ApoCanD

Mutation Data (+)

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	BCP1	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_150634	c.1132G>A	p.E378K	CCLE	PASSENGER/OTHER	Probably Damaging
2	BHY	Cell Line	UPPER AERODIGESTIVE TRACT	NP_150634	c.1184C>G	p.T395R	CCLE	PASSENGER/OTHER	Probably Damaging
3	BL41	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_150634	c.689C>T	p.T230M	CCLE	PASSENGER/OTHER	Probably Damaging
4	DU145	Cell Line	PROSTATE	NP_150634	c.961G>T	p.A321S	CCLE	PASSENGER/OTHER	Benign
5	HT115	Cell Line	LARGE INTESTINE	NP_150634	c.771A>C	p.Q257H	CCLE	PASSENGER/OTHER	Benign
6	HT144	Cell Line	SKIN	NP_150634	c.616C>T	p.L206F	CCLE	PASSENGER/OTHER	Probably Damaging
7	JHH1	Cell Line	LIVER	NP_150634	c.1151C>G	p.A384G	CCLE	PASSENGER/OTHER	Benign
8	JHUEM7	Cell Line	ENDOMETRIUM	NP_150634	c.718C>T	p.R240W	CCLE	PASSENGER/OTHER	Benign
9	JHUEM7	Cell Line	ENDOMETRIUM	NP_150634	c.889G>T	p.D297Y	CCLE	PASSENGER/OTHER	Probably Damaging
10	JMSU1	Cell Line	URINARY TRACT	NP_150634	c.830C>G	p.P277R	CCLE	PASSENGER/OTHER	Probably Damaging
11	LNCAPCLONEFGC	Cell Line	PROSTATE	NP_150634	c.262G>T	p.G88*	CCLE	NP	NP
12	NCIH2286	Cell Line	LUNG	NP_150634	c.196_196delG	p.A66fs	CCLE	NP	NP
13	NCIH2286	Cell Line	LUNG	NP_150634	c.865A>T	p.S289C	CCLE	PASSENGER/OTHER	Benign
14	SKNFI	Cell Line	AUTONOMIC GANGLIA	NP_150634	c.623C>T	p.A208V	CCLE	PASSENGER/OTHER	Probably Damaging
15	SNGM	Cell Line	ENDOMETRIUM	NP_150634	c.242G>A	p.S81N	CCLE	PASSENGER/OTHER	Benign
16	SNUC5	Cell Line	LARGE INTESTINE	NP_150634	c.221C>T	p.T74I	CCLE	PASSENGER/OTHER	Benign
17	SW48	Cell Line	LARGE INTESTINE	NP_150634	c.868C>A	p.P290T	CCLE	PASSENGER/OTHER	Benign
18	141	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000533400	c.950C>A	p.A317D	COSMIC	NP	NP
19	TCGA-23-1024-01	Tumour	OVARY	ENST00000533400	c.985G>A	p.A329T	COSMIC	NP	NP
20	TCGA-23-1027-01	Tumour	OVARY	ENST00000533400	c.614A>T	p.N205I	COSMIC	NP	NP
21	TCGA-AA-3811-01	Tumour	LARGE INTESTINE	ENST00000533400	c.1158G>A	p.M386I	COSMIC	NP	NP
22	TCGA-AA-3977-01	Tumour	LARGE INTESTINE	ENST00000533400	c.804G>T	p.K268N	COSMIC	NP	NP
23	BCP1	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_150634	c.1132G>A	p.E378K	CCLE	PASSENGER/OTHER	Probably Damaging
24	BHY	Cell Line	UPPER AERODIGESTIVE TRACT	NP_150634	c.1184C>G	p.T395R	CCLE	PASSENGER/OTHER	Probably Damaging
25	BL41	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_150634	c.689C>T	p.T230M	CCLE	PASSENGER/OTHER	Probably Damaging
26	DU145	Cell Line	PROSTATE	NP_150634	c.961G>T	p.A321S	CCLE	PASSENGER/OTHER	Benign
27	HT115	Cell Line	LARGE INTESTINE	NP_150634	c.771A>C	p.Q257H	CCLE	PASSENGER/OTHER	Benign
28	HT144	Cell Line	SKIN	NP_150634	c.616C>T	p.L206F	CCLE	PASSENGER/OTHER	Probably Damaging
29	JHH1	Cell Line	LIVER	NP_150634	c.1151C>G	p.A384G	CCLE	PASSENGER/OTHER	Benign
30	JHUEM7	Cell Line	ENDOMETRIUM	NP_150634	c.718C>T	p.R240W	CCLE	PASSENGER/OTHER	Benign
31	JHUEM7	Cell Line	ENDOMETRIUM	NP_150634	c.889G>T	p.D297Y	CCLE	PASSENGER/OTHER	Probably Damaging
32	JMSU1	Cell Line	URINARY TRACT	NP_150634	c.830C>G	p.P277R	CCLE	PASSENGER/OTHER	Probably Damaging
33	LNCAPCLONEFGC	Cell Line	PROSTATE	NP_150634	c.262G>T	p.G88*	CCLE	NP	NP
34	NCIH2286	Cell Line	LUNG	NP_150634	c.196_196delG	p.A66fs	CCLE	NP	NP
35	NCIH2286	Cell Line	LUNG	NP_150634	c.865A>T	p.S289C	CCLE	PASSENGER/OTHER	Benign
36	SKNFI	Cell Line	AUTONOMIC GANGLIA	NP_150634	c.623C>T	p.A208V	CCLE	PASSENGER/OTHER	Probably Damaging
37	SNGM	Cell Line	ENDOMETRIUM	NP_150634	c.242G>A	p.S81N	CCLE	PASSENGER/OTHER	Benign
38	SNUC5	Cell Line	LARGE INTESTINE	NP_150634	c.221C>T	p.T74I	CCLE	PASSENGER/OTHER	Benign
39	SW48	Cell Line	LARGE INTESTINE	NP_150634	c.868C>A	p.P290T	CCLE	PASSENGER/OTHER	Benign
40	141	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000533400	c.950C>A	p.A317D	COSMIC	NP	NP
41	TCGA-23-1024-01	Tumour	OVARY	ENST00000533400	c.985G>A	p.A329T	COSMIC	NP	NP
42	TCGA-23-1027-01	Tumour	OVARY	ENST00000533400	c.614A>T	p.N205I	COSMIC	NP	NP
43	TCGA-AA-3811-01	Tumour	LARGE INTESTINE	ENST00000533400	c.1158G>A	p.M386I	COSMIC	NP	NP
44	TCGA-AA-3977-01	Tumour	LARGE INTESTINE	ENST00000533400	c.804G>T	p.K268N	COSMIC	NP	NP

