ApoCanD

#	Name/ID	Cell Line/Tumor sample	Tissue of Origin	Reference ID	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	BCPAP	Cell Line	THYROID	NP_892007	c.954_splice	p.R318_splice	CCLE	NP	NP
2	HEC251	Cell Line	ENDOMETRIUM	NP_892007	c.77T>G	p.L26W	CCLE	PASSENGER/OTHER	Possibly Damaging
3	HPBALL	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_892007	c.606A>T	p.R202S	CCLE	PASSENGER/OTHER	Possibly Damaging
4	HT	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_892007	c.1492A>G	p.T498A	CCLE	PASSENGER/OTHER	Possibly Damaging
5	HT	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_892007	c.932A>G	p.Q311R	CCLE	PASSENGER/OTHER	Benign
6	KMBC2	Cell Line	URINARY TRACT	NP_892007	c.606A>T	p.R202S	CCLE	PASSENGER/OTHER	Possibly Damaging
7	LNCAPCLONEFGC	Cell Line	PROSTATE	NP_892007	c.905G>A	p.W302*	CCLE	NP	NP
8	MFE319	Cell Line	ENDOMETRIUM	NP_892007	c.103A>G	p.T35A	CCLE	PASSENGER/OTHER	Probably Damaging
9	MIAPACA2	Cell Line	PANCREAS	NP_892007	c.1210C>G	p.L404V	CCLE	PASSENGER/OTHER	Possibly Damaging
10	MOLP2	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_892007	c.812T>G	p.V271G	CCLE	PASSENGER/OTHER	Probably Damaging
11	NCIH1703	Cell Line	LUNG	NP_892007	c.1072G>T	p.E358*	CCLE	NP	NP
12	NCIH2073	Cell Line	LUNG	NP_892007	c.1679G>T	p.C560F	CCLE	CANCER	Probably Damaging
13	NCIH2110	Cell Line	LUNG	NP_892007	c.1788G>T	p.K596N	CCLE	CANCER	Probably Damaging
14	PL21	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_892007	c.708A>C	p.E236D	CCLE	PASSENGER/OTHER	Possibly Damaging
15	SNGM	Cell Line	ENDOMETRIUM	NP_892007	c.1478G>C	p.R493T	CCLE	PASSENGER/OTHER	Possibly Damaging
16	SNU1040	Cell Line	LARGE INTESTINE	NP_892007	c.773G>A	p.R258H	CCLE	CANCER	Probably Damaging
17	SNU5	Cell Line	STOMACH	NP_892007	c.403C>T	p.R135C	CCLE	PASSENGER/OTHER	Possibly Damaging
18	SUDHL1	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_892007	c.1607C>T	p.T536I	CCLE	PASSENGER/OTHER	Possibly Damaging
19	SUDHL5	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_892007	c.674A>G	p.H225R	CCLE	CANCER	Probably Damaging
20	T3M10	Cell Line	LUNG	NP_892007	c.403C>T	p.R135C	CCLE	PASSENGER/OTHER	Possibly Damaging
21	17D	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000263464	c.1281_1285delAAGGG	p.E429fs*7	COSMIC	NP	NP
22	BN19T	Tumour	LIVER	ENST00000263464	c.1621+3A>G	p.?	COSMIC	NP	NP
23	ESO-859	Tumour	OESOPHAGUS	ENST00000263464	c.606A>G	p.R202R	COSMIC	NP	NP
24	HCT-15	Cell Line	LARGE INTESTINE	ENST00000263464	c.601G>T	p.D201Y	COSMIC	NP	NP
25	LPJ023	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000263464	c.953G>C	p.R318T	COSMIC	NP	NP
26	LUAD-F00282	Tumour	LUNG	ENST00000263464	c.92A>C	p.Y31S	COSMIC	NP	NP
27	LUAD-NYU1219	Tumour	LUNG	ENST00000263464	c.914G>T	p.G305V	COSMIC	NP	NP
28	MZ7-mel	Cell Line	SKIN	ENST00000263464	c.890G>A	p.G297D	COSMIC	NP	NP
29	PC-9ER	Cell Line	LUNG	ENST00000263464	c.710A>T	p.N237I	COSMIC	NP	NP
30	RK071	Tumour	C01 LIVER	ENST00000263464	c.1642T>C	p.L548L	COSMIC	NP	NP
31	RK165	Tumour	C01 LIVER	ENST00000263464	c.1622-1G>T	p.?	COSMIC	NP	NP
32	TCGA-05-4397-01	Tumour	LUNG	ENST00000263464	c.1438G>A	p.D480N	COSMIC	NP	NP
