ApoCanD

Mutation Data (+)

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	RCM1	Cell Line	LARGE INTESTINE	NP_115904	c.391G>A	p.A131T	CCLE	PASSENGER/OTHER	Probably Damaging
2	LC	Tumour	C32 LUNG	ENST00000318407	c.150G>A	p.W50*	COSMIC	NP	NP
3	LUAD-RT-S01477	Tumour	LUNG	ENST00000318407	c.525C>A	p.L175L	COSMIC	NP	NP
4	SF268	Cell Line	CENTRAL NERVOUS SYSTEM	ENST00000318407	c.410G>A	p.C137Y	COSMIC	NP	NP
5	TCGA-23-2078-01	Tumour	OVARY	ENST00000318407	c.275T>C	p.L92P	COSMIC	NP	NP
6	TCGA-66-2768-01	Tumour	LUNG	ENST00000318407	c.537C>T	p.V179V	COSMIC	NP	NP
7	TCGA-67-3772-01	Tumour	LUNG	ENST00000318407	c.286C>T	p.L96L	COSMIC	NP	NP
8	TCGA-85-6175-01	Tumour	LUNG	ENST00000318407	c.525C>T	p.L175L	COSMIC	NP	NP
9	TCGA-97-7547-01	Tumour	LUNG	ENST00000318407	c.600C>T	p.F200F	COSMIC	NP	NP
10	TCGA-A6-2672-01	Tumour	LARGE INTESTINE	ENST00000318407	c.539G>A	p.S180N	COSMIC	NP	NP
11	TCGA-A6-6653-01	Tumour	LARGE INTESTINE	ENST00000318407	c.390C>T	p.A130A	COSMIC	NP	NP
12	TCGA-AA-3663-01	Tumour	LARGE INTESTINE	ENST00000318407	c.324C>A	p.A108A	COSMIC	NP	NP
13	TCGA-AD-6895-01	Tumour	LARGE INTESTINE	ENST00000318407	c.314C>T	p.A105V	COSMIC	NP	NP
14	TCGA-B5-A0JY-01	Tumour	ENDOMETRIUM	ENST00000318407	c.468C>A	p.F156L	COSMIC	NP	NP
15	TCGA-B5-A11G-01	Tumour	ENDOMETRIUM	ENST00000318407	c.256C>A	p.R86S	COSMIC	NP	NP
16	TCGA-BT-A2LA-01	Tumour	URINARY TRACT	ENST00000318407	c.384G>A	p.A128A	COSMIC	NP	NP
17	TCGA-CM-6168-01	Tumour	LARGE INTESTINE	ENST00000318407	c.276G>A	p.L92L	COSMIC	NP	NP
18	BT474	Cell Line	BREAST	ENST00000318407	c.555C>G	p.L185L	COSMIC	NP	NP
19	JURKAT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000318407	c.257G>A	p.R86H	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
20	NCIH740	Cell Line	LUNG	ENST00000318407	c.324C>T	p.A108A	COSMIC	NP	NP
21	SKLMS1	Cell Line	SOFT_TISSUE	ENST00000318407	c.514-4C>A	p.?	COSMIC	NP	NP
22	T98G	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000318407	c.384G>A	p.A128A	COSMIC	NP	NP
23	RCM1	Cell Line	LARGE INTESTINE	NP_115904	c.391G>A	p.A131T	CCLE	PASSENGER/OTHER	Probably Damaging
24	LC	Tumour	C32 LUNG	ENST00000318407	c.150G>A	p.W50*	COSMIC	NP	NP
25	LUAD-RT-S01477	Tumour	LUNG	ENST00000318407	c.525C>A	p.L175L	COSMIC	NP	NP
26	SF268	Cell Line	CENTRAL NERVOUS SYSTEM	ENST00000318407	c.410G>A	p.C137Y	COSMIC	NP	NP
27	TCGA-23-2078-01	Tumour	OVARY	ENST00000318407	c.275T>C	p.L92P	COSMIC	NP	NP
28	TCGA-66-2768-01	Tumour	LUNG	ENST00000318407	c.537C>T	p.V179V	COSMIC	NP	NP
29	TCGA-67-3772-01	Tumour	LUNG	ENST00000318407	c.286C>T	p.L96L	COSMIC	NP	NP
30	TCGA-85-6175-01	Tumour	LUNG	ENST00000318407	c.525C>T	p.L175L	COSMIC	NP	NP
31	TCGA-97-7547-01	Tumour	LUNG	ENST00000318407	c.600C>T	p.F200F	COSMIC	NP	NP
32	TCGA-A6-2672-01	Tumour	LARGE INTESTINE	ENST00000318407	c.539G>A	p.S180N	COSMIC	NP	NP
33	TCGA-A6-6653-01	Tumour	LARGE INTESTINE	ENST00000318407	c.390C>T	p.A130A	COSMIC	NP	NP
34	TCGA-AA-3663-01	Tumour	LARGE INTESTINE	ENST00000318407	c.324C>A	p.A108A	COSMIC	NP	NP
35	TCGA-AD-6895-01	Tumour	LARGE INTESTINE	ENST00000318407	c.314C>T	p.A105V	COSMIC	NP	NP
36	TCGA-B5-A0JY-01	Tumour	ENDOMETRIUM	ENST00000318407	c.468C>A	p.F156L	COSMIC	NP	NP
37	TCGA-B5-A11G-01	Tumour	ENDOMETRIUM	ENST00000318407	c.256C>A	p.R86S	COSMIC	NP	NP
38	TCGA-BT-A2LA-01	Tumour	URINARY TRACT	ENST00000318407	c.384G>A	p.A128A	COSMIC	NP	NP
39	TCGA-CM-6168-01	Tumour	LARGE INTESTINE	ENST00000318407	c.276G>A	p.L92L	COSMIC	NP	NP
40	BT474	Cell Line	BREAST	ENST00000318407	c.555C>G	p.L185L	COSMIC	NP	NP
41	JURKAT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000318407	c.257G>A	p.R86H	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
42	NCIH740	Cell Line	LUNG	ENST00000318407	c.324C>T	p.A108A	COSMIC	NP	NP
43	SKLMS1	Cell Line	SOFT_TISSUE	ENST00000318407	c.514-4C>A	p.?	COSMIC	NP	NP
44	T98G	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000318407	c.384G>A	p.A128A	COSMIC	NP	NP