*NP: Not Predicted

Copy number variation and expression profile (+)

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	4.2731	3.997	-0.2433	-0.1185
BILIARY TRACT	5.9526	5.5344	-0.4362	-0.3536
BONE	5.7011	5.423	-0.0032	-0.0033
BREAST	5.3484	4.50275	-0.1577	-0.04385
CENTRAL NERVOUS SYSTEM	7.1884	7.4892	-0.1443	-0.0773
ENDOMETRIUM	5.1326	4.2094	-0.0138	-0.0087
HAEMATOPOIETIC AND LYMPHOID TISSUE	7.3398	7.8193	0.0121	-0.004838
KIDNEY	5.8343	5.0885	-0.2745	-0.1976
LARGE INTESTINE	5.2223	4.38465	0.0591	-0.005012
LIVER	5.7399	5.2084	-0.0424	0.05235
LUNG	5.1191	4.2389	0.0890	0.12525
OESOPHAGUS	7.3466	8.11265	-0.2245	0.24415
OVARY	5.2601	4.7301	0.0779	0.1005
PANCREAS	5.9378	5.264	0.2035	0.2523
PLEURA	6.6433	6.7161	-0.1663	-0.1774
PROSTATE	4.0699	4.07145	0.0955	0.04605
SALIVARY GLAND	8.8130	8.813	-0.4050	-0.405
SKIN	6.2363	5.9658	-0.3170	-0.1878
SMALL INTESTINE	4.1688	4.1688	-0.0067	-0.0067
SOFT TISSUE	6.0333	4.5721	-0.0533	-0.022675
STOMACH	5.0841	4.5389	0.0887	0.10805
THYROID	6.4405	6.4383	0.0004	-0.01511
UPPER AERODIGESTIVE TRACT	9.0006	9.04215	-0.0140	0.020045
URINARY TRACT	7.2695	7.2152	-0.0758	-0.00175

Gene Essentiality Data (+)

Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.

test

Tertiary structure (+)

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Modelled Structure	Structures available in PDB
	1BMQ, 1IBC, 1ICE, 1RWK, 1RWM, 1RWN, 1RWO, 1RWP, 1RWV, 1RWW, 1RWX, 1SC1, 1SC3, 1SC4, 2FQQ, 2H48, 2H4W, 2H4Y, 2H51, 2H54, 2HBQ, 2HBR, 2HBY, 2HBZ, 3D6F, 3D6H, 3D6M, 3E4C, 3NS7

Structure Domains (+)

1. PFAM Domains:

Domain ID	Domain Name	Start Site	End Site	E-value
PF00619	CARD	4	89	8.2e-24
PF00656	Peptidase_C14	163	399	1.2e-43
PF00619	CARD	4	89	8.2e-24
PF00656	Peptidase_C14	163	399	1.2e-43

2. Superfamily Domains:

Domain ID	Start Site	End Site	E-value
0039807	140	403	2.09e-83
0036420	3	89	1.51e-23
0039807	140	403	2.09e-83
0036420	3	89	1.51e-23

Sequence Alignment (+)

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1. Variants are not present in 1000 Genomes!!

2. Sequence alignment with CCLE mutants:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

3. Sequence alignment with COSMIC mutants:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

4. Sequence alignment with homologus proteins:

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Sequence Profiles (+)

HMM
With Uniprot database	With Mutants	With 1000 Genome Variants

PSSM
With Uniprot database	With Mutants	With 1000 Genome Variant

Post Translational Modifications (+)

S. No.	Position	Amino acid	Type	Description
1	103	D	Proteolytic Cleavage	none
2	119	D	Proteolytic Cleavage	none
3	297	D	Proteolytic Cleavage	none
4	316	D	Proteolytic Cleavage	none
5	376	S	Phosphorylation	Phosphoserine
6	376	S	Phosphorylation (PAK1)	Phosphoserine
7	103	D	Proteolytic Cleavage	none
8	119	D	Proteolytic Cleavage	none
9	297	D	Proteolytic Cleavage	none
10	316	D	Proteolytic Cleavage	none
11	376	S	Phosphorylation	Phosphoserine
12	376	S	Phosphorylation (PAK1)	Phosphoserine

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
CASP1	CASP1	CASP1	ENSP00000344132	P29466
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
P29466	CASP1	ENSP00000344132	CASP1	P29466
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
CASP1	ENSP00000344132	147678	P29466	PA26083

Protein: CASP1

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)