33	TCGA-13-0884-01	Tumour	OVARY	ENST00000263464	c.743C>G	p.S248C	COSMIC	NP	NP
34	TCGA-23-1110-01	Tumour	OVARY	ENST00000263464	c.1607C>G	p.T536R	COSMIC	NP	NP
35	TCGA-24-1469-01	Tumour	OVARY	ENST00000263464	c.369A>G	p.S123S	COSMIC	NP	NP
36	TCGA-34-5928-01	Tumour	LUNG	ENST00000263464	c.1646G>A	p.R549Q	COSMIC	NP	NP
37	TCGA-37-3789-01	Tumour	LUNG	ENST00000263464	c.1102G>A	p.E368K	COSMIC	NP	NP
38	TCGA-37-3789-01	Tumour	LUNG	ENST00000263464	c.1255G>C	p.D419H	COSMIC	NP	NP
39	TCGA-64-5781-01	Tumour	LUNG	ENST00000263464	c.1198C>T	p.Q400*	COSMIC	NP	NP
40	TCGA-A6-3809-01	Tumour	LARGE INTESTINE	ENST00000263464	c.343T>G	p.S115A	COSMIC	NP	NP
41	TCGA-A6-5660-01	Tumour	LARGE INTESTINE	ENST00000263464	c.1608A>G	p.T536T	COSMIC	NP	NP
42	TCGA-A6-5665-01	Tumour	LARGE INTESTINE	ENST00000263464	c.742T>C	p.S248P	COSMIC	NP	NP
43	TCGA-AA-3663-01	Tumour	LARGE INTESTINE	ENST00000263464	c.367T>C	p.S123P	COSMIC	NP	NP
44	TCGA-AA-3821-01	Tumour	LARGE INTESTINE	ENST00000263464	c.1414G>A	p.G472R	COSMIC	NP	NP
45	TCGA-AA-A010-01	Tumour	LARGE INTESTINE	ENST00000263464	c.832A>C	p.S278R	COSMIC	NP	NP
46	TCGA-AG-A002-01	Tumour	LARGE INTESTINE	ENST00000263464	c.1102G>T	p.E368*	COSMIC	NP	NP
47	TCGA-AG-A002-01	Tumour	LARGE INTESTINE	ENST00000263464	c.20G>T	p.S7I	COSMIC	NP	NP
48	TCGA-AG-A002-01	Tumour	LARGE INTESTINE	ENST00000263464	c.515G>T	p.R172I	COSMIC	NP	NP
49	TCGA-AG-A02N-01	Tumour	LARGE INTESTINE	ENST00000263464	c.1343G>A	p.R448Q	COSMIC	NP	NP
50	TCGA-AG-A02N-01	Tumour	LARGE INTESTINE	ENST00000263464	c.1463C>T	p.T488M	COSMIC	NP	NP
51	TCGA-AP-A0LM-01	Tumour	ENDOMETRIUM	ENST00000263464	c.1494G>A	p.T498T	COSMIC	NP	NP
52	TCGA-AY-5543-01	Tumour	LARGE INTESTINE	ENST00000263464	c.889G>C	p.G297R	COSMIC	NP	NP
53	TCGA-AY-6196-01	Tumour	LARGE INTESTINE	ENST00000263464	c.889G>T	p.G297C	COSMIC	NP	NP
54	TCGA-B5-A0JY-01	Tumour	ENDOMETRIUM	ENST00000263464	c.1060G>T	p.D354Y	COSMIC	NP	NP
55	TCGA-B5-A0K6-01	Tumour	ENDOMETRIUM	ENST00000263464	c.303C>T	p.S101S	COSMIC	NP	NP
56	TCGA-B5-A11E-01	Tumour	ENDOMETRIUM	ENST00000263464	c.505G>A	p.E169K	COSMIC	NP	NP
57	TCGA-BP-4161-01	Tumour	KIDNEY	ENST00000263464	c.163T>C	p.F55L	COSMIC	NP	NP
58	TCGA-BS-A0TD-01	Tumour	ENDOMETRIUM	ENST00000263464	c.1366C>A	p.Q456K	COSMIC	NP	NP
59	TCGA-BS-A0UV-01	Tumour	ENDOMETRIUM	ENST00000263464	c.1324+2T>C	p.?	COSMIC	NP	NP
60	TCGA-CA-6718-01	Tumour	LARGE INTESTINE	ENST00000263464	c.1690G>T	p.E564*	COSMIC	NP	NP
61	TCGA-CJ-4923-01	Tumour	KIDNEY	ENST00000263464	c.1327G>A	p.D443N	COSMIC	NP	NP
62	TCGA-CM-5868-01	Tumour	LARGE INTESTINE	ENST00000263464	c.367T>C	p.S123P	COSMIC	NP	NP
63	TCGA-D1-A103-01	Tumour	ENDOMETRIUM	ENST00000263464	c.1330T>G	p.L444V	COSMIC	NP	NP
64	TCGA-D1-A176-01	Tumour	ENDOMETRIUM	ENST00000263464	c.217C>T	p.L73L	COSMIC	NP	NP
65	TCGA-D5-6929-01	Tumour	LARGE INTESTINE	ENST00000263464	c.367T>C	p.S123P	COSMIC	NP	NP
66	TCGA-DK-A3IS-01	Tumour	URINARY TRACT	ENST00000263464	c.446G>C	p.R149T	COSMIC	NP	NP
67	TCGA-EI-6508-01	Tumour	LARGE INTESTINE	ENST00000263464	c.368C>T	p.S123L	COSMIC	NP	NP
68	TCGA-EW-A1PB-01	Tumour	BREAST	ENST00000263464	c.1536_1537delCT	p.L514fs*4	COSMIC	NP	NP
