
LUNG	4.6369	4.63135	0.0419	0.0332
OESOPHAGUS	4.7664	4.675	-0.3760	-0.27755
OVARY	4.7295	4.7394	0.0273	0.04754
PANCREAS	4.8007	4.7901	0.0950	0.1188
PLEURA	4.6270	4.6081	0.1439	0.1769
PROSTATE	4.5557	4.572	-0.0755	-0.030465
SALIVARY GLAND	4.6136	4.6136	0.0894	0.0894
SKIN	4.5759	4.5561	0.1123	0.1091
SMALL INTESTINE	4.5387	4.5387	0.0182	0.01817
SOFT TISSUE	4.5649	4.46095	0.0797	-0.00402
STOMACH	4.7207	4.7108	0.0310	0.017325
THYROID	4.6037	4.6169	-0.0385	-0.07963
UPPER AERODIGESTIVE TRACT	5.0120	4.97415	-0.0785	-0.0107936
URINARY TRACT	4.7129	4.6995	-0.0087	-0.0207

Domain ID	Domain Name	Start Site	End Site	E-value
PF01335	DED	20	101	7.8e-19
PF01335	DED	115	192	4.3e-19
PF00656	Peptidase_C14	284	468	5.7e-37
PF01335	DED	20	101	7.8e-19
PF01335	DED	115	192	4.3e-19
PF00656	Peptidase_C14	284	468	5.7e-37

Domain ID	Start Site	End Site	E-value
0039807	270	472	1.00e-67
0048274	19	124	3.65e-25
0045697	112	189	5.65e-15
0039807	270	472	1.00e-67
0048274	19	124	3.65e-25
0045697	112	189	5.65e-15

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
CASP10	CASP10	CASP10	ENSP00000272879	Q92851
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
Q92851	CASP10	ENSP00000272879	CASP10	Q92851
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
CASP10	ENSP00000272879	601762	Q92851	PA26084

Protein: CASP10

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)

Modelled Structure	Structures available in PDB
	Structure is not available in PDB