ApoCanD

Mutation Data (+)

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	GP2D	Cell Line	LARGE INTESTINE	NP_004043	c.193G>A	p.D65N	CCLE	NP	NP
2	HRT18	Cell Line	LARGE INTESTINE	NP_004043	c.125A>G	p.D42G	CCLE	NP	NP
3	IM95	Cell Line	STOMACH	NP_004043	c.326T>C	p.I109T	CCLE	NP	NP
4	NCIH1341	Cell Line	LUNG	NP_004043	c.517C>T	p.H173Y	CCLE	NP	NP
5	NCIH2106	Cell Line	LUNG	NP_004043	c.104C>T	p.S35L	CCLE	NP	NP
6	SNU175	Cell Line	LARGE INTESTINE	NP_004043	c.206G>A	p.R69H	CCLE	NP	NP
7	SW1116	Cell Line	LARGE INTESTINE	NP_004043	c.581T>G	p.F194C	CCLE	NP	NP
8	7	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000368636	c.122G>A	p.G41E	COSMIC	NP	NP
9	CRC-9	Tumour	LARGE INTESTINE	ENST00000368636	c.448G>A	p.V150I	COSMIC	NP	NP
10	ESO-005	Tumour	OESOPHAGUS	ENST00000368636	c.187C>T	p.H63Y	COSMIC	NP	NP
11	MZ7-mel	Cell Line	SKIN	ENST00000368636	c.247G>A	p.D83N	COSMIC	NP	NP
12	NCI-H1770	Cell Line	LUNG	ENST00000368636	c.104C>T	p.S35L	COSMIC	NP	NP
13	TCGA-86-6851-01	Tumour	LUNG	ENST00000368636	c.239C>G	p.S80C	COSMIC	NP	NP
14	TCGA-AA-3672-01	Tumour	LARGE INTESTINE	ENST00000368636	c.561G>T	p.L187L	COSMIC	NP	NP
15	TCGA-AA-3950-01	Tumour	LARGE INTESTINE	ENST00000368636	c.556C>A	p.R186S	COSMIC	NP	NP
16	TCGA-AN-A0FW-01	Tumour	BREAST	ENST00000368636	c.429C>G	p.L143L	COSMIC	NP	NP
17	TCGA-AX-A05Z-01	Tumour	ENDOMETRIUM	ENST00000368636	c.556C>T	p.R186C	COSMIC	NP	NP
18	TCGA-BG-A0M3-01	Tumour	ENDOMETRIUM	ENST00000368636	c.422C>A	p.A141D	COSMIC	NP	NP
19	TCGA-D1-A103-01	Tumour	ENDOMETRIUM	ENST00000368636	c.411G>A	p.P137P	COSMIC	NP	NP
20	TCGA-G2-A2EF-01	Tumour	URINARY TRACT	ENST00000368636	c.205C>T	p.R69C	COSMIC	NP	NP
21	DBTRG05MG	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000368636	c.513C>T	p.L171L	COSMIC	NP	NP
22	GP5D	Cell Line	LARGE_INTESTINE	ENST00000368636	c.193G>A	p.D65N	COSMIC	CANCER	BENIGN
23	H2461	Cell Line	PLEURA	ENST00000368636	c.487A>G	p.K163E	COSMIC	CANCER	PROBABLY DAMAGING
24	IM95	Cell Line	STOMACH	ENST00000368636	c.326T>C	p.I109T	COSMIC	CANCER	BENIGN
25	MZ7MEL	Cell Line	SKIN	ENST00000368636	c.247G>A	p.D83N	COSMIC	CANCER	BENIGN
26	NCIH1341	Cell Line	LUNG	ENST00000368636	c.517C>T	p.H173Y	COSMIC	CANCER	PROBABLY DAMAGING
27	NCIH1770	Cell Line	LUNG	ENST00000368636	c.104C>T	p.S35L	COSMIC	CANCER	PROBABLY DAMAGING
28	NCIH2066	Cell Line	LUNG	ENST00000368636	c.198-6G>A	p.?	COSMIC	NP	NP
29	SNU175	Cell Line	LARGE_INTESTINE	ENST00000368636	c.206G>A	p.R69H	COSMIC	CANCER	PROBABLY DAMAGING
30	SW1116	Cell Line	LARGE_INTESTINE	ENST00000368636	c.581T>G	p.F194C	COSMIC	CANCER	PROBABLY DAMAGING