69	TCGA-F4-6808-01	Tumour	LARGE INTESTINE	ENST00000263464	c.368C>A	p.S123*	COSMIC	NP	NP
70	TCGA-G5-6235-01	Tumour	LARGE INTESTINE	ENST00000263464	c.368C>T	p.S123L	COSMIC	NP	NP
71	YUDUTY	Tumour	SKIN	ENST00000263464	c.505G>A	p.E169K	COSMIC	NP	NP
72	YUKIL	Tumour	SKIN	ENST00000263464	c.118C>T	p.P40S	COSMIC	NP	NP
73	ccRCC-80	Tumour	KIDNEY	ENST00000263464	c.1332delA	p.L444fs*3	COSMIC	NP	NP
74	pfg008T	Tumour	STOMACH	ENST00000263464	c.1462A>C	p.T488P	COSMIC	NP	NP
75	BC3	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000263464	c.1309G>A	p.E437K	COSMIC	PASSENGER/OTHER	BENIGN
76	BCPAP	Cell Line	THYROID	ENST00000263464	c.954-2A>G	p.?	COSMIC	NP	NP
77	BONNA12	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000263464	c.260A>C	p.K87T	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
78	CAL39	Cell Line	VULVA	ENST00000263464	c.405T>C	p.R135R	COSMIC	NP	NP
79	COLO824	Cell Line	BREAST	ENST00000263464	c.1262T>G	p.L421R	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
80	CTV1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000263464	c.309C>A	p.N103K	COSMIC	PASSENGER/OTHER	BENIGN
81	D247MG	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000263464	c.994C>T	p.R332C	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
82	EB2	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000263464	c.1082-4A>G	p.?	COSMIC	NP	NP
83	HCT15	Cell Line	LARGE_INTESTINE	ENST00000263464	c.601G>T	p.D201Y	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
84	HEC1	Cell Line	ENDOMETRIUM	ENST00000263464	c.504C>T	p.N168N	COSMIC	NP	NP
85	HT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000263464	c.1492A>G	p.T498A	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
86	ISTMEL1	Cell Line	SKIN	ENST00000263464	c.405T>C	p.R135R	COSMIC	NP	NP
87	KPNYS	Cell Line	AUTONOMIC_GANGLIA	ENST00000263464	c.403C>T	p.R135C	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
88	L363	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000263464	c.1344G>A	p.R448R	COSMIC	NP	NP
89	LNCAPCLONEFGC	Cell Line	PROSTATE	ENST00000263464	c.905G>A	p.W302*	COSMIC	NP	NP
90	MESSA	Cell Line	SOFT_TISSUE	ENST00000263464	c.1646G>A	p.R549Q	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
91	MEWO	Cell Line	SKIN	ENST00000263464	c.687T>C	p.F229F	COSMIC	NP	NP
92	MFE319	Cell Line	ENDOMETRIUM	ENST00000263464	c.103A>G	p.T35A	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
93	MIAPACA2	Cell Line	PANCREAS	ENST00000263464	c.1210C>G	p.L404V	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
94	MMACSF	Cell Line	SKIN	ENST00000263464	c.1387C>T	p.P463S	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
95	MZ7MEL	Cell Line	SKIN	ENST00000263464	c.890G>A	p.G297D	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
96	NCIH1155	Cell Line	LUNG	ENST00000263464	c.1580-1G>A	p.?	COSMIC	NP	NP
97	NCIH1703	Cell Line	LUNG	ENST00000263464	c.1072G>T	p.E358*	COSMIC	NP	NP
98	NCIH1993	Cell Line	LUNG	ENST00000263464	c.1679G>T	p.C560F	COSMIC	CANCER	PROBABLY DAMAGING
99	NCIH2110	Cell Line	LUNG	ENST00000263464	c.1788G>T	p.K596N	COSMIC	CANCER	PROBABLY DAMAGING
