ApoCanD

Mutation Data (+)

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	KM12	Cell Line	LARGE INTESTINE	ENST00000380629	c.293C>T	p.P98L	COSMIC	NP	NP
2	TCGA-AA-A00E-01	Tumour	LARGE INTESTINE	ENST00000380629	c.230A>G	p.D77G	COSMIC	NP	NP
3	TCGA-AA-A00W-01	Tumour	LARGE INTESTINE	ENST00000380629	c.388G>A	p.E130K	COSMIC	NP	NP
4	TCGA-AA-A01R-01	Tumour	LARGE INTESTINE	ENST00000380629	c.287C>A	p.P96H	COSMIC	NP	NP
5	TCGA-AP-A0LM-01	Tumour	ENDOMETRIUM	ENST00000380629	c.216G>T	p.E72D	COSMIC	NP	NP
6	TCGA-AU-3779-01	Tumour	LARGE INTESTINE	ENST00000380629	c.639A>G	p.T213T	COSMIC	NP	NP
7	TCGA-CA-6718-01	Tumour	LARGE INTESTINE	ENST00000380629	c.223C>A	p.L75I	COSMIC	NP	NP
8	AN3CA	Cell Line	ENDOMETRIUM	ENST00000380629	c.466T>C	p.F156L	COSMIC	CANCER	PROBABLY DAMAGING
9	CW2	Cell Line	LARGE_INTESTINE	ENST00000380629	c.278G>A	p.C93Y	COSMIC	CANCER	PROBABLY DAMAGING
10	DND41	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000380629	c.512A>G	p.K171R	COSMIC	CANCER	BENIGN
11	EKVX	Cell Line	LUNG	ENST00000380629	c.611+10G>A	p.?	COSMIC	NP	NP
12	GP5D	Cell Line	LARGE_INTESTINE	ENST00000380629	c.453T>C	p.I151I	COSMIC	NP	NP
13	HCC2998	Cell Line	LARGE_INTESTINE	ENST00000380629	c.284+4A>C	p.?	COSMIC	NP	NP
14	KM12	Cell Line	LARGE_INTESTINE	ENST00000380629	c.293C>T	p.P98L	COSMIC	CANCER	BENIGN
15	SARC9371	Cell Line	BONE	ENST00000380629	c.180A>T	p.V60V	COSMIC	NP	NP
16	KM12	Cell Line	LARGE INTESTINE	ENST00000380629	c.293C>T	p.P98L	COSMIC	NP	NP
17	TCGA-AA-A00E-01	Tumour	LARGE INTESTINE	ENST00000380629	c.230A>G	p.D77G	COSMIC	NP	NP
18	TCGA-AA-A00W-01	Tumour	LARGE INTESTINE	ENST00000380629	c.388G>A	p.E130K	COSMIC	NP	NP
19	TCGA-AA-A01R-01	Tumour	LARGE INTESTINE	ENST00000380629	c.287C>A	p.P96H	COSMIC	NP	NP
20	TCGA-AP-A0LM-01	Tumour	ENDOMETRIUM	ENST00000380629	c.216G>T	p.E72D	COSMIC	NP	NP
21	TCGA-AU-3779-01	Tumour	LARGE INTESTINE	ENST00000380629	c.639A>G	p.T213T	COSMIC	NP	NP
22	TCGA-CA-6718-01	Tumour	LARGE INTESTINE	ENST00000380629	c.223C>A	p.L75I	COSMIC	NP	NP
23	AN3CA	Cell Line	ENDOMETRIUM	ENST00000380629	c.466T>C	p.F156L	COSMIC	CANCER	PROBABLY DAMAGING
24	CW2	Cell Line	LARGE_INTESTINE	ENST00000380629	c.278G>A	p.C93Y	COSMIC	CANCER	PROBABLY DAMAGING
25	DND41	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000380629	c.512A>G	p.K171R	COSMIC	CANCER	BENIGN
26	EKVX	Cell Line	LUNG	ENST00000380629	c.611+10G>A	p.?	COSMIC	NP	NP
27	GP5D	Cell Line	LARGE_INTESTINE	ENST00000380629	c.453T>C	p.I151I	COSMIC	NP	NP
28	HCC2998	Cell Line	LARGE_INTESTINE	ENST00000380629	c.284+4A>C	p.?	COSMIC	NP	NP
29	KM12	Cell Line	LARGE_INTESTINE	ENST00000380629	c.293C>T	p.P98L	COSMIC	CANCER	BENIGN
30	SARC9371	Cell Line	BONE	ENST00000380629	c.180A>T	p.V60V	COSMIC	NP	NP

*NP: Not Predicted

Copy number variation and expression profile (+)

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	10.6057	10.583	0.0385	0.004316
BILIARY TRACT	9.7068	9.6707	-0.3629	-0.3805
BONE	11.2596	11.349	0.0832	0.0105
BREAST	10.0787	9.9152	-0.5586	-0.51305
CENTRAL NERVOUS SYSTEM	10.8585	11.047	-0.0624	0.0225
ENDOMETRIUM	10.2955	10.327	-0.0133	-0.0028
HAEMATOPOIETIC AND LYMPHOID TISSUE	10.3005	10.217	0.0613	0.0282
KIDNEY	10.9072	11.03	-0.2635	-0.0994
LARGE INTESTINE	9.4441	9.35955	-0.2898	-0.05174
LIVER	10.2216	10.703	-0.3556	-0.3489
LUNG	10.2471	10.2965	-0.3165	-0.3011
OESOPHAGUS	10.2595	10.313	-0.1440	-0.051625
OVARY	10.3541	10.397	-0.2868	-0.2529
PANCREAS	10.1864	10.288	-0.3916	-0.4395
PLEURA	10.3994	10.676	-0.2296	-0.1697
PROSTATE	10.8500	10.627	-0.1271	-0.15955
SALIVARY GLAND	10.8760	10.876	-0.3860	-0.386
SKIN	10.6988	10.675	-0.0023	0.0275
SMALL INTESTINE	9.6385	9.6385	0.0155	0.0155
SOFT TISSUE	10.6917	10.7	-0.0247	0.0136393
STOMACH	9.8473	10.001	-0.1625	-0.11385
THYROID	11.0636	11.2805	-0.2678	-0.2923
UPPER AERODIGESTIVE TRACT	10.2230	10.325	-0.4723	-0.4799
URINARY TRACT	10.3496	10.4245	-0.3076	-0.3258

Gene Essentiality Data (+)

Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.

test

Tertiary structure (+)

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Modelled Structure	Structures available in PDB
	Structure is not available in PDB

Structure Domains (+)

1. PFAM domains are not present!!

2. Superfaimly domains are not present!!

Sequence Alignment (+)

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1. Sequence alignment with 1000 genome variations:

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2. Mutants are not present in CCLE!!

3. Sequence alignment with COSMIC mutants:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

4. Sequence alignment with homologus proteins:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

Sequence Profiles (+)

HMM
With Uniprot database	With Mutants	With 1000 Genome Variants

PSSM
With Uniprot database	With Mutants	With 1000 Genome Variant

Post Translational Modifications (+)

Post translational modifications are not found!!

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
BNIP3L	BNIP3L	BNIP3L	ENSP00000370003	O60238
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
O60238	BNIP3L	ENSP00000370003	BNIP3L	O60238
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
BNIP3L	ENSP00000370003	605368	O60238	PA25395

Protein: BNIP3L

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)