31	GP2D	Cell Line	LARGE INTESTINE	NP_004043	c.193G>A	p.D65N	CCLE	NP	NP
32	HRT18	Cell Line	LARGE INTESTINE	NP_004043	c.125A>G	p.D42G	CCLE	NP	NP
33	IM95	Cell Line	STOMACH	NP_004043	c.326T>C	p.I109T	CCLE	NP	NP
34	NCIH1341	Cell Line	LUNG	NP_004043	c.517C>T	p.H173Y	CCLE	NP	NP
35	NCIH2106	Cell Line	LUNG	NP_004043	c.104C>T	p.S35L	CCLE	NP	NP
36	SNU175	Cell Line	LARGE INTESTINE	NP_004043	c.206G>A	p.R69H	CCLE	NP	NP
37	SW1116	Cell Line	LARGE INTESTINE	NP_004043	c.581T>G	p.F194C	CCLE	NP	NP
38	7	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000368636	c.122G>A	p.G41E	COSMIC	NP	NP
39	CRC-9	Tumour	LARGE INTESTINE	ENST00000368636	c.448G>A	p.V150I	COSMIC	NP	NP
40	ESO-005	Tumour	OESOPHAGUS	ENST00000368636	c.187C>T	p.H63Y	COSMIC	NP	NP
41	MZ7-mel	Cell Line	SKIN	ENST00000368636	c.247G>A	p.D83N	COSMIC	NP	NP
42	NCI-H1770	Cell Line	LUNG	ENST00000368636	c.104C>T	p.S35L	COSMIC	NP	NP
43	TCGA-86-6851-01	Tumour	LUNG	ENST00000368636	c.239C>G	p.S80C	COSMIC	NP	NP
44	TCGA-AA-3672-01	Tumour	LARGE INTESTINE	ENST00000368636	c.561G>T	p.L187L	COSMIC	NP	NP
45	TCGA-AA-3950-01	Tumour	LARGE INTESTINE	ENST00000368636	c.556C>A	p.R186S	COSMIC	NP	NP
46	TCGA-AN-A0FW-01	Tumour	BREAST	ENST00000368636	c.429C>G	p.L143L	COSMIC	NP	NP
47	TCGA-AX-A05Z-01	Tumour	ENDOMETRIUM	ENST00000368636	c.556C>T	p.R186C	COSMIC	NP	NP
48	TCGA-BG-A0M3-01	Tumour	ENDOMETRIUM	ENST00000368636	c.422C>A	p.A141D	COSMIC	NP	NP
49	TCGA-D1-A103-01	Tumour	ENDOMETRIUM	ENST00000368636	c.411G>A	p.P137P	COSMIC	NP	NP
50	TCGA-G2-A2EF-01	Tumour	URINARY TRACT	ENST00000368636	c.205C>T	p.R69C	COSMIC	NP	NP
51	DBTRG05MG	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000368636	c.513C>T	p.L171L	COSMIC	NP	NP
52	GP5D	Cell Line	LARGE_INTESTINE	ENST00000368636	c.193G>A	p.D65N	COSMIC	CANCER	BENIGN
53	H2461	Cell Line	PLEURA	ENST00000368636	c.487A>G	p.K163E	COSMIC	CANCER	PROBABLY DAMAGING
54	IM95	Cell Line	STOMACH	ENST00000368636	c.326T>C	p.I109T	COSMIC	CANCER	BENIGN
55	MZ7MEL	Cell Line	SKIN	ENST00000368636	c.247G>A	p.D83N	COSMIC	CANCER	BENIGN
56	NCIH1341	Cell Line	LUNG	ENST00000368636	c.517C>T	p.H173Y	COSMIC	CANCER	PROBABLY DAMAGING
57	NCIH1770	Cell Line	LUNG	ENST00000368636	c.104C>T	p.S35L	COSMIC	CANCER	PROBABLY DAMAGING
58	NCIH2066	Cell Line	LUNG	ENST00000368636	c.198-6G>A	p.?	COSMIC	NP	NP
59	SNU175	Cell Line	LARGE_INTESTINE	ENST00000368636	c.206G>A	p.R69H	COSMIC	CANCER	PROBABLY DAMAGING
60	SW1116	Cell Line	LARGE_INTESTINE	ENST00000368636	c.581T>G	p.F194C	COSMIC	CANCER	PROBABLY DAMAGING