100	NCIH720	Cell Line	LUNG	ENST00000263464	c.111C>T	p.S37S	COSMIC	NP	NP
101	NCISNU5	Cell Line	STOMACH	ENST00000263464	c.403C>T	p.R135C	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
102	PL21	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000263464	c.708A>C	p.E236D	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
103	RPMI8866	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000263464	c.895C>T	p.L299F	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
104	SLVL	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000263464	c.1296_1299delAGAA	p.R434fs*12	COSMIC	NP	NP
105	SNGM	Cell Line	ENDOMETRIUM	ENST00000263464	c.1478G>C	p.R493T	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
106	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000263464	c.494C>G	p.A165G	COSMIC	PASSENGER/OTHER	BENIGN
107	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000263464	c.773G>A	p.R258H	COSMIC	CANCER	PROBABLY DAMAGING
108	SNU182	Cell Line	LIVER	ENST00000263464	c.105G>C	p.T35T	COSMIC	NP	NP
109	SNU182	Cell Line	LIVER	ENST00000263464	c.1232G>A	p.R411K	COSMIC	PASSENGER/OTHER	BENIGN
110	SNU182	Cell Line	LIVER	ENST00000263464	c.49G>A	p.A17T	COSMIC	PASSENGER/OTHER	BENIGN
111	SNU81	Cell Line	LARGE_INTESTINE	ENST00000263464	c.476G>T	p.R159I	COSMIC	PASSENGER/OTHER	BENIGN
112	SUDHL1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000263464	c.1607C>T	p.T536I	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
113	SUDHL5	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000263464	c.674A>G	p.H225R	COSMIC	CANCER	PROBABLY DAMAGING
114	SW1088	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000263464	c.435T>C	p.P145P	COSMIC	NP	NP
115	TGBC24TKB	Cell Line	BILIARY_TRACT	ENST00000263464	c.403C>T	p.R135C	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
116	BCPAP	Cell Line	THYROID	NP_892007	c.954_splice	p.R318_splice	CCLE	NP	NP
117	HEC251	Cell Line	ENDOMETRIUM	NP_892007	c.77T>G	p.L26W	CCLE	PASSENGER/OTHER	Possibly Damaging
118	HPBALL	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_892007	c.606A>T	p.R202S	CCLE	PASSENGER/OTHER	Possibly Damaging
119	HT	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_892007	c.1492A>G	p.T498A	CCLE	PASSENGER/OTHER	Possibly Damaging
120	HT	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_892007	c.932A>G	p.Q311R	CCLE	PASSENGER/OTHER	Benign
121	KMBC2	Cell Line	URINARY TRACT	NP_892007	c.606A>T	p.R202S	CCLE	PASSENGER/OTHER	Possibly Damaging
122	LNCAPCLONEFGC	Cell Line	PROSTATE	NP_892007	c.905G>A	p.W302*	CCLE	NP	NP
123	MFE319	Cell Line	ENDOMETRIUM	NP_892007	c.103A>G	p.T35A	CCLE	PASSENGER/OTHER	Probably Damaging
124	MIAPACA2	Cell Line	PANCREAS	NP_892007	c.1210C>G	p.L404V	CCLE	PASSENGER/OTHER	Possibly Damaging
125	MOLP2	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_892007	c.812T>G	p.V271G	CCLE	PASSENGER/OTHER	Probably Damaging
126	NCIH1703	Cell Line	LUNG	NP_892007	c.1072G>T	p.E358*	CCLE	NP	NP
127	NCIH2073	Cell Line	LUNG	NP_892007	c.1679G>T	p.C560F	CCLE	CANCER	Probably Damaging
128	NCIH2110	Cell Line	LUNG	NP_892007	c.1788G>T	p.K596N	CCLE	CANCER	Probably Damaging