*NP: Not Predicted

Copy number variation and expression profile (+)

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	6.1620	6.0467	0.0786	0.0205
BILIARY TRACT	8.0640	8.553	0.0993	0.1086
BONE	7.2965	7.9087	0.0653	0.007404
BREAST	7.6772	7.8919	-0.2019	-0.09945
CENTRAL NERVOUS SYSTEM	5.6905	5.5159	-0.0050	0.03441
ENDOMETRIUM	7.6514	7.8905	-0.0291	0.0045
HAEMATOPOIETIC AND LYMPHOID TISSUE	4.6109	4.4703	-0.0639	-0.0076
KIDNEY	8.0902	8.2292	0.1581	0.09315
LARGE INTESTINE	7.2660	7.4956	0.0150	0.01525
LIVER	8.0781	7.9621	0.1025	0.0603
LUNG	6.9162	7.23505	-0.0294	0.02325
OESOPHAGUS	7.5536	7.48945	-0.2488	-0.21485
OVARY	7.0920	7.148	-0.1915	-0.0236
PANCREAS	7.8106	7.9146	0.0129	0.103
PLEURA	8.2627	8.2908	0.1132	0.2156
PROSTATE	7.8276	7.96395	-0.1572	-0.12685
SALIVARY GLAND	7.7852	7.7852	0.0849	0.0849
SKIN	6.3109	6.6055	-0.0716	0.02134
SMALL INTESTINE	8.6455	8.6455	0.0388	0.0388
SOFT TISSUE	7.5402	7.52965	0.1468	0.0334
STOMACH	7.6170	8.0641	0.0043	0.0164
THYROID	6.4539	6.28	-0.0665	-0.0492
UPPER AERODIGESTIVE TRACT	7.3928	7.53675	-0.1910	-0.09684
URINARY TRACT	7.4375	7.5889	-0.1472	-0.07242

Gene Essentiality Data (+)

Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.

test

Tertiary structure (+)

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Modelled Structure	Structures available in PDB
	Structure is not available in PDB

Structure Domains (+)

1. PFAM Domains:

Domain ID	Domain Name	Start Site	End Site	E-value
PF00452	Bcl-2	70	171	7.3e-28
PF00452	Bcl-2	70	171	7.3e-28

2. Superfamily Domains:

Domain ID	Start Site	End Site	E-value
0048479	22	209	1.70e-43
0048479	22	209	1.70e-43

Sequence Alignment (+)

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1. Sequence alignment with 1000 genome variations:

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2. Sequence alignment with CCLE mutants:

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3. Sequence alignment with COSMIC mutants:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

4. Sequence alignment with homologus proteins:

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Sequence Profiles (+)

HMM
With Uniprot database	With Mutants	With 1000 Genome Variants

PSSM
With Uniprot database	With Mutants	With 1000 Genome Variant

Post Translational Modifications (+)

S. No.	Position	Amino acid	Type	Description
1	25	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
2	8	S	Phosphorylation	Phosphoserine
3	25	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
4	8	S	Phosphorylation	Phosphoserine

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
BOK	BOK	BOK	ENSP00000314132	Q9UMX3
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
Q9UMX3	BOK	ENSP00000314132	BOK	Q9UMX3
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
BOK	ENSP00000314132	605404	Q9UMX3	PA165696337

Protein: BOK

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)