*NP: Not Predicted

Copy number variation and expression profile (+)

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	11.1302	11.044	-0.0975	-0.04021
BILIARY TRACT	8.0221	8.5562	0.0233	0.0386
BONE	11.4399	11.547	-0.0704	-0.0182
BREAST	10.5971	10.903	-0.1120	-0.06862
CENTRAL NERVOUS SYSTEM	11.4870	11.49	-0.2787	-0.1516
ENDOMETRIUM	11.0718	11.058	-0.0494	0.0075
HAEMATOPOIETIC AND LYMPHOID TISSUE	9.1432	9.6327	-0.1200	-0.02849
KIDNEY	11.9355	11.987	0.1195	0.0764
LARGE INTESTINE	7.2153	5.6108	-0.0316	-0.0065145
LIVER	11.6562	11.592	0.0628	0.1032
LUNG	10.9688	11.1155	-0.1719	-0.11435
OESOPHAGUS	9.3074	10.3225	-0.0100	0.02465
OVARY	10.8878	11.014	-0.0398	0.0148
PANCREAS	7.2998	7.472	-0.0170	0.1028
PLEURA	11.4170	11.46	-0.0519	0.0784
PROSTATE	12.0863	12.2425	-0.1405	-0.04841
SALIVARY GLAND	12.2670	12.267	0.0933	0.09331
SKIN	11.0213	10.987	-0.2979	-0.2014
SMALL INTESTINE	4.5913	4.5913	0.0299	0.0299
SOFT TISSUE	11.4899	11.075	-0.0576	-0.005055
STOMACH	7.6581	7.67975	-0.1202	-0.0781
THYROID	11.6130	11.31	-0.0977	-0.0571
UPPER AERODIGESTIVE TRACT	10.9273	10.6685	0.0830	0.02065
URINARY TRACT	10.0430	10.7805	-0.1906	-0.1387

Gene Essentiality Data (+)

Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.

test

Tertiary structure (+)

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Modelled Structure	Structures available in PDB
	2J5D, 2KA1, 2KA2

Structure Domains (+)

1. PFAM Domains:

Domain ID	Domain Name	Start Site	End Site	E-value
PF06553	BNIP3	1	192	4.2e-79
PF06553	BNIP3	1	192	4.2e-79

2. Superfaimly domains are not present!!

Sequence Alignment (+)

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1. Variants are not present in 1000 Genomes!!

2. Sequence alignment with CCLE mutants:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

3. Sequence alignment with COSMIC mutants:

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4. Sequence alignment with homologus proteins:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

Sequence Profiles (+)

HMM
With Uniprot database	With Mutants	With 1000 Genome Variants

PSSM
With Uniprot database	With Mutants	With 1000 Genome Variant

Post Translational Modifications (+)

S. No.	Position	Amino acid	Type	Description
1	140	T	Phosphorylation	Phosphothreonine
2	142	T	Phosphorylation	Phosphothreonine
3	148	T	Phosphorylation	Phosphothreonine
4	149	S	Phosphorylation	Phosphoserine
5	86	S	Phosphorylation	Phosphoserine
6	90	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
7	92	S	Phosphorylation	Phosphoserine
8	93	S	Phosphorylation	Phosphoserine
9	93	S	Phosphorylation	Phosphoserine.
10	95	S	Phosphorylation	Phosphoserine
11	140	T	Phosphorylation	Phosphothreonine
12	142	T	Phosphorylation	Phosphothreonine
13	148	T	Phosphorylation	Phosphothreonine
14	149	S	Phosphorylation	Phosphoserine
15	86	S	Phosphorylation	Phosphoserine
16	90	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
17	92	S	Phosphorylation	Phosphoserine
18	93	S	Phosphorylation	Phosphoserine
19	93	S	Phosphorylation	Phosphoserine.
20	95	S	Phosphorylation	Phosphoserine

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
BNIP3	BNIP3	BNIP3	ENSP00000357625	Q12983
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
Q12983	BNIP3	ENSP00000357625	BNIP3	Q12983
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
BNIP3	ENSP00000357625	603293	Q12983	PA25394

Protein: BNIP3

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)