129	PL21	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_892007	c.708A>C	p.E236D	CCLE	PASSENGER/OTHER	Possibly Damaging
130	SNGM	Cell Line	ENDOMETRIUM	NP_892007	c.1478G>C	p.R493T	CCLE	PASSENGER/OTHER	Possibly Damaging
131	SNU1040	Cell Line	LARGE INTESTINE	NP_892007	c.773G>A	p.R258H	CCLE	CANCER	Probably Damaging
132	SNU5	Cell Line	STOMACH	NP_892007	c.403C>T	p.R135C	CCLE	PASSENGER/OTHER	Possibly Damaging
133	SUDHL1	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_892007	c.1607C>T	p.T536I	CCLE	PASSENGER/OTHER	Possibly Damaging
134	SUDHL5	Cell Line	HAEMATOPOIETIC AND LYMPHOID TISSUE	NP_892007	c.674A>G	p.H225R	CCLE	CANCER	Probably Damaging
135	T3M10	Cell Line	LUNG	NP_892007	c.403C>T	p.R135C	CCLE	PASSENGER/OTHER	Possibly Damaging
136	17D	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000263464	c.1281_1285delAAGGG	p.E429fs*7	COSMIC	NP	NP
137	BN19T	Tumour	LIVER	ENST00000263464	c.1621+3A>G	p.?	COSMIC	NP	NP
138	ESO-859	Tumour	OESOPHAGUS	ENST00000263464	c.606A>G	p.R202R	COSMIC	NP	NP
139	HCT-15	Cell Line	LARGE INTESTINE	ENST00000263464	c.601G>T	p.D201Y	COSMIC	NP	NP
140	LPJ023	Tumour	HAEMATOPOIETIC AND LYMPHOID TISSUE	ENST00000263464	c.953G>C	p.R318T	COSMIC	NP	NP
141	LUAD-F00282	Tumour	LUNG	ENST00000263464	c.92A>C	p.Y31S	COSMIC	NP	NP
142	LUAD-NYU1219	Tumour	LUNG	ENST00000263464	c.914G>T	p.G305V	COSMIC	NP	NP
143	MZ7-mel	Cell Line	SKIN	ENST00000263464	c.890G>A	p.G297D	COSMIC	NP	NP
144	PC-9ER	Cell Line	LUNG	ENST00000263464	c.710A>T	p.N237I	COSMIC	NP	NP
145	RK071	Tumour	C01 LIVER	ENST00000263464	c.1642T>C	p.L548L	COSMIC	NP	NP
146	RK165	Tumour	C01 LIVER	ENST00000263464	c.1622-1G>T	p.?	COSMIC	NP	NP
147	TCGA-05-4397-01	Tumour	LUNG	ENST00000263464	c.1438G>A	p.D480N	COSMIC	NP	NP
148	TCGA-13-0884-01	Tumour	OVARY	ENST00000263464	c.743C>G	p.S248C	COSMIC	NP	NP
149	TCGA-23-1110-01	Tumour	OVARY	ENST00000263464	c.1607C>G	p.T536R	COSMIC	NP	NP
150	TCGA-24-1469-01	Tumour	OVARY	ENST00000263464	c.369A>G	p.S123S	COSMIC	NP	NP
151	TCGA-34-5928-01	Tumour	LUNG	ENST00000263464	c.1646G>A	p.R549Q	COSMIC	NP	NP
152	TCGA-37-3789-01	Tumour	LUNG	ENST00000263464	c.1102G>A	p.E368K	COSMIC	NP	NP
153	TCGA-37-3789-01	Tumour	LUNG	ENST00000263464	c.1255G>C	p.D419H	COSMIC	NP	NP
154	TCGA-64-5781-01	Tumour	LUNG	ENST00000263464	c.1198C>T	p.Q400*	COSMIC	NP	NP
155	TCGA-A6-3809-01	Tumour	LARGE INTESTINE	ENST00000263464	c.343T>G	p.S115A	COSMIC	NP	NP
156	TCGA-A6-5660-01	Tumour	LARGE INTESTINE	ENST00000263464	c.1608A>G	p.T536T	COSMIC	NP	NP
157	TCGA-A6-5665-01	Tumour	LARGE INTESTINE	ENST00000263464	c.742T>C	p.S248P	COSMIC	NP	NP
158	TCGA-AA-3663-01	Tumour	LARGE INTESTINE	ENST00000263464	c.367T>C	p.S123P	COSMIC	NP	NP
159	TCGA-AA-3821-01	Tumour	LARGE INTESTINE	ENST00000263464	c.1414G>A	p.G472R	COSMIC	NP	NP
160	TCGA-AA-A010-01	Tumour	LARGE INTESTINE	ENST00000263464	c.832A>C	p.S278R	COSMIC	NP	NP
161	TCGA-AG-A002-01	Tumour	LARGE INTESTINE	ENST00000263464	c.1102G>T	p.E368*	COSMIC	NP	NP
162	TCGA-AG-A002-01	Tumour	LARGE INTESTINE	ENST00000263464	c.20G>T	p.S7I	COSMIC	NP	NP
163	TCGA-AG-A002-01	Tumour	LARGE INTESTINE	ENST00000263464	c.515G>T	p.R172I	COSMIC	NP	NP
164	TCGA-AG-A02N-01	Tumour	LARGE INTESTINE	ENST00000263464	c.1343G>A	p.R448Q	COSMIC	NP	NP
165	TCGA-AG-A02N-01	Tumour	LARGE INTESTINE	ENST00000263464	c.1463C>T	p.T488M	COSMIC	NP	NP
166	TCGA-AP-A0LM-01	Tumour	ENDOMETRIUM	ENST00000263464	c.1494G>A	p.T498T	COSMIC	NP	NP
167	TCGA-AY-5543-01	Tumour	LARGE INTESTINE	ENST00000263464	c.889G>C	p.G297R	COSMIC	NP	NP
168	TCGA-AY-6196-01	Tumour	LARGE INTESTINE	ENST00000263464	c.889G>T	p.G297C	COSMIC	NP	NP
169	TCGA-B5-A0JY-01	Tumour	ENDOMETRIUM	ENST00000263464	c.1060G>T	p.D354Y	COSMIC	NP	NP
170	TCGA-B5-A0K6-01	Tumour	ENDOMETRIUM	ENST00000263464	c.303C>T	p.S101S	COSMIC	NP	NP
171	TCGA-B5-A11E-01	Tumour	ENDOMETRIUM	ENST00000263464	c.505G>A	p.E169K	COSMIC	NP	NP
172	TCGA-BP-4161-01	Tumour	KIDNEY	ENST00000263464	c.163T>C	p.F55L	COSMIC	NP	NP
173	TCGA-BS-A0TD-01	Tumour	ENDOMETRIUM	ENST00000263464	c.1366C>A	p.Q456K	COSMIC	NP	NP
174	TCGA-BS-A0UV-01	Tumour	ENDOMETRIUM	ENST00000263464	c.1324+2T>C	p.?	COSMIC	NP	NP
175	TCGA-CA-6718-01	Tumour	LARGE INTESTINE	ENST00000263464	c.1690G>T	p.E564*	COSMIC	NP	NP
176	TCGA-CJ-4923-01	Tumour	KIDNEY	ENST00000263464	c.1327G>A	p.D443N	COSMIC	NP	NP
177	TCGA-CM-5868-01	Tumour	LARGE INTESTINE	ENST00000263464	c.367T>C	p.S123P	COSMIC	NP	NP
178	TCGA-D1-A103-01	Tumour	ENDOMETRIUM	ENST00000263464	c.1330T>G	p.L444V	COSMIC	NP	NP
179	TCGA-D1-A176-01	Tumour	ENDOMETRIUM	ENST00000263464	c.217C>T	p.L73L	COSMIC	NP	NP
180	TCGA-D5-6929-01	Tumour	LARGE INTESTINE	ENST00000263464	c.367T>C	p.S123P	COSMIC	NP	NP
181	TCGA-DK-A3IS-01	Tumour	URINARY TRACT	ENST00000263464	c.446G>C	p.R149T	COSMIC	NP	NP
182	TCGA-EI-6508-01	Tumour	LARGE INTESTINE	ENST00000263464	c.368C>T	p.S123L	COSMIC	NP	NP
183	TCGA-EW-A1PB-01	Tumour	BREAST	ENST00000263464	c.1536_1537delCT	p.L514fs*4	COSMIC	NP	NP
184	TCGA-F4-6808-01	Tumour	LARGE INTESTINE	ENST00000263464	c.368C>A	p.S123*	COSMIC	NP	NP
185	TCGA-G5-6235-01	Tumour	LARGE INTESTINE	ENST00000263464	c.368C>T	p.S123L	COSMIC	NP	NP
186	YUDUTY	Tumour	SKIN	ENST00000263464	c.505G>A	p.E169K	COSMIC	NP	NP
187	YUKIL	Tumour	SKIN	ENST00000263464	c.118C>T	p.P40S	COSMIC	NP	NP
188	ccRCC-80	Tumour	KIDNEY	ENST00000263464	c.1332delA	p.L444fs*3	COSMIC	NP	NP
189	pfg008T	Tumour	STOMACH	ENST00000263464	c.1462A>C	p.T488P	COSMIC	NP	NP
190	BC3	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000263464	c.1309G>A	p.E437K	COSMIC	PASSENGER/OTHER	BENIGN
191	BCPAP	Cell Line	THYROID	ENST00000263464	c.954-2A>G	p.?	COSMIC	NP	NP
192	BONNA12	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000263464	c.260A>C	p.K87T	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
193	CAL39	Cell Line	VULVA	ENST00000263464	c.405T>C	p.R135R	COSMIC	NP	NP
194	COLO824	Cell Line	BREAST	ENST00000263464	c.1262T>G	p.L421R	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
195	CTV1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000263464	c.309C>A	p.N103K	COSMIC	PASSENGER/OTHER	BENIGN
196	D247MG	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000263464	c.994C>T	p.R332C	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
197	EB2	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000263464	c.1082-4A>G	p.?	COSMIC	NP	NP
198	HCT15	Cell Line	LARGE_INTESTINE	ENST00000263464	c.601G>T	p.D201Y	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
199	HEC1	Cell Line	ENDOMETRIUM	ENST00000263464	c.504C>T	p.N168N	COSMIC	NP	NP
200	HT	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000263464	c.1492A>G	p.T498A	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
201	ISTMEL1	Cell Line	SKIN	ENST00000263464	c.405T>C	p.R135R	COSMIC	NP	NP
202	KPNYS	Cell Line	AUTONOMIC_GANGLIA	ENST00000263464	c.403C>T	p.R135C	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
203	L363	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000263464	c.1344G>A	p.R448R	COSMIC	NP	NP
204	LNCAPCLONEFGC	Cell Line	PROSTATE	ENST00000263464	c.905G>A	p.W302*	COSMIC	NP	NP
205	MESSA	Cell Line	SOFT_TISSUE	ENST00000263464	c.1646G>A	p.R549Q	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
206	MEWO	Cell Line	SKIN	ENST00000263464	c.687T>C	p.F229F	COSMIC	NP	NP
207	MFE319	Cell Line	ENDOMETRIUM	ENST00000263464	c.103A>G	p.T35A	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
208	MIAPACA2	Cell Line	PANCREAS	ENST00000263464	c.1210C>G	p.L404V	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
209	MMACSF	Cell Line	SKIN	ENST00000263464	c.1387C>T	p.P463S	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
210	MZ7MEL	Cell Line	SKIN	ENST00000263464	c.890G>A	p.G297D	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
211	NCIH1155	Cell Line	LUNG	ENST00000263464	c.1580-1G>A	p.?	COSMIC	NP	NP
212	NCIH1703	Cell Line	LUNG	ENST00000263464	c.1072G>T	p.E358*	COSMIC	NP	NP
213	NCIH1993	Cell Line	LUNG	ENST00000263464	c.1679G>T	p.C560F	COSMIC	CANCER	PROBABLY DAMAGING
214	NCIH2110	Cell Line	LUNG	ENST00000263464	c.1788G>T	p.K596N	COSMIC	CANCER	PROBABLY DAMAGING
215	NCIH720	Cell Line	LUNG	ENST00000263464	c.111C>T	p.S37S	COSMIC	NP	NP
216	NCISNU5	Cell Line	STOMACH	ENST00000263464	c.403C>T	p.R135C	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
217	PL21	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000263464	c.708A>C	p.E236D	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
218	RPMI8866	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000263464	c.895C>T	p.L299F	COSMIC	PASSENGER/OTHER	PROBABLY DAMAGING
219	SLVL	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000263464	c.1296_1299delAGAA	p.R434fs*12	COSMIC	NP	NP
220	SNGM	Cell Line	ENDOMETRIUM	ENST00000263464	c.1478G>C	p.R493T	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
221	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000263464	c.494C>G	p.A165G	COSMIC	PASSENGER/OTHER	BENIGN
222	SNU1040	Cell Line	LARGE_INTESTINE	ENST00000263464	c.773G>A	p.R258H	COSMIC	CANCER	PROBABLY DAMAGING
223	SNU182	Cell Line	LIVER	ENST00000263464	c.105G>C	p.T35T	COSMIC	NP	NP
224	SNU182	Cell Line	LIVER	ENST00000263464	c.1232G>A	p.R411K	COSMIC	PASSENGER/OTHER	BENIGN
225	SNU182	Cell Line	LIVER	ENST00000263464	c.49G>A	p.A17T	COSMIC	PASSENGER/OTHER	BENIGN
226	SNU81	Cell Line	LARGE_INTESTINE	ENST00000263464	c.476G>T	p.R159I	COSMIC	PASSENGER/OTHER	BENIGN
227	SUDHL1	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000263464	c.1607C>T	p.T536I	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING
228	SUDHL5	Cell Line	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	ENST00000263464	c.674A>G	p.H225R	COSMIC	CANCER	PROBABLY DAMAGING
229	SW1088	Cell Line	CENTRAL_NERVOUS_SYSTEM	ENST00000263464	c.435T>C	p.P145P	COSMIC	NP	NP
230	TGBC24TKB	Cell Line	BILIARY_TRACT	ENST00000263464	c.403C>T	p.R135C	COSMIC	PASSENGER/OTHER	POSSIBLY DAMAGING

*NP: Not Predicted

Tissue Type	Mean Expression Value	Median Expression Value	Mean CNV	Median CNV

AUTONOMIC GANGLIA	4.0644	3.9125	-0.2415	-0.1185
BILIARY TRACT	7.4471	6.9297	0.1386	0.0239
BONE	5.1193	4.7746	0.0761	-0.0018
BREAST	5.5779	4.8165	-0.0514	-0.0027
CENTRAL NERVOUS SYSTEM	6.2796	6.0834	-0.0897	-0.0787
ENDOMETRIUM	7.0430	7.3693	0.0044	-0.0087
HAEMATOPOIETIC AND LYMPHOID TISSUE	7.3676	7.1572	-0.0558	-0.007687
KIDNEY	9.3848	9.4159	-0.1745	-0.1612
LARGE INTESTINE	6.6847	6.35775	0.0800	0.0018
LIVER	6.7068	6.5733	-0.0337	0.01136
LUNG	6.7359	6.2968	0.1089	0.1252
OESOPHAGUS	6.4096	6.207	0.4137	0.3079
OVARY	7.3638	7.1486	0.2766	0.1634
PANCREAS	8.9134	9.3158	0.2905	0.2872
PLEURA	8.5746	8.9072	-0.1639	-0.1592
PROSTATE	6.4348	6.4643	0.0859	0.04605
SALIVARY GLAND	5.1707	5.1707	-0.4050	-0.405
SKIN	5.3139	4.9715	-0.2082	-0.1475
SMALL INTESTINE	4.8939	4.8939	-0.0067	-0.0067
SOFT TISSUE	5.1937	4.9736	-0.0156	-0.014875
STOMACH	6.9171	7.1432	0.2262	0.1871
THYROID	5.5276	4.9735	0.0040	-0.0025
UPPER AERODIGESTIVE TRACT	8.6613	8.7622	0.2260	0.20045
URINARY TRACT	7.0319	6.58675	0.1112	0.0499

Domain ID	Domain Name	Start Site	End Site	E-value
PF00653	BIR	32	97	1.1e-20
PF00653	BIR	172	235	5.4e-23
PF00653	BIR	258	322	2.8e-22
PF07223	DUF1421	346	401	0.79
PF00619	CARD	446	526	1.3e-19
PF10217	DUF2039	550	593	0.55
PF13920	zf-C3HC4_3	554	596	2.9e-15
PF00653	BIR	32	97	1.1e-20
PF00653	BIR	172	235	5.4e-23
PF00653	BIR	258	322	2.8e-22
PF07223	DUF1421	346	401	0.79
PF00619	CARD	446	526	1.3e-19
PF10217	DUF2039	550	593	0.55
PF13920	zf-C3HC4_3	554	596	2.9e-15

Domain ID	Start Site	End Site	E-value
0036727	249	336	5.23e-45
0036727	161	252	2.22e-32
0036727	21	112	1.31e-30
0045502	441	537	1.13e-21
0036727	249	336	5.23e-45
0036727	161	252	2.22e-32
0036727	21	112	1.31e-30
0045502	441	537	1.13e-21

S. No.	Position	Amino acid	Type	Description
1	11	S	Phosphorylation	Phosphoserine
2	211	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
3	7	S	Phosphorylation	Phosphoserine
4	11	S	Phosphorylation	Phosphoserine
5	211	K	Ubiquitylation	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
6	7	S	Phosphorylation	Phosphoserine

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
BIRC3	BIRC3	BIRC3	ENSP00000263464	Q13489
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
Q13489	BIRC3	ENSP00000263464	BIRC3	Q13489
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
BIRC3	ENSP00000263464	601721	Q13489	PA25360

Protein: BIRC3

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)

Modelled Structure	Structures available in PDB
	2UVL, 3EB5, 3EB6, 3M0A, 3M0D